scholarly journals A Disorder of Menstrual Function Regularization and its Influence on a Female Reproductive Potential

2017 ◽  
Vol 24 (3) ◽  
Author(s):  
Oksana Makarchuk ◽  
Volodymyr Dziombak
Keyword(s):  
Risk Factors ◽  
Menstrual Cycle ◽  
Pregnant Women ◽  
Luteal Phase ◽  
Comparison Group ◽  
Inflammatory Diseases ◽  
Main Group ◽  
The Body ◽  
Obstetric Complications ◽  
Menstrual Function

Obstetric complications in women of reproductive age are often the result of puberty disorders which remain underestimated and not taken into account in pregnancy monitoring programs in such patients, leading to an increase of habitual non-carrying of pregnancy and negative obstetric effects.The objective of the research is to carry out a comprehensive multivariate assessment of the disturbances of the body adaptive processes in teenage girls, taking into account the data of anamnesis regarding the specifics of menstrual function regularization during puberty, and to determine the main factors of complicated pregnancy in this category of patients.Materials and methods. To carry out the task, 110 pregnant women with a disorder of menstrual function regularizationhave been prospectively examined (the main group); the examination was performed at the preconception stage and in the periods of 6-12, 22-24 and 32-36 weeks of pregnancy. The comparison group consisted of 30 patients with a normal menstrual cycle. In order to identify risk factors and predict complications, the odds ratio (OR) and its 95% confidence interval were used.Results. Extragenital pathology plays a significant role in the formation of pathological course of puberty and obstetric complications; 87.27% ofsuch cases were demonstrated in our study. Among the disorders of the ovarian-menstrual cycle, the structural significance is characteristic to the failure of the luteal phase and anovulatory disorders (78.18% of cases). Gynaecologic pathology includes inflammatory diseases of the pelvic organs (35.45%), cervical background processes (41.66%), ovarian tumour lesions (21.81), and primary infertility(14.54%). The obtained results of the structure of pregnancy complications in patients of the main group show reproductive losses in early pregnancy (11.8%), subchorionic hematoma (28.18%) and the threat of late spontaneous abortion; these data are notedthree times more often than in the comparison group. Many cases of preeclampsia (28.18%), gestational anaemia in more than half of the observations, fetal distress during pregnancy (32.72%) and birth of children with a low weight (17.27%) are associated with the development of the primary placental dysfunction and pathology of vascular and thrombocytic component of haemostasis.Conclusions. Analysis of the obtained data confirmed that pregnant women with a disorder of menstrual function regularization in puberty are characterized by a significant number of complications during pregnancy and delivery, high rates of spontaneous abortions and missed miscarriages; all these factsshould be considered as potential risk factors. The key factors are the following: endocrine imbalance by type of oligomenorrhea and luteal phase deficiency (OR – 9.16; 2.21-23.24), inflammatory diseases of the genital tract, such as asymptomatic bacteriuria and bacterial vaginosis (OR – 14.26; 3.26-32.12), premature deliveryin past medical history, the risk of spontaneous miscarriages and subchorionic hematoma.

scholarly journals The СYP24A gene expression the placental tissue during pregnancy

2016 ◽  
Vol 65 (6) ◽  
pp. 61-67
Author(s):  
Ekaterina S Shelepova ◽  
Olga A Freylikhman ◽  
Nikita R Riabokon ◽  
Daria A Zhebrun ◽  
Anna A Kostareva ◽  
...  
Keyword(s):  
Gene Expression ◽  
Risk Factors ◽  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Placental Tissue ◽  
Normal Pregnancy ◽  
Main Group ◽  
The Body ◽  
Leningrad Region

