The Novel Technoeconomic Paradigm. Emergency Technology and Profession of Future

2021 ◽  
Vol 23 (6) ◽  
pp. 279-284
Author(s):  
V.V. Luchinin ◽  
Keyword(s):  
Life Safety ◽  
The Novel ◽  
New Generation

Here are placed basic imaginations of creation industrial new generation society located in boundaries of development emergency technology for novel profession of future in next directions: Nature technology, Biointerface technology, Life safety.

scholarly journals Recent Advancements in Polythiophene-Based Materials and Their Biomedical, Geno Sensor and DNA Detection

2021 ◽  
Vol 22 (13) ◽  
pp. 6850
Author(s):  
Seyyed Mojtaba Mousavi ◽  
Seyyed Alireza Hashemi ◽  
Sonia Bahrani ◽  
Khadije Yousefi ◽  
Gity Behbudi ◽  
...  
Keyword(s):  
Biomedical Engineering ◽  
High Efficiency ◽  
Polymeric Materials ◽  
The Novel ◽  
Electrode Coating ◽  
Effective Response ◽  
Hiv Drugs ◽  
New Generation ◽  
New Compounds ◽  
Anti Hiv

In this review, the unique properties of intrinsically conducting polymer (ICP) in biomedical engineering fields are summarized. Polythiophene and its valuable derivatives are known as potent materials that can broadly be applied in biosensors, DNA, and gene delivery applications. Moreover, this material plays a basic role in curing and promoting anti-HIV drugs. Some of the thiophene’s derivatives were chosen for different experiments and investigations to study their behavior and effects while binding with different materials and establishing new compounds. Many methods were considered for electrode coating and the conversion of thiophene to different monomers to improve their functions and to use them for a new generation of novel medical usages. It is believed that polythiophenes and their derivatives can be used in the future as a substitute for many old-fashioned ways of creating chemical biosensors polymeric materials and also drugs with lower side effects yet having a more effective response. It can be noted that syncing biochemistry with biomedical engineering will lead to a new generation of science, especially one that involves high-efficiency polymers. Therefore, since polythiophene can be customized with many derivatives, some of the novel combinations are covered in this review.

scholarly journals Strategies for Vaccination: Conventional Vaccine Approaches Versus New-Generation Strategies in Combination with Adjuvants

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 140
Author(s):  
Abdellatif Bouazzaoui ◽  
Ahmed A. H. Abdellatif ◽  
Faisal A. Al-Allaf ◽  
Neda M. Bogari ◽  
Saied Al-Dehlawi ◽  
...  
Keyword(s):  
Viral Vectors ◽  
Protein Production ◽  
Vaccine Development ◽  
Effective Vaccine ◽  
The Novel ◽  
Research Teams ◽  
Advantages And Disadvantages ◽  
Rapid Spread ◽  
New Generation ◽  
Conventional Vaccine

The current COVID-19 pandemic, caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), has raised significant economic, social, and psychological concerns. The rapid spread of the virus, coupled with the absence of vaccines and antiviral treatments for SARS-CoV-2, has galvanized a major global endeavor to develop effective vaccines. Within a matter of just a few months of the initial outbreak, research teams worldwide, adopting a range of different strategies, embarked on a quest to develop effective vaccine that could be effectively used to suppress this virulent pathogen. In this review, we describe conventional approaches to vaccine development, including strategies employing proteins, peptides, and attenuated or inactivated pathogens in combination with adjuvants (including genetic adjuvants). We also present details of the novel strategies that were adopted by different research groups to successfully transfer recombinantly expressed antigens while using viral vectors (adenoviral and retroviral) and non-viral delivery systems, and how recently developed methods have been applied in order to produce vaccines that are based on mRNA, self-amplifying RNA (saRNA), and trans-amplifying RNA (taRNA). Moreover, we discuss the methods that are being used to enhance mRNA stability and protein production, the advantages and disadvantages of different methods, and the challenges that are encountered during the development of effective vaccines.

