scholarly journals CLINICAL MANIFESTATIONS OF INFECTIOUS MYOCARDITIS IN MEN AND WOMEN

The Clinician ◽  
2017 ◽  
Vol 11 (1) ◽  
pp. 45-49
Author(s):  
V. A. Sergeeva ◽  
A. S. Shmoylova
Keyword(s):  
Clinical Manifestations ◽  
Men And Women

scholarly journals Gender characteristics of gout and differences in response to taking xanthioxidase inhibitors

2021 ◽  
pp. 164-169
Author(s):  
V. V. Tsurko ◽  
M. A. Gromova
Keyword(s):  
Uric Acid ◽  
Clinical Characteristics ◽  
Clinical Manifestations ◽  
Joint Damage ◽  
Chronic Arthritis ◽  
Upper Extremities ◽  
Pronounced Increase ◽  
Men And Women ◽  
Lowering Therapy ◽  
Gender Characteristics

Introduction. To date, there is no consensus regarding the gender characteristics of the course of gout. There is little data on the possible difference between men and women in response to uric acid-lowering therapy.Aim. To compare the clinical characteristics of the course of gout and evaluate the differences in response to urate-lowering therapy (ULT) with allopurinol and febuxostat in men and women.Material and methods. The retrospective cohort study included 279 men and 83 women diagnosed with gout (ACR/EULAR, 2015). The comparative analysis of the clinical characteristics of gout, as well as responses to the intake of xanthioxidase (XO) inhibitors in representatives of different sexes, was carried out. We compared the gender characteristics of obtaining a positive response to ULT, defined as achieving a target serum uric acid (sUA) level of < 360 μmol / l within 6 months of treatment, while taking allopurinol and febuxostat.Results. By the age at which the onset of gout took place, women were older than men, the duration of the disease in them was shorter. Men showed a shorter duration of the first attack of arthritis. Chronic arthritis was diagnosed in 56% of men and 35% of women (p < 0.05). The process involved the joints of both the lower and upper extremities. However, more often the joints of the lower extremities were affected in men, and in the upper extremities in women. Tophus were detected in 35% of patients, of whom 30.3% were men, 4.7% were women (p < 0.05). Allopurinol was prescribed to 216 men and 54 women, and febuxostat was prescribed to 63 men and 29 women. After six months, the proportion of women who achieved the target sUA was 57.5% and 65.8%, the proportion of men – 60.4% and 76.2% for allopurinol and febuxostat, respectively.Conclusion. The clinical manifestations of gout in men and women differ. Due to the pronounced increase in the level of uric acid, men develop more severe joint damage due to the tendency to chronicity. However, the study did not reveal gender differences in the response to XO inhibitors, which indicates that there is no need to choose therapy depending on the patient’s gender.

ETHIOLOGY OF PURULENT INFLAMMATORY PROCESSES IN THE GENITAL TRACT: SUSPICIONS OF CLINICISTS AND PROBLEMS OF LABORATORY CONFIRMATION

2020 ◽  
Vol 65 (5) ◽  
pp. 328-331
Author(s):  
D. A. Oborin ◽  
N. V. Nikolaeva ◽  
A. P. Godovalov ◽  
T. I. Karpunina
Keyword(s):  
Genital Tract ◽  
Culture Media ◽  
Clinical Manifestations ◽  
Reproductive Age ◽  
Gardnerella Vaginalis ◽  
Sufficient Information ◽  
Gonococcal Infection ◽  
Men And Women ◽  
Inflammatory Processes ◽  
Study Laboratory

