The degree of severity and structure of cognitive disorders in patients with cerebrovascular disease, depending on the level of 25-hydroxycalciferol

BACKGROUND: In recent years, a significant increase in cerebrovascular pathology, which is often accompanied by cognitive deficits, has been noted all over the world. AIM: The aim of this study is to determine the severity and structure of cognitive disorders depending on the level of 25(OH)D in patients with cerebrovascular disease. MATERIALS AND METHODS: 146 patients with cerebrovascular disease aged from 30 to 80 years were examined. The comparison group consisted of 40 patients, comparable in age and gender, without the studied pathology. During the study, the level of 25(OH)D, interleukin-6, highly sensitive C-reactive protein in the peripheral blood was determined in patients and a neuropsychological examination was performed. RESULTS: In patients with cerebrovascular disease, the level of 25(OH)D it was lower in comparison with patients without this pathology. Patients with higher rates of inflammatory factors had significantly lower concentrations of 25(OH)D in the peripheral blood. The study revealed a correlation between the level of 25(OH)D in peripheral blood and the results of neuropsychological testing: direct MMSE, MoCA, FAB and reverse Schulte tables (performance). When assessing cognitive disorders in patients with cerebrovascular disease, according to the results of neuropsychological testing, it was possible to identify significantly significant differences between the main and the comparison group according to the following scales: MMSE (p = 0.04), MoCA (p = 0.001), FAB (p = 0.007), Schulte Tables (performance) (p = 0.06), respectively. When interpreting the MMSE scale, significantly significant differences between the groups were found in the attention assessment (p = 0.03), and in the analysis of the MoCA scale in the sections delayed reproduction (p = 0.03) and conceptualization (p = 0.04), respectively. In patients with cerebrovascular disease, memory is most affected by the type of delayed reproduction failure, which was observed in 53-76% of cases in our study. CONCLUSIONS: The study found that the higher the concentration of 25(OH)D and the lower the level of interleukin-6 and highly sensitive CRP in the peripheral blood, the less likely it is to develop cognitive disorders. In patients with cerebrovascular disease, memory is most affected by the type of delayed reproduction failure.

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Effect of vitamin D3 (cholecalciferol) levels on the development of cognitive and psychoemotional disorders in patients with cerebrovascular disease

Medical academic journal ◽

10.17816/maj19225 ◽

2020 ◽

Vol 20 (1) ◽

pp. 93-100

Author(s):

Sergey V. Lobzin ◽

Grigoriy I. Shvartsman ◽

Evgenia M. Pervova ◽

Inga V. Chistova ◽

Ekaterina A. Yurkina

Keyword(s):

Quality Of Life ◽

Cerebrovascular Disease ◽

Interleukin 6 ◽

Peripheral Blood ◽

Comparison Group ◽

Interleukin 1 ◽

Quality Of Life Indicators ◽

Highly Sensitive ◽

The Relationship

In recent years, the problem of vascular cognitive impairment is becoming increasingly important due to the increasing prevalence of cerebrovascular disease. The aim of this study was to determine the relationship between 25(OH)D, highly sensitive CRP, interleukin-1, interleukin-6 and cognitive function in patients with cerebrovascular disease and to assess their impact on quality of life. Materials and methods. 58 patients with cerebrovascular disease aged 3181 years were examined. The comparison group consisted of 24 patients, comparable in age and sex, without the studied pathology. In the study, patients were determined by the level of 25(OH)D, interleukin-1, interleukin-6, highly sensitive CRP in peripheral blood. All patients underwent neuropsychological, psychometric examination and study of their quality of life. Results. In the study, the level of 25(OH)D in patients with cerebrovascular disease was lower compared to the group without this pathology. Concentrations of interleukin-1, interleukin-6, and highly sensitive CRP in patients in the main group were statistically significantly higher than in those in the comparison group. Higher concentrations of highly sensitive CRP, interleukin-1, and interleukin-6 were found in patients with low vitamin D availability. The study obtained direct correlations between the level of 25(OH)D in peripheral blood and the results of neuropsychological testing (MMSE, MoCA, FAB, Schulte tables (performance), the Drawing hours test) and the inverse with the degree of workability (Schulte tables). An inverse correlation of average strength was observed between the results of psychometric testing and the level of 25(OH)D in peripheral blood. The study confirmed the relationship between the level of 25(OH)D in peripheral blood and quality of life indicators, in the form of a direct correlation. Conclusion. The study found that the higher the concentration of 25 (OH)D and the lower the level of interleukin-1, interleukin-6, and highly sensitive CRP in the peripheral blood, the less likely it is to develop cognitive and psychoemotional disorders. The study confirmed the relationship between the level of 25(OH)D and quality of life indicators.