Why Do So Few Consumers Use Health Care Quality Report Cards? A Framework for Understanding the Limited Consumer Impact of Comparative Quality Information

2018 ◽  
Vol 76 (5) ◽  
pp. 515-537 ◽  
Author(s):  
Neeraj Bhandari ◽  
Dennis P. Scanlon ◽  
Yunfeng Shi ◽  
Rachel A. Smith
Keyword(s):  
Health Care Quality ◽  
Care Quality ◽  
Report Cards ◽  
Quality Information ◽  
The Novel ◽  
Cognitive Limitations ◽  
Provider Quality ◽  
The Media ◽  
New Generation ◽  
Novel Design

Despite growing investment in producing and releasing comparative provider quality information (CQI), consumer use of CQI has remained poor. We offer a framework to interpret and synthesize the existing literature’s diverse approaches to explaining the CQI’s low appeal for consumers. Our framework cautions CQI stakeholders against forming unrealistic expectations of pervasive consumer use and suggests that they focus their efforts more narrowly on consumers who may find CQI more salient for choosing providers. We review the consumer impact of stakeholder efforts to apply the burgeoning knowledge of consumers’ cognitive limitations to the design and dissemination of the new generation of report cards; we conclude that while it is too limited to draw firm conclusions, early evidence suggests consumers are responding to the novel design and dissemination strategies. We find that consumers continue to have difficulty accessing reliable report cards, while the media remains underused in the dissemination of report cards.

scholarly journals Haemocompatibility and ion exchange capability of nanocellulose polypyrrole membranes intended for blood purification

2012 ◽  
Vol 9 (73) ◽  
pp. 1943-1955 ◽  
Author(s):  
Natalia Ferraz ◽  
Daniel O. Carlsson ◽  
Jaan Hong ◽  
Rolf Larsson ◽  
Bengt Fellström ◽  
...  
Keyword(s):  
Ion Exchange ◽  
Platelet Adhesion ◽  
Conductive Polymer ◽  
Exchange Capacity ◽  
The Novel ◽  
Isotonic Solution ◽  
Solution Ph ◽  
Heparin Coating ◽  
New Generation ◽  
Cellulose Composite

Composites of nanocellulose and the conductive polymer polypyrrole (PPy) are presented as candidates for a new generation of haemodialysis membranes. The composites may combine active ion exchange with passive ultrafiltration, and the large surface area (about 80 m 2 g −1 ) could potentially provide compact dialysers. Herein, the haemocompatibility of the novel membranes and the feasibility of effectively removing small uraemic toxins by potential-controlled ion exchange were studied. The thrombogenic properties of the composites were improved by applying a stable heparin coating. In terms of platelet adhesion and thrombin generation, the composites were comparable with haemocompatible polymer polysulphone, and regarding complement activation, the composites were more biocompatible than commercially available membranes. It was possible to extract phosphate and oxalate ions from solutions with physiological pH and the same tonicity as that of the blood. The exchange capacity of the materials was found to be 600 ± 26 and 706 ± 31 μmol g −1 in a 0.1 M solution (pH 7.4) and in an isotonic solution of phosphate, respectively. The corresponding values with oxalate were 523 ± 5 in a 0.1 M solution (pH 7.4) and 610 ± 1 μmol g −1 in an isotonic solution. The heparinized PPy–cellulose composite is consequently a promising haemodialysis material, with respect to both potential-controlled extraction of small uraemic toxins and haemocompatibility.

scholarly journals I. Turgenev’s novel “Rudin” in Chinese literary studies

2019 ◽  
Vol 24 (3) ◽  
pp. 433-443
Author(s):  
Siwen Guo
Keyword(s):  
Literary Criticism ◽  
Chinese Literature ◽  
Great Influence ◽  
Russian Literature ◽  
The Novel ◽  
Ivan Sergeevich Turgenev ◽  
Future Studies ◽  
Russian Literary ◽  
Similar Images ◽  
New Generation

