Survival and risk factors for premature mortality in patients with parkinson’s disease

2021 ◽  
Vol LIII (3) ◽  
pp. 5-10
Author(s):  
Fatima N. Aliyeva
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Survival Rate ◽  
Confidence Interval ◽  
Causes Of Death ◽  
Age Of Onset ◽  
Premature Mortality ◽  
Parkinsons Disease ◽  
Cerebrovascular Accidents ◽  
Relationship Of

Aim. To assess the survival rate and risk factors for premature mortality in patients with Parkinsons disease in Baku. Material and research methods. The observation was carried out retrospectively, information was collected on all patients (110 patients) in whom the diagnosis of Parkinsons disease was first established in 20092010. These patients are provided with drugs free of charge, which made it possible to provide them with diagnostic monitoring in polyclinics. During 20102019, 94 patients with a diagnosis of Parkinsons disease died. All medical death certificates were selected for analysis. The diagnoses in column a of these documents were accepted as direct causes of death, regardless of the presence or absence of a causal relationship of these diagnoses with Parkinsons disease. Therefore, the reported cases were interpreted not as death due to Parkinsons disease, but as the death of a patient diagnosed with Parkinsons disease. Results. Noteworthy is the prevalence of men (72.7%) and people without dementia (70.9%) among patients. Within 10 years, 85.5% of patients died from various causes. The immediate causes of death were acute cerebrovascular accidents (36.2%) and acute myocardial infarction (24.5%). The annual survival rate of the observed patients was high (94%; 95% confidence interval 51100%). The five-year survival rate is 76% (95% confidence interval 42100%). Conclusions. (1) The survival rate of patients with Parkinsons disease within 10 years after the onset of signs ranges from 0.94 to 0.41 (five-year survival rate is 0.76). (2) The immediate causes of mortality in patients with Parkinsons disease were cerebrovascular accidents (36.2%), myocardial infarction (24.5%), pulmonary embolism (11.7%), pneumonia (10.6%) and others (17%). (3) The effect of age of onset and signs of Parkinsons disease, gender, comorbidity and dementia on survival is statistically significant (p 0.05).

scholarly journals Sex differences in risk factors for myocardial infarction: cohort study of UK Biobank participants

BMJ ◽  
2018 ◽  
pp. k4247 ◽  
Author(s):  
Elizabeth R C Millett ◽  
Sanne A E Peters ◽  
Mark Woodward
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Blood Pressure ◽  
Type 1 Diabetes ◽  
Sex Differences ◽  
Confidence Interval ◽  
Systolic Blood Pressure ◽  
Uk Biobank ◽  
Hazard Ratios

AbstractObjectivesTo investigate sex differences in risk factors for incident myocardial infarction (MI) and whether they vary with age.DesignProspective population based study.SettingUK Biobank.Participants471 998 participants (56% women; mean age 56.2) with no history of cardiovascular disease.Main outcome measureIncident (fatal and non-fatal) MI.Results5081 participants (1463 (28.8%) of whom were women) had MI over seven years’ mean follow-up, resulting in an incidence per 10 000 person years of 7.76 (95% confidence interval 7.37 to 8.16) for women and 24.35 (23.57 to 25.16) for men. Higher blood pressure indices, smoking intensity, body mass index, and the presence of diabetes were associated with an increased risk of MI in men and women, but associations were attenuated with age. In women, systolic blood pressure and hypertension, smoking status and intensity, and diabetes were associated with higher hazard ratios for MI compared with men: ratio of hazard ratios 1.09 (95% confidence interval 1.02 to 1.16) for systolic blood pressure, 1.55 (1.32 to 1.83) for current smoking, 2.91 (1.56 to 5.45) for type 1 diabetes, and 1.47 (1.16 to 1.87) for type 2 diabetes. There was no evidence that any of these ratios of hazard ratios decreased with age (P>0.2). With the exception of type 1 diabetes, the incidence of MI was higher in men than in women for all risk factors.ConclusionsAlthough the incidence of MI was higher in men than in women, several risk factors were more strongly associated with MI in women compared with men. Sex specific associations between risk factors and MI declined with age, but, where it occurred, the higher relative risk in women remained. As the population ages and the prevalence of lifestyle associated risk factors increase, the incidence of MI in women will likely become more similar to that in men.

