scholarly journals The role of genetic factors in the development of liver cirrhosis in viral hepatitis B/D

2016 ◽  
Vol 21 (4) ◽  
pp. 206-210
Author(s):  
Aziza S. Khikmatullaeva ◽  
E. I Musabaev
Keyword(s):  
Liver Cirrhosis ◽  
Genetic Factors ◽  
Research Study ◽  
Non Invasive ◽  
Disease Outcomes ◽  
Viral Hepatitis B ◽  
Traditional Risk Factors ◽  
Hdv Infection ◽  
The Impact

In the article there is presented the influence of genetic variation in the IL28B gene on the risk of the development of liver cirrhosis and possibility offorecasting disease outcomes of HB/DV infected patients. The purpose of the research: Study of the influence of genetic variations in the IL28V gene on the risk of the development of liver cirrhosis and the ability to forecast the disease outcome of HB/DV infected patients. Materials and methods: For the assessment of the impact of IL28Brs8099917 SNP among the observed groups there was determined the genotype of rs8099917 in the IL28B locus TaqMan SNP by means of genotyping of 94 persons, including 72 patients with liver cirrhosis associated with HDV infection. For the comparison, there was taken a group of 22 patients with liver cirrhosis of HBV etiology. Results of executed studies have shown the distribution of genotypes in liver cirrhosis of HBV etiology to be differed considerably from liver cirrhosis of HDV etiology, as for rs8099917 TT genotype (P < 0.001) as well in rs8099917 TG genotype (P < 0.001). Traditional risk factors for the liver cirrhosis (sex, age, viral load, comorbidities) hardly influenced on the outcome of chronic viral hepatitides. Results ofperformed studies have shown the distribution of genotypes with liver cirrhosis induced by HDV to be significantly differed from the liver cirrhosis of HBV etiology, as well of TT genotype as TG genotype. Conclusion: Thus, the genetic analysis is a promising method for the non-invasive diagnosis of risk for development of liver cirrhosis.

scholarly journals Role of liver biopsy versus non-invasive biomarkers for diagnosis of significant fibrosis and cirrhosis: a web-based survey

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mohamed Alboraie ◽  
Marwa Khairy ◽  
Aisha Elsharkawy ◽  
Noha Asem ◽  
Mohamed El Kassas ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Liver Biopsy ◽  
Hepatic Fibrosis ◽  
Serum Biomarkers ◽  
Response To Treatment ◽  
Web Based ◽  
Non Invasive ◽  
Single Method ◽  
Radiological Methods

Abstract Background Liver biopsy is the standard reference for staging hepatic fibrosis. Non-invasive methods for assessment of hepatic fibrosis and cirrhosis are becoming increasingly popular. Objective We aimed at exploring the change in practice regarding the use of liver biopsy and non-invasive methods for staging hepatic fibrosis and cirrhosis among hepatologists. Methods We performed a survey-based study that recruited hepatologists from various Egyptian institutions. Physicians were deemed eligible if they had a degree in internal medicine with hepatology as a subspecialty. We utilized an online-based survey that assessed the acceptability and reliability of liver biopsy, serum biomarkers, and radiological tools for evaluating liver fibrosis and cirrhosis. Results A total of 573 responses were retrieved (response rate = 80.3%). Out of them, 58% were having more than 15 years of experience as a hepatologist. Liver biopsy is still considered the gold standard for assessment of hepatic fibrosis and cirrhosis by 61% of participants. Liver biopsy was accepted by 44% of their patients. 84% reported the need for a more practical alternative to liver biopsy to assess disease progression or response to treatment. 78.34% of participants know serum biomarkers, 84.08% reported that they were acceptable by their patients, 37.79% thought they are reliable. 95.4% were familiar with radiological methods of non-invasive assessment of hepatic fibrosis, 89.1% reported that radiological methods were acceptable by their patients, 62% think that they are reliable and 78% reported they were applicable in clinical practice. Sixty-five percent think that combining non-invasive methods is better than using a single method. Forty percent of participants thought that radiological methods are easier to use for assessment of hepatic fibrosis followed by a combination of non-invasive methods, serum biomarkers, and liver biopsy respectively. Conclusion In conclusion, liver biopsy is still considered the most reliable method for evaluation and staging of liver cirrhosis by hepatologists in Egyptian institutions, despite the modest acceptance by the patients. Nonetheless, non-invasive methods are gaining acceptance by Egyptian physicians and patients, and most of them consider these methods as reliable and applicable tools for predicting the course of liver cirrhosis.

