scholarly journals The spectrum of vital activity restrictions in disabled people due to thyroid cancer

2021 ◽  
Vol 24 (2) ◽  
pp. 33-40
Author(s):  
Gagik E. Pogosyan ◽  
Andrey V. Grechko ◽  
Sergey N. Puzin ◽  
Marina A. Shurgaya ◽  
Servir S. Memetov
Keyword(s):  
Thyroid Cancer ◽  
Dynamic Assessment ◽  
Adult Population ◽  
Malignant Neoplasm ◽  
Endocrine System ◽  
The Elderly ◽  
Malignant Neoplasms ◽  
Disabled People ◽  
Degree Of Disability ◽  
Significant Disability

BACKGROUND: The most common malignant neoplasm of the endocrine system is thyroid cancer. In Russia, as in other countries of the world, the incidence rate is steadily increasing. Thus, it is extremely important to assess the problem of health disorders due to thyroid cancer within the framework of socially significant disability caused by malignant neoplasms in the Russian Federation. AIMS: To analyze the spectrum of types and degree of disability in people with disabilities due to thyroid cancer. MATERIAL AND METHODS: The article presents the results of the analysis of the spectrum of the main types of disability in the general contingent of disabled people due to thyroid cancer among the adult population of Moscow (20152019). RESULTS: The dynamics of disability both in the contingent of first recognized and in the contingent of re-recognized disabled people (VPI and PPI) was characterized by an increase in the number of disabled people and the transformation of the structure of general disability. There is a clear change in the ratio towards an increase in the share of PPI from 55.1% in 2015. up to 68.0% in 2019, while the share of VPI decreased from 44.9% in 2015 to 32.0% in 2019. The predominant gender cohort was women, and the age category was the elderly. The main types of life restrictions were the restriction of the ability to self-serve (98.6% of the VPI and 97.9% of the PPI), to work (94.7% of the VPI and 94.6% of the PPI) and to move (21.3% of the VPI, 21.8% of the PPI). A low proportion of restrictions on the ability to control ones behavior, learning, communication and orientation was revealed (0.31.2%). The first degree of disability prevailed in the contingents of VPI and PPI (p 0.0001). In the contingent of men, the proportion of disabled people with the third degree of disability was higher compared to the contingent of women. CONCLUSION: Dynamic assessment of the degree of severity of functional disorders and associated life restrictions should be carried out at all stages of medical and social rehabilitation in order to monitor the effectiveness of medical and rehabilitation measures, assess the quality of life and prevent progression (secondary prevention of disability).

RESULTS OF MONITORING OF REPEATED DISABILITY DUE TO THYROID CANCER IN THE ADULT POPULATION IN MOSCOW

2020 ◽  
Vol 3 ◽  
pp. 38-46
Author(s):  
G.E. Pogosyan ◽  
Keyword(s):  
Thyroid Cancer ◽  
Adult Population ◽  
Age Groups ◽  
Malignant Neoplasm ◽  
Endocrine System ◽  
Malignant Neoplasms ◽  
Group Iii ◽  
Group I ◽  
Disability Group ◽  
Group Ii

Among socially significant diseases that are characterized by high prevalence rates, malignant neoplasms occupy the leading positions. Thyroid cancer is the most common malignant neoplasm of the endocrine system. Purpose of the study. Analysis of recurrent disability due to thyroid cancer in the adult population in Moscow (2015–2019). Materials and research methods. The structure of repeated disability due to thyroid cancer by sex, age and disability group was studied. The dynamics of the number of the PPI contingent was traced and the level of repeated disability due to this pathology was determined. The number of observations was 4660 PPI. Research results. It was found that in the structure of repeated disability due to thyroid cancer, women predominated by gender. The trend towards an increase in the number of PPI took place in all major age groups of the adult population. The prevalence of PPI with group III disability, the proportion of which was 66.0% (PPI with group II – 32.5%, PPI with group I – 1.5%). The visibility indicator in 2019 in relation to 2015 (taken as 100%) was equal in the general contingent of PPI among disabled people of group I – 142.9%, group II – 374.1%, group III – 249.3% ...

