scholarly journals A study of chronic kidney disease patients with no known risk factors coming to tertiary care hospital

2017 ◽  
Vol 5 (5) ◽  
pp. 2030
Author(s):  
Arti Muley ◽  
Mitali Rathod ◽  
Kunjan Shah ◽  
Nikhil Patel ◽  
Aakash Patel ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Family History ◽  
Kidney Disease ◽  
Age Of Onset ◽  
Renal Involvement ◽  
Tertiary Care ◽  
Heat Exposure ◽  
Care Hospital ◽  
History Of

Background: Chronic kidney disease (CKD) has become a major cause of morbidity and. in some parts of the world CKD incidence has increased regardless of hypertension, diabetes mellitus or metabolic syndrome. This study was done to identify the unknown factors which can be contributing to the increased incidence of CKD.Methods: It was a case control study. There were 61 cases and 50 controls. A detailed history regarding residence, occupation, addiction, drug intake, family history, diet and environmental factors was taken. The data was analysed to identify a common factor amongst the CKD patients who did not have history of any known risk factors of CKD.Results: Age of onset of CKD in 48% of cases was <40 years. Much higher percentage of cases gave family history of CKD (10%), history of consumption of NSAIDs (20%) and smoking for >5 years (30%) as compared to controls. Much more cases as compared to controls gave history of mixed diet (46% vs 26%). Much higher proportion of cases had history of heat exposure, excessive heating and sugarcane exposure (72%, 70% and 48% respectively) as compared to controls.Conclusions: This study supports the association of sugarcane exposure, heat exposure and excessive sweating with CKD and reports a changing trend of renal involvement starting at an earlier age. It highlights need of study with sufficient sample size and greater emphasis on family history, smoking, extent of heat exposure and sugarcane exposure to help identifying area of further research and guide policy making.

scholarly journals A prospective study of peripheral arterial diseases in chronic kidney disease patient attending tertiary care hospital Andhra Pradesh

2021 ◽  
Vol 8 (7) ◽  
pp. 974
Author(s):  
Ramswarup K. Jawaharlal ◽  
Vamsi Krishna Mootha
Keyword(s):  
Chronic Kidney Disease ◽  
Risk Factor ◽  
Kidney Disease ◽  
Tertiary Care ◽  
Ankle Brachial Index ◽  
Disease Patient ◽  
Care Hospital ◽  
Male Predominance ◽  
Peripheral Arterial Diseases ◽  
History Of

Background: Around 10% populations worldwide develop chronic kidney disease and two million people require frequent dialysis due to it1. Cardiovascular diseases related complications are more common in chronic kidney patients and responsible for greater morbidity and mortality. This study is designed to determine the peripheral artery disease in patients with chronic kidney disease in our clinical setup and risk factor associated with them.Methods: In present study 140 patients with chronic kidney disease were enrolled for this study. Demographic profile of each patient was recorded. Detailed history of patients regarding claudication was taken. Ankle-brachial index was calculated in each patient with CKD for diagnosis of PAD based on American heart association guideline.Results: There was male predominance. History of smocking was present in 80 (57.14%) patients and absent in 60 (42.85%) patients. Symptom of PAD was present in 28 (20%) patients and absent in 114(80%) patients. Ankle-Brachial Index was positive in 38(27.14%) patients and absent in 102 (72.85%) patients. 80 (57.14%) patients were in stage 3 and 24 (17.14%) patients were in stage 4. Diabetes mellitus was present in 26 (18.57%) patients, Hypertension was present in 64 (45.71%), IHD was present in 22 (15.71%) remaining have no risk factor.Conclusions: From present study we can conclude that PAD was common in CKD patients more than 50 years of age and here is male predominance. It is more common in smoker and in most of the patients it was asymptomatic. Prevalence of PAD was 27.14% in CKD patients. In our study PAD was more common in stage 3 CKD and least common in stage 2, and cardiovascular risk factor was more common in PAD patients then CKD in general.

