Features of menstrual function in women with infertility and thyroid gland pathology

2017 ◽  
pp. 40-44
Author(s):  
T.G. Romanenko ◽  
◽  
O. Chayka ◽  
Keyword(s):  
Menstrual Cycle ◽  
Thyroid Gland ◽  
Detection Rate ◽  
Comparison Group ◽  
Thyroid Diseases ◽  
Menstrual Function ◽  
Thyroid Pathology ◽  
Group I ◽  
Clinical Variants ◽  
Cycle Disorders

The objective: the identification of features of menstrual cycle disorders (DMC) in women with infertility on the background of thyroid diseases (thyroid gland). Patients and methods. According to the purpose of the scientific research, 50 women with infertility and NMCs were examined on the background of thyroid diseases, which were included in the main group (group I). In patients of the comparison group (group II; n= 30), DMC was observed without thyroid pathology. Patients of group I, depending on the type of HMC and thyroid functional status, were distributed as follows: 8 patients had hypomenstrual syndrome with hypothyroidism, 7 patients with hyperthyroidism and 17 patients with euthyroid goiter. In 4 patients, the DMC was diagnosed as a hyperpolymenorea with hypothyroidism, in 12 patients with hyperthyroidism and in 2 patients with euthyroidism. Results. Application of the developed algorithm of examination of women with infertility allowed to increase the detection rate of their combined pathology in the form of thyroid disorders and menstrual function disorders. Conclusion. Reliable in comparison with women with infertility with violations of the menstrual cycle, but without the pathology of the thyroid gland, changes and peculiarities of the secretion of the spectrum of the studied hormones that correspond to the clinical variants of the combined pathology were recorded in the group of women with infertility on the background of thyroid gland diseases and accompanying violations of the menstrual function. Key words: menstrual cycle disorders, thyroid pathology, infertility.

Aspects of reproductive health in women with small and large for gestational age birth weight

2016 ◽  
pp. 53-55
Author(s):  
N.S. Nestertsova ◽  
◽  
L.G. Nazarenko ◽  
Keyword(s):  
Body Weight ◽  
Birth Weight ◽  
Menstrual Cycle ◽  
Reproductive Health ◽  
Minimally Invasive ◽  
Gestational Age ◽  
Large For Gestational Age ◽  
Menstrual Function ◽  
Group I ◽  
The Relationship

The aim of the research was to determine the characteristics of menstrual function and the spectrum of disorders of reproductive health among women born with low weight and overweight. Materials and methods. The study included 122 healthy women of reproductive age, the city dwellers of the Eastern Ukraine, 53 (group I) of them were born weighing 2500 g or less, and 69 (group II) with body weight of 4000 g or more. To achieve this purpose conducted an anonymous survey and personal interviews. Were estimated characteristics of the formation of the menstrual function, its characteristics, the frequency of violation of menstrual cycle and the spectrum of pathology that requires medical, surgical or minimally invasive intervention. Results. This study determined the relationship of family history, perinatal development, the formation of the menstrual cycle and reproductive function in women with various deviations of body weight at birth. There was stated the relationship between weight at birth and fertility in the future. Were updated perinatal risk factors for female infertility. Were discovered the relationship between the deviation from normal body weight at birth and increased frequency of gynecological pathology, which require surgical or minimally invasive treatment, trigger factors for hormonal-metabolic disorders in the population of Eastern women. It was determined the necessity of a differentiated approach to medical care of women with different variants of the deviations of weight growth indicators at birth. Conclusion. Thus, the obtained data about the delay in sexual development and later about the high incidence of infertility in women who are born with low body weight are in agreement with the literature data, reflecting the parallelism of woman's ability to conceive, weight and growth parameters at birth. Key words: low birth weight, large for gestational age fetus, gynecological pathology, infertility.

