scholarly journals Maladaptive neuropathological syndrome of blood vessel aging

2019 ◽  
pp. 33-40
Author(s):  
A. A. Artemenkov
Keyword(s):  
Cerebral Cortex ◽  
Blood Vessel ◽  
Blood Vessels ◽  
Cortical Neurons ◽  
Circulatory System ◽  
Vascular Wall ◽  
Modern Human ◽  
Wall Thickening ◽  
Additional Risk Factor ◽  
The Relationship

This article discusses the relationship between maladaptation and blood vessel aging. The work shows that upright posture created an additional load on the circulatory system, and the lifestyle of a modern human is an additional risk factor of cardiovascular diseases. It has been suggested that a disorder of the nervous regulation of vascular tone is the main etiopathogenetic mechanism of morphofunctional changes in blood vessels and their aging. We discussed the statute that vascular reactions in humans is based on the formation of a maladaptive circuit in the cerebral cortex, consisting of a matrix of motor, sensory and associative cortical neurons involved in the maladaptive process. This hypothesis is based on the fact that any irritations entering the cerebral cortex from the periphery (thermal, pain, and others) cause cortical-vascular reflex reactions that change their tonic activity. Based on this principle, a model of vascular aging is further constructed, which is based on the maladaptive damage to all layers of the vascular wall (intima, media and adventitia). The opinion is expressed about the need for early diagnosis and prevention of vascular disorders to maintain human health. In conclusion, it is concluded that if the age of a person is really determined by the age of his blood vessels, then in order to achieve active longevity it is necessary to normalize the relationship in the adaptation-maladaptation-environment. Detailed study of hypertrophy and calcification of blood vessels is needed, since aging always reveals vascular wall thickening and stiffness increase.

EVALUATION OF THE VESSEL AGE BY APPLYING THE ACCELERATION PLETHYSMOGRAM ANALYSIS

2021 ◽  
pp. 61-67
Author(s):  
Елизавета Александровна Молчанова ◽  
Петр Вячеславович Лужнов
Keyword(s):  
Blood Vessels ◽  
Pulse Wave ◽  
Vascular System ◽  
Vascular Wall ◽  
Second Derivative ◽  
Contour Analysis ◽  
Physiological Factors ◽  
Vascular Age ◽  
Relationship Of ◽  
The Relationship

В работе приведены понятия жесткости, эластичности и тонуса сосудов, а также же их взаимосвязь с общим состоянием сосудистой стенки. Описан индекс, объединяющий влияние вышеперечисленных факторов на состояние сосудистой системы и дающий представление о возрасте сосудов пациента, а также показана связь этого индекса с возрастом человека. Представлен обзор способов определения возраста сосудов с помощью контурного анализа пульсовой волны. Среди предложенных способов был выделен подход на основе контурного анализа сигнала пульсовой волны, а также ее второй производной. В данном исследовании проводилась разработка алгоритма расчета показателя возраста сосудов (VA), базирующаяся на анализе сигнала и его второй производной. При этом особое внимание уделялось физической интерпретации параметров, входящих в состав расчетной формулы. С помощью представленного алгоритма в группе из трех испытуемых был определен сосудистый возраст. Из анализа полученных результатов было выявлено влияние физиологических факторов на значение возраста сосудов. Предложены методики, позволяющие исключить влияние этих факторов на значения показателя VA и тем самым получить более точные результаты. Также представлены стратегии дальнейшего развития исследований в этом направлении In The paper presents the concepts of rigidity, elasticity and tone of blood vessels, as well as their relationship with the general state of the vascular wall. An index is described that combines the influence of the above factors on the state of the vascular system and gives an idea of the age of the patient's vessels, and also shows the relationship of this index with the age of a person. An overview of the methods for determining the age of blood vessels using the contour analysis of the pulse wave is presented. Among the proposed methods, an approach based on the contour analysis of the pulse wave signal, as well as its second derivative, was singled out. In this study, an algorithm was developed for calculating the indicator of vascular age (VA), based on the analysis of the signal and its second derivative. In this case, special attention was paid to the physical interpretation of the parameters included in the calculation formula. Using the presented algorithm, vascular age was determined in a group of three subjects. From the analysis of the results obtained, the influence of physiological factors on the value of the age of the vessels was revealed. Methods are proposed that allow to exclude the influence of these factors on the values of the VA indicator and thereby obtain more accurate results. Also presented are strategies for the further development of research in this direction

scholarly journals Efficient finite element hyperelasticity solver for blood vessel simulations

