scholarly journals Infant feeding practices and risk of occurrence of diarrheal and respiratory infections in infancy-a hospital based study

2017 ◽  
Vol 4 (5) ◽  
pp. 1717
Author(s):  
Rakesh Sharma ◽  
Arvind Sood ◽  
Priyanka Niar
Keyword(s):  
Diarrheal Disease ◽  
Respiratory Infections ◽  
Modern Society ◽  
Cost Effective ◽  
Infantile Diarrhoea ◽  
Child Health Outcomes ◽  
Feeding Modes ◽  
One Year ◽  
Suboptimal Breastfeeding ◽  
Breast Fed

Background: Breastfeeding is the most cost-effective intervention for protecting children against various childhood morbidities. Suboptimal breastfeeding has been linked with numerous adverse child health outcomes including increased incidence of diarrheal disease and pneumonia.Methods: A sample of 360 infants was surveyed during the period of one year (2013-2014). The socio-demographic characteristics and feeding modes were collected from the parents of the children during the interview.Results: A total of 228 (63.3%) were suffering from acute gastroenteritis and 132 (37.7%) were suffering from pneumonia. The risk of diarrhea and pneumonia was higher and statistically significant in partially breastfed and non- exclusive breast fed as compared to exclusive breast fed. Infants who were bottle fed had higher risk of morbidity. Infants who were breast fed for longer duration (more than 4 months) has lesser risk of morbidity as compare to counterparts who were fed for lesser duration.Conclusions: These results indicate that promoting exclusive breastfeeding will play an important role in reducing the risk of infantile diarrhoea and pneumonia. This observation is important given the growing concern of the modern society wherein breastfeeding is on the decline. 

Sonographically guided, transcatheter foam sclerotherapy of the great saphenous vein

Phlebologie ◽  
2007 ◽  
Vol 36 (06) ◽  
pp. 309-312 ◽  
Author(s):  
T. Schulz ◽  
M. Jünger ◽  
M. Hahn
Keyword(s):  
Saphenous Vein ◽  
Great Saphenous Vein ◽  
Clinical Stage ◽  
Clinical Signs ◽  
Cost Effective ◽  
Duplex Sonography ◽  
Foam Sclerotherapy ◽  
Average Loss ◽  
One Year ◽  
The Cost

Summary Objective: The goal of the study was to assess the effectiveness and patient tolerability of single-session, sonographically guided, transcatheter foam sclerotherapy and to evaluate its economic impact. Patients, methods: We treated 20 patients with a total of 22 varicoses of the great saphenous vein (GSV) in Hach stage III-IV, clinical stage C2-C5 and a mean GSV diameter of 9 mm (range: 7 to 13 mm). We used 10 ml 3% Aethoxysklerol®. Additional varicoses of the auxiliary veins of the GSV were sclerosed immediately afterwards. Results: The occlusion rate in the treated GSVs was 100% one week after therapy as demonstrated with duplex sonography. The cost of the procedure was 207.91 E including follow-up visit, with an average loss of working time of 0.6 days. After one year one patient showed clinical signs of recurrent varicosis in the GSV; duplex sonography showed reflux in the region of the saphenofemoral junction in a total of seven patients (32% of the treated GSVs). Conclusion: Transcatheter foam sclerotherapy of the GSV is a cost-effective, safe method of treating varicoses of GSV and broadens the spectrum of therapeutic options. Relapses can be re-treated inexpensively with sclerotherapy.

Pollution, Toxicity and Carcinogenicity of Organic Dyes and their Catalytic Bio-Remediation

2019 ◽  
Vol 25 (34) ◽  
pp. 3645-3663 ◽  
Author(s):  
Muhammad Ismail ◽  
Kalsoom Akhtar ◽  
M.I. Khan ◽  
Tahseen Kamal ◽  
Murad A. Khan ◽  
...  
Keyword(s):  
Water Pollution ◽  
Textile Industry ◽  
Pathogenic Bacteria ◽  
Diarrheal Disease ◽  
Organic Dyes ◽  
Chemical Reduction ◽  
Cost Effective ◽  
Agricultural Runoff ◽  
E Coli ◽  
Sanitation Services

