scholarly journals A comparative study of moxifloxacin versus combination of doxycycline and metronidazole for treatment of uncomplicated pelvic inflammatory disease

2019 ◽  
Vol 8 (5) ◽  
pp. 956
Author(s):  
Priyadharshini M. ◽  
Sarmila Nath ◽  
Gourisankar Kamilya ◽  
Raja Roy
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Vaginal Discharge ◽  
Visual Analogue Score ◽  
Treated Group ◽  
Vaginal Swab ◽  
Reproductive Age ◽  
Number Of Patients ◽  
Group B ◽  
Organism Identification

Background: Pelvic inflammatory disease (PID), a common condition among women of reproductive age caused by various aerobic and anaerobic organisms, may sometimes lead to complications like infertility, ectopic pregnancy and chronic pelvic pain. Moxifloxacin is a broad spectrum bactericidal antibiotic acting against many gram positive, gram negative aerobic organisms and anaerobes. Rapid absorption and high bioavailability allow single daily dosing and improves compliance. The present study was done to compare the clinical and microbiological outcomes in  PID patients treated with conventional doxycycline- metronidazole  and moxifloxacin therapy.Methods: Women with uncomplicated PID, randomized into two groups either received 400 mg single dose of moxifloxacin daily for 14 days (group A) or doxycycline 100 mg + metronidazole 500 mg twice daily for 14 days (group B). Temperature, TLC count, ESR, CRP, microbiological assessment, Visual analogue score for pain, vaginal discharge, dyspareunia and backache were noted. The bacteriological cure was assessed by high vaginal swab for organism identification by gram stain, 10% KOH and blood sample by ELISA.Results: Total 60 women were enrolled and randomized into two groups. There was significant reduction of CRP and improved TLC in the moxifloxacin treated group. Visual analogue scores for pain, vaginal discharge and malaise were significantly reduced in the group treated with moxifloxacin.  Nausea, vomiting, metallic taste, dyspepsia and diarrhoea were complained by a significant number of patients of doxycycline + metronidazole group, in contrast to the patients receiving moxifloxacin.Conclusions: Moxifloxacin 400 mg once daily, is effective and safe for treatment of PID.

scholarly journals ANTIBIOTIC PROPHYLACTICS ON CURETTAGE FOR PREVENTING PELVIC INFLAMMATORY DISEASE EVENTS: IS IT NECESSARY?

2018 ◽  
Vol 11 (11) ◽  
pp. 267
Author(s):  
Fauna Herawati ◽  
Abdul Rahem ◽  
Dwi Handayani ◽  
Rika Yulia
Keyword(s):  
Antibiotic Prophylaxis ◽  
Pelvic Inflammatory Disease ◽  
Sedimentation Rate ◽  
Inflammatory Disease ◽  
Vaginal Discharge ◽  
Pain Scale ◽  
Prophylactic Antibiotics ◽  
Erythrocyte Sedimentation ◽  
Group A ◽  
Group B

Objective: This study aimed to compare pelvic inflammatory disease (PID) symptoms in curettage procedure with three antibiotic prophylaxis strategies.Methods: The patients were allocated to three Groups (A, B, and C). Group A was patients receiving prophylactic antibiotics and post-curettage antibiotics, Group B received prophylactic antibiotics without post-curettage antibiotics, and Group C did not receive prophylactic antibiotics but received post-curettage antibiotics. The outcomes measured to identify the occurrence of PID symptoms included leukocytes, erythrocyte sedimentation rate, temperature, pain, vaginal discharge, and bleeding.Results: This study shows that there were no significant differences in any PID symptoms between antibiotic strategies except for pain scale (p=0.03).Conclusion: The PID symptoms between the three strategies of antibiotic prophylaxis were similar.

scholarly journals A study in a teritary centre for clinical assessment of pelvic inflammatory disease risk among women attending outpatient department

2017 ◽  
Vol 6 (9) ◽  
pp. 3823
Author(s):  
Sowmya D. ◽  
Sowjanya D.
Keyword(s):  
Risk Factors ◽  
Confidence Interval ◽  
Pelvic Inflammatory Disease ◽  
Birth Control ◽  
Inflammatory Disease ◽  
Odds Ratio ◽  
Vaginal Discharge ◽  
Reproductive Age ◽  
P Value ◽  
Factors Associated