Triiodothyronine (T3), inflammation and mortality risk in patients with acute myocardial infarction

2022 ◽  
Author(s):  
Salman Razvi ◽  
Avais Jabbar ◽  
Arjola Bano ◽  
Lorna Ingoe ◽  
Peter Carey ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Confidence Interval ◽  
Mortality Risk ◽  
Fold Increase ◽  
Lower Serum ◽  
Reactive Protein ◽  
All Cause Mortality ◽  
Relationship Of ◽  
The Relationship

Objectives: To study the relationship between serum free T3 (FT3), C-reactive protein (CRP), and all-cause mortality in patients with acute myocardial infarction (AMI). Design: Prospective multicentre longitudinal cohort study. Methods: Between December 2014 and December 2016, thyroid function and CRP were analysed in AMI (both ST- and non-ST-elevation) patients from the ThyrAMI-1 study. The relationship of FT3 and CRP at baseline with all-cause mortality up to June 2020 was assessed. Mediation analysis was performed to evaluate if CRP mediated the relationship between FT3 and mortality. Results: In 1919 AMI patients [29.2% women, mean (SD) age 64.2 (12.1) years and 48.7% STEMI] followed over a median (inter-quartile range) period of 51 (46 to 58) months, there were 277 (14.4%) deaths. Overall, lower serum FT3 and higher CRP levels were associated with higher risk of mortality. When divided into tertiles based on levels of FT3 and CRP, the group with the lowest FT3 and highest CRP levels had 2.5-fold increase in mortality risk [adjusted hazard ratio (95% confidence interval) of 2.48 (1.82 to 3.16)] compared to the group with the highest FT3 and lowest CRP values. CRP mediated 9.8% (95% confidence interval 6.1 to 15.0%) of the relationship between FT3 and mortality. Conclusions: In AMI patients, lower serum FT3 levels on admission are associated with a higher mortality risk, which is partly mediated by inflammation. Adequately designed trials to explore potential benefits of T3 in AMI patients are required.

Do Biologics Protect Patients With Psoriasis From Myocardial Infarction? A Retrospective Cohort

2016 ◽  
Vol 20 (6) ◽  
pp. 536-541 ◽  
Author(s):  
Wayne P. Gulliver ◽  
Shane Randell ◽  
Susanne Gulliver ◽  
Sean Connors ◽  
Hervé Bachelez ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Retrospective Cohort ◽  
Biologic Therapy ◽  
Age Of Onset ◽  
Significant Risk ◽  
Severe Psoriasis ◽  
Inflammatory Disorder ◽  
Dermatology Clinic ◽  
Increased Risk

Background: Psoriasis is a chronic immune-mediated inflammatory disorder that affects approximately 2% to 3% of the population, which translates to 17 million in North America and Europe and approximately 170 million people worldwide. Although psoriasis can occur at any age, most cases develop before age 40 years. Some larger studies have noted bimodal age at onset with the first peak occurring at approximately age 30 years and the second peak at around 55 to 60 years, but most patients have a younger age of onset (15-30 years). Psoriasis is associated with multiple comorbidities, decreased quality of life, and decreased longevity of life. Two recent systematic reviews and a meta-analysis concluded that psoriasis patients are at increased risk of major adverse cardiovascular events. Multiple studies confirm that many of the comorbidities found in patients with psoriasis are also important risk factors for cardiovascular disease, stroke, diabetes mellitus, hypertension, hyperlipidemia, obesity, and metabolic syndrome. Methods: We conducted a retrospective cohort study using charts from a dermatology clinic combined with an administrative database of patients with moderate to severe psoriasis in Newfoundland and Labrador, Canada. We examined the role of clinical predictors (age of onset of psoriasis, age, sex, biologic use) in predicting incident myocardial infarction (MI). Results: Logistic regression revealed that age of onset (odds ratio [OR], 8.85; P = .005), advancing age (OR, 1.07; P < .0001), and being male (OR, 3.64; P = .018) were significant risk factors for the development of MI. Neither biologic therapy nor duration of biologic therapy were statistically significant risk factors for the development of MI. Our study found that in patients with psoriasis treated with biologics, there was a nonsignificant trend in reduced MI by 78% (relative risk, 0.18; 95% confidence interval, 0.24-1.34; P = .056). Conclusion: Our study demonstrated a trend toward decreased MI in patients with moderate to severe psoriasis on biologics. Patients with an early age of onset of psoriasis (<25 years) were nearly 9 times more likely to have an MI. Clinicians should consider appropriate cardiovascular risk reduction strategies in patients with psoriasis.

