scholarly journals High density lipoprotein as prognostic indicator in patient with diabetic foot

2020 ◽  
Vol 8 (5) ◽  
pp. 1671
Author(s):  
Arie Rafael Singara ◽  
Chaeruddin Rasjad ◽  
Jufri Latief ◽  
Nasser Mustari ◽  
Arman Bausat
Keyword(s):  
High Density Lipoprotein ◽  
Diabetic Foot ◽  
Density Lipoprotein ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
High Density ◽  
Vascular Disorder ◽  
Cross Sectional ◽  
Significant Difference ◽  
Acting Agent

Background: Diabetic is a chronic metabolic disease with vascular disorder and HDL (High Density Lipoprotein) is a vascular protector acting agent. One of the most difficult complication of diabetics are diabetic foot with often lead to an amputation due to vascular disorder. Objective of this study aims to determine the relationship of HDL levels with diabetic foot severity by comparing HDL levels in each diabetic foot grade according to the Wagner classification.Methods: This is a cross sectional study, with new inpatient and outpatient with diabetic foot ulcer that never received therapy in Wahidin Sudirohusodo Hospital as a study population in April 2018 to June 2018 time period. Frequency distribution, Spearman’s Correlation, Anova, and Chi Square statistical analytic was done with p <0.05 considered as significant.Results: HDL level was wound highest in Grade I and lowest in Grade IV and V. HDL level comparison according to Wagner comparison shows significant difference, p<0.001.Conclusions: There were a negative correlation as an analysis results shows between HDL level and Wagner classification, whereas the lower HDL level, the higher diabetic foot grade and HDL can be used as a prognosis predictor and planning therapy.

scholarly journals COMPARISON OF LIPID PROFILE IN PATIENTS WITH DIABETIC NEUROPATHY AND WITHOUT NEUROPATHY; A CROSS SECTIONAL STUDY

2021 ◽  
Vol 71 (Suppl-1) ◽  
pp. S202-06
Author(s):  
Kanwal Huma ◽  
Khadija Mehbob ◽  
Amir Rashid ◽  
Fatima Fuad ◽  
Muhammad Mamoon Mujahid ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
High Density Lipoprotein ◽  
Lipid Profile ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Cross Sectional ◽  
Group I ◽  
Significant Difference

Objective: To compare lipid profile in patients with diabetic neuropathy and without neuropathy. Study Design: Cross-sectional comparative study. Place and Duration of Study: This study was carried out at Multidisciplinary Lab-1, Department of Biochemistry and Molecular Biology, Army Medical College, from Jan 2020 to Sep 2020 in collaboration with Pak-Emirates Military Hospital, Rawalpindi. Methodology: Eighty-four subjects were selected and divided into three groups, twenty-eight in each. Group Iincluded diagnosed patients with type 2 diabetes mellitus with peripheral neuropathy, group II included diagnosed patients with type 2 diabetes mellitus without peripheral neuropathy and group III consisted of healthy individuals. Biochemical parameters including total cholesterol, triglycerides, high density lipoprotein cholesterol and low density lipoprotein cholesterol were measured. Data was analyzed by SPSS version 22.0. One way ANOVA test was used that followed by post-Hoc Tukey test for group comparison. Results: There was significant difference in triglycerides (p-value 0.001) and high density lipoprotein cholesterol(0.003) levels among group I and III. While, between group II and III significant difference of high density lipoprotein cholesterol was present. There was no significant difference between group I and II regarding all lipid profile parameters. Conclusion: There was significant increase of triglycerides levels and decrease of high density lipoproteincholesterol in patients with diabetic peripheral neuropathy as compared to healthy controls. No significantdifference was observed for all parameters of lipid profile between patients with diabetic peripheral neuropathyand without peripheral neuropathy.