2020 ◽  
Vol 14 ◽  
pp. 174830262093101
Author(s):  
Xinhong Wang ◽  
Zhengzheng Yan ◽  
Yi Jiang ◽  
Rongliang Chen
Keyword(s):  
Finite Element ◽  
Blood Vessel ◽  
Blood Vessels ◽  
High Performance ◽  
Soft Tissues ◽  
Circulatory System ◽  
Numerical Algorithms ◽  
External Pressure ◽  
Patient Specific ◽  
Schwarz Method

The blood vessels play a key role in the human circulatory system. As a tremendous amount of efforts have been devoted to develop mathematical models for investigating the elastic behaviors of human blood vessels, high performance numerical algorithms aiming at solving these models have attracted attention. In this work, we present an efficient finite element solver for an elastodynamic model which is commonly used for simulating soft tissues under external pressure loadings. In particular, the elastic material is assumed to satisfy the Saint–Venant–Kirchhoff law, the governing equation is spatially discretized by a finite element method, and a fully implicit backward difference method is used for the temporal discretization. The resulting nonlinear system is then solved by a Newton–Krylov–Schwarz method. It is the first time to apply the Newton–Krylov–Schwarz method to the Saint–Venant–Kirchhoff model for a patient-specific blood vessel. Numerical tests verify the efficiency of the proposed method and demonstrate its capability for bioengineering applications.

Primary versus secondary structural changes of the blood vessels in hypertension

1985 ◽  
Vol 63 (4) ◽  
pp. 392-401 ◽  
Author(s):  
Robert M. K. W. Lee ◽  
John S. Smeda
Keyword(s):  
Blood Pressure ◽  
Blood Vessels ◽  
Structural Changes ◽  
Vascular Wall ◽  
Wall Thickening ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Wistar Kyoto ◽  
Pressure Independent ◽  
Hypertension Development

Various researchers have hypothesized that the thickening of the vascular wall plays an important role in the maintenance of hypertension. Such an alteration can increase the vascular resistance by exerting two effects. A thickened vascular wall could occlude the lumen of the blood vessel and (or) cause the artery to hyperreact to contractile stimuli. Until recently, it has been a general conclusion that such alterations were a secondary adaptation produced by the elevation of blood pressure. Consistent with this view, certain classes of larger arteries do exhibit a thickened vascular wall late during hypertension development and such changes can be prevented from occurring by antihypertensive treatment. However, recent studies involving the mesenteric and renal arteries of Wistar-Kyoto spontaneously hypertensive rats have shown that wall thickening of the vasculature occurs prior to hypertension development and is present even under conditions where the blood pressure has been normalized throughout the animal's life. These latter observations suggest that some structural alterations in the blood vessels observed in hypertension are pressure independent and could be of etiological importance in the initiation of hypertension.

Study of Sushrutokta Vedhya Sira of Urdhavshakha In Siravedhan Vidhi

2019 ◽  
Vol 7 (02) ◽  
Author(s):  
Sachin S. Bhagwat
Keyword(s):  
Blood Vessel ◽  
Blood Vessels ◽  
Circulatory System ◽  
Upper Extremities ◽  
Anatomical Structures ◽  
Contemporary Science