scholarly journals ОСОБЛИВОСТІ МЕНСТРУАЛЬНОГО ЦИКЛУ ЖІНОК ФЕРТИЛЬНОГО ВІКУ, ЩО ЗАЗНАЛИ КОНТУЗІЇ ПІД ЧАС БОЙОВИХ ДІЙ

World Science ◽  
2021 ◽  
Author(s):  
Serbenuyk A. V. ◽  
Kaminskiy V. V.
Keyword(s):  
Menstrual Cycle ◽  
Women Veterans ◽  
The State ◽  
Reproductive Age ◽  
Stress Factors ◽  
Women Of Reproductive Age ◽  
Menstrual Function ◽  
Group I ◽  
Menstrual Irregularities ◽  
The Relationship

The article presents an analysis of literature data and the results of our own retrospective studies of the characteristics of the menstrual cycle in female combatants who have undergone concussion. Clinical and anamnestic factors have been identified that negatively affect the menstrual function of women of reproductive age, who received contusions during hostilities. The relationship between the state of mental health of women and menstrual irregularities has been established. Aim: to identify and evaluate changes in the menstrual function of women - veterans of reproductive age. Also, to establish the relationship between menstrual irregularities in women - veterans of reproductive age who have undergone contusion, and the state of their somatic and mental health.Materials and method: The research was conducted at the Department of Obstetrics, Gynecology and Reproductology of the National University of Health of Ukraine named after P.L. Shupika. To achieve this goal, a comprehensive clinical and laboratory examination was performed in 567 women of reproductive age (main group and comparison group) who participated in hostilities and suffered contusions, the average age of the subjects was 27.08 ± 4.23 years.The period of stay in the combat zone is 29.34 ± 9.21 months, the time from the moment of receiving a mild traumatic brain injury (contusion) is 18.8 ± 9.2 months. Group I - 399 fertile women who suffered contusions during the fighting with PKS. Group II - 168 women of childbearing age who suffered contusions during hostilities without PKS (mean age 32.21 ± 7.32 years).Results: The results of the studies revealed statistically significant deviations in the characteristics of the menstrual cycle of women who participated in hostilities who were injured with PKS, compared with women without PKS. It has been proven that women-viskovosluzhvits more often develop menstrual irregularities, namely a decrease or increase in the number, lengthening or shortening of the menstrual cycle by 7 days. Taking into account the revealed menstrual irregularities in the women under study, it can be argued that the detected changes are due to the influence of both craniocerebral trauma and stress factors associated with military service. This justifies the need to develop a program for monitoring and supporting the reproductive health of women-viyskovoservices, as well as medical and psychological rehabilitation of veterans, aimed at their full adaptation to a peaceful life.

scholarly journals A Disorder of Menstrual Function Regularization and its Influence on a Female Reproductive Potential

2017 ◽  
Vol 24 (3) ◽  
Author(s):  
Oksana Makarchuk ◽  
Volodymyr Dziombak
Keyword(s):  
Risk Factors ◽  
Menstrual Cycle ◽  
Pregnant Women ◽  
Luteal Phase ◽  
Comparison Group ◽  
Inflammatory Diseases ◽  
Main Group ◽  
The Body ◽  
Obstetric Complications ◽  
Menstrual Function

