scholarly journals Multisystem inflammatory syndrome-neonate: youngest COVID survivor

2021 ◽  
Vol 8 (9) ◽  
pp. 1615
Author(s):  
Sushil Singla ◽  
Mohitesh Kumar ◽  
Yaswanth C. Raavi
Keyword(s):  
Virus Disease ◽  
Age Groups ◽  
Severe Infection ◽  
Health Concern ◽  
The Novel ◽  
Global Public Health ◽  
Limited Data ◽  
Corona Virus ◽  
Inflammatory Syndrome ◽  
Respiratory Droplets

The novel corona virus disease (COVID-19) caused by the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is a global public health concern, primarily transmitted through respiratory droplets; though other routes of transmission are documented but not been fully demonstrated. At risk included all age groups, somehow for reasons unknown infants and children appears to be at a lower risk of severe infection, but recently children with hyper inflammatory syndrome and multi-organ dysfunction associated with COVID-19 have been increasingly reported. We report a case of 31-week neonate of 1.292 kg confirmed with SARS-CoV-2 infection, at birth, born to a COVID positive mother, initially developed respiratory distress at birth and abrupt progression to severe distress and later developed pneumothorax and hyper-inflammation (MIS-N). Respiratory support, corticosteroids, enoxaparin, antimicrobials, and other preterm care were given, and finally recovered and discharged after 30 days (1.812 kg). This case highlights the severe presentation of COVID-19 in a pre-term neonate. To the best of our knowledge this is apparently the youngest covid survivor till date reported in world. Clinical data on COVID-19 in new-born is extremely limited, so it is important to understand that these conclusions are based on limited data and our understanding will continue to evolve. 

scholarly journals How prepared were we? A study to assess the knowledge, attitude and practice of dental surgeons regarding the Covid 19 pandemic in district Dehradun

2021 ◽  
Vol 7 (2) ◽  
pp. 123-130
Author(s):  
Yogeshwari ◽  
Anubha Agarwal ◽  
Himanshu Aeran
Keyword(s):  
Virus Disease ◽  
Good Practice ◽  
World Health ◽  
Good Knowledge ◽  
Family Welfare ◽  
The Novel ◽  
Global Public Health ◽  
Online Questionnaire ◽  
Corona Virus ◽  
Knowledge And Practice

The novel corona virus disease 2019 has been declared a global public health emergency & is affecting people across the globe. Dental Surgeons are at an invariably high risk of contracting COVID 19. Since all dentists are slowly resuming their full practice they shall be fully prepared. Aim of the study is to assess the knowledge, attitude & practise of Dental Surgeons regarding the novel Corona Virus Disease 2019 in District, Dehradun. An online Questionnaire was circulated among dental surgeons in District, Dehradun. The Questionnaire consisted of 5 sections: 1. Consent, 2. Epidemiological Data, 3. Knowledge Based Questions (11 Questions), 4. