scholarly journals Physical exercise in rats with epilepsy is protective against seizures: evidence of animal studies

2009 ◽  
Vol 67 (4) ◽  
pp. 1013-1016 ◽  
Author(s):  
Ricardo Mario Arida ◽  
Fulvio Alexandre Scorza ◽  
Vera Cristina Terra ◽  
Roberta Monterazzo Cysneiros ◽  
Esper Abrão Cavalheiro
Keyword(s):  
Physical Activity ◽  
Physical Exercise ◽  
Physical Training ◽  
Animal Studies ◽  
Training Programs ◽  
Experimental Studies ◽  
Exercise Program ◽  
Pharmacological Treatments ◽  
Preventative Measures ◽  
Spontaneous Seizures

People with epilepsy have been discouraged from participating in physical activity due to the fear that it will exacerbate seizures. Clinical and animal studies indicate a reduction of seizure frequency as well as decrease susceptibility to subsequently evoked seizures after an exercise program. Analyses from experimental studies of animals with epilepsy submitted to physical training programs were performed. In all studies the physical training was able to reduce the number of spontaneous seizures in rats with epilepsy. Seizure occurrence during exercise was relatively absent in the majority of studies. No death was found in animals with epilepsy during 1680 h of exercise. Based on these results it is plausible encouraging persons with epilepsy to non-pharmacological treatments and preventative measures such as physical exercise.

Are palliative cancer patients willing and able to participate in a physical exercise program?

2005 ◽  
Vol 3 (4) ◽  
pp. 281-287 ◽  
Author(s):  
LINE M. OLDERVOLL ◽  
JON H. LOGE ◽  
HANNE PALTIEL ◽  
MAY B. ASP ◽  
UNNI VIDVEI ◽  
...  
Keyword(s):  
Palliative Care ◽  
Physical Exercise ◽  
Training Program ◽  
Cancer Patients ◽  
Physical Training ◽  
Exercise Program ◽  
Group Exercise ◽  
Medical Problems ◽  
Incurable Cancer ◽  
The Individual

Objective: The primary aim of the present article was to identify palliative care patient populations who are willing to participate in and able to complete a group exercise/physical training program designed specifically for the individual patient.Method: We conducted a prospective phase II intervention study examining the willingness and ability of palliative care cancer patients to participate in a group exercise physical training program. Patients who were diagnosed with incurable cancer and had a life expectancy of less than 1 year at two outpatient clinics were invited to participate in an exercise program in the hospitals. The groups met twice a week over a 6-week period.Results: One hundred one consecutive patients were asked for inclusion. Sixty-three patients agreed to participate. Sixteen (25%) of the 63 patients dropped out after consent was given, but before the program started due to medical problems, social reasons, or death. Thus, 47 patients started the exercise program. Thirteen patients withdrew during the program due to sudden death, medical problems, or social reasons. The most frequent reasons for withdrawal were increased pain or other symptoms. Thirty-four patients completed the exercise program.Significance of results: A high proportion of incurable cancer patients were willing to participate (63%) in a structured exercise program. The attrition rate was high, but despite being severely ill, 54% of the patients completed the exercise period. This shows that a physical exercise program tailored to the individual patient is feasible in this population.

scholarly journals Physical exercise during pregnancy and its influence in the type of birth

2012 ◽  
Vol 10 (4) ◽  
pp. 409-414 ◽  
Author(s):  
Lílian Cristina da Silveira ◽  
Conceição Aparecida de Mattos Segre
Keyword(s):  
Physical Activity ◽  
Physical Exercise ◽  
Basic Education ◽  
Exercise Program ◽  
Regular Physical Activity ◽  
Control Group ◽  
Significance Level ◽  
Vaginal Deliveries ◽  
Significant Difference ◽  
Primiparous Women