Obstetric complications in women of reproductive age are often the result of puberty disorders which remain underestimated and not taken into account in pregnancy monitoring programs in such patients, leading to an increase of habitual non-carrying of pregnancy and negative obstetric effects.The objective of the research is to carry out a comprehensive multivariate assessment of the disturbances of the body adaptive processes in teenage girls, taking into account the data of anamnesis regarding the specifics of menstrual function regularization during puberty, and to determine the main factors of complicated pregnancy in this category of patients.Materials and methods. To carry out the task, 110 pregnant women with a disorder of menstrual function regularizationhave been prospectively examined (the main group); the examination was performed at the preconception stage and in the periods of 6-12, 22-24 and 32-36 weeks of pregnancy. The comparison group consisted of 30 patients with a normal menstrual cycle. In order to identify risk factors and predict complications, the odds ratio (OR) and its 95% confidence interval were used.Results. Extragenital pathology plays a significant role in the formation of pathological course of puberty and obstetric complications; 87.27% ofsuch cases were demonstrated in our study. Among the disorders of the ovarian-menstrual cycle, the structural significance is characteristic to the failure of the luteal phase and anovulatory disorders (78.18% of cases). Gynaecologic pathology includes inflammatory diseases of the pelvic organs (35.45%), cervical background processes (41.66%), ovarian tumour lesions (21.81), and primary infertility(14.54%). The obtained results of the structure of pregnancy complications in patients of the main group show reproductive losses in early pregnancy (11.8%), subchorionic hematoma (28.18%) and the threat of late spontaneous abortion; these data are notedthree times more often than in the comparison group. Many cases of preeclampsia (28.18%), gestational anaemia in more than half of the observations, fetal distress during pregnancy (32.72%) and birth of children with a low weight (17.27%) are associated with the development of the primary placental dysfunction and pathology of vascular and thrombocytic component of haemostasis.Conclusions. Analysis of the obtained data confirmed that pregnant women with a disorder of menstrual function regularization in puberty are characterized by a significant number of complications during pregnancy and delivery, high rates of spontaneous abortions and missed miscarriages; all these factsshould be considered as potential risk factors. The key factors are the following: endocrine imbalance by type of oligomenorrhea and luteal phase deficiency (OR – 9.16; 2.21-23.24), inflammatory diseases of the genital tract, such as asymptomatic bacteriuria and bacterial vaginosis (OR – 14.26; 3.26-32.12), premature deliveryin past medical history, the risk of spontaneous miscarriages and subchorionic hematoma.

scholarly journals Thyroid diseases detection rate in screenings of the population of the Kherson region

1994 ◽  
Vol 40 (4) ◽  
pp. 13-14
Author(s):  
V. I. Yaroshenko ◽  
A. I. Golunov
Keyword(s):  
Thyroid Gland ◽  
Detection Rate ◽  
Clinical Medicine ◽  
Thyroid Diseases ◽  
The State ◽  
Steady Increase ◽  
Natural Consequence ◽  
Epidemiological Analysis ◽  
The Past ◽  
The World

In many regions of the world, regardless of the presence of iodine endemic, a steady increase in thyroid pathology has been recorded over the past three decades. Given the unfavorable environmental situation that is typical for most countries today, one can think that this trend will continue and problems of the state of the thyroid gland will take place among the most relevant and significant in modern clinical medicine. A natural consequence of this is the growing interest of scientists and practitioners of endocrinologists in the issues of early diagnosis and monitoring, the etiology and epidemiology of thyroid diseases. In this study, we assessed the state of the thyroid gland with the aim of epidemiological analysis of the frequency of various forms of goiter in 5423 people living in 18 districts of Kherson region.

scholarly journals Integrated ultrasound investigation and magnetic resonance tomography in the diagnosis of focal thyroid pathology

2012 ◽  
Vol 93 (3) ◽  
pp. 484-487 ◽  
Author(s):  
L A Timofeeva
Keyword(s):  
Magnetic Resonance ◽  
Thyroid Gland ◽  
Diagnostic Accuracy ◽  
Ultrasound Examination ◽  
Magnetic Resonance Tomography ◽  
Primary Diagnosis ◽  
Thyroid Diseases ◽  
Focal Lesions ◽  
Thyroid Pathology ◽  
Ultrasound Investigation

Aim. To determine the features an integrated ultrasound investigation and magnetic resonance tomography in the diagnosis of focal thyroid pathology. Methods. Integrated ultrasound examination was conducted in 1440 patients with focal lesions of the thyroid gland at the age of 17-76 years, and magnetic resonance tomography was performed in 91 patients (65 females and 26 males). Results. It was established that the informativeness of the ultrasound investigation is characterized by the following parameters: sensitivity - 92.1%, specificity - 78.6%, and diagnostic accuracy - 90.3%; the informativeness of magnetic resonance tomography: sensitivity - 94.1%, specificity - 89.6 %, and diagnostic accuracy - 91.0%. Conclusion. Integrated use of ultrasound investigation and magnetic resonance tomography significantly increases the informativeness during primary diagnosis of focal thyroid diseases.

