scholarly journals Pharmacological correction of amnesticdisorders in mammalians(evolutionary aspects of investigation)

2013 ◽  
Vol 11 (3) ◽  
pp. 55-65
Author(s):  
Tatyana Nikolayevna Sollertinskaya ◽  
Mstistlav Vladilenovich Shorokhov
Keyword(s):  
Early Stage ◽  
Memory Processes ◽  
Long Duration ◽  
Operative Memory ◽  
Nervous Function ◽  
Inhibitory Type ◽  
Short Time ◽  
New Generation ◽  
Evolutionary Aspects

The present work is devoted to the study of the peptides bioregulators of new generation (Cortexin, Semax, Selank) in the compensation of the disturbed Higher Nervous Functions ih the ascending row of mammls (insectivores, rodents, primates). The new data have been established that at the early stage of mammals (in insectivores) Cortexin, Semax and Selank induced the more significant and long lasted effect on inherent forms of behaviour. Their effects on the compensation of the disturbed Higher Nervous Functions have nonspecific, facilatory short time lasted character. Contrary to insectivores, rodents have a clear tendency to compesation for Higher Nervous Function disturbances. At the Semax and Selank background, the delayed conditional reflexes were restored. It has been established that the cerebroprotective effects of Selank exerted more significant influences upon the brain function disturbances in neurotic rats. Contrary to the results found in lower mammals, the application of Cortexin, Semax and Selank to neurotic monkeys exerted differnt effects upon the Higher Nervous Functions disturbances. The compensatory effects of drugs are dose dependant in nature being more effective with intranasal administration and having different effects on the various types of neurosis. The long duration compensation of the mental disturbances (the EEG homeostatic parameters of memory processes) took place during the Selank (30 mkg/ kg) administration. The cerebroprotective effects of Semax are especially significant on the operative memory. Cortexin antiamnestic and cerebroprotective effects especially significant at the inhibitory type of neurosis. The data collected on the compensatory Cortexin, Semax and Selank influeces on the disturbed memory processes and cognitive deficit of monkey’s may serve as neurophysiological basis for the more intensive and specific role of these drugs in the neurological clibic.

scholarly journals Nanotechnology as a Shield against COVID-19: Current Advancement and Limitations

Viruses ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1224
Author(s):  
Mahendra Rai ◽  
Shital Bonde ◽  
Alka Yadav ◽  
Arpita Bhowmik ◽  
Sanjay Rathod ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Global Health ◽  
Global Economy ◽  
Early Stage ◽  
Close Contact ◽  
Diagnostic Tools ◽  
Rate Of Spread ◽  
New Generation ◽  
Global Health Problem

The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global health problem that the WHO declared a pandemic. COVID-19 has resulted in a worldwide lockdown and threatened to topple the global economy. The mortality of COVID-19 is comparatively low compared with previous SARS outbreaks, but the rate of spread of the disease and its morbidity is alarming. This virus can be transmitted human-to-human through droplets and close contact, and people of all ages are susceptible to this virus. With the advancements in nanotechnology, their remarkable properties, including their ability to amplify signal, can be used for the development of nanobiosensors and nanoimaging techniques that can be used for early-stage detection along with other diagnostic tools. Nano-based protection equipment and disinfecting agents can provide much-needed protection against SARS-CoV-2. Moreover, nanoparticles can serve as a carrier for antigens or as an adjuvant, thereby making way for the development of a new generation of vaccines. The present review elaborates the role of nanotechnology-based tactics used for the detection, diagnosis, protection, and treatment of COVID-19 caused by the SARS-CoV-2 virus.

A modern method of treating initial caries for children using the infltration method

2020 ◽  
Vol 20 (1) ◽  
pp. 4-8
Author(s):  
A. U. Zamurayeva ◽  
Е. T. Supiyeva ◽  
B Sh. Orynbayeva
Keyword(s):  
Pathogenic Bacteria ◽  
Early Stage ◽  
Modern Method ◽  
Modern Technology ◽  
White Spot ◽  
Tooth Decay ◽  
Low Viscosity ◽  
Initial Caries ◽  
Short Time ◽  
Infiltration Method

Relevance. The modern method of infiltration provides an opportunity to stop the spread of pathogenic bacteria and the development of caries at the white spot stage, replacing the destroyed enamel cells with special polymers having low viscosity and high penetrating ability. The stabilization of the process is achieved in a short time with the maximum safety of their tissues. Purpose. Treatment of initial tooth decay in children by infiltration, assessment of the effectiveness and advantages of modern technology. Materials and methods. Clinical examination was carried out according to generally accepted methods. Additionally, a laser diagnostic method was used using the KaVo DIAGNOdent device (Germany). The LLP Dentistry Center «Zhaik Dent» and the LLP «Concept» used the Icon system for the treatment of initial caries and after orthodontic treatment for 25 children with 54 teeth. Results. At the end of tooth treatment with the Icon infiltration method, parents and the child were given recommendations: from the next day, brush your teeth 2 times a day, rinse your mouth regularly after eating, do not drink drinks, products with coloring substances. To monitor the result of treatment, the child was prescribed for reexamination after 7-10 days, after one month, in the following periods – once a year.After working with the material of the Icon system, the authors noted the pronounced effects of the treatment of initial caries by the method of infiltration.Conclusions. 1. The method of infiltration is a modern and promising technology for the treatment of dental caries at an early stage without losing healthy tissues. 2. The Icon infiltration method makes it possible to stop the spread of pathogenic bacteria and develop tooth decay at the white spot stage, replacing the destroyed enamel cells with special polymers having low viscosity and high penetrating ability. 3. The stabilization of the carious process is achieved in a short time with the maximum preservation of the tooth's tissues. 