scholarly journals P1034EVALUATION OF RISK FACTORS FOR DIABETIC NEPHROPATHY AMONG NEWLY DIAGNOSED TYPE 2 DIABETIC SUBJECTS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Muhammad Abdur Rahim ◽  
Shahana Zaman ◽  
Samira Humaira Habib ◽  
Faria Afsana ◽  
Wasim Md Mohosin Ul Haque ◽  
...  
Keyword(s):  
Risk Factors ◽  
Diabetic Retinopathy ◽  
Diabetic Nephropathy ◽  
Family History ◽  
Tertiary Care ◽  
Positive Family History ◽  
Care Hospital ◽  
History Of ◽  
Type 2 Diabetic

Abstract Background and Aims Diabetes mellitus (DM) is the leading cause of chronic kidney disease in developed as well as in developing countries, principally resulting from the increasing prevalence of type 2 DM (T2DM). Patients with T2DM pass through pre-diabetic stages and half of the T2DM patients remain undiagnosed. During diagnosis, one-third to half of the T2DM patients may have different macro- and micro-vascular complications including diabetic nephropathy. This study was designed to evaluate risk factors for diabetic nephropathy among newly detected T2DM subjects. Method A case-control study was done at out-patient department of a tertiary care hospital in Dhaka, Bangladesh from October 2016 to June 2017. Newly detected (&lt;3 months) adult (≥18 years) T2DM patients of either sex, who underwent test for urine albumin-to-creatinine ratio (UACR) at least twice, at least 6 weeks apart, within a 6-month period, were included in this study. Patients with diagnosed kidney diseases, features of glomerulonephritis, systemic diseases like systemic lupus erythematosus and vasculitis, history of recent fever and exercise, urinary tract infection and pregnancy were excluded. Patients with UACR ≥30 mg/g in at least two (of three, if done) samples were cases and those with UACR &lt;30 mg/g were controls. Results Total patients were 100, including 35 cases [moderately increased proteinuria (previously, microalbuminuria) (UACR 30-299 mg/g) = 33 and severely increased proteinuria (previously, overt proteinuria) (UACR ≥300 mg/g) = 2] and 65 controls. Mean age was 46.6±12.3 years and there was female predominance (male:female ratio was 1:2). Twenty four percent patients were smokers, 50% were hypertensive and 46% had dyslipidaemia. Seventy five percent of the study participants had positive family history of DM and 39% had family history of diabetic nephropathy. Mean body mass index (BMI) was 26.3±2.9 kg/m2. Mean fasting blood glucose (mmol/L), 2-h post glucose value (mmol/L) and mean glycated haemoglobin (HbA1c) (%) were 9.2±2.9, 14.5±4.1 and 7.9±1.3 respectively. Eighty percent of the patients were asymptomatic regarding DM. Besides nephropathy, other chronic complications of DM were diabetic retinopathy (17%), neuropathy (11%), coronary artery disease (11%) and cerebrovascular disease (4%). Regarding risk factors for diabetic nephropathy, family history of DM (OR 1.62, p 0.0001) and diabetic nephropathy (OR 25.13, p 0.003), presence of hypertension (OR 4.93, p 0.001) and coexisting diabetic retinopathy (OR 14.18, p 0.046) were significant. On multivariate logistic regression, family history of DM (OR 1.77, p 0.001) and diabetic nephropathy (OR 24.31, p 0.001), higher BMI (&gt;25 kg/m2) (OR 2.11, p 0.013), hypertension (OR 4.31, p 0.003) and diabetic retinopathy (OR 14.09, p 0.021) were significant. Conclusion One-third of the newly detected type 2 diabetic subjects had diabetic nephropathy in this study. Family history of DM and diabetic nephropathy, higher BMI, presence of hypertension and diabetic retinopathy were significant risk factors for diabetic nephropathy.