Aim. To study the nature of CYP24A1 gene expression in the placental tissue in women with different saturation of the body with vitamin D during normal pregnancy and preeclampsia.Materials and methods. Cohort retrospective and prospective study. There were examined 110 pregnant women in Saint Petersburg and Leningrad region, who took multivitamin complex containing 400 IU of vitamin D from 12 weeks of pregnancy. Time of inclusion is from September to June. All pregnant women were taken blood samples with the following determination of the level of 25-hydroxycalciferol, fragments of placental tissue with the following study of mRNA expression of CYP24A1 gene.Results. There were analyzed two groups of pregnant women. During the analysis of the saturation level of the body with vitamin D there were revealed the following things: the frequency of vitamin D deficiency in the main group was 69.6% in the group of comparison vitamin D deficiency was not found. The frequency of vitamin D insufficiency in the main group was 21.5% in the group of comparison – 18.5%. The frequency of the normal level of vitamin D in the main group was 8.9% in the group of comparison – 81.5%. Differences between the main group and the group of comparison are reliable (p < 0,0001). There revealed a statistically significant increase of the relative expression of mRNA of CYP24A1 gene in the placental tissue in women with preeclampsia (31,8 ± 20,6), in comparison with women with physiological pregnancy (11,2 ± 17,9) (p = 0.03)Conclusion. In women with preeclampsia low level of vitamin D in blood serum (less than 30 ng/ml) is 5 times more common, that is why insufficiency and deficiency of vitamin D in pregnant women can be attributed to risk factors for the development of preeclampsia. Expression of mRNA of CYP24A1 gene in placental tissue in patients with preeclampsia is three times higher in comparison with patients with a normal pregnancy. Thus, the increased expression of CYP24A1 gene in the placental tissue can be considered as one of the risk factors for the development of preeclampsia.

scholarly journals Особливості поширеності та клінічного перебігу генералізованого пародонтиту початкового та І ступенів у вагітних жінок на тлі залізодефіцитної анемії

2018 ◽  
Author(s):  
O. H. Boychuk-Tovsta
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Iron Deficiency Anemia ◽  
Comparison Group ◽  
Periodontal Diseases ◽  
Main Group ◽  
The Body ◽  
Deficiency Anemia ◽  
Initial Degree ◽  
Comparison Groups

Summary.The attention of scientists attracts the task of preserving the health of the mother and the fetus in general, as well as studying the oral cavity during pregnancy, in order to prevent the formation of a «dental chroniospermic hearth». The issue of dental morbidity in pregnant women with somatic pathology remains relevant. This is due to many factors, in particular: a significant prevalence of periodontal diseases among the population, an increase in the frequency of extragenital diseases in pregnant women, the influence of infection on the body of the pregnant woman and the fetus. Frequent complications of pregnancy are iron deficiency anemia (IDA), which ranks first among all the complications of the gestation period.The aim of the study – to learn the prevalence and peculiarities of the clinical course of generalized periodontitis of primary and grade I in pregnant women on the background of IDA.Materials and Methods. For solving our tasks, we examined 352 women in the 2nd–3rd trimester of pregnancy at the age of 18–35 years. The original form of generalized periodontitis were observed in 141 individuals with iron deficiency anemia medium and light that formed the core group. The comparison group comprised 98 pregnant women with generalized periodontitis of primary and grade I without concomitant iron deficiency anemia.Results and Discussion. According to research results, the main group generalized periodontitis initial degree met in (43.97±4.18) % of the patients, which was 1.3 times less than in the comparison group. However, the number of cases of generalized periodontitis of the 1st degree in the main group exceeded 1.4 times the similar indicator of the comparison group with values (59.18±4.96) % and (40.82±4.96) % respectively. At the age of 18–26 years, generalized periodontitis of primary level was diagnosed in 1.4 times less than in the surveyed comparison group (48.05±5.69) % vs. (67.92±6.41) %. In the age range of 27–35 years in the main group, generalized periodontitis of initial degree was registered in (39.06±6.10) % of the examined, which was 1.3 times lower than that of the comparison group (48.89±7.45) %. Generalized periodontitis of the degree 1 in patients of the main group aged 18–26 years was recorded in (51.95±5.69)% of the surveyed, which significantly exceeded this index of the comparison group by 1.6 times (32.07±6.41) %. With the increase in age to 27–35 years, the number of cases of generalized periodontitis of the degree 1 in the main group exceeded the similar number of comparison groups in 1.2 times: (60.93±6.10) % and (51.11±7.45) % respectively. In the main group at the age of 18–26, the number of cases of generalized periodontitis degree 1 was insignificantly higher than the number of diagnosed generalized periodontitis of initial degree: (51.95±5.69) % versus (48.05±5.69) %, respectively. However, in the age interval 27–35 years degree generalized periodontitis and generalized periodontitis prevailed entry level 1.6 times. The analysis of objective symptoms of the course of generalized periodontitis in the patients of the study groups showed that in pregnant women with iron deficiency anemia, the clinical picture of GP was significantly more pronounced than in women with uncomplicated pregnancy. In the main group, the expressive (63.12 %) bleeding gums in 1.8 times prevailed in the comparator group (35.71 %). Moderate bleeding in the main group was 1.8 times less (36.88 %) than in the comparison group (64.29 %). 66.67 % of the surveyed main group, against 40.82 % of the comparison group, pointed out the tenderness of the gums. The absence of pain in the gums was noted by 33.33 % of the patients with IDA and 59.18 % of the comparison groups under study. In pregnant women of the main group, severe hyperemia of the gums was 1.5 times more frequent compared to the comparison group (65.25 % versus 43.88 %, respectively). At the same time, a slight redness of gums determined 1.6 times more often in women without pregnancy complications than pregnant women with IDA (56.12 % vs. 34.75 %, respectively).Conclusions. Thus, as a result of the analysis of the parodontium tissue condition found that prevalence, intensity and expressiveness of clinical symptoms of generalized periodontitis were significantly higher in pregnant women compared to women with generalized periodontitis without complications of pregnancy. This fact indicates the negative effect of iron deficiency like physical disease, periodontal status in pregnant women.

