Prevalence of vitamin D deficiency in antenatal women

Background: Vitamin D has an increasingly recognised repertoire of non-classical actions, such as promoting insulin action and secretion, immune modulation and lung development. It therefore has the potential to influence many factors in the developing fetus. Several studies reported the relationship between maternal vitamin D deficiency and adverse maternal and fetal outcomes including gestational diabetes, preeclampsia, preterm labour, low birth weight and increased rate of caesarean section. The present study was undertaken to study the prevalence of vitamin D deficiency in antenatal women of Shimla, India.Methods: The study was conducted in the department of Obstetrics and Gynaecology, Kamla Nehru Hospital, Shimla, India over a period of 12 months. Six hundred women were included in the study.Results: Out of 600 subjects, 568 (94.67%) subjects had vitamin D deficiency and only 32 (5.33%) subjects had sufficient vitamin D levels. Vitamin D deficiency was more common in the vegetarians, dark skinned subjects and in those who were taking vitamin D supplements.Conclusions: It is concluded from this study that there is high prevalence of vitamin D deficiency in antenatal women of Shimla, India.

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Vitamin D deficiency and maternal complications

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20202303 ◽

2020 ◽

Vol 9 (6) ◽

pp. 2314

Author(s):

Anu B. Chandel ◽

Rita Mittal ◽

Anoop Sharma ◽

Shivika Mittal

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Preterm Labour ◽

Maternal Complications ◽

Tropical Country ◽

Maternal Vitamin ◽

Vitamin D Levels ◽

The World ◽

Sufficient Vitamin ◽

The Relationship

Background: Vitamin D deficiency is prevalent in India, a finding that is unexpected in a tropical country with abundant sunshine. Vitamin D deficiency is recognized as the most untreated nutritional deficiency currently in the world. Several studies reported the relationship between maternal vitamin D deficiency and adverse maternal and fetal outcomes including gestational diabetes, preeclampsia, preterm labour, low birth weight and increased rate of caesarean section.Methods: The study was conducted in the department of obstetrics and gynecology, Kamla Nehru Hospital, Shimla, Himachal Pradesh, India over a period of 12 months. Six hundred women were included in the study.Results: Forty-eight (8%) subjects developed preeclampsia-eclampsia syndrome, of which none had sufficient vitamin D levels, whereas 48 (100%) subjects had vitamin D deficiency.Conclusions: Maternal antenatal complications are more common in vitamin D deficient group.

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The Prevalence of Vitamin D Deficiency in Iran: A Literature Review

Current Nutrition & Food Science ◽

10.2174/1573401316666200123100453 ◽

2020 ◽

Vol 16 (7) ◽

pp. 1015-1027

Author(s):

Mohammad Bagherniya ◽

Zahra Khorasanchi ◽

Mina S. Bidokhti ◽

Gordon A. Ferns ◽

Mitra Rezaei ◽

...

Keyword(s):

Vitamin D ◽

Literature Review ◽

Vitamin D Deficiency ◽

Medical Condition ◽

Scientific Information ◽

Age Groups ◽

Public Health Problem ◽

Major Public Health Problem ◽

Vitamin D Levels ◽

High Prevalence

Background: Vitamin D deficiency is a common medical condition worldwide. In Iran, it has been reported that between 30-90% of people have vitamin D deficiency. However, its distribution in different parts of the country and among different age and regional groups is unclear. Therefore, the aim of this study was to review the recent literature on vitamin D deficiency in Iran. Methods: The literature review was performed using Web of Science, PubMed-Medline, Scopus and Scientific Information Database (SID) with a cut-off date of November 2016 to identify articles on vitamin D status in Iran published in the last 10 years. Studies in English and Persian that reported vitamin D levels in male and female subjects of all age groups and in healthy populations were included. Results: From 325 studies that were initially retrieved, 82 articles met the inclusion criteria. A high prevalence of vitamin D deficiency was reported, and in some regions, this was reported as >90% and was found in all age groups and in all regions of Iran. Conclusion: This review highlights the very high prevalence of vitamin D deficiency in Iran. It will be important to recognize the importance of vitamin D deficiency as a major public health problem in Iran.