Despite the long history of the study, laboratory diagnosis of gonococcal infection remains a complex task that does not have a clearly regulated effective solution. Aim of investigation was to assess the species diversity of the microbiota of the genital tract of men and women with suspected acute genital gonococcal infection (AGGI) using test systems of Russian manufacturers. A study of samples of the contents of the urethra of 69 men and posterior vaginal fornix fluids of 33 women of reproductive age with characteristic clinical manifestations and a presumptive diagnosis of AGGI was made. Cultivation was carried out using elective culture media with subsequent identification of strains by biochemical properties. Detection of DNA of Neisseria gonorrhoeae, Staphylococcus spp., Streptococcus spp., Enterobacteriaceae, Gardnerella vaginalis, Atopobium vaginae, Lactobacillus spp. performed by PCR using Vektor-Best and InterLab Service kits (Russia). All patients were divided into groups according to the results of the bacteriological method and PCR. A metagenomic study of 16S ribosomal RNA samples was performed on the Illumina MiSeq platform using the MiSeq Reagent Kits v3 kit (600-Cycle Kit). Statistical analysis of the data was performed using criterion x2. As a result of a laboratory study, the presumptive clinical diagnosis of «AGGI» found its bacteriological confirmation in 35.3% of cases only, among which fragments of the N. gonorrhoeae genome were detected in 63.9% of the samples only. Moreover, a wide variety of microorganisms in the genital tract of both men and women was found in metagenomic analysis. However, this technique does not allow us to assess the viability of the detected bacteria, and the microflora spectrum is excessively wide. In addition, the high level of genetic polymorphism of different strains of N. gonorrhoeae complicates the interpretation of the results. Deciphering the composition of microbiota allows the use of InterLab Service kits. The decoding of the etiology of purulent-inflammatory processes in the genital tract, which presents serious difficulties, is greatly facilitated by the use of Russian kits for molecular genetic analysis, which, in our opinion, provide the necessary and sufficient information for practice.

scholarly journals Clinical and MRI peculiarities of chronical forms of cerebral circulation disorders in men and women with arterial hypertension

2002 ◽  
Vol XXXIV (1-2) ◽  
pp. 16-21
Author(s):  
A. T. Zabbarova ◽  
E. I. Bogdanov ◽  
M. M. Ibatullin
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Arterial Hypertension ◽  
Clinical Manifestations ◽  
Cognitive Disorders ◽  
Ischemic Heart ◽  
Edge Zone ◽  
Men And Women ◽  
Brain Substance ◽  
High Level

It had been performed a correlation of clinical and MRI characteristics of hypertonic angioencellopathy of cronical forms in men and women. It was done for the purpose of investigating sexual factor significance in cerebrovascular pathology. 50 men and 35 women who had clinical manifestations of discirculatory encephalopathy have been examined. It was revealed that in men paresis development is manly determined by total volume of brain substance lesion and by presence of large cortical-subcortical infactions, striocapsular infarctions and edge-zone infarctions; in women cognitive disorders are determined by total volume of brain substance. Diffuse forms are spread in men with accompanying ischemic heart disease, in women with prolonged arterial hypertension and with high level of arterial pressure. Ischemic heart disease in women is a result of the disease focal form.

Clinical manifestations and pathogenesis of reversible cerebral vasoconstriction syndrome

2020 ◽  
pp. 22-26
Author(s):  
M. Yu. Afanasyeva ◽  
V. V. Goldobin ◽  
E. G. Klocheva
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Clinical Manifestations ◽  
Reversible Cerebral Vasoconstriction Syndrome ◽  
Brachiocephalic Artery ◽  
Resonance Imaging ◽  
Men And Women ◽  
Cerebral Vasoconstriction ◽  
Significant Difference ◽  
The Brain

The data of patients with reversible cerebral vasoconstriction syndrome (RCVS) who were examined and treated in 2013–2020 are presented. 136 patients were examined (37.3 ± 11.4 years) – 107 (78.7 %) women, 29 (21.3 %) men. Detailed neurological examination, magnetic resonance imaging of the brain, magnetic resonance angiography and magnetic resonance venography were performed. Results. Primary RCVS was detected in 29 (21.3%), secondary RCVS – in 69 patients (50.7%), and a combination of primary and secondary RCVS factors – in 38 (28.0%) patients. In 95 (69.8%) patients (80 women, 15 men; p < 0.05) signs of cerebral artery angiodysplasia were identified. Hypoplasia of venous sinuses (transverse and/or sigmoid) was found in 34 patients (29 women and 5 men). Conclusions. RCVS is developed in women more often than men, but there was no significant difference in risk factors between men and women. Predisposing factors of both primary and secondary RCVS can be revealed simultaneously. Women were more likely to have variants of brachiocephalic artery development. Clarification of angiodysplasia variant influence to the development and severity of RCVS requires further study.