The work of I. Turgenev was translated into Chinese in the first half of the twentieth century and later spread widely in China, having a great influence on the new generation of Chinese writers. At the same time, more and more literary critics began to study the works of Turgenev. Extensive research and analysis, as well as the study of works from different angles, contributed to a better understanding of Turgenev and Russian literature by Chinese readers. The article discusses the publications of Chinese litterateurs and critics from the second half of the 20th to beginning of the 21st century, the work of Ivan Sergeevich Turgenev, notes the enduring interest of the Chinese audience to the work of Russian prose writer, in particular, to the novel “Rudin”. Special attention is paid to the prose writer's “path” to the novel; it is proved that the high interest of scientists to Dmitry Rudin, the protagonist of this novel, caused by Chinese specifics and the relevance of many problems associated with this image. The article explains the evolution of the attitude of the Chinese to Rudin: from agreement with Russian researchers considering him as a superfl person to disagreement with them. At the same time, Rudin is compared with typically similar images in Chinese literature. An analysis of Turgenev's works by Chinese literary critics will provide detailed information for future studies in international literary circles, and can also lay the foundation for finding differences between Chinese and Russian literary criticism.

scholarly journals Autofiction and the Diary: The Radicalization of Autofiction in Works by Hervé Guibert and Christine Angot

2022 ◽  
pp. 267-285
Author(s):  
Sam Ferguson
Keyword(s):  
Real World ◽  
Experimental Writing ◽  
The Novel ◽  
The Real ◽  
New Generation ◽  
Herve Guibert

AbstractAutofiction has often been viewed as a hybrid of autobiography and the novel. This chapter argues that a new generation of writers who emerged from the 1990s onward drew heavily on the diary instead of autobiography to develop their own innovative autofictional forms and practices. Whereas some critics have argued that the diary is fundamentally attached to truth and resistant to fiction, Hervé Guibert’s Voyage avec deux enfants (“Journey with Two Children,” 1982) and Christine Angot’s Léonore, toujours (“Léonore, Always,” 1993) provide two examples of experimental writing projects where the diary provides the means for new modalities of truth and fiction, allowing the authors to adopt a new relation to their writing and the real world.

scholarly journals In Silico Design of Multi-Epitope ESAT-6:Ag85b:Fcγ2a Fusion Protein as a Novel Candidate for Tuberculosis Vaccine

2020 ◽  
Vol 15 (2) ◽  
Author(s):  
Masoud Keikha ◽  
Mohsen Karbalaei ◽  
Kiarash Ghazvini
Keyword(s):  
Targeted Delivery ◽  
High Morbidity ◽  
The Novel ◽  
Online Tools ◽  
Basic Parameters ◽  
A Subunit ◽  
Immunodominant Antigens ◽  
Antigen Presenting ◽  
New Generation ◽  
Selection Of

: Mycobacterium tuberculosis (MTB), which is the causative agent of tuberculosis (TB), is among the most important infectious bacteria with high morbidity and mortality rates worldwide. Bacilli Calmette-Guerin (BCG) vaccine has been discovered for about a century, and it is considered as a major vaccine for humans. However, some factors, such as its attenuated nature and its inefficacy against the latent form of the disease, have led to the use of alternative vaccines. Multi-epitope subunit vaccines are new-generation vaccines that are being developed in clinical trial phases. For the production of a subunit vaccine, the selection of immunodominant antigens and targeted delivery systems to antigen presenting cells (APCs) are considered as basic parameters. In the present study, we designed the novel multi-epitope ESAT-6:Ag85B:Fcγ2a, which was evaluated completely by various online tools as an optimum vaccine against TB. The early secreted antigenic target of 6 kDa (ESAT-6) and antigen 85B (Ag85B) are two immunodominant antigens, and Fcγ2a is a targeted delivery system. This vaccine candidate can be used for future preclinical studies.

scholarly journals Molecularly Imprinted Polymer-Based Hybrid Materials for the Development of Optical Sensors

Polymers ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1173 ◽  
Author(s):  
Alberto Rico-Yuste ◽  
Sergio Carrasco
Keyword(s):  
Hybrid Materials ◽  
Optical Sensors ◽  
Materials Science ◽  
Synergetic Effect ◽  
Optical Signal ◽  
The Novel ◽  
Molecularly Imprinted ◽  
Recognition Ability ◽  
Recognition Elements ◽  
New Generation

