scholarly journals Comparison of rimonabant and sibutramine treatment effects on food compulsion in rats

2009 ◽  
Vol 24 (6) ◽  
pp. 454-459
Author(s):  
Honório Sampaio Menezes ◽  
Verônica Ciulla ◽  
Paulo Sampaio Camargo ◽  
Cora Albrecht Correa ◽  
Tatiana Medina Costa de Oliveira
Keyword(s):  
Clinical Trial ◽  
Weight Gain ◽  
Control Group ◽  
Cb1 Receptors ◽  
Statistic Analysis ◽  
Test Results ◽  
Control Groups ◽  
Tukey Test ◽  
Student Test ◽  
And Control

PURPOSE: To compare the therapeutic effect of rimonabant, a new drug which is a selective antagonist of CB1 receptors, with the sibutramine. METHODS: It is an experimental clinical trial, prospective, placebo controlled. Our test was performed in 38 rats, adults females with a hyper caloric diet. We collected their blood 3 times and weighted them once a week. We divided the rats in 3 groups: Rimonabant, Sibutramine and Control. Statistic analysis has been made through ANOVA test, Tukey test and t Student test. RESULTS: The Rimonabant group demonstrated a significant reduction of the weight increase in rats. The Sibutramine group showed a significant reduction on blood glycemia compared to Rimonabant group and Control group. CONCLUSIONS: Rimonabant showed to be more effective than Sibutramine by decreasing weight gain. Sibutramine has been more effective than Rimonabant and Control groups by decreasing the blood glycemia.

Effect of prenatal recommendations of Traditional Persian Medicine on obstetric outcomes: a randomized clinical trial

2018 ◽  
Vol 15 (3) ◽  
Author(s):  
Mansoor Keshavarz ◽  
Maryam Kashanian ◽  
Soodabeh Bioos ◽  
Yasaman Vazani
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Intervention Group ◽  
Active Phase ◽  
Obstetric Outcomes ◽  
Control Group ◽  
Control Groups ◽  
Persian Medicine ◽  
Traditional Persian Medicine ◽  
And Control

Abstract Background Traditional Persian Medicine (TPM) is an ancient medical system that provides suggestions to improve the health of mothers and children during pregnancy and labor. Persian physicians believed that these instructions made labor easier, safer, and less painful. Methods The present randomized clinical trial was conducted among women at 33–38 weeks of pregnancy in Tehran, Iran. TPM instructions consisted of diet, bathing, and application of oil from the 38th week of pregnancy to the onset of labor. The primary outcome was the duration of the active phase of labor. Results The mean duration of the active phase was 331.60 ± 151.48 min for the intervention group and 344.40 ± 271.46 min for the control groups, but it was not statistically significant. The active phase was significantly shorter in women who had better compliance (p=0.03). The need for oxytocin augmentation was 53.3% in the control group and 38.5% in the intervention group (p=0.17). The rate of perineal infection was 13% in the control group and 0% in the intervention group (p=0.11). Conclusions The active phase was not different in the intervention and control groups, but it was shorter in compliant women. It is possible that prolonged use of these recommendations in combination with a sitz baths and a larger sample size could result in more significant outcomes.

scholarly journals The effect of delivery ball and warm shower on the childbirth experience of nulliparous women: A randomized controlled clinical trial

2021 ◽  
Author(s):  
parvaneh sharifipour ◽  
Masoomeh Kheirkhah ◽  
Mojgan Rajati ◽  
hamid haghani
Keyword(s):  
Clinical Trial ◽  
Pregnant Women ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Control Groups ◽  
Childbirth Experience ◽  
Nulliparous Women ◽  
Significant Difference ◽  
The Mean ◽  
And Control