Efficacy of Aloe vera/ Plantago Major Gel in Diabetic Foot Ulcer: A Randomized Double-Blind Clinical Trial

2019 ◽  
Vol 16 (2) ◽  
pp. 223-231 ◽  
Author(s):  
Younes Najafian ◽  
Zahra M. Khorasani ◽  
Mona N. Najafi ◽  
Shokouh S. Hamedi ◽  
Marjan Mahjour ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Diabetic Foot ◽  
Intervention Group ◽  
Aloe Vera ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Control Group ◽  
Plantago Major ◽  
Double Blind ◽  
Significant Difference

Background:Diabetic foot ulcer (DFU) is one of the most common complications of diabetic patients. Mostly, non-healing DFU leads to infection, gangrene, amputation and even death. High costs and poor healing of the wounds need a new treatment such as alternative medicine. So, the aim of this study was to evaluate the efficacy of Aloe vera/ Plantago major gel (Plantavera gel) in healing of DFUMethods:Forty patients with DFU enrolled in a double-blind randomized clinical trial. The patients who were randomly assigned into the intervention group (n = 20), received topical Plantavera gel in addition to the routine cares, whereas the patients in the control group (n = 20), received topical Placebo gel in addition to the routine cares. Intervention was done twice a day for 4 weeks in the both groups. Photography and an evaluation of DFU healing were conducted by a checklist and then were scored at baseline and at the end of each week. The collected data was analyzed by SPSS software.Results:At the end of the study, there was a significant difference between the two groups in terms of total ulcer score (P<0.001) and Plantavera gel significantly reduced the ulcer surface comparing with the control group (P=0.039). However, there was not a significant difference between the two groups (P=0.263) in terms of the ulcer depth. During this study, no side effect was observed for Plantavera gel in the intervention group.Conclusion:Topical Plantavera gel seems to be an effective, cheap and safe treatment. Of course, further studies are required to confirm the properties of the wound healing of this gel.

Clinical Utility of the Ankle-Brachial Index and Toe Brachial Index in Patients with Diabetic Foot Ulcers

2020 ◽  
Vol 16 (3) ◽  
pp. 270-277 ◽  
Author(s):  
Mutasem Ababneh ◽  
Mousab Y. Al Ayed ◽  
Asirvatham A. Robert ◽  
Mohamed A. Al Dawish
Keyword(s):  
Diabetic Foot ◽  
Statistical Significance ◽  
Ankle Brachial Index ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Arterial Disease ◽  
Cross Sectional Study ◽  
Screening Tests ◽  
Cross Sectional ◽  
Toe Brachial Index

Background: This cross sectional study investigated the clinical use of the ankle-brachial index (ABI) and toe brachial index (TBI) in 91 type 2 diabetic foot ulcer patients who visited the diabetic foot clinic, Prince Sultan Military Medical City, Saudi Arabia during July 2017 and January 2018. Materials and Methods: The ABI and TBI facilitated the detection of peripheral arterial disease (PAD) and the patients’ medical records were used to collect the clinical and demographic variables. The variables of duration (p = 0.047) and treatment (p = 0.046) of the ABI showed significant differences. Age (p = 0.034) and duration (p = 0.001) were the factors related to the diagnosis of TBI by the “χ2” test. Results: From the TBI, 26.4% of the patients were found to have PAD, while the ABI showed that 21.8% of patients had the condition. However, no statistical significance was noted. From the regression analysis, the variable duration of diabetes (≥ 20 years of age) was recognized as an independent risk factor for TBI. Conclusion: In conclusion, it is recommended both the ABI and TBI to be used as screening tests for PAD in diabetic foot ulcer patients.