scholarly journals Characteristics of Puberty Period in Adolescent Girls and Major Risk Factors of Menstrual Function Disorders Against the Background of Endemic Goiter

2020 ◽  
Vol 27 (2) ◽  
pp. E202029
Author(s):  
Svitlana Hafiichuk
Keyword(s):  
Risk Factors ◽  
Menstrual Cycle ◽  
Thyroid Gland ◽  
Adolescent Girls ◽  
Iodine Deficiency ◽  
Premenstrual Syndrome ◽  
Thyroid Dysfunction ◽  
Endocrine Disorders ◽  
Menstrual Disorders ◽  
Menstrual Function

Disorders of menstrual function are often the result of thyroid dysfunction and disorders of the neuroendocrine regulation, initiated by iodine deficiency, and are the most destructive in puberty period. The objective of the study was to clarify the peculiarities of establishment of menstrual function and the degree of interaction between the hypothalamic-pituitary-ovarian system and thyroid gland against the background of iodine deficiency in adolescence. Materials and methods of research. Analytical analysis of medical records and sociomedical audit were carried out by interviewing 490 girls of puberty age, the purpose of which was to estimate the prevalence of thyroid dysfunction and possible factors of development of menstrual disorders. Results of the study and their discussion. The proportion of thyroid dysfunction in adolescent girls is quite significant; hypofunction was diagnosed 3.4 times more frequent than its increased activity. Less than half of the studied had regular menstrual cycle, while girls with thyroid dysfunction suffered much more often from menstrual dysfunction in the form of hypomenstrual syndrome (1.5-fold, p<0.05), algodismenorrhea (1.6-fold, p<0.05) and amenorrhea (1.4-fold, p<0.05), premenstrual syndrome and anovulatory conditions associated with polycystic ovary syndrome. Such somatic diseases as neuro-vegetative dysfunction, diseases of the gastrointestinal tract, chronic tonsillitis, frequent lacunar angina and acute respiratory viral diseases are common. Clinical manifestations included symptoms of thyroid hypofunction, androgen-associated dermopathy, hirsutism syndrome, and concomitant endocrine-associated pathology of the mammary glands (mastalgia, mastopathy, and galactorrhea). Conclusions. The burden of perinatal history, the presence of thyroid pathology and other manifestations of metabolic and endocrine disorders in first-degree relatives are unfavourable prognostic factors of disorders of the menstrual cycle against the background of thyroid dysfunction. The findings obtained allow us to determine the leading risk factors for problematic menstruation establishment and menstrual disorders, especially when combined with thyroid dysfunction. Hypomenstrual syndrome and algodysmenorrhea, as well as manifestations of premenstrual syndrome and anovulatory cycles, belong to major disorders of the menstrual cycle in case of thyroid gland dysfunction.

scholarly journals SOME DISCUSSION ISSUES OF THE HYPOTHYROIDISM PROBLEM

2021 ◽  
Vol 19 (4) ◽  
Author(s):  
P.M. Lіаshuk ◽  
R.P. Lіаshuk ◽  
I.V. Skhodnуtskуi
Keyword(s):  
Menstrual Cycle ◽  
Thyroid Gland ◽  
Significant Role ◽  
Subclinical Hypothyroidism ◽  
Clinical Observation ◽  
Reproductive Function ◽  
Metabolic Changes ◽  
Cycle Disorders ◽  
Criteria For Diagnosis

The notion “subclinical hypothyroidism”, its significance in the genesis of metabolismdisorders, debatable approaches to the treatment as well as the role of the thyroidgland hypofunction in pathogenesis of the menstrual cycle disorders and infertility onthe example of the own clinical observation is given in the article.Objective – to designate the criteria for diagnosis and approaches to the treatmentof subclinical hypothyroidism, as well as to confirm the role of the manifestedhypothyroidism in the pathogenesis of the reproductive function disorders in women.Conclusions. 1. The thyroid gland hypofunction plays a significant role in the genesisof metabolic changes and development of the menstrual cycle disorders, galactorrheaand infertility. 2. The problem of hypothyroidism in general and, subclinicalhypothyroidism, in particular, requires further study in order to reduce the risk ofmetabolic diseases development.