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Interleukin-6: A Novel Target for Cardio-Cerebrovascular Diseases

Frontiers in Pharmacology ◽

10.3389/fphar.2021.745061 ◽

2021 ◽

Vol 12 ◽

Author(s):

Jian-Hui Su ◽

Meng-Yi Luo ◽

Na- Liang ◽

Shao-Xin Gong ◽

Wei Chen ◽

...

Keyword(s):

Cerebrovascular Disease ◽

Interleukin 6 ◽

Cerebrovascular Diseases ◽

Cerebral Injury ◽

Inflammatory Factors ◽

Cerebrovascular Event ◽

Novel Target ◽

Novel Strategy ◽

The Stability ◽

Infarction Heart

Cardio-Cerebrovascular Disease is a collective term for cardiovascular disease and cerebrovascular disease, being a serious threat to human health. A growing number of studies have proved that the content of inflammatory factors or mediators determines the stability of vascular plaque and the incidence of cardio-cerebrovascular event, and involves in the process of Cardio-Cerebrovascular Diseases. Interleukin-6 is a widely used cytokine that causes inflammation and oxidative stress, which would further result in cardiac and cerebral injury. The increased expression of interleukin-6 is closely related to atherosclerosis, myocardial infarction, heart failure and ischemic stroke. It is a key risk factor for these diseases by triggering inflammatory reaction and inducing other molecules release. Therefore, interleukin-6 may become a potential target for Cardio-Cerebrovascular Diseases in the future. This paper is aimed to discuss the expression changes and pathological mechanisms of interleukin-6 in Cardio-Cerebrovascular Diseases, and to provide a novel strategy for the prevention and treatment of Cardio-Cerebrovascular Diseases.

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Glucose-dependent interleukin 6 and tumor necrosis factor production by human peripheral blood monocytes in vitro

Diabetes ◽

10.2337/diabetes.45.7.954 ◽

1996 ◽

Vol 45 (7) ◽

pp. 954-959 ◽

Cited By ~ 42

Author(s):

M. Morohoshi ◽

K. Fujisawa ◽

I. Uchimura ◽

F. Numano

Keyword(s):

Tumor Necrosis Factor ◽

Interleukin 6 ◽

Peripheral Blood ◽

Tumor Necrosis ◽

Human Peripheral Blood ◽

Blood Monocytes ◽

Tumor Necrosis Factor Production ◽

Peripheral Blood Monocytes ◽

Necrosis Factor

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Rapid, highly sensitive and quantitative detection of interleukin 6 based on SERS magnetic immunoassay

Analytical Methods ◽

10.1039/d0ay02304c ◽

2021 ◽

Vol 13 (15) ◽

pp. 1823-1831

Author(s):

Xiaomei Wang ◽

Li Ma ◽

Shijiao Sun ◽

Tingwei Liu ◽

Hao Zhou ◽

...

Keyword(s):

Interleukin 6 ◽

High Sensitivity ◽

Quantitative Detection ◽

Detection Time ◽

Highly Sensitive ◽

Sandwich Method

We have developed a SERS magnetic immunoassay method based on the principle of sandwich method for rapid and quantitative detection of IL-6. The developed SERS method has the advantages of high sensitivity and detection time is only 15 min.