Abstract 3645: Alcohol Volume, Not Drinking Frequency, Increases Plasma High-Density Lipoprotein Sub-Class Particle Concentration

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Linton R Harriss ◽  
Dallas R English ◽  
Rory Wolfe ◽  
Andrew M Tonkin ◽  
Kerin O’Dea ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Alcohol Intake ◽  
Particle Concentration ◽  
Density Lipoprotein ◽  
High Density ◽  
Resonance Spectroscopy ◽  
Cross Sectional ◽  
Men And Women ◽  
Beverage Type ◽  
Drinking Frequency

Introduction: Alcohol intake is positively associated with high-density lipoprotein (HDL) cholesterol, however no studies have investigated the association with lipoprotein sub-classes using nuclear magnetic resonance spectroscopy (NMR). Hypothesis: We assessed the hypothesis that usual daily alcohol intake (volume), beverage type and drinking frequency influence plasma HDL sub-class concentrations as determined by NMR. Methods: Six hundred and ninety volunteers (389 women) aged 40 – 69 years at baseline (1990 –1994) participated in a cross-sectional study using the Melbourne Collaborative Cohort Study, Australia. Measures included self-reported alcohol intake using beverage-specific quantity-frequency questions (volume) and a drinking diary for previous week (frequency). Results: Median alcohol intake was 15.2 g/d (2.7, 32.0) for men and 1.0 g/d (0, 9.6) for women. Alcohol volume was positively associated with total HDL particle concentration in men and women. For men, a 10 g/d increment in alcohol intake increased total HDL particle concentration by 0.62 μmol/L (95% CI: 0.27, 0.98) and small HDL particle concentration by 0.34 μmol/L (0.01, 0.68). For women, total HDL particle concentration increased 1.06 μmol/L (0.60, 1.53) for every 10 g/d increment in alcohol intake. Alcohol volume was positively associated with large HDL particle concentration in premenopausal women [0.67 μmol/L (0.19, 1.15)] and small HDL particle concentration in postmenopausal women [0.82 μmol/L (0.14, 1.51)]. Beer, wine and spirits were all positively associated with total HDL concentration for men. Beer and wine were both positively associated with total HDL concentration for women. Drinking frequency was not associated with total HDL particle concentration or any of its’ sub-classes. Conclusions: Alcohol volume (and not drinking frequency) was positively associated with NMR-determined plasma total HDL particle concentration for men and women. These associations appeared to be regardless of beverage type, although comparison of beverage types was not possible for women. These results suggest that for any given weekly volume of alcohol, the number of drinking days does not influence HDL particle concentration.

Abstract P193: High Density Lipoprotein is Superior to Triglyceride as a Biomarker of Physiologic Stress in African Immigrants: The Africans in America Study

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Rafeal L Baker ◽  
Jean N Utumatwishima ◽  
Stephanie T Chung ◽  
Anne E Sumner
Keyword(s):  
High Density Lipoprotein ◽  
Allostatic Load ◽  
Density Lipoprotein ◽  
African Immigrants ◽  
Cardiac Risk ◽  
The United States ◽  
High Density ◽  
Significant Difference ◽  
Group 2 ◽  
Group 1

Introduction: For Africans living in the United States, the extent to which stress-induced physiologic dysfunction varies by reason for immigration is unknown. Allostatic load score (ALS) is used to assess physiologic stress. ALS has biomarkers in 3 domains: cardiovascular, metabolic and immune. However, there are many ALS equations and the number of biomarkers in each domain varies. In the cardiac domain of ALS, equations use either triglyceride (TG) or high density lipoprotein (HDL). A specific problem for African descent populations is that HDL may be superior to TG as a marker of insulin resistance and cardiac risk. Objective: Our primary goal in 95 African immigrants (71% male, age 42±10, (mean±SD), range 22-62y) was to determine if ALS varied by reason for immigration. Our secondary goal was to evaluate 4 different ALS equations to determine if there was a difference in ALS performance depending on whether HDL or TG was the included biomarker. Methods and Results: For all 4 equations, the reasons for immigration from lowest to highest ALS were: family reunification, lottery for self and immediate family, marriage, asylum, work and study (Figure 1). As the first 3 reasons for immigration promoted family unity, they were grouped together (Group 1). The Africans who came for other reasons were grouped together (Group 2). Equations 1 and 2 included HDL as a biomarker. For these equations, ALS in Group 1 vs. Group 2 were: 1.7±1.3 vs. 2.8±1.7, P <0.01 and 1.4±1.2 vs. 2.3±1.7, P <0.01 resp. Equations 3 and 4 used TG. For these two equations ALS in Group 1 vs. Group 2 were: 2.2±1.6 vs. 2.9±2.0, P =0.08 and 2.1±1.4 vs. 2.9±2.0, P =0.03 resp. In Equations 1 and 2, when HDL was replaced by TG, the significant difference in ALS between groups declined. In Equations 3 and 4, when TG was replaced by HDL, the significant difference in ALS between groups increased. Conclusions: ALS varies by reason for immigration and is easier to detect in ALS equations which use HDL rather than TG.