: Water pollution due to waste effluents of the textile industry is seriously causing various health problems in humans. Water pollution with pathogenic bacteria, especially Escherichia coli (E. coli) and other microbes is due to the mixing of fecal material with drinking water, industrial and domestic sewage, pasture and agricultural runoff. Among the chemical pollutants, organic dyes due to toxic nature, are one of the major contaminants of industrial wastewater. Adequate sanitation services and drinking quality water would eliminate 200 million cases of diarrhea, which results in 2.1 million less deaths caused by diarrheal disease due to E. coli each year. Nanotechnology is an excellent platform as compared to conventional treatment methods of water treatment and remediation from microorganisms and organic dyes. In the current study, toxicity and carcinogenicity of the organic dyes have been studied as well as the remediation/inactivation of dyes and microorganism has been discussed. Remediation by biological, physical and chemical methods has been reviewed critically. A physical process like adsorption is cost-effective, but can’t degrade dyes. Biological methods were considered to be ecofriendly and cost-effective. Microbiological degradation of dyes is cost-effective, eco-friendly and alternative to the chemical reduction. Besides, certain enzymes especially horseradish peroxidase are used as versatile catalysts in a number of industrial processes. Moreover, this document has been prepared by gathering recent research works related to the dyes and microbial pollution elimination from water sources by using heterogeneous photocatalysts, metal nanoparticles catalysts, metal oxides and enzymes.

Cost Avoidance and Clinical Benefits Derived from a Pharmacy-Managed Anemia Program

2000 ◽  
Vol 35 (2) ◽  
pp. 169-175 ◽  
Author(s):  
Robert A. Quercia ◽  
Ronald Abrahams ◽  
C. Michael White ◽  
John D'Avella ◽  
Mary Campbell
Keyword(s):  
Cost Savings ◽  
Cost Effective ◽  
Hemodialysis Patients ◽  
Cost Avoidance ◽  
Number Of Patients ◽  
Epoetin Alpha ◽  
Clinical Benefits ◽  
Unit Dose ◽  
One Year ◽  
Alpha Therapy

A pharmacy-managed anemia program included distribution and clinical components, with the goal of making epoetin alpha therapy for hemodialysis patients more cost-effective. The Pharmacy Department prepared epoetin alpha doses for patients in unit-dose syringes, utilizing and documenting vial overfill. Pharmacists dosed epoetin alpha and iron (oral and intravenous) per protocol for new and established patients. Baseline data were obtained in 1994, one year prior to implementation of the program, and were re-evaluated in 1995 and 1998. Cost avoidance from utilization of epoetin alpha vial overfill in 1995 and 1998 was $83,560 and $91,148 respectively. In 1995 and 1998, cost avoidance from pharmacy management of anemia was $191,159 and $203,985 respectively. The total cost avoidance from 1995 through 1998 was estimated at $1,018,638. The number of patients with hematocrits under 31% decreased from 32% in 1994 to 21% and 14% in 1995 and 1998 respectively. We conclude that a pharmacy-managed anemia program for hemodialysis patients results in significant cost savings and better achievement of target hematocrits.

scholarly journals Multiplexed detection of SARS-CoV-2 and other respiratory infections in high throughput by SARSeq

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Ramesh Yelagandula ◽  
◽  
Aleksandr Bykov ◽  
Alexander Vogt ◽  
Robert Heinen ◽  
...  
Keyword(s):  
Influenza A ◽  
Respiratory Infections ◽  
High Sensitivity ◽  
Cost Effective ◽  
Massively Parallel ◽  
Rt Pcr ◽  
Viral Spread ◽  
Saliva Analysis ◽  
Double Blinded ◽  
Generation Sequencing

AbstractThe COVID-19 pandemic has demonstrated the need for massively-parallel, cost-effective tests monitoring viral spread. Here we present SARSeq, saliva analysis by RNA sequencing, a method to detect SARS-CoV-2 and other respiratory viruses on tens of thousands of samples in parallel. SARSeq relies on next generation sequencing of multiple amplicons generated in a multiplexed RT-PCR reaction. Two-dimensional, unique dual indexing, using four indices per sample, enables unambiguous and scalable assignment of reads to individual samples. We calibrate SARSeq on SARS-CoV-2 synthetic RNA, virions, and hundreds of human samples of various types. Robustness and sensitivity were virtually identical to quantitative RT-PCR. Double-blinded benchmarking to gold standard quantitative-RT-PCR performed by human diagnostics laboratories confirms this high sensitivity. SARSeq can be used to detect Influenza A and B viruses and human rhinovirus in parallel, and can be expanded for detection of other pathogens. Thus, SARSeq is ideally suited for differential diagnostic of infections during a pandemic.