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Vitamin D levels in pregnant women in Uttarakhand, India

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20175840 ◽

2017 ◽

Vol 7 (1) ◽

pp. 169

Author(s):

Nikita Pahuja ◽

Nidhi Chauhan ◽

Vinita Kalra

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Bone Growth ◽

Innate Immune ◽

Vitamin D Status ◽

Medical Sciences ◽

Healthy Pregnancy ◽

Vitamin D Levels ◽

Increase Risk ◽

Sufficient Vitamin

Background: A balanced, nutritious diet is an important aspect of a healthy pregnancy and its outcome. Vitamin D plays an important role in regular bone growth and in adequate function of innate immune system, including barrier function of mucous membrane. Vitamin D deficiency in adult females may increase risk of pre-eclampsia, gestational diabetes, bacterial vaginosis. The present study was undertaken to find the prevalence of Vitamin D deficiency in the women of Uttarakhand, India.Methods: The study was conducted in the Department of Obstetrics and Gynecology, Himalayan Institute of Medical Sciences (HIMS), Swami Ram Nagar, Dehradun, India over a period of 12 months. Sample size was 100 pregnant females attending antenatal clinic.Results: Out of 100 subjects, 21 (21%) had deficient, 69 (69%) had insufficient and 10 (10%) had sufficient vitamin D status. Out of 21 deficient subjects, 18 (85.71%) were Hindus, 2 (9.52%) were Muslims, 1 (4.76%) was Sikh and no deficiency was seen in Christian. In the present study, deficient vitamin D status was seen in 1 (4.76%) in lower, 16 (76.19%) in middle and 4 (19.04%) subjects in upper socioeconomic status.Conclusions: It is concluded from our study that there is serious vitamin D deficiency and insufficiency in the women of Uttarakhand, India.

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Severe hypovitaminosis D in pregnant refugees arriving in Europe: neonatal outcomes and importance of prenatal intervention

Endocrine Connections ◽

10.1530/ec-21-0412 ◽

2021 ◽

Author(s):

Anna Liori ◽

Damaskini Polychroni ◽

Georgios K Markantes ◽

Maria Stamou ◽

Sarantis Livadas ◽

...

Keyword(s):

Vitamin D ◽

Pregnant Women ◽

Vitamin D Deficiency ◽

Hypovitaminosis D ◽

Neonatal Health ◽

Host Countries ◽

Effective Interventions ◽

Vitamin D Levels ◽

High Prevalence ◽

Prenatal Intervention

Adequate vitamin D levels are particularly important in pregnant women for both the maternal and neonatal health. Prior studies have shown a significantly high prevalence of vitamin D deficiency (VDD) among refugees. However, no study has addressed the prevalence of VDD in pregnant refugees and its effects on neonatal health. In this study, we examined the prevalence of VDD in refugee pregnant women living in Greece and compared our results with Greek pregnant inhabitants. Vitamin D deficiency was frequent in both groups but was significantly more common in refugees (92.2% vs 67.3% of Greek women, p=0.003) with 70.6% of refugees having severe hypovitaminosis D (<10 ng/ml). As a result, most newborns had Vitamin D deficiency, which affected refugee newborns to a greater extent. Our results suggest a need to screen newcomer children and pregnant women for vitamin D deficiency in all host countries around the world. Such a screen will appropriately guide early and effective interventions with the goal to prevent adverse neonatal and maternal outcomes.

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Association between Vitamin D Level and Acne, and Correlation with Disease Severity: A Meta-Analysis

Dermatology ◽

10.1159/000517514 ◽

2021 ◽

pp. 1-8

Author(s):

Yusuf Hasamoh ◽

Kunlawat Thadanipon ◽

Premjit Juntongjin

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Meta Analysis ◽

Inverse Association ◽

Hydroxyvitamin D ◽

Vitamin D Levels ◽

Newcastle Ottawa Scale ◽

25 Hydroxyvitamin D ◽

The Relationship ◽

Ottawa Scale

Background: Vitamin D deficiency is frequently associated with several medical conditions. However, a comprehensive meta-analysis assessing the association between vitamin D level and acne is lacking. Objective: To determine the relationship between vitamin D level and acne, and to assess the association between vitamin D level and acne severity. Methods: This meta-analysis was assessed by using the PubMed, EMBASE, Cochrane, and Scopus databases following the PRISMA guidelines. Serum/plasma 25-hydroxyvitamin D (25[OH]D) level, vitamin D deficiency, and the severity association between acne patients and healthy controls (HCs) were evaluated. The quality assessment was performed by using the Newcastle-Ottawa Scale. Results: Thirteen articles with a total of 1,362 acne patients and 1,081 HCs were included. The circulating 25(OH)D levels were significantly lower in patients with acne than in HCs (pooled MD = –9.02 ng/mL, 95% CI = –13.22 to –4.81, p < 0.0001). Vitamin D deficiency was more prevalent in acne patients than in HCs (pooled OR = 2.97, 95% CI = 1.68–5.23, I2 = 72%). Also, vitamin D levels were negatively correlated with acne severity. Conclusion: This meta-analysis demonstrated the significantly low vitamin D levels in acne patients. Also, there was evidence of an inverse association between vitamin D levels and acne severity. Therefore, vitamin D might be involved in the pathogenesis of acne.