scholarly journals Hormonal and ultrasound features of formation of feto-placental complex in women with beneficial tumours of the uterus

2019 ◽  
pp. 184-190
Author(s):  
E. F. Khamidullina ◽  
L. Yu. Davidyan ◽  
D. R. Kasymova ◽  
A. Yu. Bogdasarov
Keyword(s):  
Pregnant Women ◽  
Ultrasound Imaging ◽  
Comparison Group ◽  
Clinical Manifestations ◽  
Uterine Fibroids ◽  
Genetic Mutation ◽  
Main Group ◽  
Biochemical Tests ◽  
Almost All ◽  
Ultrasound Features

The purpose and objectives of the study is to identify the hormonal, biochemical and ultrasound features of the gestation course in women with beneficial tumours of the uterus. Results. We conducted a complete clinical examination and prospective observation of 182 pregnant women. Of which, 98 puerperas with a verified diagnosis of uterine fibroids and/or endometriosis, which developed before gestation, but did not prevent the onset of pregnancy, were included into the main group. The comparison group included 84 women with physiological pregnancy. The studies showed that 14 pregnant women in the main group had C677T (Ala222Val) T/T mutation, while only 2 women in the comparison group had a decrease in enzyme activity due to genetic mutation. Accordingly, the homocysteine level was almost 3 times lower in the comparison group than in the main group. The women with hyperhomocisteinemia (HHC) and uterine fibroid in the main group showed the lowest estriol level and hCG level, while women without HHC had higher estriol level and hCG levels. It was found that almost all patients with HHC had subclinical hypothyroidism. Ultrasound imaging and biochemical tests at the beginning of the 2nd trimester: no ultrasound markers of fetal anomalies were identified in women from both groups; however, signs of retrochorial hematoma were detected in 57 women from the main group, which was confirmed by clinical manifestations and previous ultrasound imaging in earlier gestation periods. Conclusion. Thus, placenta formation in women with HHC and uterine fibroids is accompanied by relative hormonal insufficiency, which is clinically manifested as a threat of miscarriage in the early stages, but carrying a child is possible due to appropriate management of a patient as part of the preserving therapy. However, the issue of preventing the development of fetoplacental insufficiency is a valid one for further investigation.

scholarly journals Ocular Risk Factors in the Primary Formation of Diabetic Macular Edema in Patients with Type 2 Diabetes Mellitus

2019 ◽  
Vol 16 (2) ◽  
pp. 225-229
Author(s):  
M. V. Pshenichnov ◽  
O. V. Kolenko ◽  
E. L. Sorokin ◽  
Ya. E. Pashentcev
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Macular Edema ◽  
Comparison Group ◽  
Mean Value ◽  
Main Group ◽  
The Mean

