scholarly journals Evaluation of corpora amylacea in refractory epilepsy

2020 ◽  
Vol 105 (105(810)) ◽  
pp. 103-107
Author(s):  
J. García-Fernández ◽  
M. M. García-Fernández ◽  
M. García-Fernández ◽  
C. J. Acal-González ◽  
R. García-del-Moral ◽  
...  
Keyword(s):  
Histological Analysis ◽  
Refractory Epilepsy ◽  
Age Of Onset ◽  
Clinical Parameters ◽  
Corpora Amylacea ◽  
Significant Evidence ◽  
Direct Association ◽  
Pas Staining ◽  
Hematoxylin Eosin

Objectives: The purpose of this study is to check whether there is or not a relationship between CoA density and different clinical parameters of the disease established. Compare the assessment of CoA with Hematoxylin-Eosin technique against PAS staining. It is also intended to check if it exists a relationship between hippocampal CoA density and Nestine overexpression. Methods: Histological analysis of 14 patients. For the counting of the CoA, raw scores were used interchangeably, as well as discretized values on a semi-quantitative scale according to Cherian et al. criteria. The modified Engel scale was used to measure post-surgical evolution. Results: The proportion of CoA in the hippocampus matches the proportion found in different studies: 64.3%. At α=0.05, there is significant evidence to observe that the counting is different depending on the type of staining used in the slides. The average number of CoA is higher with the PAS. It is seen that the density of CoA in the hippocampus and cortex is directly related to its density in parahypocampal structures. With regard to the relation between CoA density and age of onset, there are signs of significance. As well as in the post-surgical evolution. With regard to the duration of the crisis period, was found that both variables are independent. Finally, it is observed that there is a direct association between Nestine overexpression and hippocampal CoA density. Conclusion: In patients with Refractory Epilepsy (ER), CoA presence is commonly verified, with a better evaluation with PAS staining. Respectfully to the relation between CoA density and age of onset, there are signs of significance, as well as post-surgical evolution with the modified Engel scale. It would be convenient to continue with the investigations in this field to contrast the role of CoA in ER.

Effect of Neuroinflammation on ABC Transporters: Possible Contribution to Refractory Epilepsy

2018 ◽  
Vol 17 (10) ◽  
pp. 728-735 ◽  
Author(s):  
Xiaolin Deng ◽  
Yangmei Xie ◽  
Yinghui Chen
Keyword(s):  
Antiepileptic Drugs ◽  
Abc Transporters ◽  
Refractory Epilepsy ◽  
Vascular Endothelial Cells ◽  
Efflux Transporters ◽  
Vascular Endothelial ◽  
Intracellular Signalling Pathways ◽  
The Brain ◽  
Transporter Expression

Background & Objective: Epilepsy is a common and serious chronic neurological disorder that is mainly treated with antiepileptic drugs. Although current antiepileptic drugs used in clinical practice have advanced to the third generation, approximately one-third of patients are refractory to these treatments. More efficacious treatments for refractory epilepsy are therefore needed. A better understanding of the mechanism underlying refractory epilepsy is likely to facilitate the development of a more effective therapy. The abnormal expression and/or dysfunction of efflux transporters, particularly ABC transporters, might contribute to certain cases of refractory epilepsy. Inflammation in the brain has recently been shown to regulate the expression and/or function of ABC transporters in the cerebral vascular endothelial cells and glia of the blood-brain barrier by activating intracellular signalling pathways. Conclusion: Therefore, in this review, we will briefly summarize recent research advances regarding the possible role of neuroinflammation in regulating ABC transporter expression in epilepsy.

scholarly journals Role of SES on the association between childhood parental death and adulthood suicidal ideation: a mediation analysis using longitudinal dataset in South Korea

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jaehong Yoon ◽  
Ja Young Kim ◽  
Ji-Hwan Kim ◽  
Seung-Sup Kim
Keyword(s):  
Suicidal Ideation ◽  
South Korea ◽  
Mediation Analysis ◽  
Household Income ◽  
Parental Death ◽  
Middle Adulthood ◽  
Late Adulthood ◽  
Mediating Role ◽  
Direct Association