Effective Pharmacist led interventional strategies to improve outcomes in hypertensive patients: a narrative review

2021 ◽  
Vol 3 (2) ◽  
Author(s):  
Samra Bashir ◽  
Akash Syed
Keyword(s):  
Pharmaceutical Care ◽  
Cost Effective ◽  
Pharmacist Intervention ◽  
Care Plan ◽  
Hypertensive Patients ◽  
Disease Outcomes ◽  
Cost Effective Alternative ◽  
The Impact

The role of pharmacist intervention as a cost-effective alternative to physician in disease management is increasingly been recognized. Studies have demonstrated that pharmaceutical care can improve drug therapy as well as patient satisfaction in chronic health conditions including cardiovascular diseases. This study is aimed to review and outline a comprehensive pharmaceutical care plan from the randomized controlled trials previously conducted to assess the impact of pharmacist-managed care on disease outcomes in hypertensive patients. Compared with usual care, the pharmaceutical intervention involved patient evaluation, patient education and counselling, medication review and management, patient monitoring and follow-up, and feedback to the primary physician as major strategies.

scholarly journals Evolving Perspectives on Innate Immune Mechanisms of IPF

2021 ◽  
Vol 8 ◽  
Author(s):  
Genta Ishikawa ◽  
Angela Liu ◽  
Erica L. Herzog
Keyword(s):  
Innate Immunity ◽  
Genetic Factors ◽  
Suppressor Cells ◽  
Innate Immune ◽  
Lymphoid Cells ◽  
Animal Modeling ◽  
Myeloid Suppressor Cells ◽  
Disease Outcomes ◽  
Molecular Patterns

While epithelial-fibroblast interactions are viewed as the primary drivers of Idiopathic Pulmonary Fibrosis (IPF), evidence gleaned from animal modeling and human studies implicates innate immunity as well. To provide perspective on this topic, this review synthesizes the available data regarding the complex role of innate immunity in IPF. The role of substances present in the fibrotic microenvironment including pathogen associated molecular patterns (PAMPs) derived from invading or commensal microbes, and danger associated molecular patterns (DAMPs) derived from injured cells and tissues will be discussed along with the proposed contribution of innate immune populations such as macrophages, neutrophils, fibrocytes, myeloid suppressor cells, and innate lymphoid cells. Each component will be considered in the context of its relationship to environmental and genetic factors, disease outcomes, and potential therapies. We conclude with discussion of unanswered questions and opportunities for future study in this area.

scholarly journals The impact of PNPLA3 and TM6SF2 in cirrhosis related complications

2021 ◽  
Author(s):  
Haruki Uojima ◽  
Xue Shao ◽  
Taeang Arai ◽  
Yuji ogawa ◽  
Toru Setsu ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Liver Disease ◽  
Hepatic Encephalopathy ◽  
Odds Ratio ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
Fibrosis Progression ◽  
Cirrhotic Patients ◽  
The Impact

Patatin-like phospholipase domain-containing 3 (PNPLA3) and transmembrane 6-superfamily member 2 (TM6SF2) polymorphisms have major impact for fibrosis due to steatohepatitis. However, there are scant data about correlations between cirrhosis-related complications and the polymorphisms of these genes. Therefore, we aimed to determine the role of the PNPLA3 and TM6SF2 polymorphisms in fibrosis progression for patients with liver cirrhosis. A multicenter study was performed at six hospitals in Japan enrolling 400 patients with liver cirrhosis caused by virus (n = 157), alcohol (n = 104), nonalcoholic fatty liver disease (NAFLD) (n = 106), or autoimmune disease (n = 33). These cirrhotic patients included those with complications of variceal bleeding, hepatic ascites, and/or hepatic encephalopathy and those without. To assess the role of the PNPLA3 and TM6SF2 polymorphisms in patients with cirrhosis related complications, we calculated the odds ratio and relative risk for the rs738409 and rs58542926 polymorphisms. We also accessed whether or not the interaction between these two polymorphisms contributed to cirrhosis related complications. As a result, the odds ratio for complications in the NAFLD group significantly increased in the presence of the rs738409 GG genotype when the CC genotype was used as the reference. There were no significant risks between complications and the presence of the rs738409 G allele in the virus or alcohol groups. There were no significant risks of complications in the frequency of the rs58542926 T polymorphism regardless of the etiology of liver cirrhosis. The interaction between the trs738409 and rs58542926 polymorphisms had the highest odds ratio of 2.415 for complications in the rs738409 GG + rs58542926 (CT+TT) group when rs738409 (CC+CG) + TM6SF2 CC was used as the reference in the NAFLD group.