scholarly journals NOSOLOGICAL SPECTRUM OF THE DISABILITY IN THE ELDERLY POPULATION OF THE ELDERLY CATEGORY IN THE RUSSIAN FEDERATION AND PECULIARITIES OF REHABILITATION-EXPERT DIAGNOSTICS, REHABILITATION AND ABILITATION

2017 ◽  
Vol 20 (3) ◽  
pp. 136-143
Author(s):  
Marina A. Shurgaya
Keyword(s):  
Elderly People ◽  
Social Services ◽  
Russian Federation ◽  
Population Aging ◽  
Adult Population ◽  
The Elderly ◽  
Developed Countries ◽  
Disabled People ◽  
Elderly Age ◽  
The Russian Federation

Disability of the elderly age group of the population is the most important problem of public health and social services of all developed countries over the world without exception. In the Russian Federation, this age segment is characterized by the gain, reflecting the global process of population aging. The aim of the study was to analyze the nosological structure of the primary and secondary disability in elderly people in comparison with the main age categories of the adult population in the Russian Federation and the evaluation of rehabilitation / rehabilitation activities for disabled people. The volume of the study was 34,840,933 people aged of from 18 years and over, recognized as disabled, including the disabled elderly - 12,971,062. The subject of a special study was the nature of functional disorders, the degree of the disability, the nosological spectrum of causes of the disability of elderly people and the effectiveness of implemented measures of medical and social rehabilitation (rehabilitation and expert characterization). The study was selective, the sample size account of 370 people. The results of the research demonstrate the nosological structure of the pathology, the associated types of impairments and the nature of the disability to determine the severity of the disability in elderly people, the complexity of the formation and implementation of individual programs for the rehabilitation and rehabilitation of disabled people (IPRA). The improvement of the quality of life and integrating disabled people into the society has been and remains a difficult task for rehabilitation and habilitation activities. Rehabilitation and provision of technical means of rehabilitation, to a lesser extent - social and professional rehabilitation are the most feasible for the implementation.

scholarly journals REPEATED DISABILITY DUE TO CANCER IN THE CHECHEN REPUBLIC

2018 ◽  
Vol 21 (3-4) ◽  
pp. 152-155
Author(s):  
Liliya S. Idrisova
Keyword(s):  
Young People ◽  
Russian Federation ◽  
Adult Population ◽  
The Elderly ◽  
Malignant Neoplasms ◽  
Middle Aged ◽  
Growth Trend ◽  
The Russian Federation ◽  
Visibility Index ◽  
Negative Growth

The article presents the results of a study of the dynamics of recurrent disability due to malignant neoplasms (ZNO) of the adult population in the Chechen Republic for the period 2008-2017. in comparison with the figures for the Russian Federation. In the Russian Federation, the dynamics of re-disability of the adult population due to the ZNO in the period 2008-2017 was characterized by an increase in the number of repeatedly recognized disabled (PPI), the level of which increased from 19.9 to 27.0 per 10 thousand people. Compared to 2008 (taken as 100%), the indicator of visibility of PPI was 135%. In the PPI contingent, the elderly prevailed with a negative trend of growth in their numbers. The proportion of young and middle-aged PPI decreased. In the Chechen Republic, the epidemiological picture of the disability of the adult population due to the ZNO was characterized by different dynamics. The number of PPI due to ZNO in the country decreased. Compared to 2008 (taken as 100%), the visibility index of the PPI was 57.0%; In the structure of recurrent disability due to ZNO, middle-aged and old-aged PPI prevailed, however, their proportion declined. There is a negative growth trend in the proportion of young people.

scholarly journals The main trends in the primary incidence of malignant neoplasms in the adult population of the oil and gas producing region

2020 ◽  
Vol 99 (3) ◽  
pp. 303-308
Author(s):  
Арстан Абдраманович Мамырбаев ◽  
Д.К. K. Егизбаева ◽  
П.Ж. Zh. Айтмаганбет ◽  
В.М. M. Сабырахметова ◽  
Г.А. A. Умарова ◽  
...  
Keyword(s):  
Oil And Gas ◽  
Malignant Tumors ◽  
Adult Population ◽  
Sharp Decrease ◽  
The Elderly ◽  
Epidemiological Methods ◽  
Malignant Neoplasms ◽  
Strong Correlations ◽  
Third Place ◽  
The Third

The article analyzes statistical data for the adult population of the oil and gas producing region at the Aktobe district over 2011-2015. Data on the incidence of malignant (reporting statistical forms No. 35 and No. 7) of the adult population of Mugalzhar, Temirsky district in the Aktobe region were studied in the process of the implementation of the research. In the work, there were used statistical and epidemiological methods. There was a decline in the primary incidence of malignant tumors (MT) in the adult population in Mugalzhar region (there is a gradual decrease from 2011 till 2014, in 2015 -the sharp decrease of the indices of the primary incidence) and Kobdinsky region (there is a decrease of the MT from 2013 and an increase in the rate of growth in Temirsky region (the incidence of MT decreases from 2011 till 2013, the trend of increasing primary indices is traced from 2013) during the period under review. Ranking of the MT with the first time established diagnosis among the adult population living in the Mugalzhar district showed the women’s breast cancer to held the first place, the second - the esophagus, the third place is the uterus. The elderly population of the Temir district is ranked first with MT of the esophagus, on the second - MT of tracheaetracheae, bronchus, lung, in third place - MT of the women’s breast. Among the adult population of the Kobda district, which is the control, the MT of the stomach is leading, after it the MT of tracheae, bronchus, lung, the MT esophagus is on the third place. The statistically significant direct, strong correlations between the annual average daily concentration of carbon monoxide, nitric oxide, hydrocarbon in the atmospheric air and the index of the MT incidence (body of uterus, uterine cervix, breast, mammary gland) at the adult population was revealed. In the Mugalzharsky and Kobdinsky districts the proportion of people living by 2015 more than 5 years from the date of diagnosis is higher than in the Temir district. In the Temir district, the detection rate among newly registered MT patients, in comparison with the Mugalzhar and Kobdinsky regions is high at the I-II stages, and at the IV stage.

Mortality from malignant neoplasms of the digestive system in the cities of the Chelyabinsk region affected by radiation accidents

2021 ◽  
Vol 100 (6) ◽  
pp. 568-579
Author(s):  
Lidiya G. Konshina
Keyword(s):  
Adult Population ◽  
Age Groups ◽  
The Elderly ◽  
Adult Mortality ◽  
Gastric Ulcers ◽  
Malignant Neoplasms ◽  
Digestive Organs ◽  
Effects Of Radiation ◽  
Chelyabinsk Region ◽  
Intestinal Ulcers

Introduction. Due to the long-term radioactive contamination of a part of the territory of the Chelyabinsk region, much attention is paid to the analysis of the health status of the population. One of the adverse effects of radiation is the occurrence of neoplasms. The highest doses of radiation as a result of many emergencies were received by the digestive organs. Material and methods. The study of adult mortality in the cities Kasli and Kyshtym over 50 years from 1947 to 1996. The following age groups were studied: 20-29, 30-39, 40-49, 50-59, 60-69, 70 years, and older. Results. An increase in the mortality rate from malignant neoplasms of the esophagus, stomach, intestines, and other digestive organs in the adult population over 50 years was found. The growth of indices has been observed since 1952. The maximum mortality values from esophageal and gastric ulcers were recorded from 1962 to 1971, from intestinal ulcers from 1972 to 1981. Several waves of increasing mortality were recorded: in the early 50s, after 1957, after 1967, in the late 70’s - early 80‘s of the XX century. The increase in mortality from malignant neoplasms of the digestive organs of all localities in the studied cities among women and people of the elderly (60-69 yrs) and (70 yrs and older) age, as a rule, began five years earlier. Among the population under 50 years of age, differences in cancer mortality from control values were poorly expressed. Conclusion. Mortality rates from malignant neoplasms of the esophagus, stomach, intestines, and other unspecified digestive organs in the adult population, especially in the ages of 50-59, 60-69, and 70 and older, in the cities of Kasli and Kyshtym in some periods significantly exceed the control values.

scholarly journals RESULTS OF AN EPIDEMIOLOGICAL STUDY OF PRIMARY DISABILITY DUE TO MALIGNANT NEOPLASMS OF THE ADULT POPULATION IN THE RUSSIAN FEDERATION

2018 ◽  
Vol 21 (3-4) ◽  
pp. 144-148
Author(s):  
S. N Puzin ◽  
M. A Shurgaya ◽  
G. E Pogosyan ◽  
T. A Chludeeva ◽  
L. S Idrisova
Keyword(s):  
Russian Federation ◽  
Adult Population ◽  
Regional Differentiation ◽  
Malignant Neoplasms ◽  
Disabled People ◽  
Elderly Age ◽  
Primary Disability ◽  
The Russian Federation ◽  
All Diseases

The article presents the results of the analysis of the long-term dynamics of indicators of primary disability due to malignant neoplasms of the adult population in the Russian Federation. The study volume was 1919677 people aged 18 years and older. An increase in the share of newly recognized disabled people (VPI) in the structure of the total number of VPI as a result of all diseases from 17.6% in 2008 to 32.4% in 2017 (an average of 24.2% per year) was found. In the structure of the primary disability due to ZNO, elderly and middle age IDDs prevail. The level of primary disability among the middle-aged population is decreasing, while among the young and elderly age segments, is increasing. The structure of primary disability due to ZNO by severity is characterized by the predominance of VPI II and I groups of disability with a lower proportion of VPI III group. It has been established that in the Russian Federation there is a regional differentiation of subjects according to the level of disability due to EIT, which allows us to identify regions with an unfavorable situation and the need to optimize measures for primary and secondary medical and social prevention and rehabilitation.

scholarly journals THE MAIN TRENDS IN THE PRIMARY INCIDENCE OF MALIGNANT NEOPLASMS IN THE ADULT POPULATION OF THE OIL AND GAS PRODUCING REGION

2020 ◽  
Vol 99 (3) ◽  
pp. 303-308
Author(s):  
Arstan A. Mamyrbaev ◽  
D. K. Egizbaeva ◽  
P. Zh. Aitmaganbet ◽  
V. M. Sabyrakhmetova ◽  
G. A. Umarova ◽  
...  
Keyword(s):  
Oil And Gas ◽  
Malignant Tumors ◽  
Adult Population ◽  
Sharp Decrease ◽  
The Elderly ◽  
Epidemiological Methods ◽  
Malignant Neoplasms ◽  
Strong Correlations ◽  
Third Place ◽  
The Third

The article analyzes statistical data for the adult population of the oil and gas producing region at the Aktobe district over 2011-2015. Data on the incidence of malignant (reporting statistical forms No. 35 and No. 7) of the adult population of Mugalzhar, Temirsky district in the Aktobe region were studied in the process of the implementation of the research. In the work, there were used statistical and epidemiological methods. There was a decline in the primary incidence of malignant tumors (MT) in the adult population in Mugalzhar region (there is a gradual decrease from 2011 till 2014, in 2015 -the sharp decrease of the indices of the primary incidence) and Kobdinsky region (there is a decrease of the MT from 2013 and an increase in the rate of growth in Temirsky region (the incidence of MT decreases from 2011 till 2013, the trend of increasing primary indices is traced from 2013) during the period under review. Ranking of the MT with the first time established diagnosis among the adult population living in the Mugalzhar district showed the women’s breast cancer to held the first place, the second - the esophagus, the third place is the uterus. The elderly population of the Temir district is ranked first with MT of the esophagus, on the second - MT of tracheaetracheae, bronchus, lung, in third place - MT of the women’s breast. Among the adult population of the Kobda district, which is the control, the MT of the stomach is leading, after it the MT of tracheae, bronchus, lung, the MT esophagus is on the third place. The statistically significant direct, strong correlations between the annual average daily concentration of carbon monoxide, nitric oxide, hydrocarbon in the atmospheric air and the index of the MT incidence (body of uterus, uterine cervix, breast, mammary gland) at the adult population was revealed. In the Mugalzharsky and Kobdinsky districts the proportion of people living by 2015 more than 5 years from the date of diagnosis is higher than in the Temir district. In the Temir district, the detection rate among newly registered MT patients, in comparison with the Mugalzhar and Kobdinsky regions is high at the I-II stages, and at the IV stage.

scholarly journals Indicators of Disability in Diseases of the Endocrine System of the Adult Population of Osh City (Kyrgyzstan)

2021 ◽  
Vol 7 (12) ◽  
pp. 104-108
Author(s):  
N. Sherieva
Keyword(s):  
Health Promotion ◽  
Social Protection ◽  
Adult Population ◽  
Endocrine System ◽  
Disabled People ◽  
Modern Health Care ◽  
Quality Of Medical Care ◽  
High Level ◽  
The City

The article examines the indicators of disability in diseases of the endocrine system of the population of Osh city (Kyrgyzstan). Health promotion, disease prevention, rehabilitation of disabled people are the main tasks in modern health care and social protection of the population. The number of people with disabilities is increasing from year to year in Kyrgyzstan. This growth is associated with a high level of morbidity and traumatism of the population, inadequate quality of medical care, and unfavorable environmental conditions. The study compares the five-year rate of disability in diseases of the endocrine system of the population of Osh. In the periods studied (2016, 2018, 2020), an increase in the number of primary disabilities in diseases of the endocrine system among residents of the city of Osh was revealed.

AGE-RELATED ASPECTS AND GENDER DIFFERENTIATION OF PRIMARY DISABILITY DUE TO THYROID CANCER IN THE ADULTS POPULATION OF MOSCOW

2021 ◽  
pp. 764-770
Author(s):  
А.В. Гречко ◽  
Г.Э. Погосян ◽  
С.Н. Пузин ◽  
М.А. Шургая
Keyword(s):  
Thyroid Cancer ◽  
Adult Population ◽  
Endocrine System ◽  
The Body ◽  
Health Concern ◽  
Gender Differentiation ◽  
Age Related ◽  
Severe Impairment ◽  
Primary Disability ◽  
And Gender