scholarly journals IMPACTS OF AEROBIC EXERCISE ON HDL LEVEL OF ADULTS; IT’S SOCIAL IMPLICATIONS IN EDUCATIONAL INSTITUTES

2021 ◽  
Vol 9 (4) ◽  
pp. 65-68
Author(s):  
Noor Muhammad Marwat ◽  
Shah Khalid ◽  
Pir Muhammad Abdul Aziz Shah ◽  
Fayaz ul Hasnain ◽  
Rashid Naeem Khan
Keyword(s):  
High Density Lipoprotein ◽  
Aerobic Exercise ◽  
Heart Valves ◽  
Density Lipoprotein ◽  
High Density ◽  
Social Implications ◽  
Exercise Protocol ◽  
Post Intervention ◽  
The Social ◽  
Significant Difference

Purpose: The purpose of this study to find out the impacts of a 6-weeks supervised aerobic exercise protocol on High-Density Lipoprotein among adults aged between 25-35 years was evaluated. Methodology: Researchers through a non-probability sampling procedure selected thirty (30) volunteers ranging from 25-35 untrained adults from Lakki Marwat. Researchers used a six-week aerobic exercise protocol to collect relevant information from the targeted dependent variables. The CHOD PAP method was used to measure the High-Density Lipoprotein (HDL) of adults. All the data collected from pre-and post- (HDL) tests were recorded in numerical form and analyzed by using a t-test. Main Findings: The results of the study indicate that the six-week aerobic exercise protocol program had no significant difference on pre-and post-intervention quantities of HDL of Experimental Group which is (P>0.05). The implication of the Study: The aerobic exercise programs used for this particular study may help adults to improve and maintain their health status, proper social stature, and lipid profile. An increase in the HLD is ideal as this increase in the HDL helps to prevent cardiovascular diseases particularly the heart valves from stroke and cardiac arrest and academic achievements of the participants. Novelty: So far, no particular research has been conducted on the social implications of exercise effects on adults. Future researchers may work on the social habits of physically fit adults and their input to society.

scholarly journals Prevalence and Predictors of Dyslipidemia in Children and Adolescents in Yazd Greater Area, Yazd, Iran

2021 ◽  
Keyword(s):  
High Density Lipoprotein ◽  
Children And Adolescents ◽  
Lifestyle Modification ◽  
Age Groups ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Cluster Sampling ◽  
Cross Sectional