OBJECTIVE: To verify if medium intensity exercise performed during pregnancy can influence in the type of delivery, and to observe compliance to an exercise program among primiparous women with different levels of schooling. METHODS: A study carried out at the Centro de Incentivo ao Aleitamento Materno, in São Sebastiao (SP), between April 7, 2008, and April 14, 2009. A prospective study involving 66 primiparous women who were divided into two groups: an Exercise Group, engaged in regular physical activity during pregnancy, and the Control Group, that did not participate in regular physical activity during the same period. Significance level in this project was 5% (p=0.05). RESULTS: The group that did engage in regular exercise had a higher rate of vaginal deliveries, with a statistically significance difference evaluated by the χ² test (p=0.031). The pregnant women with the highest level of schooling showed greater compliance with the exercise program, with a statistically significant difference (p=0.01736). CONCLUSION: Physical exercise in primiparous women increased the chances of vaginal deliveries, and there was greater compliance with the exercise program among those with a higher level of schooling when compared to those with a basic education.

scholarly journals Gait Pattern, Impact to the Skeleton and Postural Balance in Overweight and Obese Children: A Review

Sports ◽  
2018 ◽  
Vol 6 (3) ◽  
pp. 75 ◽  
Author(s):  
Nili Steinberg ◽  
Dan Nemet ◽  
Michal Pantanowitz ◽  
Alon Eliakim
Keyword(s):  
Physical Activity ◽  
Physical Exercise ◽  
Postural Balance ◽  
Exercise Program ◽  
Gait Pattern ◽  
Musculoskeletal Injuries ◽  
Overuse Injuries ◽  
Obese Children ◽  
Exercise Programs ◽  
Biomechanical Factors

The article reviews the biomechanical factors that may cause overweight/obese children to reduce their level of physical activity, while increasing their risk of overuse injuries and exercise-related pain. Recommendations would be to screen those children for any gait or postural impairments before they join any exercise program, and to provide them with specific gait treatments and/or physical exercise programs, in order to decrease their risk for future musculoskeletal injuries and pain.

A phase II-III, multicenter, randomized, open study evaluating the feasibility and efficacy of a supervised home-based standard physical exercise program for metastatic cancer patients receiving oral targeted therapy: The UNICANCER SdS 01 QUALIOR study (ID-RCB: 2015-A01922-47).

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. TPS10126-TPS10126
Author(s):  
Florence Joly Lobbedez ◽  
Laurence Vanlemmens ◽  
Jean-Marc Descotes ◽  
Sophie Abadie-Lacourtoisie ◽  
Claude Boiron ◽  
...  
Keyword(s):  
Physical Activity ◽  
Physical Exercise ◽  
Cancer Patients ◽  
Phase Ii ◽  
Metastatic Cancer ◽  
Exercise Program ◽  
Well Being ◽  
Phase Iii ◽  
Ethic Committee Approval ◽  
Home Based

TPS10126 Background: Fatigue is a frequent side effect with oral targeted therapies (OTT). Physical activity has been reported to improve fatigue and quality of life (QoL). However, few studies focused on metastatic cancer patients and mainly among patients treated with chemotherapy. Furthermore, recent guidelines recommend evaluation and optimization of standardized exercise programs. The aim of our study is to evaluate home-based standard physical exercise program (SPEP) for metastatic cancer patients treated with OTT. Methods: This phase II-III study will randomize (2:1) patients starting first-line OTT for metastatic cancer between an individualized SPEP supervised by a personal coach, and recommended physical exercises via a booklet. Eligible patients will have received ≤2 lines of metastatic chemotherapy, ECOG PS ≤2, controlled pain (VAS < 3/10), and life expectancy ≥3 months. The phase II part (120 patients) will evaluate the feasibility of a 3-month SPEP using the rate of patients performing ≥50% of SPEP (2-stage Fleming: one-sided α = 5%; β = 85%). An interim analysis is planned after the phase II. The phase III will compare the efficacy of an SPEP as opposed to recommendations to reduce fatigue and/or improve physical well-being (PWB) dimensions of QoL (evaluated with FACT-G and FACT-F questionnaires). To show a difference of ≥5 points in PWB and 2.5 for fatigue (α = 2.5%; β = 80%), 312 patients are required in the phase III trial. . Secondary objectives include: PFS, OS, other dimensions of QoL, tolerability and observance of OTT, change in body composition, physical benefits, and a medico-economic study. The SPEP was developed by specialized coaches involved in physical activity and cancer. The study has Ethic committee approval and accrual is planned in 18 French centers in April 2017, for 30 months. This is the first randomized trial dedicated to patients with metastatic cancer treated with OTT evaluating the feasibility and the efficacy of a well design home based SPEP on fatigue and physical well-being.