Relationship of penile brachial pressure index to myocardial infarction and cerebrovascular accidents in older men

1988 ◽  
Vol 84 (3) ◽  
pp. 445-448 ◽  
Author(s):  
John E. Morley ◽  
Stanley G. Korenman ◽  
Fran E. Kaiser ◽  
Arshag D. Mooradian ◽  
Sharon P. Viosca
Keyword(s):  
Myocardial Infarction ◽  
Older Men ◽  
Cerebrovascular Accidents ◽  
Pressure Index ◽  
Relationship Of

Relationship of Penile Brachial Pressure Index to Myocardial Infarction and Cerebrovascular Accidents in Older Men

1988 ◽  
Vol 140 (3) ◽  
pp. 690-690
Author(s):  
J.E. Morley ◽  
S.G. Korenman ◽  
F.E. Kaiser ◽  
A.D. Mooradian ◽  
S.P. Viosca
Keyword(s):  
Myocardial Infarction ◽  
Older Men ◽  
Cerebrovascular Accidents ◽  
Pressure Index ◽  
Relationship Of

P16 Relationship of plasma long Pentraxin-3 concentration with clinical and angiographic outcomes of patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary

2020 ◽  
Vol 41 (Supplement_1) ◽  
Author(s):  
N Y Sari ◽  
S Dharma ◽  
R Sukmawan ◽  
I Dakota ◽  
S V Rao
Keyword(s):  
Myocardial Infarction ◽  
Confidence Interval ◽  
Primary Pci ◽  
Pentraxin 3 ◽  
St Segment Elevation ◽  
Segment Elevation Myocardial Infarction ◽  
Timi Flow ◽  
St Segment ◽  
Percutaneous Coronary ◽  
Relationship Of

Abstract Background Inflammation has an important role for the progression of coronary plaque vulnerability to acute coronary thrombosis. Long pentraxin-3 (PTX3) is a sensitive marker of inflammation released upon exposure to primary inflammatory signals. Whether concentration of PTX3 affects coronary thrombus severity and impaired coronary flow in patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) is unknown. Purpose This study sought to evaluate the relationship of plasma PTX3 concentration with coronary thrombus severity and final TIMI flow after primary PCI in patients with acute STEMI. Methods We prospectively enrolled 335 consecutive patients with acute STEMI undergoing primary PCI between 1 January 2018 and 2 August 2018. Plasma PTX3 concentrations were measured at admission by ELISA method.  Results Compared to low PTX3 group (&lt;0.33 ng/mL; N = 223), patients in the high PTX3 group (≥ 0.33 ng/mL; N = 112) had higher proportion of thrombus grade 4 and 5 on initial coronary angiogram (83% vs. 72%, p= 0.03), final TIMI flow &lt;3 (66% vs. 51%, p= 0.01), incomplete ST segment resolution after primary PCI (85% vs. 72%, p= 0.002) and Killip classification II-IV at entry (34.8% vs. 13%, adjusted odds ratio= 3.38, p&lt; 0.001). High PTX3 concentration was associated with an increased risk of 30-day mortality (adjusted hazard ratio= 3.41, 95% confidence interval, 1.27 to 9.11, p= 0.01).  Conclusion High plasma PTX3 concentration is associated with worse clinical and angiographic outcomes among patients undergoing primary PCI for STEMI. Further study is needed to eludicate whether PTX3 is a causal agent for adverse outcomes and whether therapies directed at reducing PTX3 levels are effective. Table 1. Variable Hazard ratio (95% confidence interval) P-value Long pentraxin-3 ≥0.33 ng/mL 3.41 (1.27 - 9.11) 0.01 Age &gt;65 years 0.38 (0.11 - 1.41) 0.15 Male gender 0.43 (0.13 - 1.44) 0.16 Diabetes Mellitus 1.24 (0.44 - 3.52) 0.68 Hypertension 0.64 (0.23 - 1.80) 0.39 Baseline creatinine ≥1.3 mg/dL 4.06 (1.43 - 11.53) 0.009 TIMI risk score &gt; 4 8.31 (2.69 - 25.59) &lt; 0.001 Multivariable Cox regression analysis showing association between PTX3 concentration and selected confounding variables for all-cause death at 30 day.

scholarly journals A Common Prothrombin Variant (20210 G to A) Increases the Risk of Myocardial Infarction in Young Women

