Evaluation of perilipin 2 and melanocortin 5 receptor serum levels with sebogenesis in acne vulgaris patients

BACKGROUND: Acne vulgaris is a chronic inflammatory skin disorder that commonly found in pilosebaceous units which can have an impact on the patient’s psychological burden. The relationship between dermatology and mental health is increasingly understood by the evidence shows that functional integrity and microbes in the gastrointestinal tract may play a role in mediating skin inflammation and emotional behaviour. The gut-brain-skin theory was first described in 1930 by Stokes and Pillsbury, became the basis of many current studies that look for clinical implications of the relationship between the gastrointestinal tract, brain and skin in acne vulgaris. Probiotics are live microorganisms which can provide a healthy effect to the hosts when consumed in adequate amounts. AIM: To determine the effect of oral probiotic on the interleukin-10 serum levels in acne vulgaris and also to determine the side effect of oral probiotic on acne vulgaris. METHODS: This is a pre-experimental clinical study with a pretest-posttest design involving 33 subjects with acne vulgaris. The subjects in this study were measured for IL-10 serum levels before and after oral probiotic was given for 30 days. This research has been approved by the Health Research Ethics Commission of the Faculty of Medicine, Universitas Sumatera Utara. RESULTS: This study found an increase in serum IL-10 levels after oral probiotic in acne vulgaris. The value of serum IL-10 levels before oral probiotic administration was 5.27 ± 1.49 pg/ml, while the value of serum IL-10 levels after oral probiotic administration was 6.19 ± 1.68 pg/ml) with p values obtained through Wilcoxon test was 0,0001 (p < 0.05). The side effect of oral probiotic found in this study is bloating that was found in 2 subjects within the first week using oral probiotic. CONCLUSION: Oral probiotic trigger elevated IL-10 serum levels of acne vulgaris. This study supports previous studies that suggested oral probiotic can be considered as adjuvant acne vulgaris therapy and its side effect is quite safe and tolerable.

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The Effect of Forkhead Box Class O1, Mammalian Target of Rapamycin Complex 1, Survivin, and Interleukin-17 on the Degree of Acne Vulgaris Based on Serum Levels

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2020.3522 ◽

2020 ◽

Vol 8 (B) ◽

pp. 401-407

Author(s):

Sri Yusfinah Masfah Hanum ◽

Ellyza Nasrul ◽

Nelva Karmila Jusuf ◽

Eti Yerizel

Keyword(s):

Acne Vulgaris ◽

Venous Blood ◽

Mammalian Target Of Rapamycin ◽

Serum Levels ◽

Statistical Test ◽

Target Of Rapamycin ◽

Observational Research ◽

Interleukin 17 ◽

Cross Sectional ◽

Forkhead Box

BACKGROUND: Acne vulgaris (AV) is a health problem that is routinely found throughout the world and has an impact on the quality of life of sufferers. Several studies have shown that forkhead box Class O1 (FoxO1), the mammalian target of rapamycin complex 1 (mTORC1), survivin, and interleukin-17 (IL-17) play a role in the pathogenesis of multifactorial AV. AIM: The study aims to determine the relationship between serum levels of FoxO1, mTORC1, survivin, and IL-17 with the severity of AV. METHODS: This is observational research with cross-sectional design. Samples from venous blood sufferers of AV mild, moderate, and severe, each of 20 people were colected. Classification of AV was based on the criteria of Lehmann et al. Examination of serum levels of FoxO1, mTORC1, survivin, and IL-17 using the ELISA technique was done. The statistical test used was the ANOVA test and the Kruskal–Wallis test. RESULTS: The results showed that average levels of FoxO1 decreased with increasing degree of severity of AV. An average increase in mTORC1, survivin, IL-17 levels with an increase in the severity of AV was found. Statistical test results showed a significant correlation of FoxO1, mTORC1, survivin levels, and the severity of AV (p < 0.05). IL-17 levels were not related to the severity of AV (p > 0.05). CONCLUSION: This study concluded that FoxO1 levels decrease at increasing severity. Conversely, levels of mTORC1, survivin, and IL-17 increase with increasing degrees of the severity of AV.

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Frequency of Helicobacter pylori infection in patients of acne vulgaris

10.53350/pjmhs211561411 ◽

2021 ◽

Vol 15 (6) ◽

pp. 1411-1414

Author(s):

Z. Khalid ◽

H. B. A. Kalhoro ◽

A. Ashraf ◽

H. Mughal ◽

K. Bukhsh ◽

...