Background: Dyslipidemia, a genetic and multifactorial disorder of lipoprotein metabolism, is defined by elevations in levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non–HDL-C), triglyceride, or some combination thereof, as well as lower levels of high-density lipoprotein (HDL) cholesterol. Objectives: This study aimed to investigate the prevalence and predictors of dyslipidemia in children and adolescents in the Yazd Greater Area, Yazd, Iran. Methods: This cross-sectional study was conducted as a part of the national project implemented in Yazd Greater Area, Yazd, Iran. The sampling was performed using a multi-stage cluster sampling method on three age groups of girls and boys (6-9, 10-14, and 15-18 years old). Out of the total 1,035 children and adolescents who participated in this study, only 784 participants remained in the study until the end. Data collection was performed using lifestyle questionnaires including Kiddie-SADS-Present and Lifetime Version. Results: The prevalence of high triglyceride was estimated at 1.4% and 4.2% in 6-9 and 10-18 years old children and adolescents, respectively. The prevalence of high cholesterol, LDL, and HDL was 3.2%, 3.2%, and 25.6%, respectively. The prevalence of dyslipidemia in the total population of children and adolescents in terms of demographic variables was 64.6% and 57.3% in boys and girls, respectively (P=0.038). Gender and increase in body mass index were significantly associated with dyslipidemia with OR=1.35; 95% CI: 1.01-1.81 and OR=13.781; 95% CI: 3.78- 46.43, respectively. However, after adjustment for other factors, only an increase in BMI was significantly associated with dyslipidemia (OR=16.08; 95% CI: 4.49-57.59). Conclusions: Overweight and obese adolescents had a higher concentration of serum blood triglycerides, compared to other adolescents. Weight control, lifestyle modification, and diet are three ways to reduce lipid disorders in adolescents.

scholarly journals Prevalence of Diabetic Foot Ulcer and Associated Factors among Adult Diabetic Patients Who Attend the Diabetic Follow-Up Clinic at the University of Gondar Referral Hospital, North West Ethiopia, 2016: Institutional-Based Cross-Sectional Study

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Tesfamichael G. Mariam ◽  
Abebaw Alemayehu ◽  
Eleni Tesfaye ◽  
Worku Mequannt ◽  
Kiber Temesgen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Cross Sectional Study ◽  
Care Practice ◽  
Diabetic Patients ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factors Associated

Diabetes mellitus is a metabolic disorder which is characterized by multiple long-term complications that affect almost every system in the body. Foot ulcers are one of the main complications of diabetes mellitus. However, there is limited evidence on the occurrence of foot ulcer and influencing factors in Ethiopia. An institutional-based cross-sectional study was conducted in Gondar University Hospital, Ethiopia, to investigate foot ulcer occurrence in diabetic patients. Systematic random sampling was used to select 279 study participants. Bivariate and multivariable logistic regression model was fitted to identify factors associated with diabetic foot ulcer. Odds ratio with 95% confidence interval was computed to determine the level of significance. Diabetic foot ulcer was found to be 13.6%. Rural residence [AOR = 2.57; 95% CI: 1.42, 5.93], type II diabetes mellitus [AOR = 2.58; 95% CI: 1.22, 6.45], overweight [AOR = 2.12; 95% CI: 1.15, 3.10], obesity [AOR = 2.65; 95% CI: 1.25, 5.83], poor foot self-care practice [AOR = 2.52; 95% CI: 1.21, 6.53], and neuropathy [AOR = 21.76; 95% CI: 8.43, 57.47] were factors associated with diabetic foot ulcer. Diabetic foot ulcer was found to be high. Provision of special emphasis for rural residence, decreasing excessive weight gain, managing neuropathy, and promoting foot self-care practice would decrease diabetic foot ulcer.

Blood Triglyceride and High-Density Lipoprotein Levels Are Associated with Plasma Amyloid-β Transport: A Population-Based Cross-Sectional Study

2021 ◽  
pp. 1-12
Author(s):  
Shan Wei, ◽  
Suhang Shang ◽  
Liangjun Dang ◽  
Fan Gao ◽  
Yao Gao ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Amyloid Β ◽  
Density Lipoprotein ◽  
Underlying Mechanism ◽  
Population Based ◽  
High Density ◽  
Soluble Form ◽  
Cross Sectional ◽  
Low Hdl ◽  
Positive Correlations