scholarly journals Factors predicting poor anticoagulant control on warfarin in a Thai population with non-valvular atrial fibrillation (NVAF): the ACAChE score

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Piyoros Lertsanguansinchai ◽  
Anurut Huntrakul ◽  
Voravut Rungpradubvong ◽  
Ronpichai Chokesuwattanaskul ◽  
Somchai Prechawat
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Roc Curve ◽  
Scoring System ◽  
Tertiary Care ◽  
Discrimination Performance ◽  
Care Hospital ◽  
Thai Population ◽  
History Of ◽  
New Scoring

Abstract Background In many low- to middle-income countries in Asia, patients with NVAF usually received warfarin for thromboembolic prevention due to cost-effectiveness. The SAMe-TT2R2 score has been proposed to predict TTR in NVAF patients. However, the SAMe-TT2R2 score has not been much validated in Asian population. Interestingly, it may overestimate patients who had TTR < 65% due to regarding being Asians as a risk factor. Objectives To determine the factors predicting poor anticoagulant control on warfarin, create new scoring system, and compare with the SAMe-TT2R2 score in a Thai population with NVAF. Methods This is a retrospective study in a tertiary care hospital. We enrolled NVAF patients who received warfarin from January 2014 to December 2018. TTR was calculated based on Rosendaal method. Multiple logistic regression and AUC-ROC curve were used for analysis. Results A total of 864 patients were enrolled with mean age of 73.6 ± 11.58 years. The mean TTR was 48.1 ± 25.2%. Using multivariate regression analysis, the predictive factors for TTR < 65% were antiplatelet use (OR 4.49, p ≤ 0.001), LVEF < 40% (OR 1.92, p = 0.037), chronic kidney disease (GFR < 50 ml/min/1.73 m2) (OR 1.68, p = 0.013), history of CHF (OR 1.7, p = 0.047), and age ≥ 75 years (OR 1.4, p = 0.037). Based on the regression coefficients, we developed the new scoring system called ACAChE score [A, antiplatelet use (4 points); C, chronic kidney disease, GFR < 50 ml/min/1.73 m2 (2 points); A, age ≥ 75 years (1 point); Ch, history of CHF (2 points); E, LVEF < 40% (2 points)]. ROC curve showed discrimination performance of the ACAChE score and SAMe-TT2R2 score for prediction of TTR < 65% with the C-statistic of 0.62 (95%CI 0.57–0.65) and 0.54 (95%CI 0.50–0.58), respectively. Conclusion In Thai NVAF patients, the ACAChE score (antiplatelet use, chronic kidney disease (GFR < 50 ml/min/1.73 m2), age ≥ 75 years, history of congestive heart failure, and LVEF < 40%) has better prediction for TTR < 65% than SAMe-TT2R2 score. Thus, it expected to guide the selection of oral anticoagulation in Asian patients with NVAF.

scholarly journals Evaluation of risk factors for diabetic nephropathy among newly diagnosed type 2 diabetic subjects: preliminary report from a tertiary care hospital of Bangladesh

2020 ◽  
Vol 10 (2) ◽  
pp. 88-91
Author(s):  
Rahim MA ◽  
Shahana Zaman ◽  
Samira Humaira Habib ◽  
Faria Afsana ◽  
Wasim Md Mohosin Ul Haque ◽  
...  
Keyword(s):  
Risk Factors ◽  
Diabetic Retinopathy ◽  
Diabetic Nephropathy ◽  
Family History ◽  
Tertiary Care ◽  
Fasting Blood Glucose ◽  
Positive Family History ◽  
Care Hospital ◽  
History Of