scholarly journals Economic Perspectives of Trademarks

2018 ◽  
Vol 9 ◽  
pp. 73-83
Author(s):  
Rishi Ram Chapagai
Keyword(s):  
Intellectual Property ◽  
Global Economy ◽  
Service Sector ◽  
Research Study ◽  
Global Marketplace ◽  
Business Context ◽  
Trademark Protection ◽  
Economic Perspectives ◽  
The Impact

Primarily, this paper examines the role of trademark in global economy, as an intellectual property the value of trademark and brand in the global marketplace, and the economic potentiality of trademarks to generate more value and surplus in the economy. This paper also discusses the contribution of the trademarks for creating brand and value of business enterprises. The article is basically conceptual and descriptive in nature. Based on the literature review, the purposes of this paper are; to assess the perceived value of a trademark and brand, to examine the trademark roles for creating brand and value and to understand the impact of trademark on economy.The article deals with trademark and its economic perspectives. This article is valuable to understand the value of trademark in marketplace. The article helps academicians and practitioner to know the concept of trademark as an intellectual property and to understand that it can be used by market economy to generate more income, value, and surplus in the economy. The economic perspective of trademark can be applicable to many segments of Nepalese business context; ranging from manufacturing to service sector and importantly for the entrepreneurship development. Finally, the article is recommending for further empirical research study to examine the impact of trademark protection system for the countries’ economic growth. The Sapta Gandaki JournalVol. IX, 2018 Feb. Page: 73-83

scholarly journals LEADERSHIP PRINCIPLES FOR MANAGERS LEADING THE INDIAN INFORMATION TECHNOLOGY SECTOR

2021 ◽  
Author(s):  
Divya S
Keyword(s):  
Leadership Styles ◽  
Organizational Justice ◽  
Authentic Leadership ◽  
Research Study ◽  
Positive Perception ◽  
Physical Strain ◽  
Technology Sector ◽  
The Core ◽  
The Impact

In today’s global economic turmoil, organizations are challenged every day to stay not only in competition but also ahead, for the sake of its stakeholders. It is the leaders of an organization who spearhead the changes and handle contingent situations. After the leaders, the employees are the core strength of an organization. The top management invest a lot to ensure a contented workforce. Employees in all levels, give importance to the way they are being treated- with respect and dignity. They demand that the compensation and remuneration they receive are justified and deserving. If there is a conflict of these situations, then an employee is under undue stress to perform better, even when not satisfied with the workplace- leading to emotional exhaustion, cynicism, feeling unaccomplished and physical strain. In short, the employee experiences burnout. In this research study, two leadership styles- authentic leadership and transformational leadership are analyzed with respect to their influence on an employee’s perception about organizational justice and the burnout experienced. The impact of these leadership styles in ensuring a positive perception of organizational justice in employees is studied along with their influence in reducing employee burnout. The role of organizational justice is studied in a mediating capacity.

Abstract 97: The Impact of “Traditional” Risk Factors for Incident Versus Recurrent Stroke

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
George Howard ◽  
Brett Kissela ◽  
Dawn O Kleindorfer ◽  
Monika M Safford ◽  
Mary Cushman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Proportional Hazards ◽  
Recurrent Stroke ◽  
Absolute Risk ◽  
Stroke Risk Factors ◽  
Increased Risk ◽  
Traditional Risk Factors ◽  
Age Range ◽  
The Impact