Background: Pelvic inflammatory disease (PID) is associated with major medical and economic consequences for women of reproductive age. Identification of the risk factors associated with PID is crucial to efforts for prevention of these consequences. This study is done to evaluate the risk factors for PID in women attending OPD at Gangori hospital.Methods: This Study is an observational study, Conducted in Department of Obstetrics and Gynecology, Gangori hospital, SMS Medical College, Jaipur, From January 2015 to June 2015. Risk factors of PID were assessed in 70 women with PID (study group) and then it was compared with 70 controls attending the Women's Clinic at the same institution. Significance of difference in proportion in various variables of PID in both the group was inferred by odd’s ratio and Chi-square test. Logistic regression analysis was used to adjust for confounding variables.Results: A total of 70 women with PID and an equal number of controls were included. Cases were significantly younger than controls (p<0.001). The women were mainly of lower socioeconomic status. Risk factors identified by bivariate analysis were less than secondary level education, Odds ratio [OR] 5.29; (95% confidence interval: 1.680 to 16.675) P value 0.005. Parity >0, Odds ratio 2.521 (95% CI: 1.140 to 5.577) P value 0.033. Spontaneous abortion >0, Odds ratio 3.11 (95% CI: 1.311 to 7.362) P value 0.015. Lack of a birth control method, Odds ratio 7.18 (95% confidence interval: 3.091 to 16.662) p value<0.001. younger than 18 years at age of first sex, Odds ratio 2.84 (95% CI: 1.404 to 5.753) P value 0.006. Sex during the previous menses Odds ratio 5.39 (95% CI: 2.317 to 12.529) P value <0.001. Vaginal discharge/bleeding, Odds ratio 5.84 (confidence interval 2.717 to 12.578) P value <0.001. With multivariate analysis to control for confounders the risks still identified were sex during the previous menses, parity >0, lack of contraception, vaginal discharge and age at first sex.Conclusions: Identification of the risk factors associated with PID is most important effort for prevention of the disease and its sequelae. Educating the women, encouraging the use of condoms and other methods of contraception for PID prevention, sexually transmitted disease prevention and also birth control. Another finding is that, it is better to avoid coitus during the menses.

scholarly journals Clinical Findings of Pelvic Inflammatory Diseases among women in Reproductive Age

2021 ◽  
Vol 7 (1) ◽  
pp. 52-55
Author(s):  
Ismat Ara Laizu ◽  
Laila Anjuman Banu ◽  
Fowzia Abul Fayez
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Vaginal Discharge ◽  
Inflammatory Diseases ◽  
Clinical Findings ◽  
Reproductive Age ◽  
Age Group ◽  
College Hospital ◽  
Medical College ◽  
Reproductive Age Group

Background: Pelvic Inflammatory disease is a very common gynaecological condition among the women in reproductive age group. Objectives: The purpose of the present study was to find out the clinical findings of Pelvic inflammatory diseases among the women during reproductive age group. Methodology: This cross-sectional study was carried out in the Department of Obstetrics and Gynaecology at Mymensingh Medical College Hospital, Mymensingh, Bangladesh from January 2008 to June 2009 for a period of one (01) and a half year. Women who were presented with pelvic inflammatory disease (PID) attended at the OPD of gynecology Department at Mymensingh Medical College Hospital, Mymensingh, Bangladesh were selected as study population. Detailed clinical history of each patient was taken and thorough physical examination was performed. Result: A total number of 300 cases were recruited. The mean age with SD was 30.3±9.57 years. Majority of the patients had tenderness in the lower abdomen which was 96(64.0%) cases. However, 152(50.7%) patients had vaginal discharge and 34(11.3%) patients had uterovaginal proplapse. However, cervical tear was present in 96(32.0%) cases and chronic cervicitis was present in 138(46.0%) cases. Conclusion: In conclusion most common clinical feature is lower abdominal tenderness followed by vaginal discharge. Journal of National Institute of Neurosciences Bangladesh, January 2021, Vol. 7, No. 1, pp. 52-55

scholarly journals 183. chlamydia Trachomatis Seroprevalence with a pgp3 Serologic Assay and Association with Pelvic Inflammatory Disease Among Women, United States, 2013–2016