Background: Diabetes mellitus (DM) is the leading cause of chronic kidney disease through-out the world andhalf of the type 2 DM (T2DM) patients remain undiagnosed. During diagnosis, one-third to half of the T2DMpatients may have different macro- and micro-vascular complications including diabetic nephropathy. This studyaimed to evaluate selected risk factors for diabetic nephropathy among newly detected T2DM subjects. Methods: A case-control study was done at out-patient department of BIRDEM General Hospital, Dhaka,Bangladesh from October 2016 to June 2017. Newly detected (<3 months) adult (³18 years) T2DM patientswere included in this study. Patients with diagnosed kidney diseases, features of glomerulonephritis, systemicdiseases like systemic lupus erythematosus and vasculitis, history of recent fever and exercise, urinary tractinfection and pregnancy were excluded. Patients with urine albumin-creatinine ratio (UACR) ³30 mg/g in atleast two (of three, if done) samples were cases and those with UACR <30 mg/g were controls. Results: Total patients were 100, including 35 cases [microalbuminuria (UACR 30-299 mg/g) = 33 and overtproteinuria (UACR ³300 mg/g) = 2] and 65 controls. Mean age was 46.6±12.3 years and there was femalepredominance (male:female ratio was 1:2). One-fourth patients were smokers, half were hypertensive andtwo-fifths had dyslipidaemia. Three-fourths of the study participants had positive family history of DM andtwo-fifths had family history of diabetic nephropathy. Mean body mass index (BMI) was 26.26±2.97 kg/m2.Mean fasting blood glucose (mmol/L), 2-h post glucose value (mmol/L) and mean glycatedhaemoglobin(HbA1c) (%) were 9.2±2.9, 14.5±4.1 and 7.9±1.3 respectively. Eighty percent of the patients were asymptomaticregarding DM. Besides nephropathy, other chronic complications of DM were diabetic retinopathy (17%),neuropathy (11%), coronary artery disease (11%) and cerebrovascular disease (4%). Regarding risk factorsfor diabetic nephropathy, family history of DM (OR 1.62, p 0.0001) and diabetic nephropathy (OR 25.13,p 0.003), presence of hypertension (OR 4.93, p 0.001) and coexisting diabetic retinopathy (OR 14.18, p 0.046)were significant. On multivariate logistic regression, family history of DM (OR 1.77, p 0.001) and diabeticnephropathy (OR 24.31, p 0.001), higher BMI (>25 kg/m2) (OR 2.11, p 0.013), hypertension (OR 4.31,p 0.003) and diabetic retinopathy (OR 14.09, p 0.021) were significant. Conclusions: One-third of the newly detected T2DM subjects had diabetic nephropathy in this study. Familyhistory of DM and nephropathy, higher BMI, presence of hypertension and diabetic retinopathy were significantrisk factors for diabetic nephropathy. Birdem Med J 2020; 10(2): 88-91

scholarly journals Prevalence of Pregnancy-Induced Hypertension and Its High-Risk Factors among the Antenatal Women

2021 ◽  
Author(s):  
Sony John ◽  
M. Vanitha ◽  
Athira Babu ◽  
Priya Sushma ◽  
Ashihrii Eloni Regina ◽  
...  
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Tertiary Care ◽  
Previous History ◽  
Total Sample ◽  
Hypertensive Disorder ◽  
Care Hospital ◽  
Pregnancy Induced Hypertension ◽  
Induced Hypertension ◽  
History Of