Abstract Background Childbirth is a unique experience that affects women’s life. Therefore, this study was performed to determine the effect of delivery ball and warm shower on the childbirth experience of primiparous women. Methods This study is a clinical trial that was carried out on primiparous pregnant women referred to Motazedi Hospital in Kermanshah, Iran. Sampling was done by continuous method and pregnant women were divided into three groups of delivery ball-warm shower (n = 33), delivery ball (n = 33) and control (n = 33). Exercise with ball at the dilation of 4 cm was similar in the two groups of delivery ball-warm shower and delivery ball, but the first group also used warm shower at the dilatation of 7 cm. The control group only received the routine delivery care. Demographic information form consisting of pregnancy history and information about the mother and infant were completed and the childbirth experience questionnaire (CEQ) were completed by the women two hours after the childbirth. Results There was a statistically significant difference in the mean score of childbirth experience after the intervention between the two groups of delivery ball-warm shower and control (P = 0.001), and also between the delivery ball and control groups (P = 0.001). There was a statistically significant difference in the mean scores of professional support between the two groups of delivery ball-warm shower and control (P = 0.02) and also between the delivery ball and control groups (p = 0.02). There was a statistically significant difference in the mean scores of participation between the two groups of delivery ball-warm shower and control (P = 0.003) and also between the delivery ball and control groups (P = 0.01). There was also a statistically significant difference in the mean scores of sense of security between the two groups of delivery ball-warm shower and control (P = 0.01). Conclusion Delivery ball and warm shower were effective interventions to create a positive childbirth experience. This method was more effective than using delivery ball alone in childbirth experience. To achieve a positive experience of childbirth in mothers, the use of both intervention (delivery ball and warm shower) is recommended.

scholarly journals The Spheno-Occipital Synchondrosis and Morphometry of Sella Turcica Association with Different Phenotype Factors Related to Ectopic Eye Tooth/Teeth

2021 ◽  
Vol 12 (1) ◽  
pp. 112
Author(s):  
Mohammad Khursheed Alam ◽  
Anil Kumar Nagarajappa ◽  
Ahmed Ali Alfawzan ◽  
Fatema Akhter ◽  
Haytham Jamil Alswairki ◽  
...  
Keyword(s):  
Matched Control ◽  
Three Dimensional ◽  
Sella Turcica ◽  
Cone Beam ◽  
Two Dimensional ◽  
Test Results ◽  
Control Groups ◽  
Tukey Test ◽  
Post Hoc ◽  
And Control

Objectives: This study investigates the prevalence of Spheno-Occipital Synchondrosis (SOS) and sella turcica morphometry (STM) association with different phenotype factors related to ectopic eye tooth/teeth (EET) using cone beam computed tomography (CBCT) imaging. Methods: This comparative retrospective study analyzed 252 CBCT images. Subjects in the EET group consisted of 197 CBCT images with the phenotype factor in number, i.e., unilateral (13, n = 62; 23, n = 59) or bilateral (1323, n = 76) and matched control (n = 55). SOS and STM were investigated using 3D OnDemand Software. Seven parameters of STM were measured. To test the association X2 used for SOS prevalence, disparities in STM were tested using ANOVA and post hoc Tukey test. Results: The prevalence of unfused SOS was 48.4% and 16.1% in the 1323 and control groups, respectively. Fused SOS prevalence was quite similar in all four groups. Phenotype factor in number, i.e., unilateral 13, 23, or bilateral EET group showed significant disparities in six out of seven parameters (p = 0.044 to p ≥ 0.001). Additionally, phenotype factor in position, i.e., occlusal, buccal, or palatal group showed insignificant disparities (p = 0.463 to p = 1.00). Conclusion: SOS in the ectopic eye tooth group (EETG) was prevalent in the 1323 and buccal position groups. Differing from previous two-dimensional (2D) studies, there were statistically significant disparities in all seven measured variables of STM among control, and three different phenotype factors in numbers were revealed using three-dimensional (3D) CBCT imaging.

scholarly journals Effect of Foot Reflexology on Postoperative Pain in Patients Undergoing Tibia Plating Surgery: A Randomized Clinical Trial

2020 ◽  
Vol 10 (3) ◽  
pp. 258-269
Author(s):  
Fatemeh Imani ◽  
◽  
Ebrahim Nasiri ◽  
Houshang Akbari ◽  
Mohammad Reza Safdari ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Postoperative Pain ◽  
Randomized Clinical Trial ◽  
Repeated Measures ◽  
Intervention Group ◽  
Control Group ◽  
Control Groups ◽  
Chi Square ◽  
Chi Square Test ◽  
And Control