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S220-S220
Author(s):  
Gloria E Anyalechi ◽  
Damien Danavall ◽  
Brian H Raphael ◽  
Katherine E Bowden ◽  
Jaeyoung Hong ◽  
...  
Keyword(s):  
Black Women ◽  
Chlamydia Trachomatis ◽  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
White Women ◽  
Transmitted Disease ◽  
Population Level ◽  
Reproductive Age ◽  
Nucleic Acid Amplification ◽  
Sexually Transmitted

Abstract Background Chlamydia trachomatis (CT) causes pelvic inflammatory disease (PID) and other sequelae; however, these associations are not fully characterized. CT serologic assays including Pgp3 ELISA may detect prior CT infection and may better elucidate these associations. We used a serologic Pgp3 multiplex bead array assay (Pgp3MBA) to measure CT seroprevalence in reproductive-age US women and assess the association with PID. Methods We performed CT Pgp3MBA on sera collected from women 18–39 years old during the 2013–2016 cycles of the National Health and Nutrition Examination Survey (NHANES) who had available urine CT nucleic acid amplification test results. Weighted Pgp3MBA CT seroprevalence and 95% confidence intervals (95% CI) were calculated. We also determined weighted prevalence ratios (PRs) and 95% CIs of self-reported lifetime PID among women with and without detectable Pgp3MBA and other characteristics to estimate these US national statistics. Results Among 2,339 women, 1,725 (73.7%) had available sera. Of these women, 1,425 (or 93.4% of those with data) were sexually experienced and had a CT seroprevalence of 35.9% (95% CI 33.4–38.4). When weighted for US women, CT seroprevalence was 30.5% (95% CI 26.6–34.4%), ranging from 16.9% (95% CI 11.0–22.8%) among non-Hispanic Asian women to 70.2% (95% CI 62.4–78.0%) among non-Hispanic black women. PID was reported by 4.2% (95% CI 3.1–5.2) of 1,413 sexually-experienced women with PID data or an estimated 3.8% (95% CI 2.6–5.0) of US women. Among US women, estimated PID varied by Pgp3MBA status; 7.3% (95% CI 4.3–10.2) of Pgp3MBA-positive women were estimated to report PID versus 2.3% (95% CI 1.3–3.4) of Pgp3MBA-negative women (PR 3.1; 95% CI 1.7–5.9). PID prevalence did not vary by age, nor self-reported recent sexually transmitted disease among US women, but was higher among non-Hispanic black women compared to non-Hispanic white women (PR 2.2; 95% CI 1.4–3.5). Conclusion Nearly one-third of US women have had CT by Pgp3MBA, with differences by race/ethnicity. Women with prior CT had three times the reported PID prevalence of women without CT. Further serologic research may refine the population-level impact of CT prevention activities, such as recommended annual CT screening, on PID incidence, particularly among non-Hispanic black women. Disclosures All Authors: No reported disclosures

scholarly journals Clinico-Ultrasonographic Profile of Ectopic Pregnancy in Western Nepal

2018 ◽  
Vol 8 (1) ◽  
pp. 2-6
Author(s):  
Sangeeta Devi Gurung ◽  
Prakash Sharma
Keyword(s):  
Ectopic Pregnancy ◽  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Radiological Finding ◽  
Previous History ◽  
First Trimester ◽  
Reproductive Age ◽  
Age Group ◽  
Type Iii ◽  
Reproductive Age Group

Introduction: Ectopic pregnancy (EP) is one of the major complications in first trimester pregnancy, resulting in increased maternal morbidity and mortality. It accounts for 1.3-2.4% of all pregnancies. Previously, though laparoscopy was considered as the gold standard for diagnosis of ectopic pregnancy, due to availability of high resolution ultrasound, it has become the first line investigation for the diagnosis of ectopic pregnancy.Methods: It is a prospective study conducted in Manipal Teaching Hospital, Pokhara, from January 2015 till December 2017. All the cases diagnosed with ectopic pregnancy were included in the study.  Ultrasonological and intraoperative findings were recorded. Data was analyzed using SPSS (VERSION 16).Results: Twenty six patients were diagnosed with ectopic pregnancies. The incidence was 0.35%. It was most common among the reproductive age group between 20-40 years with mean age of 30.50 years. Pelvic inflammatory disease (n=10, 38.5%) was considered as risk factor. Radiological finding of Type III ectopic pregnancy (n=21, 80.8%) was the most common type.Conclusion: Ectopic pregnancy is common among reproductive age group with previous history of pelvic inflammatory disease. Type III is the most common type.