Blood ◽  
1997 ◽  
Vol 90 (5) ◽  
pp. 1747-1750 ◽  
Author(s):  
F.R. Rosendaal ◽  
D.S. Siscovick ◽  
S.M. Schwartz ◽  
B.M. Psaty ◽  
T.E. Raghunathan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Confidence Interval ◽  
Young Women ◽  
Odds Ratio ◽  
Factor V Leiden ◽  
Clotting Factor ◽  
Factor V ◽  
Coronary Risk Factors ◽  
Factor Ii

Abstract Using specimens from a population-based case control study among women ages 18 to 44 years in western Washington, we assessed the relationship between carriership of a genetic clotting factor II variant (20210 G→A) and myocardial infarction (MI). The factor II variant was previously shown to be present in 1% to 2% of the population, to increase the levels of factor II, and to be associated with venous thrombotic disease. Personal interviews and blood samples were obtained from 79 women with a first myocardial infarction and 381 control women identified through random-digit telephone dialing. Polymerase chain reaction (PCR) method was used to determine the factor II genotypes. The factor II 20210 G to A transition was present more often in women with MI (5.1%) than among control women (1.6%). The age-adjusted odds ratio for MI was 4.0 (95% confidence interval 1.1 to 15.1). The relative risk was high when another major cardiovascular risk factor was also present, such as smoking (odds ratio 43.3, 95% confidence interval 6.7 to 281), and the risk seemed limited to those with other risk factors. These results, in which the effect of major coronary risk factors is enhanced fourfold to sixfold by the prothrombin variant, are similar to those previously reported for another genetic clotting abnormality, factor V Leiden. We conclude that factor II 20210 G to A increases the risk of myocardial infarction in young women, especially in the women with other major risk factors for coronary heart disease.

scholarly journals КОМОРБІДНІСТЬ ТА ЇЇ ВПЛИВ НА ПРИХИЛЬНІСТЬ ДО ПОДАЛЬШОГО ЛІКУВАННЯ У ПАЦІЄНТІВ З ІНФАРКТОМ МІОКАРДА

2018 ◽  
Author(s):  
O. I. Levchyk
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Cardiovascular Disease ◽  
Clinical Practice ◽  
Digestive System ◽  
Causes Of Death ◽  
Associated Diseases ◽  
The World ◽  
Group A ◽  
Adherence To Therapy

In modern clinical practice, the doctor is increasingly faced with a combination of two or more diseases in one patient. Such states are called comorbid, concomitant pathologies, or associated diseases [1–3]. This is especially true for patients with myocardial infarction (MI), since cardiovascular disease (CVD ) remains one of the main causes of death in Ukraine and in the world (World Heart Federation, WH F, 2017).The aim of the study – to set the frequency and the structure of comorbidity in patients with myocardial infarction (IM) and its effect on adherence to further treatment.Materials and Methods. We examined 152 patients with MI, aged 38 to 89 years, on average (60.66±0.86) years (52 women and 100 men) who were divided according to the Morisky-Green questionnaire by two groups: the first – adherent to treatment (n=77), the second group – not adherent to treatment (n=75). The Charlson and CIRS comorbidity indices were determined.Results and Discussion. Both groups identified risk factors and 84% of the concomitant pathology, with the Charleston index – (5.81±1.78), and CIRS (9.32±2.79) points, the largest proportion of diseases of the digestive system. When comparing between groups for the same amount of comorbid pathology (5.66±0.19) and (5.96±0.24) points of Charlson, p<0.05) in patients in the second group a heavier course with deeper damage to organs and systems (CIRS – (8.23±0.25) versus (10.43±0.34) points, p<0.001), which reduces the level of adherence to the prescribed therapy.Conclusions. Patients with myocardial infarction often have a comorbidity, but with the same number of concomitant diseases in different patients, the severity and depth of damage to organs and systems are different. The present combined pathology has an effect on adherence to therapy. Determining the Charlson and CIRS indices allows you to predict the level of compliance individually for each patient and take measures to increase its level.

Survival rate, causes of death, and risk factors in systemic sclerosis: a large cohort study

2018 ◽  
Vol 37 (11) ◽  
pp. 3051-3056 ◽  
Author(s):  
Xue Li ◽  
Yu-quan Qian ◽  
Na Liu ◽  
Rong Mu ◽  
Yu Zuo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Systemic Sclerosis ◽  
Survival Rate ◽  
Causes Of Death ◽  
Large Cohort ◽  
Large Cohort Study
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