scholarly journals AB0310 TOLERABILITY AND SAFETY OF 23-VALENT POLYSACCHARIDE PNEUMOCOCCAL VACCINE IN PATIENTS WITH ANTIPHOSPHOLIPID SYNDROME, PRELIMINARY RESULTS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1180.3-1181
Author(s):  
G. Tarasova ◽  
B. Belov ◽  
M. Cherkasova ◽  
E. Aseeva ◽  
T. Reshetnyak ◽  
...  
Keyword(s):  
Antiphospholipid Syndrome ◽  
Lupus Erythematosus ◽  
Pneumococcal Vaccine ◽  
Respiratory Infections ◽  
Vascular Complications ◽  
Initial Increase ◽  
Post Vaccination ◽  
Preliminary Results ◽  
One Year ◽  
Polysaccharide Pneumococcal Vaccine

Background:Antiphospholipid syndrome (APS) is an autoimmune disease often associated with severe, life-threatening vascular complications. The majority of patients (and in case of secondary APS, in 100% of cases) receive immunosuppressive therapy. Immunization with pneumococcal vaccines in patients with both primary APS (PAPS) and APS+SLE or secondary (sAPS) is necessary to prevent severe respiratory infections in these patients.Objectives:Purpose of the study - to study the tolerance and safety of 23-valent polysaccharide pneumococcal vaccine (PPV-23) in patients with PAPS and sAPS.Methods:At this stage, the study included 28 patients with APS, of which 10 with PAPS, 18 with sAPS proceeding against the background of systemic lupus erythematosus (SLE), of which 23 women (82%), 5 men (18%). The average age (Me) of patients was 43 (35.5; 53.0) g. 20 patients received glucocorticoids (GC) 5-30 mg/day equivalent to prednisone, 17- hydroxychloroquine, 6- cytostatics (3-cyclophosphamide, 2-azathioprine, 1- mycophenolate mofetil), 8- biologics: 5-rituximab (RTM), 3-belimumab (BLM); 20-received anticoagulants (direct-10, indirect-10).1 dose (0.5 ml) of PPV-23 was administered subcutaneously. The follow-up time was 1 year in 23 patients and 5-5.5 months in 5-5.5 months. During the visits, standard clinical and laboratory tests were performed, immunological blood test and the level of antibodies to S.pneumoniaeResults:Vaccination was well tolerated in all patients. In 29% of cases, vaccine reactions of mild severity were observed: in 7 (25%) - a local reaction (pain in the arm for 1-3 days-at 7, redness up to 2 cm at the injection site-at 1), in 1 (3,6%), the patient experienced general weakness (moderately pronounced) for 1 month. Vaccinal reactions were completely reversible and did not require additional prescriptions. Post-vaccination complications develop, as a rule, in the first 1-2 months after vaccination. During the observation period, none of the patients had an exacerbation of the disease, reliably associated with the vaccination. There was no recurrence of thrombosis, both in patients receiving anticoagulant therapy and without it. No new autoimmune phenomena, both clinical and laboratory, were identified. The dynamics of the production of anti-streptococcal antibodies during the year was followed in 16 patients. One year after vaccination, 31% of patients showed a significant (more than 2-fold compared to the initial) increase in the concentration of antibodies to polysaccharides of the cell wall of S. pneumoniae (“responders”), 69% of patients were “non-responders” to the vaccine. At the same time, all 5 patients with PAPS were “non-responders”, and 45.5% “respondents” with sAPS.Conclusion:Preliminary results show that patients with APS tolerate PPV-23 vaccination well. In the next post-vaccination period, exacerbations of the disease, thrombosis were not recorded. Attention is drawn to the large number of “non-responders” in PAPS, however, to obtain statistically reliable results, it is necessary to continue the study and recruit more patients.Disclosure of Interests:None declared

Magnetic properties of PM in indoor/outdoor domestic environments 

2021 ◽  
Author(s):  
Aruã Da Silva Leite ◽  
Melina Macouin ◽  
Sonia Rousse ◽  
Jean-François Leon ◽  
Loïc Drigo ◽  
...  
Keyword(s):  
Iron Oxides ◽  
Cost Effective ◽  
Tree Bark ◽  
Indoor Environments ◽  
Magnetic Mineralogy ◽  
Magnetic Methods ◽  
Tree Barks ◽  
Domestic Environments ◽  
One Year ◽  
The City

