Human Dirofilariasis repens - migratory cutaneous and visceral helminthiasis: new data of "the old" disease. Analysis of cases and review

Dirofilaria repens is an emergent parasitic disease of dogs and man in Russiania. It infects humans accidentally via vectors. Occurrence D.repens in humans is most often in subcutaneous locations. Herein, we present autochtonous cases In Russiania of human dirofilariasis repens in almost all visceral organs with special attention to pulmonary dirofilariasis. Our data confirms the concept that the human being is a facultative host of Dirofilaria repens. Dirofilariasis prevalence is probably underestimated because of its non-specific clinical presentation. A national Russian prevalence study on dirofilariasis in animals and humans is called for in order to improve the management of the disease, both in veterinary and human medicine.

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Recently Recognized Cases of Ophthalmofilariasis in Hungary

European Journal of Ophthalmology ◽

10.1177/112067210901900424 ◽

2009 ◽

Vol 19 (4) ◽

pp. 675-678 ◽

Cited By ~ 14

Author(s):

Eszter Fodor ◽

Éva Fok ◽

Erika Maka ◽

Olga Lukáts ◽

Jeanette Tóth*

Keyword(s):

Clinical Presentation ◽

High Index ◽

Dirofilaria Repens ◽

The Other ◽

Slit Lamp ◽

The Past ◽

Red Eye ◽

High Index Of Suspicion ◽

Slit Lamp Biomicroscopy

Purpose To report four cases of zoonotic ophthalmodirofilariasis infection caused by Dirofilaria repens in Hungary. Methods Four cases of ophthalmofilariasis have been treated at our department during the last 14 months. A subconjunctival moving worm was observed by slit lamp biomicroscopy in two cases. In one of these a living filaria was surgically removed, but the other disappeared. Red eye and migrating edema were the presenting signs in two cases. A biopsy taken from the subcutaneous masses disclosed D repens. Results Histopathologic or parasitologic examination identified a female D repens in every case. Laboratory alterations were not found. Symptoms subsided after treatment. Conclusions The clinical presentation of filariasis is not always straightforward, and a high index of suspicion is necessary in cases presenting with orbital or periorbital inflammation. During the past 10 years the identification of locally acquired infections by D repens has increased in Hungary.

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A new case of deficiency of the R binder for cobalamin, with observations on minor cobalamin-binding proteins in serum and saliva

Blood ◽

10.1182/blood.v59.1.152.bloodjournal591152 ◽

1982 ◽

Vol 59 (1) ◽

pp. 152-156

Author(s):

R Carmel

Keyword(s):

Molecular Weight ◽

Alcohol Abuse ◽

Incidental Findings ◽

Clinical Presentation ◽

Binding Capacity ◽

Normal Serum ◽

Serum Component ◽

Almost All ◽

Normal Controls ◽

Low Serum

A patient presented at the age of 77 yr with a low serum cobalamin level. Subsequent study showed that he had persistently very low R binder (TC I) cobalamin-binding capacity in serum (less than 5 ng/liter versus 213 +/- 171 ng/liter in normal controls), and that almost all of his endogenous serum cobalamin was carried by TC II instead of TC I. His saliva also demonstrated virtually undetectable R binder (binding capacity of 31–38 ng/liter versus 41,690 +/- 23,820 ng/liter for control subjects). Unlike previous cases of R binder deficiency, he seemed to maintain normal serum cobalamin levels while receiving monthly cyanocobalamin injections. This and his normal serum unsaturated binding capacity were due to elevated TC II levels. TC II carried 72%-98% of his endogenous cobalamin, the rest being attached to minor binders. As incidental findings, the patient had a serum component of molecular weight of approximately 70,000 that carried 7%- 8% of his endogenous cobalamin and also had small quantities of TC II demonstrable in his saliva. Both these heretofore unappreciated minor peaks were identifiable because of the lack of R binder. The patient's clinical presentation supports the conclusion that R binder deficiency is a benign disorder. Whether his mild hypersegmentation of neutrophils and neuropathy were related to the R binder deficiency or, more likely, arose from coexisting folate deficiency and alcohol abuse, the overall picture contrasts dramatically with the severe clinical sequelae of TC II deficiency.