Abstract Objective A hypertensive disorder during pregnancy seriously endangers the safety of the fetus and women during pregnancy. This study was conducted to estimate the prevalence of pregnancy-induced hypertension (PIH) and its risk factors among antenatal women. The aim of this study was to find the prevalence of PIH and risk factors for PIH among antenatal women in a selected hospital in Mangaluru. Methods A descriptive study was performed. The study used the total sample size of 400 pregnant women attending the obstetrics and gynecology outpatient department according to the inclusion and exclusion criteria in a tertiary care hospital in Karnataka. The data was collected with a self-reported checklist. Data were entered and analyzed by using SPSS 23. Results The prevalence of PIH was 10.75% that is 43 antenatal women out of 400. In this study, 34.88% had a family history of PIH, 23% had a previous history of PIH, 16% had a history of gestational diabetes, and 20.93% had a history of thyroid problems. The most important risk factors found for PIH in the present study are the previous history of PIH (adjusted odds ratio [OR] = 1.276, 95% confidence interval [CI: 0.125–11.836), family history of hypertension (adjusted OR=1.930, 95% CI: 1.130–3.296), and thyroid problems (adjusted OR=1.904, CI: 0.786–4.611). Conclusion PIH is a common medical disorder associated with pregnancy. We noted that PIH is more prevalent in those who had it in their previous pregnancy. PIH is associated with multiple complications in the mother and the baby and particularly preterm delivery. The timely intervention of regular antenatal checkups, nutrition, health education, etc., can reduce the severity of PIH.

scholarly journals EVALUATION OF RISK FACTORS FOR INTRAHEPATIC CHOLESTASIS OF PREGNANCY IN PATIENTS PRESENTING TO A TERTIARY CARE CENTRE

2021 ◽  
Vol 71 (5) ◽  
pp. 1852-56
Author(s):  
Rabiah Anwar ◽  
Kashif Razzaq ◽  
Aysha Shahid ◽  
Afeera Afsheen ◽  
Amera Tariq ◽  
...  
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Pregnant Women ◽  
Intrahepatic Cholestasis ◽  
Tertiary Care ◽  
Medical Illness ◽  
Care Hospital ◽  
Intrahepatic Cholestasis Of Pregnancy ◽  
History Of ◽  
Cholestasis Of Pregnancy

Objectives: To evaluate the principal risk factors associated with development of intrahepatic cholestasis of pregnancy (ICP) in patients presenting to a tertiary care hospital. Study Design: Case control study. Place and Duration of Study: Department of Gynaecology and Obstetrics, Pakistan Naval Ship Shifa Hospital Karachi, from Jan to Dec 2019. Methodology: All pregnant women with symptoms of intrahepatic cholestasis of pregnancy confirmed on history, examination and investigations were included. A comparison cohort of pregnant women with neither hepatobiliary nor medical illness associated with pregnancy was selected. Comparison of risk factors was done between both the groups. Results: Out of 6932 obstetric patients, 90 (1.29%) had intrahepatic cholestasis of pregnancy. Pruritis was cardinal symptoms in all (100%) the patients followed by excoriation marks (75.55%). Intrahepatic cholestasis of pregnancy was significantly found in women with multiple pregnancy (OR=1.81; 95% CI 0.51-6.42), antecedent intrahepatic cholestasis of pregnancy (OR=36.81; 95% CI 8.53-158.79), family history of intrahepatic cholestasis of pregnancy (OR=17.80; 95% CI 2.29-137.91) and history of pruritis with obstetric cholestasis of pregnancy use (OR=16.25; 95% CI 0.91-289.08). Conclusion: Intrahepatic cholestasis of pregnancy was observed in less than two percent cases. Risk of intrahepatic cholestasis of pregnancy was found to be increased with multiple pregnancies, antecedent intrahepatic cholestasis of pregnancy, family history of intrahepatic cholestasis of pregnancy and history of pruritis with prior obstetric cholestasis of pregnancy use.

scholarly journals Evaluation of carotid intima media thickness and associated risk factors in patients with chronic kidney disease: a cross sectional study

2019 ◽  
Vol 6 (2) ◽  
pp. 526
Author(s):  
Mote Srikanth ◽  
Jeyapalan Kuppusamy ◽  
Hemachandar Radhakrishnan ◽  
Arun Prasath Palamalai
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
P Value ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Ckd Stage