<p>The finer fraction of the particulate matter (PM) is the most harmful health wise, as it has more capacity to reach deeper parts of the respiratory system. Among other constituents, PM also contains iron oxides, allowing for the use of magnetic methods in its investigation as proxies for the whole of PM. Those methods present advantages in comparison to traditional ones, being quick, cost effective and sensible to investigate iron oxides among PM. </p><p>To better understand the risks related to PM exposition in the domestic context, the assessment of magnetic parameters may be used in outdoor and indoor environments, giving us information on the concentration of iron oxides (and consequently, PM) and its dispersion from one environment to the other. </p><p>We developed a citizen sciences experiment in the city of Toulouse, France. Tree barks were used as bio-collectors. Garlands composed of tree bark pieces were distributed to the population in May-2019, and placed in both indoors and outdoors of flats and homes to capture PM. They were retrieved after one year. Measurement of magnetic susceptibility, ARM, SIRM, S -ratio and estimation of superparamagnetic concentration were performed. A total of 86 bio-collectors kits were successfully analyzed. The preliminary results indicate a higher concentration of iron oxides outdoors, with a mean difference between outdoor and indoor measurements of 6.58x10<sup>-9</sup>m<sup>3</sup>/kg and 1.38x10<sup>-5</sup>Am<sup>2</sup>/kg in susceptibility and SIRM respectively. The concentration of the SP fraction also follows this trend of higher outdoor values. The magnetic mineralogy is mostly dominated by low coercivity magnetite-like carriers.</p><div> <div> <div> </div> </div> <div> <div> </div> </div> </div>

scholarly journals A one-year cost–utility analysis of REBOA versus RTACC for non-compressible torso haemorrhage

Trauma ◽  
2017 ◽  
Vol 21 (1) ◽  
pp. 45-54 ◽  
Author(s):  
Maxwell S Renna ◽  
Cristiano van Zeller ◽  
Farah Abu-Hijleh ◽  
Cherlyn Tong ◽  
Jasmine Gambini ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Cost Effective ◽  
Quality Adjusted Life Year ◽  
Cost Utility ◽  
Incremental Cost Effectiveness Ratio ◽  
Cost Utility Analysis ◽  
Utility Analysis ◽  
Cost Effectiveness Ratio ◽  
One Year ◽  
Quality Adjusted Life

Introduction Major trauma is a leading cause of death and disability in young adults, especially from massive non-compressible torso haemorrhage. The standard technique to control distal haemorrhage and maximise central perfusion is resuscitative thoracotomy with aortic cross-clamping (RTACC). More recently, the minimally invasive technique of resuscitative endovascular balloon occlusion of the aorta (REBOA) has been developed to similarly limit distal haemorrhage without the morbidity of thoracotomy; cost–utility studies on this intervention, however, are still lacking. The aim of this study was to perform a one-year cost–utility analysis of REBOA as an intervention for patients with major traumatic non-compressible abdominal haemorrhage, compared to RTACC within the U.K.’s National Health Service. Methods A retrospective analysis of the outcomes following REBOA and RTACC was conducted based on the published literature of survival and complication rates after intervention. Utility was obtained from studies that used the EQ-5D index and from self-conducted surveys. Costs were calculated using 2016/2017 National Health Service tariff data and supplemented from further literature. A cost–utility analysis was then conducted. Results A total of 12 studies for REBOA and 20 studies for RTACC were included. The mean injury severity scores for RTACC and REBOA were 34 and 39, and mean probability of death was 9.7 and 54%, respectively. The incremental cost-effectiveness ratio of REBOA when compared to RTACC was £44,617.44 per quality-adjusted life year. The incremental cost-effectiveness ratio, by exceeding the National Institute for Health and Clinical Effectiveness’s willingness-to-pay threshold of £30,000/quality-adjusted life year, suggests that this intervention is not cost-effective in comparison to RTACC. However, REBOA yielded a 157% improvement in utility with a comparatively small cost increase of 31.5%. Conclusion Although REBOA has not been found to be cost-effective when compared to RTACC, ultimately, clinical experience and expertise should be the main factor in driving the decision over which intervention to prioritise in the emergency context.

scholarly journals Evaluación Nutricional en preescolares atendidos en el Hospital de Manglaralto, Santa Elena / Nutritional Evaluation of pre-school children attended in Manglaralto Hospital, Santa Elena province

Ciencia Unemi ◽  
2015 ◽  
Vol 8 (15) ◽  
pp. 103
Author(s):  
Yumy Fernandez Velez ◽  
Angel Caballero Torres ◽  
Katiuska Mederos Mollineda
Keyword(s):  
Nutritional Status ◽  
Diarrheal Disease ◽  
Respiratory Infections ◽  
Eating Habits ◽  
Normal Weight ◽  
Cross Sectional ◽  
Nutritional Evaluation ◽  
Qualitative And Quantitative ◽  
Poverty And Health ◽  
Santa Elena