Urogenital Chlamydia trachomatis Serovars in Men and Women with a Symptomatic or Asymptomatic Infection: an Association with Clinical Manifestations?

2000 ◽  
Vol 38 (6) ◽  
pp. 2292-2296 ◽  
Author(s):  
S. A. Morré ◽  
L. Rozendaal ◽  
I. G. M. van Valkengoed ◽  
A. J. P. Boeke ◽  
P. C. van Voorst Vader ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Clinical Manifestations ◽  
Asymptomatic Infection ◽  
Men And Women

scholarly journals Sex and gender aspects in vascular pathophysiology

2020 ◽  
Vol 134 (16) ◽  
pp. 2203-2207
Author(s):  
Paul J. Connelly ◽  
Karin A.M. Jandeleit-Dahm ◽  
Christian Delles
Keyword(s):  
Cardiovascular Disease ◽  
Clinical Manifestations ◽  
Sex And Gender ◽  
Men And Women ◽  
Gender Aspects ◽  
And Gender ◽  
Two Populations

Abstract Cardiovascular disease (CVD) is a leading cause of global mortality in men and women. The prevalence, pathophysiology, clinical manifestations and outcomes of CVD observed in these two populations is being increasingly recognized as distinct. In this editorial, we provide an overview of mechanisms related to differences in vascular pathophysiology between men and women and explore the contributions of both sex and gender.

scholarly journals Kynurenine and Hemoglobin as Sex-Specific Variables in COVID-19 Patients: A Machine Learning and Genetic Algorithms Approach

Diagnostics ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 2197
Author(s):  
Jose M. Celaya-Padilla ◽  
Karen E. Villagrana-Bañuelos ◽  
Juan José Oropeza-Valdez ◽  
Joel Monárrez-Espino ◽  
Julio E. Castañeda-Delgado ◽  
...  
Keyword(s):  
Machine Learning ◽  
Genetic Algorithm ◽  
Immune Response ◽  
Support Vector Machine ◽  
Clinical Manifestations ◽  
Disease Diagnosis ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Men And Women ◽  
Metabolic Alterations

Differences in clinical manifestations, immune response, metabolic alterations, and outcomes (including disease severity and mortality) between men and women with COVID-19 have been reported since the pandemic outbreak, making it necessary to implement sex-specific biomarkers for disease diagnosis and treatment. This study aimed to identify sex-associated differences in COVID-19 patients by means of a genetic algorithm (GALGO) and machine learning, employing support vector machine (SVM) and logistic regression (LR) for the data analysis. Both algorithms identified kynurenine and hemoglobin as the most important variables to distinguish between men and women with COVID-19. LR and SVM identified C10:1, cough, and lysoPC a 14:0 to discriminate between men with COVID-19 from men without, with LR being the best model. In the case of women with COVID-19 vs. women without, SVM had a higher performance, and both models identified a higher number of variables, including 10:2, lysoPC a C26:0, lysoPC a C28:0, alpha-ketoglutaric acid, lactic acid, cough, fever, anosmia, and dysgeusia. Our results demonstrate that differences in sexes have implications in the diagnosis and outcome of the disease. Further, genetic and machine learning algorithms are useful tools to predict sex-associated differences in COVID-19.

scholarly journals Urogenital Chlamydia trachomatis Serovars in Men and Women with a Symptomatic or Asymptomatic Infection: an Association with Clinical Manifestations?