Objective: One of the major problems of patients after orthopedic surgeries is acute pain. The present study aims to evaluate the effect of foot reflexology massage on postoperative pain in patients undergoing plating surgery for tibia fracture. Methods: This study is a randomized clinical trial conducted on 96 patients who were candidates for tibia plating surgery referred to Imam Ali Hospital in Bojnourd, Iran, randomly divided into intervention and control groups. Foot reflexology massage in the intervention group was performed on patients’ healthy feet for 10 minutes, one hour before surgery. In the control group, the foot sole was touched for one minute without any pressure. Pain intensity was measured using the standard Visual Analog Scale before and immediately after the intervention and 2, 4, 6, 12 and 24 hours after surgery. Data were analyzed using chi-square test, t-test, repeated measures ANOVA, Mann-Whitney U and Friedman tests. Results: The baseline pain scores in the intervention and control groups were reported 8.1±0.9 and 8.4±0.9, respectively. After the intervention, the pain score in these groups was reduced to 6.9±1.1 and 8.1±1.0, respectively (P<0.001). At other times, up to 24 hours after surgery, the pain reduction was higher in the intervention group (P<0.05). Conclusion: Foot reflexology massage reduces postoperative pain of patients undergoing tibia plating surgery. Therefore, this method can be used to reduce pain and anxiety in orthopedic surgery patients.

scholarly journals Pengaruh Do’a terhadap Tekanan Darah pada Pasien Gagal Ginjal Kronis (GGK) Pre-Hemodialysis

2018 ◽  
Vol 2 (1) ◽  
pp. 343-355
Author(s):  
Hilda Nur Afriani ◽  
Rohman Azzam ◽  
Busrja M.Nur
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Reduce Blood Pressure ◽  
T Test ◽  
Control Group ◽  
Test Results ◽  
Hospital Data ◽  
Control Groups ◽  
Before And After ◽  
And Control

Objective of this study was to determine the effect of prayer on pre-hemodialysis blood pressure of CRF patients in the hemodialysis room of the Jakarta Islamic Hospital. Data collection was done through purposive sampling. This study examined 32 respondents. The results of the study indicated there was a decrease in blood pressure in the intervention and control groups before and after giving prayers on systolic and diastolic blood pressure. The results of the paired t-test before and after being given prayers in the intervention and control groups produced a sig value of <0.05 in systolic and diastolic blood pressure, which means that there were differences before and after giving prayers. The unpaired t-test results in the intervention and control groups of systolic blood pressure produced a sig value> 0.05, which means that there was no difference between the intervention and control group. On the contrary, diastolic blood pressure produced a sig value <0.05, which means that there were differences between the intervention and control group. Finally, it can be concluded that the provision of a prayer intervention in pre-hemodialysis was effectively proven to reduce blood pressure. Keywords : chronic kidney disease, blood pressure, prayer.

scholarly journals The Efficacy and Safety of a Herbal Toothpaste in Reducing Gingivitis: A Double-Blind, Randomized, Placebo-Controlled, Parallel Allocation Clinical Trial

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Jinfeng He ◽  
Yalan Deng ◽  
Fangzhi Zhu ◽  
Ting Zhong ◽  
Nanyu Luo ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Test Group ◽  
Control Group ◽  
Efficacy And Safety ◽  
Control Groups ◽  
Double Blind ◽  
Rhizoma Chuanxiong ◽  
Baseline Status ◽  
Main Components ◽  
And Control

Aim. To examine the efficacy and safety of the toothpaste containing Rhizoma Chuanxiong and Rhizoma Imperatae extracts in reducing gingivitis. Method. A double-blind clinical trial was conducted, in which 120 volunteers were randomly assigned to the test group (N = 60) or the control group (N = 60). Tetramethylpyrazine, senkyunolide A, ferulic acid, and ligustilide are the main effective components of Rhizoma Chuanxiong and Rhizoma Imperatae contains the main components of cylindrin, carotene, 5-hydroxytryptamine, potassium, and calcium. The control group used placebo toothpaste containing neither Rhizoma Chuanxiong extract nor Rhizoma Imperatae extract. Plaque, gingivitis, and bleeding were assessed at the baseline, prior to the supragingival scaling, and at 4, 8, and 12 weeks. Results. During the trial, both test and control groups showed a decreasing trend compared to the baseline. At the end of 12 weeks, with respect to Gingival Index (GI), Bleeding Index (BI), and Bleeding on Probing percentage (BOP%) scores, there were significant differences between test and control groups (GI, P<0.001, BI, P<0.001, and BOP%, P<0.001, resp.). After 4 weeks of usage, there were no statistically significant differences in all of GI, BI, and BOP% scores between the two groups. However, the decrease became statistically significant at next two intervals (GI, P<0.001, BI, P<0.001, and BOP%, P<0.001, resp.) in the efficiency of GI, BI, and BOP% which was 8.04%, 11.02%, and 37.16%, respectively. There were no treatment-related adverse events reported. Conclusion. The toothpaste containing Rhizoma Chuanxiong and Rhizoma Imperatae extracts was well tolerated and significantly reduced gingivitis and bleeding after usage for 12 weeks. There was better improvement at molars, and the more serious the baseline status was, the better the efficacy was.