Background: Chronic kidney disease is distinguished by progressive loss of kidney function over a period of years in the end leading to irreversible kidney failure. CKD is a significant prognosticator of cardiovascular disease. Atherosclerosis is common in patients with risk factors associated with chronic kidney disease.Methods: It was a cross sectional study on CKD patients in a tertiary care hospital. About 90 CKD stage 3-5 patients aged above 18 years were enrolled in the study. Serum lipid profile, RFT, serum calcium, phosphorous, and BP were estimated among all the patient. Patient risk factors were noted and CIMT levels were compared accordingly.Results: Out of 90 patients, males were predominant. There was a significant positive correlation between stage 5 and CIMT (P value <0.001). Mean CIMT was higher in patients with type 2 Diabetes. Patients with higher phosphorous the mean CIMT was significantly higher.Conclusions: The CIMT is early marker for atherosclerosis. Author observed it was significantly higher in patients with stage 3 and 5 CKD. CIMT is a non- invasive marker which should be done in all patients with CKD which is cost effective.

scholarly journals Risk factor stratification in chronic kidney disease - A tertiary care analysis

2021 ◽  
Vol 12 (1) ◽  
pp. 571-575
Author(s):  
Aadhyyanth R Allu ◽  
Sivasubramanian K
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Family History ◽  
Kidney Disease ◽  
Tertiary Care ◽  
Positive Family History ◽  
Chi Square ◽  
Medical College ◽  
Chi Square Test ◽  
Control Study

Chronic kidney disease (CKD) has become recognized as an important issue affecting the health of millions around the world. It has been found to be highly prevalent in many countries, including India, accounting for massive health expenditure as well. The burden of CKD is on the rise in both developed and developing countries. The objectives were to identify and study the risk factors for CKD among patients attending Saveetha Medical College and Hospital, Chennai and to study the association between risk factors and CKD. The case-control study was conducted on 110 cases and 110 controls. A semi-structured questionnaire was used to collect information. Statistical Analysis was done using MS Excel 2007, and Chi-Square test was also used. Of the parameters studied, age, residence, family history, smoking and alcohol were found to be associated with CKD and were statistically significant (p<0.05). The findings suggest that positive family history, smoking and alcohol may have an impact on chronic kidney disease in patients of South India. Hence screening and creation of awareness may help in decreasing mortality.

scholarly journals Prevalence of Congenital Ocular Anomalies in Paediatric Age Group (0 - 14 Years) in a Tertiary Care Hospital at Kancheepuram, South India

2021 ◽  
Vol 8 (14) ◽  
pp. 899-903
Author(s):  
Syed Ali Nasar Waris ◽  
Rubina Huda
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Age Group ◽  
Paediatric Age ◽  
History Of ◽  
Associated Risk Factors ◽  
Global Blindness

BACKGROUND Congenital ocular anomalies are one of the important causes of childhood blindness. Blindness is a serious public health issue, and also a social and economic problem worldwide. Majority of global blindness is avoidable and curable. Most of global blindness is in developing countries. The objectives of this study were to determine the prevalence of congenital ocular anomalies in the paediatric age group and its associated risk factors in a tertiary care hospital in Kancheepuram. METHODS This cross-sectional study was conducted among children of 0 – 14 years age group attending the ophthalmology department of SRM Medical College and Hospital, Kancheepuram from December 2018 to November 2020. Congenital ocular anomalies were detected by detailed ocular examination and the type of congenital ocular anomaly was assessed. Associated risk factors like family history of congenital ocular anomalies, family history of consanguinity and significant antenatal history of the mother of the children were collected. RESULTS Out of 9865 cases, we found that 61 cases had congenital ocular anomalies. There was a male preponderance. Majority of the cases were in the age group 0 - 5 years. A positive history of consanguinity was present in 10 % of cases. The most commonly found cases were congenital cataract and congenital dacryocystitis. CONCLUSIONS Children with congenital ocular anomalies and functional vision should be given glasses and low vision aid. There is a great need for early screening, detection and treatment by paediatric or trained ophthalmologists in referral hospitals. KEYWORDS Congenital Ocular Anomalies, Paediatric Age Group, Prevalence

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