2000 ◽  
Vol 38 (6) ◽  
pp. 2292-2296 ◽  
Author(s):  
S. A. Morré ◽  
L. Rozendaal ◽  
I. G. M. van Valkengoed ◽  
A. J. P. Boeke ◽  
P. C. van Voorst Vader ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Clinical Manifestations ◽  
Asymptomatic Infection ◽  
Men And Women

scholarly journals EFFECT OF rTMS ON BLOOD CONTENT OF DEHYDROEPIANDROSTERONE-SULFATE (DEAS) AND CORTISOL IN MEN AND WOMEN WITH PARKINSON’S DISEASE (PD): A PILOT PLACEBO-CONTOLLED STUDY

2019 ◽  
Vol 19 (1S) ◽  
pp. 227-228
Author(s):  
S Ya Zhanaeva ◽  
M M Gevorgyan ◽  
S S Dzemidovich ◽  
K I Kulikova ◽  
G V Idova ◽  
...  
Keyword(s):  
Treatment Group ◽  
Hpa Axis ◽  
Primary Motor Cortex ◽  
Clinical Manifestations ◽  
Dehydroepiandrosterone Sulfate ◽  
Active Treatment Group ◽  
Dopamine Neurons ◽  
Meaningful Improvement ◽  
Men And Women ◽  
Updrs Part

PD is a neurodegenerative disease characterized with loss of dopamine neurons and associated with neuroinflamation and unbalanced in HPA-axis. We investigated the content of cortisol and DEAS - hormones of HPA-axis in patients with PD after applying rTMS. Feng S.F. et al. (2012) showed that rTMS improves the balance of HPA axis hormones during depression, which is one of the non-motor manifestations of PD. PD patients were randomized into groups with active rTMS (13 men, 11 women) and sham rTMS (10 men, 15 women).The 10Hz rTMS was performed sequentially over 2 targets: the primary motor cortex and the DLPFC daily for 20 days. Outcome measures included the indicators of MDS-UPDRS (Part 3) scale, content of cоrtisol and DEAS in the peripheral blood.The Motor Examination Part scores demonstrated clinically meaningful improvement only in the active treatment group (p < 0.01). The content of the DEAS in this group was negatively correlated with indicators of scales of clinical manifestations, stress and anxiety (p < 0.05). In this group an increase of content of DEAS in the peripheral blood of men was found (p < 0.01, Wald-Wolfowitz Runs Test). Thus, the rTMS increases the levels of a wellknown neuroprotective hormone and a modulator of DA activity DEAS only in men.

Sex differences and emerging new risk factors for atherosclerosis and its thrombotic complications

2020 ◽  
Vol 26 ◽  
Author(s):  
Teresa Padro ◽  
Natalia Muñoz-Garcia ◽  
Esther Peña ◽  
Lina Badimon
Keyword(s):  
Risk Factors ◽  
Sex Differences ◽  
Gene Expression Regulation ◽  
Current Knowledge ◽  
Clinical Manifestations ◽  
Men And Women ◽  
Thrombotic Complications ◽  
Traditional Risk Factors ◽  
Specific Disorders ◽  
Female Specific

: Cardiovascular disease (CVD) stays as the world's leading cause of death and disability in both men and women, but with different prognostic and outcome between sexes. Although the burden of CVD is generally related to the conventional risk factors, the relevance of non-traditional risk factors is increasingly recognized to explain the so-called “residual risk”. Men and women share many similarities regarding classical cardiovascular risk factors, but have different disease pathophysiology, clinical presentations, prevalence and outcome of CVD. How sex-specificities regarding effects of nontraditional risk factors may contribute to the evolution of atherosclerosis and its clinical manifestations in male and female remain largely under-analyzed. The present review summarizes the current knowledge for sex differences in atherosclerotic plaque composition and clinical evolution in association to risk factors such as inflammation, lipoprotein(a), haemostasis, intraplaque calcification and depression. We further discuss the potential sex-differential impact of chronic infectious diseases, gut microbiome and, epigenetic gene expression regulation for atherosclerosis and the effect of female-specific disorders in CVD.

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