We report on the development of new optical sensors using molecularly imprinted polymers (MIPs) combined with different materials and explore the novel strategies followed in order to overcome some of the limitations found during the last decade in terms of performance. This review pretends to offer a general overview, mainly focused on the last 3 years, on how the new fabrication procedures enable the synthesis of hybrid materials enhancing not only the recognition ability of the polymer but the optical signal. Introduction describes MIPs as biomimetic recognition elements, their properties and applications, emphasizing on each step of the fabrication/recognition procedure. The state of the art is presented and the change in the publication trend between electrochemical and optical sensor devices is thoroughly discussed according to the new fabrication and micro/nano-structuring techniques paving the way for a new generation of MIP-based optical sensors. We want to offer the reader a different perspective based on the materials science in contrast to other overviews. Different substrates for anchoring MIPs are considered and distributed in different sections according to the dimensionality and the nature of the composite, highlighting the synergetic effect obtained as a result of merging both materials to achieve the final goal.

Recent Advances in System Based Study for Anti-Malarial Drug Development Process

2019 ◽  
Vol 25 (31) ◽  
pp. 3367-3377 ◽  
Author(s):  
Brijesh S. Yadav ◽  
Navaneet Chaturvedi ◽  
Ninoslav Marina
Keyword(s):  
Drug Discovery ◽  
Large Scale ◽  
New Drugs ◽  
The Novel ◽  
Sequencing Data ◽  
Drug Molecules ◽  
Genes Expression ◽  
Depth Analysis ◽  
New Generation Sequencing ◽  
New Generation

Background: Presently, malaria is one of the most prevalent and deadly infectious disease across Africa, Asia, and America that has now started to spread in Europe. Despite large research being carried out in the field, still, there is a lack of efficient anti-malarial therapeutics. In this paper, we highlight the increasing efforts that are urgently needed towards the development and discovery of potential antimalarial drugs, which must be safe and affordable. The new drugs thus mentioned are also able to counter the spread of malaria parasites that have been resistant to the existing agents. Objective: The main objective of the review is to highlight the recent development in the use of system biologybased approaches towards the design and discovery of novel anti-malarial inhibitors. Method: A huge literature survey was performed to gain advance knowledge about the global persistence of malaria, its available treatment and shortcomings of the available inhibitors. Literature search and depth analysis were also done to gain insight into the use of system biology in drug discovery and how this approach could be utilized towards the development of the novel anti-malarial drug. Results: The system-based analysis has made easy to understand large scale sequencing data, find candidate genes expression during malaria disease progression further design of drug molecules those are complementary of the target proteins in term of shape and configuration. Conclusion: The review article focused on the recent computational advances in new generation sequencing, molecular modeling, and docking related to malaria disease and utilization of the modern system and network biology approach to antimalarial potential drug discovery and development.

scholarly journals An optimized synthesis of a key pharmaceutical intermediate methyl 4-[(1-oxopropyl)phenylamino]piperidine-4-carboxylate

2002 ◽  
Vol 67 (12) ◽  
pp. 793-802 ◽  
Author(s):  
Vesna Kiricojevic ◽  
Milovan Ivanovic ◽  
I.V. Micovic ◽  
J.B. Djordjevic ◽  
Goran Roglic ◽  
...  
Keyword(s):  
The Novel ◽  
Successive Treatment ◽  
Selective Hydrolysis ◽  
Narcotic Analgesics ◽  
Highly Active ◽  
Propionyl Chloride ◽  
Fentanyl Analogues ◽  
Basic Hydrolysis ◽  
New Generation ◽  
Hydrolysis Of

An efficient synthesis of methyl 4-[(1-oxopropyl)phenylamino]piperidine-4-carboxylate (7) has been developed starting from 1-benzylpiperidin-4-one (1). The compound is a key intermediate in the synthesis of new generation, highly active narcotic analgesics, such as remifintanil, as well as the novel classes of fentanyl analogues. An optimized Strecker-type condensation of piperidone 1 with aniline and HCN yielded the anilino-nitrile 2(?90%) which, upon selective hydrolysis with conc. H2SO4, gave the anilino-amide 3.After vigorous basic hydrolysis of 3, followed by acidification and successive treatment with SOCl2 and MeOH, the anilino-ester 5 was obtained (40?45%, in 3 steps). N-Acylation of 5 with propionyl chloride yielded the anilido-ester 6(70?80%) In the final step, the catalytic N-debenzylation of 6 was examined under various conditions and optimized to yield 7 in near quantitative yields.

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