scholarly journals The role of triptans in the management of migraine

2016 ◽  
Vol 28 (1) ◽  
pp. 49-58
Author(s):  
Meiyanti Meiyanti
Keyword(s):  
Serotonin Receptor ◽  
Treatment Options ◽  
Acute Attack ◽  
Preventive Therapy ◽  
Worker Productivity ◽  
Artery Disease ◽  
Serotonin Receptor Agonists ◽  
The Impact ◽  
Made In

Migraine is one of the most prevalent disorders seen in clinical practice today and also a major cause of disability in the workplace. The prevalence of migraine is highest during the years of peak productivity, ie, between the ages of 25 and 55 years. The triptans are a group of selective 5-hydroxtriptamine (HT)1 serotonin receptor agonists that activate the 5-HT1B/1D receptor and possibly also the 5-HT1A dan 5-HT1F receptors. To date 7 subclasses of serotonin receptors have been identified, namely subclasses 5-HT1 to 5-HT7. Triptan causes cranial vasoconstriction, inhibits peripheral trigeminal activity and the trigeminal afferents. With its triple action, triptans can control acute attacks of migraine. Triptan is contraindicated in patients with previous ischemic or coronary artery disease, cerebral or peripheral vascular disease and other cardiovascular disorders. Triptans should be given immediately after an acute attack of migraine. The triptans are useful in the management of an acute migraine, but are not indicated for preventive therapy of migraine. Several new advances in migraine management have been made in regard to the recognition of the disease, the pathogenesis of migraine, and the phenomenon of central sensitization. More treatment options become available to patients and prescribers, the impact of such therapy on worker productivity will become more important in determining the value of such interventions.

The Role of the Endothelium in Premature Atherosclerosis: Molecular Mechanisms

2020 ◽  
Vol 27 (7) ◽  
pp. 1041-1051 ◽  
Author(s):  
Michael Spartalis ◽  
Eleftherios Spartalis ◽  
Antonios Athanasiou ◽  
Stavroula A. Paschou ◽  
Christos Kontogiannis ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Low Density Lipoprotein ◽  
Critical Role ◽  
Density Lipoprotein ◽  
Number Of Genes ◽  
Causes Of Mortality ◽  
Artery Disease ◽  
Genetic And Environmental Factors ◽  
Made In

Atherosclerotic disease is still one of the leading causes of mortality. Atherosclerosis is a complex progressive and systematic artery disease that involves the intima of the large and middle artery vessels. The inflammation has a key role in the pathophysiological process of the disease and the infiltration of the intima from monocytes, macrophages and T-lymphocytes combined with endothelial dysfunction and accumulated oxidized low-density lipoprotein (LDL) are the main findings of atherogenesis. The development of atherosclerosis involves multiple genetic and environmental factors. Although a large number of genes, genetic polymorphisms, and susceptible loci have been identified in chromosomal regions associated with atherosclerosis, it is the epigenetic process that regulates the chromosomal organization and genetic expression that plays a critical role in the pathogenesis of atherosclerosis. Despite the positive progress made in understanding the pathogenesis of atherosclerosis, the knowledge about the disease remains scarce.

scholarly journals Role of PFKFB3 and PFKFB4 in Cancer: Genetic Basis, Impact on Disease Development/Progression, and Potential as Therapeutic Targets

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 909
Author(s):  
Krzysztof Kotowski ◽  
Jakub Rosik ◽  
Filip Machaj ◽  
Stanisław Supplitt ◽  
Daniel Wiczew ◽  
...  
Keyword(s):  
Current Knowledge ◽  
Treatment Options ◽  
Protein Structures ◽  
New Drugs ◽  
Proliferating Cells ◽  
Cancer Tissues ◽  
The Impact ◽  
Rate Limiting ◽  
Synthesis And Degradation

Glycolysis is a crucial metabolic process in rapidly proliferating cells such as cancer cells. Phosphofructokinase-1 (PFK-1) is a key rate-limiting enzyme of glycolysis. Its efficiency is allosterically regulated by numerous substances occurring in the cytoplasm. However, the most potent regulator of PFK-1 is fructose-2,6-bisphosphate (F-2,6-BP), the level of which is strongly associated with 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase activity (PFK-2/FBPase-2, PFKFB). PFK-2/FBPase-2 is a bifunctional enzyme responsible for F-2,6-BP synthesis and degradation. Four isozymes of PFKFB (PFKFB1, PFKFB2, PFKFB3, and PFKFB4) have been identified. Alterations in the levels of all PFK-2/FBPase-2 isozymes have been reported in different diseases. However, most recent studies have focused on an increased expression of PFKFB3 and PFKFB4 in cancer tissues and their role in carcinogenesis. In this review, we summarize our current knowledge on all PFKFB genes and protein structures, and emphasize important differences between the isoenzymes, which likely affect their kinase/phosphatase activities. The main focus is on the latest reports in this field of cancer research, and in particular the impact of PFKFB3 and PFKFB4 on tumor progression, metastasis, angiogenesis, and autophagy. We also present the most recent achievements in the development of new drugs targeting these isozymes. Finally, we discuss potential combination therapies using PFKFB3 inhibitors, which may represent important future cancer treatment options.