THYROID PATHOLOGY IN CHILDREN WITH TYPE 1 DIABETES

Vestnik ◽  
2021 ◽  
pp. 107-111
Author(s):  
С.И. Сабирова ◽  
С.Г. Надырова ◽  
А.Б. Жанзак ◽  
А.Е. Манасбаева ◽  
Ж.Ж. Нургалиева
Keyword(s):  
Type 1 Diabetes ◽  
Thyroid Gland ◽  
Thyroid Function ◽  
Thyroid Dysfunction ◽  
Development Indicators ◽  
Clinical Hospital ◽  
Number Of Children ◽  
Thyroid Pathology ◽  
Number Of Patients

Целью научной работы является изучение структуры заболеваний щитовидной железы у больных сахарным диабетом 1 типа. В данной статье мы ретроспективно проанализировали 972 историй болезни больных детей с СД 1 типа, находившихся на стационарном лечении в ДГКБ №2 г. Алматы (Казахстан) в период с 2014 по 2019 гг. Были изучены и оценены показатели физического развития, объективные данные (кожные покровы, ЧСС, АД, пальпация ЩЖ), лабораторно - уровней гормонов ТТГ, свТ4, свТ3, а/т к ТПО, а/т к ТГ в сыворотки крови, инструментально - УЗИ ЩЖ. Всего за 2014-2019 гг. через отделение эндокринологии ДГКБ №2 прошли 972 детей с диагнозом СД 1 типа. Большинство детей (382 человек, 79,9%) имели стаж болезни СД до 5 лет. 88 детей (18,5%) со стажем от 5 до 10 лет, 8 человек (1,7%) страдали СД более 10 лет. СД1 в основном был диагностирован в возрасте 7-12 лет (245-51,3%), меньше всего выявили СД 1 типа у детей до 3 лет (21 - 4,4%). Из общего количества пациентов с СД1 (972) было обследовано на функцию ЩЖ 478 детей (49,2%). Среди них было выявлено 319 детей с дисфункцией ЩЖ, что составляет 66,7%. Так, за 2014 год из 92 детей - 7 (7,6%), обследованных на функцию щитовидной железы, в результате чего было выявлено 6 (85,7%) детей с дисфункцией щитовидной железы. С каждым годом росло количество детей, которых направляли на обследование ЩЖ, так в сравнении с 2014 годом, когда из 92 детей - 7 (7,6%) были обследованы на функцию щитовидной железы, в 2019 году были обследованы уже 222 (92,1%) детей из 241. Симптомы как гиперфункции, так и гипофункции ЩЖ, особенно их субклинические варианты протекают под маской других заболевании и не сразу обнаруживаются, исходя из этого следует сразу обследовать на функцию ЩЖ при поступлении и в дальнейшим их наблюдать в динамике. В ходе исследования дисфункция щитовидной железы диагностирована у 319 (67,7%) пациентов, что должно привлечь внимание не только эндокринологов, но и врачей общей практики, педиатров и настроить их на прицельный поиск этой патологии и своевременную коррекцию гипотиреоза или другой патологии ЩЖ при его наличии The purpose of this research is to study the structure of thyroid diseases in patients with type 1 diabetes. In this article, we retrospectively analyzed 972 case histories of sick children with type 1 diabetes who were treated in the children's city clinical hospital No. 2 in Almaty (Kazakhstan) in the period from 2014 to 2019. Physical development indicators, objective data (skin, heart rate, blood pressure, thyroid palpation), laboratory levels of TSH, thyroxine, triiodothyronine, antibodies to thyroperoxidase, antibodies to thyroglobulin in blood serum, instrumental ultrasound examination of the thyroid gland were studied and evaluated. In total, in 2014-2019, 972 children with a diagnosis of type 1 diabetes mellitus passed through the endocrinology Department of the children's city clinical hospital No. 2.The majority of children (382 people, 79.9%) had a history of diabetes up to 5 years. 88 children (18.5%) with experience from 5 to 10 years, 8 people (1.7%) had diabetes for more than 10 years. Type 1 diabetes was mainly diagnosed at the age of 7-12 years (245-51. 3%), the least detected type 1 diabetes in children under 3 years (21 - 4.4%). Out of the total number of patients with type 1 diabetes (972), 478 children (49.2%) were examined for thyroid function. Among them, 319 children with thyroid dysfunction were identified, which is 66.7%. So, in 2014, out of 92 children, 7 (7.6%) were examined for thyroid function, as a result of which 6 (85.7%) children had thyroid dysfunction. Every year, the number of children referred for thyroid examination increased, so compared to 2014, when out of 92 children - 7 (7.6%) were examined for thyroid function, in 2019, 222 (92.1%) children out of 241 were examined. Symptoms of both hyperfunction and hypofunction of the thyroid gland, especially their subclinical variants, occur under the guise of other diseases and are not immediately detected, so you should immediately investigate the function of the thyroid gland at admission and further observe them in dynamics. During the study, thyroid dysfunction was diagnosed in 319 (67.7%) patients, which should attract the attention of not only endocrinologists, but also General practitioners, pediatricians and set them up for a targeted search for this pathology and timely correction of hypothyroidism or other thyroid pathology if it is present.