Role of Carboplatin in the Treatment of Triple Negative Early- Stage Breast Cancer

2015 ◽  
Vol 10 (2) ◽  
pp. 101-110 ◽  
Author(s):  
Matias E. Valsecchi ◽  
Gerrit Kimmey ◽  
Arvinder Bir ◽  
Damian Silbermins
Keyword(s):  
Breast Cancer ◽  
Triple Negative ◽  
Early Stage ◽  
Early Stage Breast Cancer

An Analysis of Professional Competence Indicator Possession among U.S. Accounting Faculty

2016 ◽  
Vol 32 (2) ◽  
pp. 17-38 ◽  
Author(s):  
Kenneth J. Smith ◽  
David J. Emerson
Keyword(s):  
Student Performance ◽  
Professional Competence ◽  
Academic Research ◽  
Practical Experience ◽  
Accounting Faculty ◽  
Accounting Practice ◽  
Cpa Exam ◽  
Primary Focus ◽  
New Generation

ABSTRACT Recently there has been much discourse regarding the existence, extent, causes, and consequences of a purported divide between accounting practice and academia. The crux of this issue relates to the charge that many new-generation faculty have a primary focus on academic research, but lack significant practical experience or certification, and the related claim that students may lack the requisite skills upon graduation. This study addresses these concerns by examining the incidence and trend in the possession of practice credentials, experience, and other activities among accounting faculty who graduated between 1994 and 2013. We evaluate how differences in institutional focus, possession of a practice credential, and proportion of credentialed faculty manifest in research propensities, current business experience, and student performance on the CPA exam. We identify a downward trend in practice credential possession that is more pronounced at research-oriented institutions. We further find significant differences in experience and publication activity across levels of both institutional focus and possession of a practice credential. We also find that students from research-oriented universities, schools with separate AACSB accounting accreditation, and those with a higher percentage credentialed faculty perform better on the CPA exam. Other results and the role of adjunct faculty in bridging this alleged divide are also examined.

scholarly journals The Ability of Metabolomics to Discriminate Non-Small-Cell Lung Cancer Subtypes Depends on the Stage of the Disease and the Type of Material Studied

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3314
Author(s):  
Tomasz Kowalczyk ◽  
Joanna Kisluk ◽  
Karolina Pietrowska ◽  
Joanna Godzien ◽  
Miroslaw Kozlowski ◽  
...  
Keyword(s):  
Metabolic Pathways ◽  
Early Stage ◽  
Chronic Obstructive ◽  
Liquid Chromatography Mass Spectrometry ◽  
Obstructive Pulmonary Disease ◽  
Cell Lung Carcinoma ◽  
Cancer Subtypes ◽  
Inflammatory State ◽  
Nsclc Patients

Identification of the NSCLC subtype at an early stage is still quite sophisticated. Metabolomics analysis of tissue and plasma of NSCLC patients may indicate new, and yet unknown, metabolic pathways active in the NSCLC. Our research characterized the metabolomics profile of tissue and plasma of patients with early and advanced NSCLC stage. Samples were subjected to thorough metabolomics analyses using liquid chromatography-mass spectrometry (LC-MS) technique. Tissue and/or plasma samples from 137 NSCLC patients were analyzed. Based on the early stage tissue analysis, more than 200 metabolites differentiating adenocarcinoma (ADC) and squamous cell lung carcinoma (SCC) subtypes as well as normal tissue, were identified. Most of the identified metabolites were amino acids, fatty acids, carnitines, lysoglycerophospholipids, sphingomyelins, plasmalogens and glycerophospholipids. Moreover, metabolites related to N-acyl ethanolamine (NAE) biosynthesis, namely glycerophospho (N-acyl) ethanolamines (GP-NAE), which discriminated early-stage SCC from ADC, have also been identified. On the other hand, the analysis of plasma of chronic obstructive pulmonary disease (COPD) and NSCLC patients allowed exclusion of the metabolites related to the inflammatory state in lungs and the identification of compounds (lysoglycerophospholipids, glycerophospholipids and sphingomyelins) truly characteristic to cancer. Our results, among already known, showed novel, thus far not described, metabolites discriminating NSCLC subtypes, especially in the early stage of cancer. Moreover, the presented results also indicated the activity of new metabolic pathways in NSCLC. Further investigations on the role of NAE biosynthesis pathways in the early stage of NSCLC may reveal new prognostic and diagnostic targets.

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