Представлены результаты анализа первичной инвалидности вследствие рака щитовидной железы у взрослого населения Москвы в период 2015-2019 гг. Выявлено увеличение численности впервые признанных инвалидами (ВПИ) вследствие данной патологии. В структуре первичной инвалидности по возрасту преобладали инвалиды пожилого возраста. Превалирующим гендерным контингентом ВПИ были женщины. Установлено, что в контингенте ВПИ преобладающее число инвалидов имели умеренную (II) степень выраженности нарушений основных функций организма. В то же время, выявлена гендерная дифференциация по тяжести стойких нарушений функций организма у инвалидов. В контингенте мужчин ВПИ удельный вес лиц с выраженной (III) и значительно выраженной (IV) степенью нарушения функции системы крови и иммунной системы и с выраженной степенью нарушения функции эндокринной системы и метаболизма был выше по сравнению с контингентом женщин ВПИ. Определено, что основными видами ограничений жизнедеятельности были ограничение способности к самообслуживанию, к трудовой деятельности, к передвижению и общению (преобладала I степень ограничений жизнедеятельности, p<0,05). Рак щитовидной железы в связи с быстрыми темпами роста заболеваемости и инвалидности является важной задачей охраны здоровья населения. Изучение показателей инвалидности у населения необходимо для разработки рациональных мер медико-социальной реабилитации больных, страдающих раком щитовидной железы, и для осуществления медико-социальной профилактики инвалидности. The results of the analysis of primary disability due to thyroid cancer of the adult population of Moscow in the period 2015-2019 are presented. An increase in the number of peaple newly recognized as disabled (PNRD) due to this pathology was revealed. In the age structure of primary disability elderly people was dominated. The predominant gender contingent of the PNRD were women. It was found that the predominant number of PNRD had a moderate impairment (II degree) of the basic functions of the body. At the same time, gender differentiation in the severity of persistent impairment of the body functions among disabled was revealed. In the contingent of disabled men the proportion of persons with severe (III degree) and complete (IV degree) impairment of the function of the blood system and the immune system and with a severe impairment of the function of the endocrine system and metabolism was higher compared to the contingent of disabled women. It was determined that the main types of capacity limitations were self-care, work, moving and communicate limitations (the first degree of difficulties in life areas prevailed (p<0,05). Thyroid cancer, due to the rapid growth of morbidity and disability, is an important public health concern. The study of disability indicators of the population is necessary for the development of rational measures of medical and social rehabilitation of patients suffering from thyroid cancer, and for the implementation of medical and social prevention of disability.

scholarly journals Computational modeling of molecular structure of microRNA inhibitors selected against microRNA over-expressed in thyroid cancer

2021 ◽  
Author(s):  
Luis Jesuino de Oliveira Andrade ◽  
Alcina Maria Vinhaes Bittencourt ◽  
Luis Matos de Oliveira ◽  
Gabriela Correia Matos de Oliveira
Keyword(s):  
Molecular Structure ◽  
Thyroid Cancer ◽  
Nucleotide Sequence ◽  
In Silico ◽  
Structure Prediction ◽  
Secondary Structure Prediction ◽  
Malignant Neoplasm ◽  
Endocrine System ◽  
Rna Secondary Structure Prediction ◽  
Alignment Algorithms

Introduction: Thyroid cancer is the most prevalent malignant neoplasm of endocrine system and advances in thyroid molecular biology studies demonstrate that microRNAs (miRNAs) seem to play a fundamental role in tumor triggering and progression. The miRNAs inhibitors are nucleic acid-based molecules that blockade miRNAs function, making unavailable for develop their usual function, also acting as gene expression controlling molecules. Objective: To develop in silico projection of molecular structure of miRNA inhibitors against miRNA over-expressed in thyroid cancer. Methods: We conducted a search of the nucleotide sequence of 12 miRNAs already defined as inhibitors against miRNA over-expressed in thyroid cancer, realizing in silico projection of the molecular structure of following miRNAs: miRNA-101, miRNA-126, miRNA-126-3p, miRNA-141, miRNA-145, miRNA-146b, miRNA-206, miRNA-3666, miRNA-497, miRNA-539, miRNA-613, and miRNA-618. The nucleotides were selected using GenBank that is the NIH genetic sequence database. The sequences obtained were aligned with the Clustal W multiple alignment algorithms. For the molecular modeling, the structures were generated with the RNAstructure, a fully automated miRNAs structure modelling server, accessible via the Web Servers for RNA Secondary Structure Prediction. Results: We demonstrated a search for nucleotide sequence and the projection of the molecular structure of the following miRNA inhibitors against miRNA over-expressed in thyroid cancer: miRNA-101, miRNA-126, miRNA-126-3p, miRNA-141, miRNA-145, miRNA-146b, miRNA-206, miRNA-3666, miRNA-497, miRNA-539, miRNA-613, and miRNA-618. Conclusion: In this study we show in silico secondary structures projection of selected of 12 miRNA inhibitors against miRNA over-expressed in thyroid cancer through computational biology. Keywords: microRNA; nucleotide analysis; molecular structure; thyroid cancer.

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