scholarly journals Effect of a supervised exercise program on overweight and obese adolescents: a quasi-experimental study

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
J Lopes ◽  
D Jove Cesar ◽  
A L P Oliveira ◽  
A F P V Silva ◽  
B L Biasi ◽  
...  
Keyword(s):  
Physical Activity ◽  
Blood Pressure ◽  
Experimental Study ◽  
Physical Exercise ◽  
Exercise Program ◽  
Supervised Exercise ◽  
Obesity And Overweight ◽  
Quasi Experimental ◽  
Overweight Adolescents ◽  
Secondary Outcomes

Abstract Background Obesity and overweight are a worldwide public health problem, and physical exercise is an important intervention to reduce these high rates. Supervised exercise programs have significant impacts on the prevalence of obesity in adolescentes and the nurses should guide on the importance of physical activity. Purpose To evaluate the effect of an exercise program on the profile of obesity and overweight in adolescents. Methods Quasi-experimental study based on TREND guidelines. Performed with 72 adolescents, who underwent a physical activity program supervised (aerobic and resistance physical exercises) by a health professional 5 times a week, each session lasting from 50 to 60 minutes. The population consisted of all obese and overweight adolescents, aged between 14 and 18 years, who were authorized by the doctor to perform physical activity, and who did not have physical mobility problems and/or cognitive alterations. Adolescents with an anthropometric index greater than or equal to the z +1 score, and waist circumference greater than the 90th percentile, and/or skinfolds greater than the 90th percentile were considered obese or overweight. Adolescents who did not perform outcome assessments before and after the intervention, or those who did not attend physical exercise sessions for a week were excluded. The primary outcomes were anthropometric measurements (body mass index, tricipital and subscapular skinfolds, estimated body fat percentage, brachial perimeter, arm fat area, waist and neck circumference measurement), while secondary outcomes were lipid profile, capillary glycemia and blood pressure. Outcomes were assessed before and the day after the program ended. The effect of the program in relation to the outcomes was analyzed using appropriate statistical tests, with p&lt;0.05 being considered significant. Results A total 520 adolescents were assessed for eligibility; of these, 129 were considered eligible and 124 agreed to participate in the study, but 20 gave up participating. Therefore, 104 started the intervention and 32 adolescents were excluded over time, as they did not show up for a week in the exercise program, which totaled 72 adolescents for analysis. A significant improvement was observed in all primary outcomes analyzed (p&lt;0.001) and in most secondary outcomes (capillary blood glucose, p=0.0001; triglycerides, p=0.0001; systolic blood pressure, p=0.005) after 12 weeks of the supervised physical exercise program. Conclusion The supervised physical exercise program showed a significant reduction in anthropometric measurements, as well as in glycemic, triglyceride and blood pressure levels. To prove the effect of physical exercise on adolescents may impact public and educational policy measures and the incorporation of this practice in adolescents' school life. FUNDunding Acknowledgement Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Conselho Nacional de Desenvolvimento Científico e Tecnolόgico (CNPq)

Physical activity in patients with unresectable pancreatic adenocarcinoma: A multicentric randomized controlled study (APACaP study).