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A highly sensitive immunoassay for interleukin-6 in dried blood spots

American Journal of Human Biology ◽

10.1002/ajhb.22324 ◽

2012 ◽

Vol 24 (6) ◽

pp. 863-865 ◽

Cited By ~ 16

Author(s):

Elizabeth M. Miller ◽

Thomas W. Mcdade

Keyword(s):

Interleukin 6 ◽

Dried Blood Spots ◽

Blood Spots ◽

Highly Sensitive

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Inverse correlation of interleukin-6 with soluble interleukin-6 receptor after transplantation of bone marrow or peripheral blood stem cells

Bone Marrow Transplantation ◽

10.1038/sj.bmt.1700936 ◽

1997 ◽

Vol 20 (9) ◽

pp. 715-720 ◽

Cited By ~ 7

Author(s):

M Steffen ◽

U Pichlmeier ◽

A Zander

Keyword(s):

Stem Cells ◽

Bone Marrow ◽

Interleukin 6 ◽

Peripheral Blood ◽

Inverse Correlation ◽

Peripheral Blood Stem Cells ◽

Interleukin 6 Receptor ◽

Blood Stem Cells

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The Role of Self- and Informant-Reports on Symptoms and Impairments in the Clinical Evaluation of Adult ADHD

Sustainability ◽

10.3390/su13084564 ◽

2021 ◽

Vol 13 (8) ◽

pp. 4564

Author(s):

Nana Guo ◽

Anselm B. M. Fuermaier ◽

Janneke Koerts ◽

Bernhard W. Mueller ◽

Christian Mette ◽

...

Keyword(s):

Clinical Evaluation ◽

Test Performance ◽

Adult Adhd ◽

Comparison Group ◽

Neuropsychological Test ◽

Neuropsychological Testing ◽

Adhd Group ◽

Adhd Symptoms ◽

Clinical Comparison

Little is known about which clinical features may aid the differentiation between attention deficit hyperactivity disorder (ADHD) and other clinical conditions. This study seeks to determine the role of self- and informant reports on symptoms and impairments in the clinical evaluation of adult ADHD and explore their association with objective neuropsychological test performance by examining data of 169 outpatients referred for a diagnostic evaluation of adult ADHD. Participants were assigned either to an ADHD group (ADHD, n = 73) or one of two clinical comparison groups, depending on whether they show indications (Clinical Comparison Group, CCG, n = 53) or no indications (Clinical Comparison Group—Not Diagnosed, CCG-ND, n = 43) of psychiatric disorders other than ADHD. All participants and their informants completed a set of questionnaires. Compared to the CCG-ND, the ADHD group obtained significantly higher scores on ADHD symptoms, impulsivity, cognitive deficits, and anxiety. Compared to the CCG, the ADHD group scored significantly higher on ADHD symptoms but lower on depression. Further regression analyses revealed that self- and informant reports failed to predict neuropsychological test performance. Self- and informant reported information may be distinct features and do not correspond to results of objective neuropsychological testing.

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Verbal memory deficits associated with fornix atrophy in carbon monoxide poisoning

Journal of the International Neuropsychological Society ◽

10.1017/s1355617701005112 ◽

2001 ◽

Vol 7 (5) ◽

pp. 640-646 ◽

Cited By ~ 36

Author(s):

SHELLI R. KESLER ◽

RAMONA O. HOPKINS ◽

LINDELL K. WEAVER ◽

DUANE D. BLATTER ◽

HOLLY EDGE-BOOTH ◽

...

Keyword(s):

Carbon Monoxide ◽

Verbal Memory ◽

Visual Memory ◽

Carbon Monoxide Poisoning ◽

Neuropsychological Testing ◽

Mr Images ◽

Cross Sectional ◽

Memory Processing ◽

Within Subjects ◽

And Gender

Magnetic resonance (MR) images and neuropsychological testing data of 69 carbon monoxide (CO) poisoned patients were prospectively obtained within 1 day of CO poisoning, two weeks and six months. CO patients' Day 1 cross-sectional fornix surface area measurements, corrected for head size by using a fornix-to-brain ratio (FBR), were compared to normal age and gender-matched controls. Additionally, a within-subjects analysis was performed comparing the mean areas between CO patients' Day 1, 2 weeks and 6-month FBR. The FBR was correlated with patients' neuropsychological data. There were no significant differences between CO patients' Day 1 fornix measurements compared to normal control subjects. However, significant atrophic changes in the fornix of CO poisoned patients occurred at two weeks with no progressive atrophy at 6 months. By 6 months, CO patients showed significant decline on tests of verbal memory (when practice effects were taken into account), whereas visual memory, processing speed and attention/concentration did not decline. This study indicates that CO results in brain damage and cognitive impairments in the absence of lesions and other neuroanatomic markers. (JINS, 2001, 7, 640–646.)

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