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Emociones del cuidador primario ante su enfermo con diagnóstico de Cáncer

Revista CuidArte ◽

10.22201/fesi.23958979e.2012.1.1.69062 ◽

2012 ◽

Vol 1 (1) ◽

pp. 22 ◽

Cited By ~ 1

Author(s):

José Antonio Nicolaz García ◽

Deyanira Vega Montes ◽

Ana Gabriel Castañeda Castro ◽

Eunice Olguín Vega

Keyword(s):

Qualitative Study ◽

Life Quality ◽

Disease Process ◽

Human Being ◽

Font Size ◽

Calidad De Vida ◽

Toma De Decisiones ◽

Almost All

Estudio cualitativo que tiene como objetivo analizar las emociones que presenta el cuidador primario ante el diagnóstico de cáncer de un ser querido, fue realizado en el Hospital Juárez de México en el servicio de pediatría.El cuidador primario tiende a desarrollar emociones, y en casi todas las circunstancias, influyen en la toma de decisiones; muchas de las grandes o pequeñas decisiones que toman los cuidadores están influenciadas por las emociones que son básicas e innatas del ser humano.Uno de los trastornos presentes y que conlleva al surgimiento de las emociones es el estrés ante la incertidumbre que desencadena el no saber el rumbo de la enfermedad.El llevar un proceso de enfermedad es difícil, aun más cuando hablamos de una enfermedad incurable en la cual sólo se puede dar una “mejor calidad de vida”. SUMMARY The present work is a qualitative study, which has as aim analyze the emotions that the primary keeper presents before the diagnosis of cancerof a dear being, it was realized in the Hospital Juárez of Mexico in the service of pediatrics. The primary keeper tends to develop emotions and in almost all the circumstances, they influence the capture of decisions; many of the big or small decisions that take the keepers are influenced by the emotions that are basic and innate of the human being. One of the present disorders and that he carries to the emergence of the emotions is the stress before the uncertainty that unleashes ignorance about the course of the disease. Facing a disease process is difficult, furthermore when talking about an incurable one, in which it is only possible to provide a better life quality.

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Human dirofilariasis due to Dirofilaria repens in Ukraine, an emergent zoonosis: epidemiological report of 1465 cases

Acta Parasitologica ◽

10.2478/s11686-013-0187-x ◽

2013 ◽

Vol 58 (4) ◽

Cited By ~ 43

Author(s):

Rusłan Sałamatin ◽

Tamara Pavlikovska ◽

Olga Sagach ◽

Svitlana Nikolayenko ◽

Vadim Kornyushin ◽

...

Keyword(s):

Skin Lesion ◽

Surveillance System ◽

Mammary Glands ◽

Dirofilaria Repens ◽

National Surveillance ◽

Registration System ◽

Western Ukraine ◽

Human Dirofilariasis ◽

Analysis Point ◽

National Surveillance System

AbstractThe filarial nematode Dirofilaria repens is currently considered to be one of the most extensively spreading human and animal parasites in Europe. In Ukraine, reporting cases of dirofilariasis has been mandatory since 1975, and the disease was included in the national surveillance system for notifiable diseases. Up until December 31st 2012, a total of 1533 cases have been registered, with 1465 cases occurring within the previous 16 years. Most of the cases of dirofilariasis were registered in 6 regions: Kyiv, and the Donetsk, Zaporizhzhya, Dnipropetrovsk, Kherson and Chernihiv oblasts. In the years 1997–2002 the highest incidence rate was noted in the Kherson oblast in the south of the country (9.79 per 100 000 people), and the lowest in western Ukraine (0.07–1.68 per 100 000 people). D. repens infections were registered in all oblasts. Parasitic lesions were most often located in the head, the subconjunctival tissue and around the eyes. D. repens lesions were also found in the limbs, torso, male sexual organs, and female mammary glands. Dirofilariasis was diagnosed in persons aged from 11 months to 90 years old, most often among people between 21–40 years of age. Most patients had only one parasitic skin lesion; the majority of isolated nematodes were female. The results of our analysis point to a constant increase in D. repens dirofilariasis incidence in humans in Ukraine. Despite educational efforts, infections have become more frequent and the territory in which the disease occurs has enlarged to encompass the whole of Ukraine. Nevertheless, the Ukrainian sanitary-epidemiological services managed to achieve some measure of success, e.g. by creating a registration system for D. repens infections and establishing proper diagnostics for the disease.

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SPIRITUAL DEVELOPMENT AS A NECESSARY CONDITION OF WAY OUT OF THE CRISIS FOR SOCIETY

The Educational Discourse a collection of scientific papers ◽

10.33930/ed.2019.5007.29(12)-1 ◽

2021 ◽

pp. 7-14

Author(s):

Svitlana Repetii

Keyword(s):

Spiritual Development ◽

Value Orientations ◽

Mental Illnesses ◽

Necessary Condition ◽

Human Being ◽

Emotional Instability ◽

Life Activity ◽

Almost All

The crisis of the present day, which covered almost all types of life activities, contributes to the development of impoverishment, degradation, leads to an increase of criminality, generates fear, emotional instability in the society. Forced isolation, threat of loss of work and value orientations contribute to the emergence of mental illnesses. Each person is responsible for his actions, thoughts and feelings – for themselves and society. Spiritual development is interpreted as a conscious life activity, transformation of negative qualities, which is considered as a daily inner action. This kind of life activity contributes to the development of unconditioned love, which we interpret as perception of a human being in its entirety without condemnation and pretensions.