2015 ◽  
Vol 33 (3_suppl) ◽  
pp. TPS506-TPS506
Author(s):  
Cindy Neuzillet ◽  
Mathieu Vergnault ◽  
Aude-Marie Foucaut ◽  
Marina Touillaud ◽  
Franck Bonnetain ◽  
...  
Keyword(s):  
Physical Activity ◽  
Insulin Resistance ◽  
Physical Exercise ◽  
Usual Care ◽  
Physical Activity Intervention ◽  
Exercise Program ◽  
Controlled Study ◽  
Number Of Patients ◽  
Health Related Qol ◽  
Health Related

TPS506 Background: Exercise during chemotherapy (CT) is a promising strategy to reduce fatigue and improve health-related quality of life (QoL). It has been shown feasible and efficient in various cancers, including at advanced stage. Effects of physical activity in advanced pancreatic ductal adenocarcinoma (PDAC) have never been explored to date. We aim to evaluate the effects of a physical activity intervention in this setting. Methods: Randomized national multicentric interventional study to test the efficacy of an unsupervised home-based 16-week physical exercise program. Specificities of PDAC for physical activity program implementation will be taken into account (physical activity partner instead of patients groups, nutritional management). Main inclusion criteria: histologically confirmed, unresectable PDAC; scheduled for CT; WHO PS 0-2; age ≥ 18; physical activity partner. Two study arms: intervention group invited for the exercise program (aerobic and resistance exercises) in addition to usual care; control group receiving usual care alone. Primary objective: effects on fatigue (MFI-20) and health-related QoL (EORTC-QLQ-C30) at week 16, unified as co-primary endpoint. Secondary objectives: effects on pain, anxiety and depression, nutritional status, insulin resistance, CT tolerance, survival; adherence to the program. Number of patients: 200. PDAC patients are strongly affected by fatigue, thus they are expected to benefit from a physical activity intervention. Moreover, exercise may have a beneficial effect on tumor outcomes, by reducing insulin resistance and insulin/IGF-1 secretions. Such intervention may appear challenging because of multiple cancer-related symptoms (fatigue, depression, pain, denutrition) that can appear as barriers to physical activity. Conversely, we hypothesize that a physical exercise program, by taking into account PDAC specificities, may improve symptoms and health-related QoL. If this intervention is proven to be feasible and effective, such standardized physical exercise programs might be proposed in complement to CT in patients with advanced PDAC as a logical next step. Clinical trial information: NCT02184663.

scholarly journals The Benefits of Physical Activity in Children and Adolescents with Epilepsy: A Systematic Review

2021 ◽  
Author(s):  
Loyane de Fátima Svierkovski ◽  
Angelica Miki Stein ◽  
Timothy Cavazzotto ◽  
Ana Carolina Paludo
Keyword(s):  
Physical Activity ◽  
Physical Exercise ◽  
Children And Adolescents ◽  
Physical Activity Intervention ◽  
Exercise Program ◽  
Well Being ◽  
Keywords Epilepsy ◽  
Evidence Database ◽  
Positive Effect

AbstractThe aim of this study was to review the literature about the effect of physical activity intervention in children and adolescents with epilepsy. Articles were searched in the central electronic databases of MEDLINE, Embase, PsycAriticles, and CINAHL for the following keywords: “epilepsy,” “seizure,” “physical activity,” “physical exercise,” “exercise therapy,” “sport,” using the Boolean operator “AND” and “OR.” The quality of the selected articles was evaluated by the Physiotherapy Evidence Database scale. Out of the 22 articles selected, 18 did not involve intervention or did not have pre- and postresults and therefore were excluded from the study. The remaining four were studies from Canada and Korea which comprised two long-period interventions and were included in the analysis. Both programs demonstrated a positive effect of physical activity on variables related to psychological well-being and cognitive function. All the four articles demonstrated a lower score of quality. In conclusion, reviewed studies suggest that physical exercise program induces some benefits in children and adolescents with epilepsy. However, the noncontrolled trials and the varied analyses (quantitative vs. qualitative) make it difficult to establish a consensus about benefits of physical activity in epilepsy.