Purpose. Revealing of the ocular risk factors in the formation of diabetic macular edema (ME) in type 2 diabetes mellitus (DM2).Patients and methods. A 3.5-year research of 80 patients (160 eyes) with DM2 without signs of ME at the beginning of the research was performed. The main group consisted of 46 patients with ME symptoms on one or both eyes during the research period, the comparison group included 34 patients without ME symptoms to the end of the research. The initial ocular characteristics were retrospect compared in groups.Results. The mean value of the axial lengths (AL) in the eyes of the main group was 23.12 ± 0.75 mm compared to 23.82 ± 0.62 mm in the comparison group (significant difference, p < 0.01). AL was less than 23.5 mm in 66 % of the eyes in the main group and only in 22 % of the eyes in the comparison group (p < 0.01). The mean value of the initial macular retina volume in the main group was significantly higher than in the comparison group — 7.51 ± 0.22 mm3 and 7.21 ± 0.12 mm3, respectively (p < 0.01). Initial background diabetic retinopathy (DR) was noted in 73 % of the eyes in the main group, which significantly differed from the comparison group, where this index was noted only in 13 % of the eyes (p < 0.01).Conclusion. Significant ocular risk factors for the formation of ME in patients with DM2 are: the initial macular retina volume more than 7.3 mm3, the value of the AL less than 23.5 mm; the initial background DR. The use of the detected morphometric parameters of eye and retina in combination with an adequate assessment of the risk factors in human organism makes it possible to assume with high degree of probability a high risk of the primary formation of diabetic ME in patients with DM2. 

scholarly journals Cutaneous Manifestations of Zika in Peru

2019 ◽  
Vol 24 (1) ◽  
pp. 33-40
Author(s):  
Willy Ramos ◽  
Miguel Luna ◽  
Tania Alarcón ◽  
Gerardo Jiménez ◽  
Jesús Díaz ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Lupus Erythematosus ◽  
Viral Infections ◽  
Inflammatory Diseases ◽  
Maculopapular Rash ◽  
Medical Advice ◽  
The Body ◽  
Cutaneous Manifestations ◽  
Primary Care Health ◽  
Care Health

This article aims to describe the cutaneous manifestations observed in the Zika epidemic in Peru during 2016 and 2017, as well as discuss the potential differential diagnoses. During the outbreak, the main reason for seeking medical advice was the development of a pruriginous maculopapular rash with a marked papular component, which started on the chest and later generalized to the rest of the body. Similar manifestations were noted in adults, children, and pregnant women. Other manifestations such as conjunctivitis, edema, or petechiae on the palate were rare. We suggest that in areas that are endemic for arboviral infections, in the differential diagnosis of a rash one must consider infections such as dengue, Zika, or chikungunya viruses. In nonendemic areas, the diagnosis is more difficult, as the rash may result from other viral infections not transmitted by arthropods and/or reactive or inflammatory diseases (urticaria, atopic dermatitis, systemic lupus erythematosus). We recommend that primary care health personnel are trained in the recognition of the mucocutaneous lesions caused by Zika virus infection, which could contribute to the identification of suspicious cases, particularly pregnant women.

THE STRUCTURE OF CONDITIONALLY PATHOGENIC MICROFLORA, ISOLATED FROM THE UROGENITAL TRACT OF WOMEN WITH PATHOLOGICAL COURSE OF PREGNANCY

2020 ◽  
Vol 65 (1) ◽  
pp. 50-54
Author(s):  
A. V. Kozlov ◽  
A. V. Lyamin ◽  
A. V. Zhestkov ◽  
O. A. Gusyakova ◽  
E. I. Popova ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Inflammatory Diseases ◽  
The Body ◽  
Urogenital Tract ◽  
Quantitative Composition ◽  
Cervical Canal ◽  
Coagulase Negative Staphylococci ◽  
Gram Positive ◽  
Gram Negative ◽  
Staphylococcus Spp

The structure of the microflora of the urogenital tract of a woman is variable and diverse, changing its qualitative and quantitative composition can affect various physiological processes in the body of a woman, including the course of pregnancy. In this study, the results of cultures of 1415 samples of urine and cervical canal discharge of pregnant women were analyzed. Species identification was carried out by MALDI-ToF mass spectrometry using Microflex LT (Bruker) mass spectrometer. Gram-positive bacteria (69.5%) dominated the structure of the cervical canal microflora, among which Staphylococcus spp prevailed., Enterococcus spp. and Lactobacillus spp. Among gram-negative bacteria most often encountered microorganisms of the order Enterobacteriales, the predominant species among which was E. coli. Also, yeast-like fungi were isolated from the material of the cervical canal, their number was 11% of the total number of crops. Qualitative microbiological composition of urine was represented by gram-positive flora (68.7%), gram-negative flora (30.1%) and Candida fungi (1.2%). There is a significant predominance of coagulase-negative staphylococci (97.3%) over coagulase-positive (2.7%) in the structure of gram-positive microorganisms. The composition of gram-negative flora is mainly represented by bacteria of the order Enterobacteriales (71.4%). The study identified microorganisms that can cause postpartum complications and the development of inflammatory diseases of the newborn, which suggests the need for regular microbiological examination for pregnant women.