THE IMPACT OF ICT IN MARKETING LIBRARY SERVICES IN ACADEMIC LIBRARY

2021 ◽  
Vol 9 (1) ◽  
pp. 150-156
Author(s):  
Salamatu Baba ◽  
◽  
Dikuma Ibrahim ◽  
Sanda Grema ◽  
◽  
...  
Keyword(s):  
Information And Communication Technology ◽  
Communication Technology ◽  
Academic Library ◽  
Library Services ◽  
Information And Communication ◽  
The Impact ◽  
Role Of Information ◽  
Descriptive Method ◽  
Made In

In order to promote utilizing the available resource made in any library information has to be taken to the door step of a clientele a such information and communication technology will serve as a catalyst in doing that. This paper has explored the role of information and communication technology ICT in academia and as well as the strategies used in propagating the available services in an academic library this is because tailor made information it is highly required so as to avoid wasting the precious time of academicians and this can be only achieving with the help of information and communication technology software, therefore, descriptive method was adopted in the methodology of this study.

scholarly journals Nucleases as molecular targets for cancer diagnosis

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Alien Balian ◽  
Frank J. Hernandez
Keyword(s):  
Enzymatic Activity ◽  
Cancer Diagnosis ◽  
Essential Feature ◽  
Treatment Options ◽  
Cancer Biomarkers ◽  
Diagnostic Biomarkers ◽  
Early Cancer Diagnosis ◽  
Novel Biomarkers ◽  
Made In

AbstractEarly cancer diagnosis is a crucial element to improved treatment options and survival. Great research efforts have been made in the search for better performing cancer diagnostic biomarkers. However, the quest continues as novel biomarkers with high accuracy for an early diagnosis remain an unmet clinical need. Nucleases, which are enzymes capable of cleaving nucleic acids, have been long considered as potential cancer biomarkers. The implications of nucleases are key for biological functions, their presence in different cellular counterparts and catalytic activity led the enthusiasm towards investigating the role of nucleases as promising cancer biomarkers. However, the most essential feature of these proteins, which is their enzymatic activity, has not been fully exploited. This review discusses nucleases interrogated as cancer biomarkers, providing a glimpse of their physiological roles. Moreover, it highlights the potential of harnessing the enzymatic activity of cancer-associated nucleases as a novel diagnostic biomarker using nucleic acid probes as substrates.

Bragg's influence on progress in optical computations

1970 ◽  
Vol 26 (2) ◽  
pp. 189-193 ◽  
Author(s):  
D. McLachlan
Keyword(s):  
The Enlightenment ◽  
Optical Computation ◽  
The Impact ◽  
Made In ◽  
Inverse Imaging

An attempt is made in this paper to indicate the impact that one small part of Sir Lawrence Bragg's gross contributions have had upon crystallography during his lifetime up to the age of eighty. The small part referred to is the growing field of optical computation. Since this paper is partly for the enlightenment of the reader as well as a salute to history, descriptions of five basic optical operations are given: I, addition; II, multiplication; III, reciprocation; IV, convolution and V, diffraction. The role of Bragg and his co-workers is woven into each description. Finally as an extrapolation, a further process is described: VI, inverse imaging.

scholarly journals Sciences and audiences along the last century: the impact of Astronomy Education

2018 ◽  
Vol 13 (S349) ◽  
pp. 474-478
Author(s):  
Rosa M. Ros ◽  
Beatriz Garca
Keyword(s):  
Secondary Teachers ◽  
Astronomy Education ◽  
Interest In Science ◽  
The Past ◽  
The World ◽  
History Of ◽  
The Impact ◽  
Made In ◽  
Science Activities

AbstractJust as in the past, the development of the natural sciences and in particular of astronomy has changed the history of humanity. If we think about the role of our discipline into the future, it shows its enormous power in the field of education, owing to the possibility of awakening interest in science in very varied audiences. Within the framework of the enormous progress made in the technologies related to astronomy, many of them of daily use, the role of the astronomer in the era of Communications acquires fundamental importance.In this presentation, we will try to make a journey through the different ways of presenting astronomical topics for different audiences over the last 100 years. In turn, we will show some specific achievements, associated with education programmes of the discipline. We discuss the impact produced by proposals that are both rigorous in terms of content, and also appeal to the development of the human being in an integral manner, within the framework of citizen science activities.For this research, we have taken into account the uninterrupted development of the NASE programme, which has performed 112 courses in 24 countries throughout the world and in different languages. NASE has involved 4966 secondary teachers in the last eight years.