scholarly journals Effect of Educational Short Message Service (SMS) on Excessive Gestational Weight Gain (GWG)

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1004-1004
Author(s):  
Hannah Holmes ◽  
Cristina Palacios ◽  
Yan Yan Wu ◽  
Jinan Banna
Keyword(s):  
Weight Gain ◽  
Gestational Weight Gain ◽  
Intervention Group ◽  
Text Messages ◽  
Control Group ◽  
Short Message ◽  
Control Groups ◽  
Gestational Weight ◽  
Message Service ◽  
And Control

Abstract Objectives The objective of this trial was to investigate the effect of educational short message service (SMS), or text messages, on gestational weight gain (GWG) in a low-income population. It was expected that the intervention group, which received text messages on nutrition and physical activity during pregnancy, would experience less GWG when compared to the control group. Methods Participants (n = 83) were recruited at WIC clinics on the island of O‘ahu, Hawai‘i at 15–20 weeks gestational age. Eligibility criteria were: body mass index (BMI) of 25–45 kg/m2 in the first trimester, 18 years of age or older at the time of recruitment, and possession of a cellular phone with the ability to receive text messages. After recruitment, participants were randomized into intervention (n = 42) and control (n = 41) groups. The intervention group received SMS on nutrition and physical activity during pregnancy per the Institute of Medicine and American College of Obstetricians and Gynecologists guidelines, respectively. The control group received SMS about general health topics during pregnancy. Both groups received one text message per week for eighteen weeks. GWG was defined as the difference between the last weight taken before delivery and participants’ self-reported weight before pregnancy. GWG in intervention and control groups was compared using a linear regression model. Results Women were age 27.7 ± 5.3y on average, 65.5% were Native Hawaiian, Pacific Islander or American Indian, 54.8% had some college or more and 37.8% were employed. The average weight before pregnancy was higher in the intervention group (80.6 + 17.7 kg) than that in the control group (76.2 + 15.9 kg), but this difference was not significant (P = 0.24). GWG was lower in the control group (14.1 + 11.4 kg) compared to the intervention group (15.5 + 11.6 kg), but this result was not significant (P = 0.58). Conclusions There was no significant difference in gestational weight gain between the intervention and control groups. Trials that begin earlier in pregnancy or before pregnancy with longer interventions and more frequent messages are needed. Funding Sources Mountain West Clinical Translational Research Infrastructure Network under a grant from the National Institute of General Medicine Sciences of the National Institutes of Health.

scholarly journals Pengaruh Video dan Leaflet tentang Menstruasi terhadap Kesiapan dalam Menghadapi Menarche

2021 ◽  
Vol 3 (1) ◽  
pp. 1-9
Author(s):  
Niken Purbowati ◽  
Willa Follona ◽  
Mustika Eka Wijayanti
Keyword(s):  
Treatment Group ◽  
Knowledge Score ◽  
Control Group ◽  
Test Results ◽  
Teenage Girl ◽  
Control Groups ◽  
Control Group Design ◽  
Quasi Experimental ◽  
Educational Videos ◽  
And Control

Introduction: Readiness to face menarche is needed by teenage girl. Lack of knowledge about menarche can lead to a misconception about menstruation. Objective: The aim of this study was to determine the effect of videos and leaflets on menstruation on the readiness of teenage girl to face menarche. Methods: We used a quasi-experimental pre-posttest study with a control group design. The population of this study were students of class IV and V, the sample was obtained by purposive sampling with a total of 60 divided into two groups, namely the treatment group (n=30) and the control group (n=30). The treatment group was given educational videos and leaflets. Data were analyzed using the Mann Whitney test. Results: There was an increase in the readiness score (mean±SD [34.09 ± 3.49]) and the knowledge score (14.3±1.48) in facing menarche was higher in the treatment group than the readiness score (32.83±4.29) and knowledge scores (9.83±0.76) in the control group. The different test results showed that there are difference in readiness score (p=0.012) and knowledge score (p=0.001) between the treatment and control groups. Conclusion: Interventions in the form of educational videos and leaflets can increase readiness and knowledge to face menarche in teenage girl.