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Human dirofilariasis due to Dirofilaria repens in the Russian Federation—remarks concerning epidemiology

International Journal of Infectious Diseases ◽

10.1016/j.ijid.2014.04.009 ◽

2014 ◽

Vol 28 ◽

pp. 225 ◽

Cited By ~ 3

Author(s):

Aleksander Masny ◽

Rusłan Sałamatin ◽

Danuta Cielecka ◽

Vitaliy O. Kharchenko ◽

David Bruce Conn ◽

...

Keyword(s):

Russian Federation ◽

Dirofilaria Repens ◽

Human Dirofilariasis ◽

The Russian Federation

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The Common Clinical Presentation of Patients Selected for Septoplasty in Northern Saudi Arabia

International Journal of Otolaryngology ◽

10.1155/2018/8536387 ◽

2018 ◽

Vol 2018 ◽

pp. 1-8 ◽

Cited By ~ 1

Author(s):

Abdullah D. Alotaibi ◽

Bassam Ahmed Almutlaq ◽

Fahad Nashmi Alshammari ◽

Hussain Gadelkarim Ahmed

Keyword(s):

Saudi Arabia ◽

Nasal Obstruction ◽

Nasal Septum ◽

Clinical Presentation ◽

Critical Role ◽

Deviated Nasal Septum ◽

Clinical Presentations ◽

Common Clinical Presentation ◽

The Common ◽

Almost All

Background. Nasal septal deviation (NSD) plays a critical role in nasal obstruction symptoms, aesthetic look of the nose, increased nasal resistance, and occasionally snoring. Septoplasty is the most common method for correction of deviated nasal septum (DNS). Therefore, the aim of the present study was to assess the association between initial clinical presentations of patients selected for septoplasty and demographical characteristics in Northern Saudi Arabia.Methodology. Archives related to all patients selected for septoplasty between 2012 and 2017 were retrieved from ENT Department at King Khalid Hospital in Hail, Northern Saudi Arabia. Only adults over 18 years of age were included in this study.Results. With regard to the clinical presentations, almost all patients presented with variable degrees of nasal congestions, nasal blockages, breathing troubles, sleeping troubles, and exercise problems.Conclusion. Nasal obstruction is prevalent in Northern Saudi Arabia with peaks being in the years 2016 and 2014 with the most etiological factor being DNS.

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Pseudo-Tumor of the Epididymis, a Rare Clinical Presentation of Human Dirofilaria repens Infection: a Report of Autochthonous Case of Dirofilariasis in Southwestern Slovakia

Acta Parasitologica ◽

10.2478/s11686-020-00170-w ◽

2020 ◽

Vol 65 (2) ◽

pp. 550-553 ◽

Cited By ~ 1

Author(s):

Vojtech Boldiš ◽

František Ondriska ◽

Vladimír Bošák ◽

Ondrej Hajdúk ◽

Daniela Antolová ◽

...

Keyword(s):

Clinical Presentation ◽

Dirofilaria Repens ◽

Autochthonous Case

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Cutaneous and pulmonary dirofilariasis due to Dirofilaria repens

British Journal of Dermatology ◽

10.1111/bjd.13859 ◽

2015 ◽

Vol 173 (3) ◽

pp. 788-791 ◽

Cited By ~ 12

Author(s):

M. Benzaquen ◽

D. Brajon ◽

M. Delord ◽

N. Yin ◽

F. Bittar ◽

...

Keyword(s):

Dirofilaria Repens ◽

Pulmonary Dirofilariasis

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Human dirofilariasis: current situation and possibilities for diagnosis

Trakia Journal of Sciences ◽

10.15547/tjs.2020.04.013 ◽

2020 ◽

Vol 18 (4) ◽

pp. 388-395

Author(s):

B. Chakarova ◽

M. Mitev

Keyword(s):

Human Body ◽

Blood Circulation ◽

Global Climate ◽

Current Situation ◽

Surgical Extraction ◽

Filarial Nematodes ◽

Human Dirofilariasis ◽

Pulmonary Dirofilariasis ◽

Vector Borne ◽

Accidental Host

Dirofilariasis in humans is a rarely diagnosed vector-borne zoonotic helminthic invasion. It is caused from filarial nematodes genus Dirofilaria & Railliet Henry, 1911 (Onchocercidae, Nematoda). Usually, the life cycle of the parasite takes place between mosquitoes (Culicidae) and carnivores. The human is an accidental host for the dirofilaria wherefore microfilariae in his blood circulation are almost always absent. The pathology of dirofilariasis results from the accidental localization of immature worms in the human body. Dirofilaria immitis caused heart and pulmonary dirofilariasis, but Dirofilaria repens, D. tenuis, and others can are found in different parts of the human body. The spread and Dirofilaria-invasive rates аrе undergone significant modifications affected by global climate change. Surgical extraction of the parasite in humans usually has a therapeutic effect, after which an etiological diagnosis is possible. The aim of the study is to review the current situation of human dirofilariasis in clinical and epidemiological aspects and possibilities for diagnosis.

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