Background: Studies have found that blood lipids are associated with plasma amyloid-β (Aβ) levels, but the underlying mechanism is still unclear. Two Aβ transporters, soluble form of low-density lipoprotein receptor related protein-1 (sLRP1) and soluble receptor of advanced glycation end products (sRAGE), are crucial in peripheral Aβ transport. Objective: The aim was to investigate the effects of lipids on the relationships between plasma Aβ and transporter levels. Methods: This study included 1,436 adults aged 40 to 88 years old. Blood Aβ, sLRP1, sRAGE, and lipid levels were measured. Univariate and multivariate analyses were used to analyze the relationships between lipids and plasma Aβ, sLRP1, and sRAGE. Results: After adjusting for all possible covariates, high-density lipoprotein (HDL-c) was positively associated with plasma Aβ 42 and sRAGE (β= 6.158, p = 0.049; β= 121.156, p <  0.001, respectively), while triglyceride (TG) was negatively associated with plasma Aβ 40, Aβ 42, and sRAGE (β= –48.389, p = 0.017; β= –11.142, p = 0.020; β= –147.937, p = 0.003, respectively). Additionally, positive correlations were found between plasma Aβ and sRAGE in the normal TG (Aβ 40: β= 0.034, p = 0.005; Aβ 42: β= 0.010, p = 0.001) and HDL-c groups (Aβ 40: β= 0.023, p = 0.033; Aβ 42: β= 0.008, p = 0.002) but not in the high TG and low HDL-c groups. Conclusion: Abnormal levels of TG and HDL-c are associated with decreased Aβ and sRAGE levels. Positive correlations between plasma Aβ and sRAGE were only found in the normal TG and HDL-c groups but not in the high TG and low HDL-c groups. These results indicated that dyslipidemia contributing to plasma Aβ levels might also be involved in peripheral Aβ clearance.

Empirical Antibiotic Treatment in Diabetic Foot Infection: A Study Focusing on the Culture and Antibiotic Sensitivity in a Population From Southern China

2017 ◽  
Vol 16 (3) ◽  
pp. 173-182 ◽  
Author(s):  
Wen-xia Wu ◽  
Dan Liu ◽  
Yi-wen Wang ◽  
Chuan Wang ◽  
Chuan Yang ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Diabetic Foot ◽  
Southern China ◽  
Foot Ulcer ◽  
Antibiotic Sensitivity ◽  
Diabetic Foot Ulcer ◽  
Severe Infection ◽  
Third Generation ◽  
Diabetic Ulcer ◽  
Significant Difference

Diabetic foot and subsequent diabetic ulcer infections are the most devastating complication of diabetes. This study was conducted to explore the bacterial spectrum, sensitivity of microbials, and analysis of the empirical antibiotic regimens in our health center. The study included patients with diabetic foot ulcer infection (DFI) seen from 2009 to 2014. The patients included had all information covering the physical examination, laboratory tests, and image examinations. We sent appropriately obtained specimens for culture prior to starting empirical antibiotic therapy in all participants. A total of 312 patients were included: 52, 112, 95 and 53 patients within uninfected, mild, moderate, and severe infection groups. The total percentages of Gram-positive cocci (GPCs) and Gram-negative rods (GNRs) were 54% and 48.8% ( P = 0.63). The most common GPC was Staphylococcus aureus (22.4%) and GNR was Pseudomonas aeruginosa (11.9%). Methicillin-resistant Staphylococcus aureus was isolated from 21 patients (6.7%). Even in the mild infection group, there was no significant difference between GPC and GNR infection, irrespective of recent antibiotic use ( P = 0.053). The most frequently used empirical antibiotics in our center were second-/third-generation cephalosporin ± clindamycin, both in the mild and moderate/severe infection groups. In our center, the amoxicillin/clavulanate or ampicillin/sulbactam (β-L-ase 1) and second-/third-generation cephalosporins were highly resistant to the common GNR (30%-60%). The ticarcillin/clavulanate, piperacillin/tazuobactam (β-L-ase 2), fluoroquinolone, and group 2 carbapenem had good sensitivity. This study presents a comprehensive microbiological survey of diabetic foot ulcers in inpatients and provides reliable evidence of the local microbial epidemiology and sensitivity of antibiotics, which may help us improve clinical outcomes in DFI patients.

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