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Vitamin D Levels in Pregnant Congolese Women and Their New-Borns, and the Association with Neonatal Outcomes – A Pilot Study

10.21203/rs.3.rs-40821/v1 ◽

2020 ◽

Author(s):

Gurpreet Dhillon ◽

Sunil Rai ◽

Harpreet Dhillon ◽

Shibu Sasidharan ◽

Costa Kimweri ◽

...

Keyword(s):

Vitamin D ◽

Pregnant Women ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Preterm Births ◽

Maternal Serum ◽

Neonatal Outcomes ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Sufficient Vitamin

Abstract Background: This study was thus undertaken to study the estimation of vitamin D levels in pregnant women and their newborns in DRC and to study its association with various neonatal outcomes. Methods: Observational study done on 569 pregnant women and their newborn babies. Sample obtained from maternal serum and cord blood from the placental end during peripartum period. The data was analysed to estimate the prevalence of vitamin D levels in mothers and newborns and to identify association, if any, between maternal vitamin D levels and neonatal outcomes.Results: 464 mothers had sufficient vitamin D (VDS) levels (>30 ng/dL) and 105 had vitamin D deficiency (VDD) with mean maternal serum vitamin D level of 35.63ng/ml (SD 6.18, range 9.2-39.8). All the newborns (n=569) were vitamin D deficient (<30ng/ml). The percentage of LBW babies born to VDD mothers was 18.09%, which was very similar to the percentage of LBW babies born to VDS mothers (18.31%) (p=0.76456749). The incidence of caesarean section was 58.09% in the vitamin D deficient (VDD) group as compared to 19.61% in the sufficient (VDS) group (p<0.0005). The incidence of preterm births was 10.77% in the sufficient group (VDS) as compared to 17.14% in the vitamin D deficient (VDD) group (p=0.038). Conclusion: Our findings will help health professionals, policy makers, and the general public in Africa aware of the high prevalence of vitamin D deficiency and the associated health risks.

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Vitamin D deficiency is related to worse emotional state

Open Medicine ◽

10.2478/s11536-011-0061-x ◽

2011 ◽

Vol 6 (5) ◽

pp. 558-566 ◽

Cited By ~ 2

Author(s):

Lina Lašaite ◽

Ieva Gailyte ◽

Paulius Puzinas ◽

Romualdas Preikša ◽

Gintautas Kazanavičius

Keyword(s):

Vitamin D ◽

Cognitive Functioning ◽

Vitamin D Deficiency ◽

Emotional State ◽

Depression Scale ◽

Adult Intelligence Scale ◽

Wechsler Adult Intelligence Scale ◽

Vitamin D Levels ◽

Sufficient Vitamin ◽

Healthy Males

AbstractThe aim was to evaluate vitamin D levels in young healthy Lithuanian males in winter and to find possible associations of vitamin D concentration to body composition, cognitive functioning, emotional state.Subjects and Methods A total of 130 healthy males (age range, 18–26 years) were divided into the subgroups according to vitamin D concentration. The Profile of Mood States (POMS) questionnaire and Hospital Anxiety and Depression Scale were employed in the assessment of emotional state. Cognitive functioning was assessed by the Trail Making Test and the Digit Symbol Test of the Wechsler Adult Intelligence Scale.Results The mean concentration of vitamin D for the entire sample was 13.0±5.3 ng/ml. Only 2 persons (1.6%) had the recommended vitamin D level. Nearly half (45.4%) of study participants had vitamin D deficiency. Lower concentrations were associated with a significantly higher score on the POMS confusion-bewilderment scale. A tendency toward a lower mean depression-dejection score in the participants with a sufficient vitamin D level was observed. Vitamin D concentration correlated positively with body mass index (BMI) and inversely with the confusion-bewilderment score.In conclusion almost half of the young healthy males participating in the study were detected to have vitamin D deficiency in winter. Low vitamin D concentrations are associated with a worse emotional state.

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Prevalence of vitamin D deficiency in pregnancy and its relation with adverse pregnancy outcome

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20203845 ◽

2020 ◽

Vol 9 (9) ◽

pp. 3718

Author(s):

Jyoti Prabha ◽

Abhijeet Kumar

Keyword(s):