Keyword(s):

Helicobacter Pylori ◽

Acne Vulgaris ◽

Serum Levels ◽

Cross Sectional Study ◽

Helicobacter Pylori Infection ◽

Pathology Laboratory ◽

Cross Sectional ◽

Dermatology Department ◽

H Pylori ◽

Very High

Background: Acne vulgaris is a common complaint throughout the world, contributing to both morbidity and healthcare costs. Helicobacter pylori (HP) infection is also a world heath problem, and recent evidence suggests that two conditions may be related. However, there is insignificant evidence to support a casual association of HP infection and acne vulgaris. Aim: To determine the frequency of helicobacter pylori infection in patients of acne vulgaris Study design: Descriptive, cross-sectional study. Settings and duration: Dermatology Department, Liaquat University of medical and health Sciences (LUMHS), Civil Hospital, Hyderabad from 22nd August 2017 to 21st February 2018 Methods: A total of 135 patients, 13 to 30 years of age of both genders with acne vulgaris were included in this study. Patients with H Pylori infection positive without acne vulgaris, family history helicobacter pylori infection, chronic smoker or alcoholics were excluded. Patients were subjected to relevant investigations i.e. HP antibody titer, for that blood sample of each patient was sent to institutional pathology laboratory for measuring of serum levels of anti H. Pylori IgG antibodies where each report was prepared by consultant pathologist. Results: Mean age was 23.33 ± 4.14 years. Out of these 135 patients, 48 (35.56%) were females and 87 (64.44%) were males with female to male ratio of 1:1.8. Frequency of helicobacter pylori infection in patients of acne vulgaris was seen in 107 (79.26%) patients. Conclusion: This study concluded that frequency of helicobacter pylori infection in patients of acne vulgaris is very high and these patients should be screened for helicobacter pylori infection Keywords: Acne, helicobacter pylori, association

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The association between low serum Vitamin B12 levels and hyperpigmentation on patients who use Isotretinonin

Volume 1, Issue 3 - Health Sciences Quarterly ◽

10.26900/hsq.1.1.04 ◽

2021 ◽

pp. 19-24

Author(s):

Sevim Baysak ◽

Ebru Karagun ◽

Havva Hilal Ayvaz

Keyword(s):

Drug Use ◽

Vitamin B12 ◽

Acne Vulgaris ◽

Serum Vitamin ◽

Serum Levels ◽

Skin Layer ◽

Oral Isotretinoin ◽

The Mean ◽

Relationship Of ◽

The Relationship

Objective: Oral isotretinoin is the most effective agent in the treatment of acne vulgaris. The risk of pigmentation due to the systemic isotretinoin may be associated with decrease in serum levels of Vit B12. The study aims to contribute to the literature by defining the association between the increase in pigmentation caused by oral isotretinoin [O-ISO] use and low vitamin B12 level [vit-B12]. Methods: In our study we evaluated 144 patients, who have facial acnes at medium degree according to FDA Acne Score and take O-ISO treatment with the dose 0.5 mg/ kg/ day for six months. The relationship of the vitamin B12 levels of the patients at the admission and 6th month and the existence of pigmentation at 6th month, the skin type and the skin layer at which the pigmentation occurs, was evaluated.Association of vit-B12 level on admission and six months post drug use with the presence of pigmentation at six months, the type of skin and the skin layer in which pigmentation occurs were evaluated. Results: In the group with pigmentation, the mean vit-B12 level after six months of drug use was statistically lower than the mean vit-B12 level on admission [p <0.001]. In patients with no pigmentation, difference between the mean levels of Vit-B12 levels was not statistically significant [p = 0,255]. Conclusion: As a result, it was determined that the mean vit-B12 level decreased due to O-ISO use and the association of hyperpigmentation and low vit-B12 level was statistically significant. Vit -B12 monitoring and supplementation, if necessary, can help us prevent hyperpigmentation that may occur during the treatment.

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Correlation of IL-8 and C - reactive protein Serum Levels with the Severity of Inflammatory Acne Vulgaris: a Comparative Study

ARC Journal of Dermatology ◽

10.20431/2456-0022.0101002 ◽

2016 ◽

Vol 1 (1) ◽

Keyword(s):

Comparative Study ◽

Acne Vulgaris ◽

Serum Levels ◽

C Reactive Protein ◽

Reactive Protein ◽

Protein Serum

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Evaluation of Serum Levels of High-Mobility Group Box 1 Protein in Acne Vulgaris

Benha Journal of Applied Sciences ◽

10.21608/bjas.2020.134417 ◽

2020 ◽

Vol 5 (1) ◽

pp. 1-4

Author(s):

A.A. Ibrahim ◽

R.M. Salem ◽

A.A. Hafez ◽

H.A.Abd Allah Abd Allah

Keyword(s):

Acne Vulgaris ◽

High Mobility ◽

Serum Levels ◽

High Mobility Group

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Serum levels of brain‐derived neurotrophic factor in patients with acne vulgaris

Journal of Cosmetic Dermatology ◽

10.1111/jocd.12940 ◽

2019 ◽

Vol 18 (6) ◽

pp. 1998-2003 ◽

Cited By ~ 4

Author(s):

Nancy W. Mikhael ◽

Ahmed M. Hamed ◽

Amira I. Mansour ◽

Eman S. Abdelrahman

Keyword(s):

Neurotrophic Factor ◽

Acne Vulgaris ◽

Serum Levels ◽

Brain Derived Neurotrophic Factor

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Clinical and Immunological Response to Doxycycline Versus Doxycycline Plus Vitamin C in Patients with Acne Vulgaris