The term “Sira” is collectively used for blood vessel ( Arteries, Veins, Capillaries and Lymphatics ) which denote the circulatory system. Some siras are not suitable for venouspuncture. These siras are called Avedhya Sira. A surgeon should not perform venesection on these sira as it may be harmful for patient; on the contrary, some sira are suitable for Siravedhan, called Vedhya Sira. The anatomical locations are available in classic texts but exact structures and the anatomical description regarding vedhya sira are not described yet. Proposed article aims to correlate urdhvashakhagat vedhya siras mentioned by our Aacharya with modern anatomical structures and review in contemporary science. For this purpose, ancient ayurvedic classics were reviewed and references are compiled for the said subject was criticaly studied to comprehend the vedhya sira in upper extremities. Primary knowledge of vedhya Sira is very important for physicians as well as surgeons. The vedhya sira mentioned in Ayurved compendia can be correlated with blood vessels, vein in modern anatomy.

scholarly journals Structural and Functional Differences Between Porcine Aorta and Vena Cava

2017 ◽  
Vol 139 (7) ◽  
Author(s):  
Jeffrey M. Mattson ◽  
Yanhang Zhang
Keyword(s):  
Treatment Options ◽  
Vena Cava ◽  
Circulatory System ◽  
Vascular Wall ◽  
Multiphoton Imaging ◽  
Functional Differences ◽  
Low Levels ◽  
And Function ◽  
The Relationship ◽  
Arteries And Veins

Elastin and collagen fibers are the major load-bearing extracellular matrix (ECM) constituents of the vascular wall. Arteries function differently than veins in the circulatory system; however as a result from several treatment options, veins are subjected to sudden elevated arterial pressure. It is thus important to recognize the fundamental structure and function differences between a vein and an artery. Our research compared the relationship between biaxial mechanical function and ECM structure of porcine thoracic aorta and inferior vena cava. Our study suggests that aorta contains slightly more elastin than collagen due to the cyclical extensibility, but vena cava contains almost four times more collagen than elastin to maintain integrity. Furthermore, multiphoton imaging of vena cava showed longitudinally oriented elastin and circumferentially oriented collagen that is recruited at supraphysiologic stress, but low levels of strain. However in aorta, elastin is distributed uniformly, and the primarily circumferentially oriented collagen is recruited at higher levels of strain than vena cava. These structural observations support the functional finding that vena cava is highly anisotropic with the longitude being more compliant and the circumference stiffening substantially at low levels of strain. Overall, our research demonstrates that fiber distributions and recruitment should be considered in addition to relative collagen and elastin contents. Also, the importance of accounting for the structural and functional differences between arteries and veins should be taken into account when considering disease treatment options.

COMPARISON OF ANTIHYPERTENSIVE EFFECT OF MOXONIDINE VERSUS CLONIDINE IN RENAL FAILURE PATIENTS.

2018 ◽  
Vol 6 (9) ◽  
Author(s):  
DR.MATHEW GEORGE ◽  
DR.LINCY JOSEPH ◽  
MRS.DEEPTHI MATHEW ◽  
ALISHA MARIA SHAJI ◽  
BIJI JOSEPH ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Failure ◽  
Blood Flow ◽  
Blood Vessel ◽  
Blood Vessels ◽  
High Blood Pressure ◽  
Antihypertensive Effect ◽  
The Body ◽  
Ability To Work ◽  
Blood Flows

Blood pressure is the force of blood pushing against blood vessel walls as the heart pumps out blood, and high blood pressure, also called hypertension, is an increase in the amount of force that blood places on blood vessels as it moves through the body. Factors that can increase this force include higher blood volume due to extra fluid in the blood and blood vessels that are narrow, stiff, or clogged(1). High blood pressure can damage blood vessels in the kidneys, reducing their ability to work properly. When the force of blood flow is high, blood vessels stretch so blood flows more easily. Eventually, this stretching scars and weakens blood vessels throughout the body, including those in the kidneys.

scholarly journals Retinal Vessel Segmentation by Deep Residual Learning with Wide Activation

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Yuliang Ma ◽  
Xue Li ◽  
Xiaopeng Duan ◽  
Yun Peng ◽  
Yingchun Zhang
Keyword(s):  
Blood Vessel ◽  
Blood Vessels ◽  
Area Under The Curve ◽  
Retinal Vessel ◽  
Vessel Segmentation ◽  
Superior Performance ◽  
Retinal Blood Vessel ◽  
Low Contrast ◽  
Blood Vessel Segmentation ◽  
Small Vessels