Introduction: Risk factors for incident stroke have been shown to also be associated with risk for recurrent stroke; however, to our knowledge there has not been a cohort with risk factors measured in a sufficient number of stroke-free and prevalent stroke cases to contrast the impact of the risk factors between incident and recurrent stroke. Methods: REGARDS recruited 30,239 participants between 2003 and 2007. Participants were stratified into those reporting and not reporting a physician-diagnosed stroke at baseline. Proportional hazards analysis was used to assess the role of risk factors for stroke. Results: Over 6.2 years of follow-up, there were 825 strokes among 25,849 (3.2%) participants without stroke/TIA at baseline, and 310 strokes among 3,101 (10.0%) with stroke/TIA at baseline. In those stroke-free at baseline, there was an age-by-race interaction (p = 0.0003) with a substantially higher risk among blacks than whites at age 45 (HR = 2.69; 95% CI: 1.85 - 3.91), but with increasing age to age 85 this disparity disappeared (HR = 0.95; 95% CI: 0.74 - 1.23). However, there was a constant (p = 0.98) 21% non-significantly higher risk among blacks over the entire age range. For both blacks and whites, the impact of increasing age had a substantially smaller impact on recurrent than incident stroke. The traditional risk factors had a generally smaller impact for recurrent than incident stroke (significantly for atrial fibrillation and heart disease), however, they remained significantly associated with increased risk for recurrent stroke (see table). Discussion: The role of race and age differed for incident versus recurrent stroke, while the traditional risk factors persisted as indicators of higher risk for recurrent stroke. The smaller impact of stroke risk factors on recurrent stroke should be interpreted with caution, as the higher event rate in this group could imply that the risk factors still have a powerful effect on absolute risk.

Addressing LGBTQ+ Inclusion: Challenges, Faith, and Resilience in the Church and her People

2021 ◽  
Vol 48 (1) ◽  
pp. 75-105
Author(s):  
Helen Harris ◽  
Gaynor Gaynor ◽  
Carolyn Cole ◽  
Vanessa Cressy ◽  
Najeeah Smith ◽  
...  
Keyword(s):  
Research Study ◽  
Significant Finding ◽  
Policy And Practice ◽  
Qualitative Research Study ◽  
Difficult Conversations ◽  
Challenges And Opportunities ◽  
Survival And Growth ◽  
The Impact ◽  
The Church

The questions of the reception of and role of Lesbian, Gay, Bisexual, Transgender, Queer, Plus (LGBTQ+) persons in the Christian faith and Christian church have increasingly called for churches and             denominations to discern a position on membership, leadership, and participation in the sacraments. Individuals, families, congregations, and denominations are impacted by the differences in perspective, policy, and practice of affirming, including, or excluding LGBTQ+ persons. This article reports on a qualitative research study of 97 interviews in      20 congregations across three denominations exploring difficult conversations, decisions, and the impact of those decisions. The challenges and opportunities in both conversations and decisions are nested in faith perspectives. One significant finding is the role of individual and corporate faith in the resilience essential to both survival and growth.     T

scholarly journals Challenges and Opportunities for Communication about the Role of Genomics in Public Health

2021 ◽  
pp. 1-7
Author(s):  
Caitlin G. Allen ◽  
Ridgely Fisk Green ◽  
Scott Bowen ◽  
W. David Dotson ◽  
Wei Yu ◽  
...  
Keyword(s):  
Public Health ◽  
Genetic Factors ◽  
Health Programs ◽  
Genomic Information ◽  
Public Health Programs ◽  
The Public ◽  
Challenges And Opportunities ◽  
Communication Challenges ◽  
The Impact

Despite growing awareness about the potential for genomic information to improve population health, lingering communication challenges remain in describing the role of genomics in public health programs. Identifying and addressing these challenges provide an important opportunity for appropriate communication to ensure the translation of genomic discoveries for public health benefits. In this commentary, we describe 5 common communication challenges encountered by the Centers for Disease Control and Prevention’s Office of Genomics and Precision Public Health based on over 20 years of experience in the field. These include (1) communicating that using genomics to assess rare diseases can have an impact on public health; (2) providing evidence that genetic factors can add important information to environmental, behavioral, and social determinants of health; (3) communicating that although genetic factors are nonmodifiable, they can increase the impact of public health programs and communication strategies; (4) addressing the concern that genomics is not ready for clinical practice; and (5) communicating that genomics is valuable beyond the domain of health care and can be integrated as part of public health programs. We discuss opportunities for addressing these communication challenges and provide examples of ongoing approaches to communication about the role of genomics in public health to the public, researchers, and practitioners.

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