scholarly journals Gut microbiota related to nutrition and physical activity: an integrative review

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Luaira Ferreira Campos
Keyword(s):  
Physical Activity ◽  
Gastrointestinal Tract ◽  
Data Collection ◽  
Literature Review ◽  
Physical Exercise ◽  
Gut Microbiota ◽  
Healthy Eating ◽  
Physical Training ◽  
Intestinal Flora ◽  
Body Work

Introduction: The gut microbiota (GM) is formed by millions of microorganisms present in the gastrointestinal tract, especially in the colon. This intestinal homeostasis can be triggered by the union of a good diet, and even recent studies have suggested that aerobic physical training can modify its composition. Objective: To analyze the influence of healthy eating added to the practice of physical exercise in changing the composition of the GM. Methods: The research was carried out with an exploratory, qualitative and bibliographic approach. A literature review that brings together important studies on the influence of physical exercise on GM. Results: Data collection for this literature review was carried out from March to September, using articles, in addition to trustworthy websites, with the following descriptors: gut microbiota, microbiota, intestinal flora, food, probiotics, and physical exercise. Conclusion: The training was efficient to change the GM composition in sedentary men, thus being able to minimize possible negative interferences of the sedentary pattern. Bacteria that reside in our body work with a commensalism strategy, where there are two different structures, the microorganism, and the individual's body, but both live together normally and thus work together to maintain the GM balance.

Exercise and resistance to neoplasia

1998 ◽  
Vol 76 (5) ◽  
pp. 581-588 ◽  
Author(s):  
Jeffrey A Woods
Keyword(s):  
Physical Activity ◽  
Body Fat ◽  
Animal Studies ◽  
Cancer Metastasis ◽  
Effective Means ◽  
Experimental Studies ◽  
Epidemiological Studies ◽  
Independent Effect ◽  
Reduced Body ◽  
Confounding Variables

Epidemiological evidence has revealed an inverse relationship such that increased physical activity as measured directly subjective recall, job classification, former athletic status, or indirectly by physical fitness is associated with decreased incidence and (or) mortality rates for various cancers. The relationship appears strongest for colon cancer and female estrogen-dependent cancers of the breast, ovary, and endometrium. While some epidemiological studies have controlled for numerous confounding variables such as smoking, body mass index, and percent body fat, it is still difficult to ascertain whether physical activity exerts an independent effect on cancer above and beyond that associated with an improved lifestyle and numerous other potential confounding variables. Experimental studies performed in animals suggests that chronic exercise, especially when performed prior to tumorigenesis, can retard, delay, or prevent the incidence, progression, or spread of experimental tumors. There is also limited animal evidence suggesting that exercise may help ameliorate cancer cachexia. Exercise or physical activity may contribute to a reduction in site-specific cancers by different physiological mechanisms. Some purported mechanisms include decreased lifetime exposure to estrogen or other hormones, reduced body fat, enhanced gut motility, improved anti-oxidant defenses, and stimulation of anti-tumor immune defenses. Unfortunately, most animal studies have failed to account for plausible biological mechanisms as to how exercise might influence cancer. In addition, the exercise or activity dosage required to provide optimal protection from cancer is unclear. Interpretation of epidemiological studies is hampered by the numerous and sometimes inaccurate assessments of physical activity. Likewise, many animal studies have utilized unrealistic exercise protocols. Clearly, more research is needed to define appropriate activity or exercise dosages definitively and to explore the mechanism(s) by which exercise helps protect against cancer. Nevertheless, moderate exercise appears to be a safe and effective means of aiding in the prevention of cancer and should be adopted by the public in addition to other prudent behavioral practices such as proper diet. More research needs to be performed regarding the effects of exercise or physical activity on those who already have cancer to determine if exercise improves their prognosis.Key words: exercise, physical activity, cancer, metastasis.

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