scholarly journals A Preliminary Study on the Safety, Efficacy and Acceptability of the Community Preparation of Siling Labuyo (Capsicum frutescens) Liniment in the Management of Knee Osteoarthritis in a Six-Week, Active-Controlled Community-Based Clinical Trial

2019 ◽  
Vol 53 (4) ◽  
Author(s):  
Elizabeth R. Paterno ◽  
Clarisse A. Pangilinan ◽  
Erna C. Arollado ◽  
Rachael Marie B. Rosario
Keyword(s):  
Clinical Trial ◽  
Knee Osteoarthritis ◽  
Control Agent ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Control Groups ◽  
Double Blind ◽  
The Difference ◽  
And Control ◽  
Experimental Group

Objective. The study determined the safety, efficacy and acceptability of a Philippine community preparation of Siling Labuyo liniment in the management of knee osteoarthritis. Methods. A 6-week randomized, double-blind, active-controlled clinical trial was conducted in three municipalities of Cavite from 2017-2018. The municipalities were randomly assigned to either the control or experimental group, using a commercially available Diclofenac 1% gel as the control agent. Knee Injury and Osteoarthritis Outcome Score (KOOS) and Pain Visual Analogue Scale (VAS) were used to measure the outcomes. Results. Forty-seven participants completed the study. Statistically significant improvement (p<0.05) in pain relief, reduction of symptoms and increase in knee functionality was reported by participants in both the experimental and control groups. Across the dimensions measured, at least 30% improvement in scores was reported by the experimental group, and at least 40% by the control group. The difference was statistically not significant (p>0.05). Itching (13%), burning sensation (11%) and reddening of the skin (15%) were experienced in both the experimental and the active control groups. Conclusion. Use of the liniment led to a modest therapeutic effect and was well-tolerated by the participants.

Effect of Traditional Food Supplementation During Pregnancy on Maternal Weight Gain and Birthweight

2002 ◽  
Vol 72 (6) ◽  
pp. 389-393 ◽  
Author(s):  
Kaseb ◽  
Kimiagar ◽  
Ghafarpoor ◽  
Valaii
Keyword(s):  
Weight Gain ◽  
Breast Milk ◽  
Control Group ◽  
Traditional Food ◽  
Maternal Weight Gain ◽  
Maternal Weight ◽  
Control Groups ◽  
Growth Trend ◽  
And Control ◽  
Experimental Group

The effects of supplementary traditional food on pregnant women were investigated in a clinical trial in Islamshahr, a suburban area 35 km southwest of Tehran. The study comprised 53 healthy mothers who were neither addicts nor on medication and were free from genetic disorders. The pregnant mothers’ health was evaluated by their weight gain, that of lactating mothers by breast milk adequacy, and that of newborns by their weight at birth. The experimental group received traditional food (rice-milk porridge, lentils, pottage, cheese, yogurt, eggs, and milk with bread), supplying an extra 400 kcal energy and 15 g protein from the fourth month of pregnancy until childbirth. All subjects were weighed monthly. To ascertain breast milk sufficiency, the duration of exclusive breastfeeding and the growth trend of infants were surveyed. The study showed the weight gain in the experimental and control groups to be 11.0 ± 2.9 and 8.5 ± 3 kg respectively; the difference was 29.4% and statistically significant (p < 0.02). The confounding variables (energy and protein intake, age, height, BMI, age at first pregnancy, parity, last pregnancy spacing, number of children, number of miscarriages, duration of residence in the area, family size, education, housing, occupation of the mother or her husband) did not reveal any significant differences. Maternal weight gain was higher in the experimental compared to the control group. Birth weights in experimental and control groups were 3.33 ± 0.4 and 3.08 ± 0.3 kg, respectively. This difference, which amounts to 8.1%, was statistically significant (p < 0.05). While the two groups of newborns had equal breastfeeding duration, heights and weights of newborns were significantly higher in the experimental group. This was also confirmed when compared to the NCHS figures.

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