Abstract Background We sought to examine the association between childhood experience of parental death (CEPD) and adulthood suicidal ideation, and the mediating role of adulthood SES in the association. Methods We analyzed a nationally representative dataset of 8609 adults from the Korea Welfare Panel Study, which is a longitudinal cohort dataset in South Korea. CEPD was measured using a question: “During your childhood (0-17 years old), have you experienced the death of parents?” We classified responses of CEPD during 2006–2011 into ‘yes,’ and the others into ‘no.’ Suicidal ideation over the past year was assessed annually during 2012–2019. As a potential mediator, adulthood educational attainment and household income in 2011 were included in the analysis. Logistic regression was applied to examine the association of CEPD with adulthood suicidal ideation across age groups (early adulthood, 19–39 years old; middle adulthood, 40–59 years old; late adulthood, ≥60 years old), after excluding people who reported lifetime suicidal ideation in 2011. Causal mediation analysis using a parametric regression model was applied to examine the mediating role of adulthood SES in the association between CEPD and adulthood suicidal ideation. Results After adjusting for potential confounders including childhood SES, CEPD was significantly associated with adulthood suicidal ideation among the late adulthood group (OR: 1.43; 95% CI: 1.13–1.81), while the association was not statistically significant among the early; and middle adulthood groups. In mediation analysis of adulthood household income, both indirect association (ORNIE: 1.05; 95% CI: 1.02–1.09) and direct association (ORNDE: 1.37; 95% CI: 1.09–1.73) were statistically significant among the late adulthood group. In the mediation analysis of adulthood education attainment among the late adulthood, only a direct association was statistically significant (ORNDE: 1.43; 95% CI: 1.14–1.80). Conclusions These results suggest that CEPD could be a risk factor for adulthood suicidal ideation. Furthermore, the findings imply that income security policy might be necessary to reduce suicide among the late adulthood group.

scholarly journals Helminth Interactions with Bacteria in the Host Gut Are Essential for Its Immunomodulatory Effect

2021 ◽  
Vol 9 (2) ◽  
pp. 226
Author(s):  
Milan Jirků ◽  
Zuzana Lhotská ◽  
Lucia Frgelecová ◽  
Oldřiška Kadlecová ◽  
Klára Judita Petrželková ◽  
...  
Keyword(s):  
Protective Effect ◽  
Intestinal Inflammation ◽  
Hymenolepis Diminuta ◽  
Clinical Parameters ◽  
Th2 Response ◽  
Histological Changes ◽  
Immunological Markers ◽  
Bacterial Microbiota ◽  
Inflammatory Effect

Colonization by the benign tapeworm, Hymenolepis diminuta, has been associated with a reduction in intestinal inflammation and changes in bacterial microbiota. However, the role of microbiota in the tapeworm anti-inflammatory effect is not yet clear, and the aim of this study was to determine whether disruption of the microflora during worm colonization can affect the course of intestinal inflammation. We added a phase for disrupting the intestinal microbiota using antibiotics to the experimental design for which we previously demonstrated the protective effect of H. diminuta. We monitored the immunological markers, clinical parameters, bacterial microbiota, and histological changes in the colon of rats. After a combination of colonization, antibiotics, and colitis induction, we had four differently affected experimental groups. We observed a different course of the immune response in each group, but no protective effect was found. Rats treated with colonization and antibiotics showed a strong induction of the Th2 response as well as a significant change in microbial diversity. The microbial results also revealed differences in the richness and abundance of some bacterial taxa, influenced by various factors. Our data suggest that interactions between the tapeworm and bacteria may have a major impact on its protective effect.

The Diagnostic Validity of Paraphrenia

1992 ◽  
Vol 26 (1) ◽  
pp. 18-29 ◽  
Author(s):  
Anne M. Hassett ◽  
Nicholas A. Keks ◽  
Henry J. Jackson ◽  
David L. Copolov
Keyword(s):  
Old Age ◽  
Classification Systems ◽  
Historical Background ◽  
Psychotic Symptoms ◽  
Clinical Parameters ◽  
Diagnostic Validity ◽  
Separate Entity ◽  
Distinct Entity ◽  
Icd 10

It remains a matter of conjecture as to whether a schizophrenia-like syndrome commencing in old age differs from the early-onset disorder in any substantial way. This article reviews both the historical background to the concept of defining paraphrenia as a distinct entity, as well as the current controversies concerning whether it should remain a separate entity: the latter is important as paraphrenia has not been included in the DSM Ill-R and ICD 10 classification systems. Clinical parameters and aetiological factors relevant to an understanding of the syndrome are discussed under the rubrics of descriptive and construct validity. Of particular importance are the role of cerebral organic factors and the pathoplastic effect of the ageing process and how both interface with the development of psychotic symptoms. Whilst the course of this syndrome has been considered relatively benign, outcome studies have yet to establish consistent features that provide a basis to determine predictive validity.

Moses Gaster, Friedrich Horn and the Background to the Settlement of Samarin (1882)

2016 ◽  
Vol 92 (1) ◽  
pp. 27-51
Author(s):  
Maria Cioată
Keyword(s):  
Personal Account ◽  
Significant Evidence

This article presents a forgotten manuscript of a personal account of one of the first Jewish settlers who departed from Romania to Palestine in 1882 and helped found the colony of Samarin, which was later taken over by Baron de Rothschild and renamed Zichron Yaakov. Friedrich Horn, a schoolmaster with Austrian nationality who had settled in Romania fifteen years before his departure to Palestine, gave the manuscript of his unfinished work Nationaltraum der Juden to Moses Gaster. Gaster kept it among his collection of manuscripts. He considered it a diary rather than as Horn obviously had in mind, a contribution to historiography intended to be published. The text provides significant evidence concerning the underappreciated role of Jews from Romania in the historiography of Zionism.