PECULIARITY OF ADAPTATION OF BABIES ARE BORN PREMATURELY FROM MOTHERS WITH UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA

2021 ◽  
Vol 74 (10) ◽  
pp. 2566-2568
Author(s):  
Tunzala V. Ibadova ◽  
Vitalii V. Maliar ◽  
Volodymyr V. Maliar ◽  
Vasyl V. Maliar
Keyword(s):  
Connective Tissue ◽  
Premature Infants ◽  
Distress Syndrome ◽  
Comparison Group ◽  
Clinical Manifestations ◽  
Main Group ◽  
Phenotypic Markers ◽  
Group I ◽  
Neonatal Respiratory Distress ◽  
Connective Tissue Dysplasia

The aim: To evaluate the peculiarity of clinical manifestations of neonatal respiratory distress syndrome (NRDS) in deeply premature infants from mothers with phenotypic markers of undifferentiated connective tissue dysplasia (UCTD). Materials and methods: The study represent the results of a retrospective clinical and statistical analysis of 268 premature birth report card and newborn report sheet. .The main (1 group) included 50 pregnants with obvious phenotypic markers of UCTD, the comparison group (group 2) consisted of 50 pregnant women without phenotypic markers of UDCTD. Results: According to the study, in 12 (24%) pregnant women of the main group at the time of admission to the clinic had contractions,which required specific therapy. Cervical cerclage was performed in 38 (76%) patients of the main group due to the presence of cervical insufficiency (CI). In these cases, the severity of the CI on the Steinber scale was 7.2 &#177; 0.4 points in the main group against 4.4 &#177; 0.2 points in the comparison group (p &#60;0.05). Group I patients were more likely to have complications of labor such as:premature rupture of membranes, uterine contraction abnormalities and fetal distress, which required in most cases cesarean delivery (7% and 2%), respectively (p &#60;0.05). The incidence of neonatal complications requiring respiratory support was 67% in group I and 48% in group II. According to our observations, the clinical manifestations of bronchopulmonary dysplasia were twice as high in infants of the main group (66%) against (44%) of the comparison group (p &#60;0.05). Conclusions:1.Neonatal respiratory distress syndrome in premature infants is more often associated from mothers with UDCTD. 2. The high importance of steroid prophylaxis of NRDS and antioxidant therapy in reducing the frequency of mechanical ventilation and the development of bronchopulmonary pathology, especially in infants from mothers with UDCTD syndrome, has been proven. 3. The possibility of diagnosing disorders of functional maturation of the lungs in the fetal period using a non-invasive method of ultrasonography has been confirmed.

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