scholarly journals Composition of Vaginal microbiota and their antibiotic susceptibility in symptomatic women

2017 ◽  
Vol 6 (2) ◽  
pp. 427
Author(s):  
Ushadevi Gopalan ◽  
Sathiyakala Rajendiran ◽  
Karthika Jayakumar ◽  
Ranganathan Karnaboopathy
Keyword(s):  
Candida Species ◽  
Antibiotic Susceptibility ◽  
Pathogenic Bacteria ◽  
Vaginal Discharge ◽  
Tertiary Care ◽  
Vaginal Swab ◽  
Reproductive Age ◽  
Klebsiella Pneumonia ◽  
Care Hospital ◽  
Age Group

Background: Bacterial vaginosis is the most prevalent lower genital tract infection in women of reproductive age. The aim of this study was to identify the causative organism in patients with vaginal discharge and to study the sensitivity of the organism to antibiotics.Methods: This was a hospital based prospective study in Department of Obstetrics and Gynecology in a tertiary care hospital over a period of two years. 2062 women with complaints of vaginal discharge were subjected to a high vaginal swab and the sample was cultured, the organisms were identified and antibiotic susceptibility was tested.Results: There was no growth found in 40.7% of patients. E. coli was found to be the most common organism isolated followed by Klebsiella pneumonia and Klebsiella oxytoca. Candida species was isolated in 1.4 % of women. An increased frequency of vaginal infection was found in the age group 26-35 years, followed by age group 36-45 years. 73.2% of the organisms were sensitive to Imipenam, 70.4 % to Amikacin and 65.7% to Gentamycin. There were 10 MRSA strains isolated all of which were sensitive to Vancomycin, Amikacin and Gentamycin.Conclusions: Our study provides information about the different microorganisms present in women with vaginal discharge. Since pathogenic bacteria were more common than Candida species it is recommended to offer treatment to patients after taking a high vaginal swab. Appropriate antibiotics based on culture and sensitivity has to be given along with antifungal agents.

scholarly journals Rapid Detection of Bacterial Vaginosis (BV) by BVBlue test

1970 ◽  
Vol 4 (1) ◽  
pp. 24-27
Author(s):  
Shameem Akhter ◽  
Humayun Satter ◽  
Shirin Tarafder ◽  
Ruhul Amin Miah ◽  
Sohely Sharmin ◽  
...  
Keyword(s):  
Bacterial Vaginosis ◽  
Vaginal Discharge ◽  
Vaginal Swab ◽  
Reproductive Age ◽  
Gram Stain ◽  
Clinical Criteria ◽  
Healthy Control ◽  
History Of ◽  
Study Population ◽  
Abnormal Vaginal Discharge

Bacterial vaginosis is the commonest cause of abnormal vaginal discharge in women of reproductive age and require laboratory test for diagnosis . A total 200 women aged 15-45 years with history of abnormal vaginal discharge were included as study population. Fifty women without such history of discharge were taken as healthy control. Three vaginal swab samples were taken from each case and control. These swab samples were subjected to test by conventional methods such as Amsel clinical criteria, Gram stain Nugent method, culture and by newly developed BV Blue test. The results of the BVBlue test were compared with these methods to find out the efficacy of BVBlue test. Rate of detection of bacterial vaginosis (BV) cases was 21.5% by Amsel clinical criteria, 21.0% by Gram stain Nugent method, 21.0% by culture and 22% by BVBlue test among the study population. When comparing with the conventional test and culture, BVBlue test was 100% sensitive and 98% specific. It is rapid, technically simple and is suitable for screening large number of patient in short time where laboratory facilities are not developed. Key words: Bacterial Vaginosis, BVBlue test, Nugent method, Abnormal vaginal discharge. DOI: http://dx.doi.org/10.3329/bjmm.v4i1.8465 BJMM 2011; 4(1): 24-27

scholarly journals BACTERIAL VAGINOSIS;

2017 ◽  
Vol 24 (02) ◽  
pp. 252-257
Author(s):  
Faiqa Saleem ◽  
Munazza Malik ◽  
Muhammad Sohaib Shahid ◽  
Muhammad Tayyab
Keyword(s):  
Bacterial Vaginosis ◽  
Vaginal Discharge ◽  
Reproductive Age ◽  
P Value ◽  
Vaginal Infections ◽  
Vaginal Gel ◽  
Vaginal Cream ◽  
Significant Difference ◽  
Group A ◽  
Group B