Con el objetivo de analizar los hábitos alimentarios, actividad física y estado nutricional de 514 niñas y niños en edades de 3 a 5 años, se realizó una investigación de corte transversal descriptiva, no experimental, y documental con técnicas cualitativas y cuantitativas para la descripción de los datos e informaciones encontradas, la cual permitió construir la labor técnica Se trabajó con encuestas, mensuraciones antropométricas e investigaciones bioquímicas (hemoglobina) en una muestra de la población atendida en la consulta ambulatoria del Hospital Manglaralto, provincia de Santa Elena, Ecuador, 2014. Se clasificó a los preescolares en desnutridos, normopeso, sobrepeso y obeso, además de identificar la existencia de anemia. Se buscó la asociación con los hábitos alimentarios, acceso y disponibilidad de alimentos, el nivel de cultura alimentaria y escolar, pobreza económica y educación sanitaria de las familias de los preescolares. Se encontró un 44.5% de desnutridos y 0,7% con sobrepeso, además de 81.7% con anemia. Se detectó asociación entre desnutrición y anemia en más de la tercera parte de la población estudiada, además de estar asociada la presentación de Infección Respiratoria Aguda y Enfermedad Diarreica Aguda con la desnutrición y la anemia. En la población estudiada existe correspondencia entre el estado nutricional y los determinantes estudiados. AbstractA cross-sectional descriptive piece of research was conducted in order to document the eating habits, physical activity and nutritional status of 514 children aged 3-5 years. Both Qualitative and quantitative techniques were used to describe the data and information found; surveys, anthropometric evaluations and biochemical investigations (hemoglobin) were carried out on a sample of the population treated at the outpatient clinic of Manglaralto Hospital in Santa Elena province, Ecuador during 2014. Preschool children were classified as malnourished, normal weight, overweight and obese, and the existence of anemia was also identified. The data was studied to observe associations between eating habits, access to and availability of food, the level of culture in terms of diet and education, economic poverty and health education for families of preschoolers. It was found that 44.5% of the group were malnourished, 0.7% overweight, and 81.7% suffered from anemia. An association was found between malnutrition and anemia in more than a third of the population studied, with a further association between both conditions and acute respiratory infections and diarrheal disease. In the population there is a relationship between nutritional status and determining variables studied.

scholarly journals Incidence of tuberculosis and opportunistic respiratory infections in cases of human immunodeficiency virus: a one-year study at a tertiary care hospital

2020 ◽  
Vol 7 (7) ◽  
pp. 1068
Author(s):  
Chintha Venkata Subrahmanyam ◽  
Mahesh Vidavaluru
Keyword(s):  
Respiratory Infections ◽  
Tertiary Care ◽  
Signs And Symptoms ◽  
Pulmonary Complications ◽  
Care Hospital ◽  
Cd4 Cell Count ◽  
Cd4 Counts ◽  
Management Protocol ◽  
One Year ◽  
Tract Infections

Background: Evaluation of respiratory signs and symptoms among HIV patients is a challenging task for a number of reasons. A definitive diagnosis is highly recommended before starting management protocol. Objectives of this study was to primarily evaluate the incidence of pulmonary tuberculosis and opportunistic respiratory infections among the cases of HIV and to estimate the CD4 counts of all the patients and correlate with the respiratory infections among the cases.Methods: The present study was a one-year study conducted at Narayana Medical College and all the cases of HIV presented with signs and symptoms of lower respiratory tract infections were included after obtaining consent. Relevant biochemical, microbiological investigations and CD4 counts of all the cases were done and noted. The data was entered in Microsoft excel spread sheet and analysed for any corrections. Mean, median and SD was calculated for all the continuous variables.Results: A total of 127 cases with 87 males and females 40 females with a ratio of 2.2:1 were included. Mean age of the total cases in the study was 46.12±8.3 years and 29.92% were above 60 years. Hetero sexual exposure was the commonest cause and 59.84% of cases were diagnosed with bacterial pneumonia. Prevalence of tuberculosis among the cases of this study was 22.05%. The mean CD4 cell count with SD among the study was 168.57±142.21.Conclusions: Knowledge of the pattern of pulmonary complications in patients with HIV infection in relation to CD4 count will help clinicians develop faster diagnostic and therapeutic approach to patient management.

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