International Journal of Pharmaceutical Quality Assurance ◽

10.25258/ijpqa.11.1.10 ◽

2020 ◽

Vol 11 (01) ◽

pp. 09-11

Author(s):

Zahraa I.J. Shubber ◽

Entisar J. Al Mukhtar ◽

Ifad K. Al-Shibly

Keyword(s):

Vitamin C ◽

Acne Vulgaris ◽

Serum Levels ◽

Enzyme Linked Immunosorbent Assay ◽

Control Group ◽

Significant Elevation ◽

Once Daily ◽

Severe Acne ◽

Tnf Α ◽

Ifn Γ

Objective: Study the influence of doxycycline versus doxycycline with vitamin C drugs in the management of acne vulgaris on some immunological parameters which include ( IL-1β, IL-8, IFN-γ, TNF-α, and TLR2) and the following objectives were adapted: 1-Selection of population for the study ( control, patients) groups and follow up the patients after one month of treatment, the first group receive doxycycline and the second group receive doxycycline with vitamin C,2- Blood samples collection and separation of serums for immunological analysis, 3- Statistical analysis. Methods: This study is a randomized clinical trial carried out in clinical dermatology in Merjan Medical City in Babylon from September 2018 to March 2019. The number of subjects enrolled in the present study was 60; their age was between (14- 30 years), among whom 30 were acne patients, the remaining 30 subjects were apparently healthy individuals, and they were served as control. A dermatologist diagnosed a total of 30 acne patients to having moderate to severe acne and divided into two groups (15 patients in each group). Patients in the first group were treated with doxycycline (100mg) once daily after meal for 30 days, while in the second group patients were treated with doxycycline (100mg) capsule once daily after a meal in combination with vitamin C (500mg) chewable tablets once daily. After 1-month of therapy, the response was evaluated clinically and immunologically by measure the concentration of pro-inflammatory cytokines (IL-8, IL-1β, IFN-γ, TNF-α) and ( TLR-2 ) by using enzyme-linked immunosorbent assay (ELISA) and the results were compared to their levels before treatment and that in the control group. Results: Significant elevation in the serum levels ( p ≤ 0.001) of immunological parameter IL-8, IL-1β, IFN-γ, TNF-α, and TLR-2 among acne patients in comparison to the control. The clinical response in the first group was good, moderate and poor in 5 (33%), 7(47%) and 3(20%) respectively, while in the second group was good, moderate and poor in 7 (47%), 7(47%) and 1(6%) respectively, the immunological results showed that the serum levels to the (IL-1β, IL-8, IFN-γ, TNF-α) and (TLR-2 ) were more reduced in the second group compared to their levels in the first group. Conclusion: Significant elevation (p less than 0.001) in the serum levels of (IL-8, IL-1β, IFN-γ, TNF-α, and TLR-2) among moderate to severe acne patients in comparison to control group. Clinically the combination of doxycycline plus vitamin C was more efficient as therapeutically in comparison to doxycycline alone. Immunologically doxycycline plus vitamin C was more effective in reducing serum levels of (IL-8, IL-1β, IFN-γ, TNF-α, and TLR-2) in comparison to doxycycline alone.

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Survivin as a Novel Biomarker in the Pathogenesis of Acne Vulgaris and Its Correlation to Insulin-Like Growth Factor-I

Disease Markers ◽

10.1155/2016/7040312 ◽

2016 ◽

Vol 2016 ◽

pp. 1-8 ◽

Cited By ~ 9

Author(s):

Hanan A. Assaf ◽

Wafaa M. Abdel-Maged ◽

Bakheet E. M. Elsadek ◽

Mohammed H. Hassan ◽

Mohamed A. Adly ◽

...

Keyword(s):

Growth Factor ◽

Acne Vulgaris ◽

Serum Levels ◽

Insulin Like Growth Factor ◽

Factor I ◽

Acne Scars ◽

Apoptosis Protein ◽

Wide Range ◽

Igf I ◽

Growth Factor I

Survivin, a member of the inhibitor of apoptosis protein family, has an important role in cell cycle regulation. Insulin-like growth factor-I (IGF-I) is a polypeptide hormone with wide range of biologic effects including stimulation of lipogenesis in sebaceous glands. Their overexpression in some fibrotic disorders suggests a possible implication of both IGF-I and survivin in the pathogenesis of acne and/or acne scars. The current study aimed to assess and correlate serum levels of IGF-I and survivin in patients with active acne vulgaris and postinflammatory acne scars and to evaluate their lesional expressions in comparison to healthy controls. Serum IGF-I and survivin were estimated using commercially available ELISA kits and their tissues expressions were investigated using Western blotting. Our findings suggest that IGF-I and survivin could play potential roles in the pathogenesis of active acne vulgaris and more importantly in postinflammatory acne scars with significant positive correlation coefficient between serum levels of IGF-I and survivin which support IGF-I-/PI3K-/AKT-mediated downregulation of nuclear expression of FoxO transcription factors resulting in enhanced survivin expression.

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