scholarly journals Specific Characteristics of Bioelectric Activity of the Brain in Women with Placental Dysfunction Considering the Type of Psychological Component of Gestation Dominant

2018 ◽  
Vol 24 (2) ◽  
Author(s):  
Nataliya Henyk ◽  
Nataliya Yakumchuk
Keyword(s):  
Pregnant Women ◽  
Comparison Group ◽  
Clinical Symptoms ◽  
Gestational Hypertension ◽  
Fetal Distress ◽  
Main Group ◽  
Software Complex ◽  
Placental Dysfunction ◽  
Psychological Component ◽  
Attitude Test

 The study of the influence of the autonomic nervous system on the course of pregnancy, childbirth and fetal state remains relevant. Changes in the parameters of electroencephalography may be detected long before the onset of clinical symptoms in the complicated course of pregnancy.  The objective of the research was to evaluate electroencephalography in women with placental dysfunction and gestational complications taking into account the type of psychological component of gestation dominant.  Materials and methods. Electroencephalography was performed in 60 pregnant women at the age of 19 to 45 years with gestational hypertension and fetal distress during pregnancy. The main group included 40 patients, who were stratified according to the type of psychological component of gestation dominant: 10 patients with euphoric type, 20 pregnant women with anxious and depressive type, 10 patients with hypogestognostic type. The comparison group comprised 20 patients with optimal type of psychological component of gestation dominant and normal course of the first half of pregnancy. The assessment of psychological component of gestation dominant was carried out according to the method proposed by Dobriakov I.V. - "Pregnant woman attitude test". Registrations, spectral and coherent analysis of electroencephalography were performed using BrainTest-24 hardware and software complex.  \textbf{Results and discussion. }Electroencephalography of the patients of the comparison group was in line with current concepts regarding the physiological norm. In the main group, there were the following changes in electroencephalography: non-sinusoidal forms of alpha-oscillations (77.5%), high index of fast rhythms, flashes of spike waves under load, disturbances of the frontal occipital gradient with the focus on the anterior sections of the hemispheres.  Conclusions. The use of electroencephalography in women with different types of psychological component of gestation dominant in case of progressive placental dysfunction and preeclampsia on its background allows identifying characteristic changes, modifying the program of therapeutic measures, differentiating obstetric tactics and terms of delivery.

scholarly journals Intraocular Risk Factors in the Primary Formation of Diabetic Macular Edema in Patients with Diabetes Mellitus Type II

2019 ◽  
Vol 16 (1) ◽  
pp. 63-69
Author(s):  
M. V. Pshenichnov ◽  
O. V. Kolenko ◽  
E. L. Sorokin ◽  
Yu. E. Pashentcev
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Comparison Group ◽  
Mean Value ◽  
Main Group ◽  
Type Ii ◽  
Diabetes Mellitus Type Ii ◽  
The Mean

Purpose. Revealing of the intraocular risk factors in the diabetic macular edema (ME) formatis in diabetes mellitus type II (DM2). Patients and methods. A 3.5-year research of 80 patients (160 eyes) with DM2 without signs of ME at the beginning of the research was performed. The main group consisted of 46 patients with ME symptoms on one or both eyes during the research period, the comparison group included 34 patients without ME symptoms to the end of the research. The initial ocular characteristics were retrospectively compared in groups.Results. The mean value of the axial lengths (AL) in the eyes of the main group was 23.12 ± 0.75 mm compared to 23.82 ± 0.62 mm in the comparison group (significant difference, p < 0.01). AL was less than 23.5 mm in 66 % eyes in the main group and only in 22 % of the eyes in the comparison group (p < 0.01). The mean value of the initial macular retina volume in the main group was significantly higher than in the comparison group — 7.51 ± 0.22 mm3 and 7.21 ± 0.12 mm3, respectively (p < 0.01). Initial background diabetic retinopathy (DR) was noted in 73 % eyes in the main group, which significantly differed from the comparison group, where this index was noted only in 13 % of the eyes (p < 0.01).Conclusion. Significant ocular risk factors for the formation of ME in patients with DM2 are: the initial macular retina volume more than 7.3 mm3, the value of the AL less than 23.5 mm; the initial background DR. The use of the detected morphometric parameters of eye and retina in combination with an adequate assessment of the risk factors in human organism makes it possible to assume a high risk of the primary formation of diabetic ME in patients with DM2 with high degree of probability.