In women of reproductive age bacterial vaginosis is a most common polymicrobialdisease and is the leading reason for vaginal discharge in this age group. Additionally itis further linked with sizeable disease burden of community problem in terms of infectiouscomplications. Clindamycin vaginal cream and metronidazole vaginal gel are effective in themanagement of vaginal infections caused by multi bacteria. Objectives: To compare thetherapeutic efficacy of Metronidazole vaginal gel and clindamycin vaginal cream as modality oftreatment for bacterial vaginosis. Study Design: Randomized control trial. Setting: Departmentof Obstetrics and Gynaecology, Unit-3 Jinnah Hospital Lahore. Period: Six months from 02-05-2011 to 01-11-2011. Material & Methods: A total of 300 patients were included in this study.They were divided into two groups. Group A received metronidazole vaginal gel (5 g dailyfor 7 days) while group B administered with clindamycin vaginal cream (5g daily for 7 days).Results: Mean age of the patient was observed 34.3+3.5 and 32.9+ 2.1 years in group –A andB respectively. Vaginal discharge was absent in 104 patients (69.3%) from group A and 127(84.7%) from group-B. Absence of clue cells on microscopy revealed in 112 patients (74.7%)from group A and 137 patients (91.3%) from group B. Absence of amine odour found in 116patients (77.3%) of group A and 134 patients (89.3%) of group B. Significant difference wasfound between two groups with p value of 0.006 in respect of efficacy. Conclusion: Clindamycinvaginal cream is more effective in comparison to Metronidazole vaginal gel for the treatment ofbacterial vaginosis.

scholarly journals Effect of Sharbat-e-Deenarin uncomplicated Pelvic Inflammatory Disease- A Clinical study

2020 ◽  
Vol 11 (4) ◽  
pp. 7634-7643
Author(s):  
Ghazala Ahmad ◽  
Ismath Shameem
Keyword(s):  
Clinical Study ◽  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
White Blood Cells ◽  
Female Genital Tract ◽  
Lower Abdominal Pain ◽  
Reproductive Age ◽  
Gynecologic Surgery ◽  
Discharge Data ◽  
Vas Score

Pelvic inflammatory disease (Waram al-Rahim)is one of the most serious gynaecological infections of the upper female genital tract with the worldwide annual rate of 10-20/1000 women of reproductive age.  The objective planned for the study was to evaluate the effect of Sharbat-e-Deenar in uncomplicated Pelvic Inflammatory Disease (uPID).  A pre and post observational single group clinical study was carried out in the Department of IlmulQabalatwaAmrazeNiswan, National Institute of Unani Medicine, Hospital, Bengaluru. Diagnosed cases (n=30) of uPID were included in the study. Patients with complicated PID, history of antibiotic therapy within seven days of recruitment; delivery, abortion or gynecologic surgery within the last 30 days,  systemic diseases, malignancies, pregnancy & lactation were excluded. Sharbat-e-Deenarconsists of Poste baikhekasniandTukhmekasni(Cichorium intybus  Linn.), Gulesurkh (Rosa damascene mill.), Tukhmekasoos(CuscutareflexaRoxb.)  and Rewandchini (Rheum emodiWall. ex Meissn) were administered orally in a dose of 20 ml twice daily for 14 days. Outcome measures were 30-70% clinical improvement in Visual Analogue Scale (VAS) score for lower abdominal pain and McCormack Pain Scale (McPS) score for abdominopelvic tenderness and White Blood Cells (WBCs) count <10 on saline microscopy of discharge. Data were analyzed using paired Student ‘t’ test, Wilcoxon Signed rank test and Paired Proportion test.Clinical improvement of 30-70% in McPS and VAS score was achieved in 96.7% (p<0.001**) and 93.3% (p<0.001**) patients respectively. WBCs count <10 on saline microscopy of discharge was achieved in 70% patients (p<0.001**).Sharbat-e-Deenarwas effective in improving the sign & symptoms of PID due to its anti-microbial, anti-inflammatory, anti-spasmodic and anti-oxidant properties. No adverse effect of the research drug was encountered during the study. Hence, Sharbat-e-Deenar serves as an effective alternative in patients with PID, proving the research hypothesis.

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