Vitamin D ◽

Pregnant Women ◽

Vitamin D Deficiency ◽

Preterm Labour ◽

Adverse Pregnancy Outcome ◽

Adverse Outcomes ◽

Strong Positive Correlation ◽

Pregnant Females ◽

Increased Risk ◽

Vitamin D Levels

Background: Vitamin D deficiency is widely prevalent in all parts of the world. Pregnant women and neonates are highly vulnerable to vitamin D deficiency. Pregnant women receive very less amount of sunlight especially in parts of Southeast Asia due to traditional norms and customs. A strong positive correlation was found between low maternal vitamin D levels with gestational hypertension/preeclampsia, gestational diabetes mellitus, preterm labour, low birth weight, intra uterine growth restriction, neonatal intensive care unit admission and Apgar score. Therefore, the present study was designed to know the prevalence of vitamin D deficiency in pregnant females and to evaluate adverse effects associated with it.Methods: Total 250 nulliparous pregnant females attending Tirath Ram Shah Hospital for delivery and carrying a viable (>/28 weeks) singleton pregnancy were selected. Women with serum 25-hydroxy vitamin D level <10 ng/ml, 10-20 ng/ml and <20 ng/ml, were diagnosed as vitamin D deficient, insufficient and sufficient groups respectively and the adverse outcomes was correlated.Results: In this study, out of 250 cases, 159 cases (63.6%) had vitamin D deficiency, 43 cases (17.2%) had insufficiency, and 48 cases (19.2%) had sufficient vitamin D levels (vitamin D ≥20 ng/ml). And, Vitamin D deficiency was associated with preeclampsia, preterm labour and increased risk of caesarean section.Conclusions: This study indicates that vitamin D deficiency is highly prevalent in pregnant females thus implicating the need of a uniform strategy of vitamin D supplementation to pregnant females.

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Investigating the Relationship between Vitamin D and Persistent Symptoms Following SARS-CoV-2 Infection

Nutrients ◽

10.3390/nu13072430 ◽

2021 ◽

Vol 13 (7) ◽

pp. 2430

Author(s):

Liam Townsend ◽

Adam H. Dyer ◽

Patrick McCluskey ◽

Kate O’Brien ◽

Joanne Dowds ◽

...

Keyword(s):

Vitamin D ◽

Exercise Tolerance ◽

Immune Modulation ◽

Case Definition ◽

Walk Test ◽

Fatigue Score ◽

Logistic Regression Models ◽

Persistent Symptoms ◽

Vitamin D Levels ◽

The Relationship

The emergence of persistent symptoms following SARS-CoV-2 infection, known as long COVID, is providing a new challenge to healthcare systems. The cardinal features are fatigue and reduced exercise tolerance. Vitamin D is known to have pleotropic effects far beyond bone health and is associated with immune modulation and autoimmunity. We hypothesize that vitamin D levels are associated with persistent symptoms following COVID-19. Herein, we investigate the relationship between vitamin D and fatigue and reduced exercise tolerance, assessed by the Chalder Fatigue Score, six-minute walk test and modified Borg scale. Multivariable linear and logistic regression models were used to evaluate the relationships. A total of 149 patients were recruited at a median of 79 days after COVID-19 illness. The median vitamin D level was 62 nmol/L, with n = 36 (24%) having levels 30–49 nmol/L and n = 14 (9%) with levels <30 nmol/L. Fatigue was common, with n = 86 (58%) meeting the case definition. The median Borg score was 3, while the median distance covered for the walk test was 450 m. No relationship between vitamin D and the measures of ongoing ill-health assessed in the study was found following multivariable regression analysis. These results suggest that persistent fatigue and reduced exercise tolerance following COVID-19 are independent of vitamin D.

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High prevalence of vitamin D deficiency in school children in Jammu: a whistle blower

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20191549 ◽

2019 ◽

Vol 7 (5) ◽

pp. 1524

Author(s):

Harleen Kaur ◽

Amarjeet Singh Bhatia

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

School Children ◽

Tertiary Care ◽

Care Hospital ◽

Vitamin D Status ◽

Jammu And Kashmir ◽

Vitamin D Levels ◽

High Prevalence ◽

Good Nutrition

Background: Vitamin D deficiency prevails in epidemic proportions among school going children in India, but there is scarcity of searchable data on vitamin D status in school children in Jammu and Kashmir; hence we have assessed the vitamin D status in school going children attending outpatient department in a tertiary care hospital Jammu.Methods: The study was conducted in the department of Biochemistry Government Medical College Jammu during June to December, 2018 and after obtaining informed consent, a total of 104 school going children between the age group of 6 years to 12 years, attending SMGS Hospital Jammu were screened for their vitamin D (25 OH-D) status by using Abbott architect chemiluminescent micro particle immunoassay.Results: Out of a total of 104 school going children screened in the study, 91 (87.5%) were found to be having insufficient vitamin D levels in their blood (<30ngm/dl) whereas 63 (60.5%) children showed severe deficiency with vitamin D levels below 20ngm/dl.Conclusions: Despite of abundant sunshine throughout the year and also with the consideration that people of this region are well off economically and can afford good nutrition, the results of our study revealing high prevalence of Vitamin D deficiency in school going children can be taken as a whistle blower for the health policy makers of the region.

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