scholarly journals The role of a balanced diet in the metabolism of nutrients

2021 ◽  
Vol 100 (4) ◽  
pp. 333-338
Author(s):  
Zoya I. Zholdakova ◽  
Rofail S. Rakhmanov ◽  
Elena S. Bogomolova ◽  
Rashid Sh. Khayrov ◽  
Ekaterina A. Olyushina
Keyword(s):  
Uric Acid ◽  
Total Cholesterol ◽  
Comparison Group ◽  
Density Lipoprotein ◽  
Food Products ◽  
Main Group ◽  
The Body ◽  
Metabolic Status ◽  
Low Density ◽  
Blood Indices

The purpose of the study was to assess the metabolic status of the body when correcting the diet with a concentrated natural product. Materials and methods. The diet of athletes was analyzed. The leading group (n = 15) received concentrated food products (CNP) for 20 days: No. 1 - 30.0 g and No. 2 - 20 g each. Blood indices including (total protein, uric acid, urea, creatinine, total cholesterol, high and low-density lipoprotein cholesterol, triglycerides, glucose, amylase) were assessed metabolic status: taken before, after, and in one month of taking CNP Results. The diet’s calorie content was 5953.2-6494.4 kcal/day in the main and the comparison group corresponding to this cohort’s physiological need. The proportions of protein and fat exceeded the recommended ones; deficiency of carbohydrates accounted for 8.7%. The inclusion of CNP increased the ratio of slow carbohydrates, vitamins, minerals, and minor food components. In the leading group, the increase in urea and uric acid was less significant in terms of average indices, and the proportion of such people increased. Creatinine was significantly higher than baseline within one month after CNP administration. The increase in the proportion of people with increased total cholesterol is 2.9 times less; the share with a borderline high level decreased by 15.5%, in the comparison group, it increased by 5.6%. The proportion with low-density lipoproteins exceeding the reference value decreased from 61.5% to 30.0% in the comparison group - without dynamics (55.6%) and signs of dyslipidemia increased. In the main group, within the normal range, 76.9% of individuals had an increase in glucose, amylase by 5.7% (p = 0.049). Conclusion. The diet is not macronutrient balanced. The use of CNP affected the metabolism of proteins, fats, and carbohydrates. It proved a more adequate energy supply for the activities of the persons of the main group. There has been shown the possibility of correcting the body’s metabolic processes with food products that reduces the risk of developing prenosological conditions during physical exertion, particularly fatigue and cardiovascular pathology.

scholarly journals Biochemical indices of urine in children with allergic diseases of airways

2020 ◽  
Vol 23 (4) ◽  
pp. 223-228
Author(s):  
Elena V. Tush ◽  
Anna N. Obuhova ◽  
Ivan I. Balabolkin ◽  
Olga V. Haletskaya ◽  
Andrey B. Stroganov ◽  
...  
Keyword(s):  
Comparison Group ◽  
Biochemical Study ◽  
Allergic Diseases ◽  
Main Group ◽  
The Body ◽  
Daily Urine ◽  
Daily Excretion ◽  
Biochemical Indices ◽  
Excretion Of Urates ◽  
Oxalate Metabolism

Currently, unsatisfactory control of the course of allergic diseases of airways (ADA) remains. There is data on the potential involvement of urate and oxalate metabolism in the pathogenesis of ADA, which determines the need to study the corresponding biomarkers. Aim of the work - to evaluate the daily urinary excretion of urates and oxalates in ADA children. Materials and methods. We examined 100 children aged 2 to 9 years, boys - 22, girls - 78, with symptoms of crystalluria. The children were divided into the main group (42 children) and the comparison group (58 people). The main group included patients with established diagnoses of ADA, and the comparison group included patients without ADA. A biochemical study of daily urine was performed in all cases. Results. It was found that the daily excretion of oxalates in ADA patients was significantly increased compared to the control, 26.5 [22.1; 32.6] mg/day and 23.3 [20.1; 27.6] mg/day, respectively. Daily urate excretion in patients of the main group was also significantly increased compared to the control, both in absolute numbers - 1.45 [1.13; 2.13] mmol/day and 1.17 [0.89; 1.5] mmol/day, respectively (p = 0.005), and in normalized to the body surface area units. Conclusion. A statistically significant increase in daily urate excretion was found in ADA children. The clinical and pathogenetic significance of this phenomenon in children with ADA requires further study.

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