Purpose. Retinal blood vessel image segmentation is an important step in ophthalmological analysis. However, it is difficult to segment small vessels accurately because of low contrast and complex feature information of blood vessels. The objective of this study is to develop an improved retinal blood vessel segmentation structure (WA-Net) to overcome these challenges. Methods. This paper mainly focuses on the width of deep learning. The channels of the ResNet block were broadened to propagate more low-level features, and the identity mapping pathway was slimmed to maintain parameter complexity. A residual atrous spatial pyramid module was used to capture the retinal vessels at various scales. We applied weight normalization to eliminate the impacts of the mini-batch and improve segmentation accuracy. The experiments were performed on the DRIVE and STARE datasets. To show the generalizability of WA-Net, we performed cross-training between datasets. Results. The global accuracy and specificity within datasets were 95.66% and 96.45% and 98.13% and 98.71%, respectively. The accuracy and area under the curve of the interdataset diverged only by 1%∼2% compared with the performance of the corresponding intradataset. Conclusion. All the results show that WA-Net extracts more detailed blood vessels and shows superior performance on retinal blood vessel segmentation tasks.

scholarly journals A Near‐Infrared Organic Fluorescent Probe for Broad Applications for Blood Vessels Imaging by High‐Throughput Screening via 3D‐Blood Vessel Models (Small Methods 8/2021)

Small Methods ◽  
2021 ◽  
Vol 5 (8) ◽  
pp. 2170036
Author(s):  
Muhammad Asri Abdul Sisak ◽  
Fiona Louis ◽  
Ichio Aoki ◽  
Sun Hyeok Lee ◽  
Young‐Tae Chang ◽  
...  
Keyword(s):  
Blood Vessel ◽  
Blood Vessels ◽  
Fluorescent Probe ◽  
High Throughput ◽  
High Throughput Screening ◽  
Near Infrared

scholarly journals Theoretical and Methodological Approaches to Ecological Changes, Social Behaviour and Human Intergroup Tolerance 300,000 to 30,000 BP

2021 ◽  
Vol 28 (1) ◽  
pp. 53-75 ◽  
Author(s):  
Penny Spikins ◽  
Jennifer C. French ◽  
Seren John-Wood ◽  
Calvin Dytham
Keyword(s):  
Social Behaviour ◽  
Environmental Variability ◽  
Raw Materials ◽  
Modern Human ◽  
Resource Exploitation ◽  
Agent Based ◽  
Advantages And Disadvantages ◽  
Ecological Changes ◽  
The Relationship ◽  
Social Behaviours

AbstractArchaeological evidence suggests that important shifts were taking place in the character of human social behaviours 300,000 to 30,000 years ago. New artefact types appear and are disseminated with greater frequency. Transfers of both raw materials and finished artefacts take place over increasing distances, implying larger scales of regional mobility and more frequent and friendlier interactions between different communities. Whilst these changes occur during a period of increasing environmental variability, the relationship between ecological changes and transformations in social behaviours is elusive. Here, we explore a possible theoretical approach and methodology for understanding how ecological contexts can influence selection pressures acting on intergroup social behaviours. We focus on the relative advantages and disadvantages of intergroup tolerance in different ecological contexts using agent-based modelling (ABM). We assess the relative costs and benefits of different ‘tolerance’ levels in between-group interactions on survival and resource exploitation in different environments. The results enable us to infer a potential relationship between ecological changes and proposed changes in between-group behavioural dynamics. We conclude that increasingly harsh environments may have driven changes in hormonal and emotional responses in humans leading to increasing intergroup tolerance, i.e. transformations in social behaviour associated with ‘self-domestication’. We argue that changes in intergroup tolerance is a more parsimonious explanation for the emergence of what has been seen as ‘modern human behaviour’ than changes in hard aspects of cognition or other factors such as cognitive adaptability or population size.

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