scholarly journals The Effect of Octapeptide Repeats on Prion Folding and Misfolding

2021 ◽  
Vol 22 (4) ◽  
pp. 1800
Author(s):  
Kun-Hua Yu ◽  
Mei-Yu Huang ◽  
Yi-Ru Lee ◽  
Yu-Kie Lin ◽  
Hau-Ren Chen ◽  
...  
Keyword(s):  
Amyloid Fibrils ◽  
Age Of Onset ◽  
Prion Diseases ◽  
Critical Role ◽  
Threshold Effect ◽  
Central Feature ◽  
Terminal Domain ◽  
Amyloid Aggregates

Misfolding of prion protein (PrP) into amyloid aggregates is the central feature of prion diseases. PrP has an amyloidogenic C-terminal domain with three α-helices and a flexible tail in the N-terminal domain in which multiple octapeptide repeats are present in most mammals. The role of the octapeptides in prion diseases has previously been underestimated because the octapeptides are not located in the amyloidogenic domain. Correlation between the number of octapeptide repeats and age of onset suggests the critical role of octapeptide repeats in prion diseases. In this study, we have investigated four PrP variants without any octapeptides and with 1, 5 and 8 octapeptide repeats. From the comparison of the protein structure and the thermal stability of these proteins, as well as the characterization of amyloids converted from these PrP variants, we found that octapeptide repeats affect both folding and misfolding of PrP creating amyloid fibrils with distinct structures. Deletion of octapeptides forms fewer twisted fibrils and weakens the cytotoxicity. Insertion of octapeptides enhances the formation of typical silk-like fibrils but it does not increase the cytotoxicity. There might be some threshold effect and increasing the number of peptides beyond a certain limit has no further effect on the cell viability, though the reasons are unclear at this stage. Overall, the results of this study elucidate the molecular mechanism of octapeptides at the onset of prion diseases.

scholarly journals Informal networks and judicial decisions: Insights from the Supreme Court of the Philippines, 1986–2015

2018 ◽  
Vol 39 (5) ◽  
pp. 616-633 ◽  
Author(s):  
Björn Dressel ◽  
Tomoo Inoue
Keyword(s):  
Supreme Court ◽  
Political Influence ◽  
The Philippines ◽  
Informal Networks ◽  
Significant Evidence ◽  
Presidential Appointments ◽  
High Profile ◽  
Judicial Decisions ◽  
The Supreme Court

To what extent do informal networks shape the decisions of the Supreme Court of the Philippines? Though often raised in the Philippines, this question has never been studied empirically. To answer it, we constructed a set of social network variables to assess how informal ties, based on university connections and work affiliations, may have influenced the court’s decisions between 1986 and 2015 in 47 politically high-profile cases. Providing statistically significant evidence for the effects of political influence (presidential appointments) and hierarchical pressure (the vote of the Chief Justice) on related networks, our analysis suggests a continuing tension on the Supreme Court bench between professionalism and informality. Because the findings advance both theoretical and empirical understanding of larger issues at the intersection of courts and society throughout the region, we recommend more attention to the role of judicial networks, external to the courts as well as within them.

scholarly journals Histological analysis of the tongue, esophagus and crop of Southern Carcará (Polyborus plancus)

2021 ◽  
Vol 10 (2) ◽  
pp. e21410212439
Author(s):  
Vanessa Sobue Franzo ◽  
Leiny Paula de Oliveira ◽  
Ana Carolina Pôssas Viana ◽  
Adriano Tony Ramos ◽  
Jéssica Fernanda Bertolino ◽  
...  
Keyword(s):  
Digestive System ◽  
Histological Analysis ◽  
Squamous Epithelium ◽  
Eating Habits ◽  
Histological Study ◽  
Pekin Ducks ◽  
The Family ◽  
Body Weights ◽  
Stratified Squamous Epithelium ◽  
Hematoxylin Eosin

The Southern Caracara is a bird of prey, of the family Falconidae, inhabits all the Brazilian territory, they are omnivorous birds adapted for hunting. The digestive system of the predators presents differences in their morphology due to their eating habits. Knowing the importance of the gastrointestinal system, this study aims to carry out a histological study of the tongue, esophagus and the crop of Polyborus plancus. For this purpose, eight avian of both sexes, with different body weights and ages were used, they were euthanized and the organs were collected, fixed, dehydrated and stained with hematoxylin-eosin. It was noted that the tongue has stratified squamous epithelium with mucous glands and with different degrees of keratinization. The esophagus and crop have four well developed muscle layers and mucous glands. Additionally, in the crop there is presence of an adventitious layer that consists of loose connective tissue. We conclude that the tongue, the esophagus and the crop of the Southern Caracara have similar histological organization of several birds like the Pekin Ducks, ostriches, domestic chicken and partridges.

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