The Oxford Handbook of Hope

2017 ◽  
Keyword(s):  
Current Knowledge ◽  
Physical And Mental Health ◽  
Comprehensive Overview ◽  
Future Directions ◽  
Theoretical Perspectives ◽  
The Many ◽  
The Impact ◽  
Made In

The Oxford Handbook of Hope provides a comprehensive overview of current knowledge regarding the science and practice of hope. Hope has long been a topic of interest to philosophers and the general public, but it was only in recent decades that hope became a focus of psychological science. Rick Snyder defined hope as a cognitive trait that helps individuals to identify and pursue goals and consists of two components: pathways, the perceived capacity to identify strategies necessary to achieve goals, and agency, the willpower or motivation to pursue those pathways to achieve goals. Hope has become one of most robust and promising topics in the burgeoning field of positive psychology. This book reviews the progress that has been made in the past 25 years regarding the origins and influence of hope. Topics covered include current theoretical perspectives on how best to define hope and how it is distinct from related constructs, current best practices for measuring and quantifying hope, interventions and strategies for promoting hope across different settings and the lifespan, the impact that hope has on many dimensions and domains of physical and mental health, and the many ways and contexts in which hope promotes resilience and positive functioning. Experts in the field both review what is currently known about the role of hope in different domains and identify topics and questions that can help to guide the next decade of research. The handbook concludes with a collaborative vision on the future directions of the science of hope.

scholarly journals Observation of the Diurnal Cycle in the Low Troposphere of West Africa

2008 ◽  
Vol 136 (9) ◽  
pp. 3477-3500 ◽  
Author(s):  
Marie Lothon ◽  
Frédérique Saïd ◽  
Fabienne Lohou ◽  
Bernard Campistron
Keyword(s):  
Boundary Layer ◽  
Water Vapor ◽  
West Africa ◽  
Planetary Boundary Layer ◽  
Diurnal Cycle ◽  
Dry Season ◽  
Nocturnal Jet ◽  
The Impact ◽  
Made In

Abstract The authors give an overview of the diurnal cycle of the low troposphere during 2006 at two different sites, Niamey (Niger) and Nangatchori (Benin). This study is partly based on the first observations of UHF wind profilers ever made in West Africa in the context of the African Monsoon Multidisciplinary Analysis (AMMA) project. Also used are the radiosoundings made in Niamey and ground station observations at Nangatchori, which allow for the study of the impact of the dynamics on the water vapor cycle and the turbulence observed at the ground. Profiler measurements revealed a very consistent year-round nocturnal low-level jet maximal around 0500 UTC and centered at 400-m above the ground, with wind speed around 15 m s−1. This jet comes either from the northeast during the dry season or from the southwest during the wet season, in relation with the position of the intertropical discontinuity. The radiosoundings made in Niamey highlight both the role of the nocturnal jet in bringing water vapor from the south during the night when the intertropical discontinuity has reached the vicinity of the considered area at the end of the dry season and the role of the daytime planetary boundary layer in mixing this water vapor within a larger depth of the troposphere. The planetary boundary layer processes play a large role in the diurnal cycle of the position of the intertropical discontinuity itself. The observations of turbulence made at the ground in Nangatchori showed that the best signature of the nocturnal jet close to surface can be seen in the turbulent kinetic energy and skewness of the air vertical velocity, rather than on the mean wind itself. They reveal the downward transport of momentum from the jet core aloft to the surface.

Role of different aberrant cell signalling pathways prevalent in acute lymphoblastic leukemia

Biologia ◽  
2014 ◽  
Vol 69 (9) ◽  
Author(s):  
Priya Gopal ◽  
Mausumi Paul ◽  
Santanu Paul
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Treatment Options ◽  
Cell Signalling ◽  
Signalling Pathways ◽  
Survival Ratio ◽  
Functional Abnormality ◽  
Important Progress ◽  
Made In

AbstractAcute lymphoblastic leukemia (ALL) is one of the major forms of leukemia that affects mostly adolescent individuals. The main cause of the development of ALL is not known though several important signal transduction pathways have been reported with functional abnormality in all the cases. Crucial signalling pathways reported in ALL include PI3K/Akt, Notch, Wnt, mTOR, JaK/Stat, etc. Over the past several decades important progress has been made in the management of ALL, however, relapses and post therapy survival ratio has not improved much. This brings the need for understanding the biology and mechanism involved in ALL occurrences and find new molecular targets for better treatment options and risk-adapted therapies to improve the outcome of ALL patients.

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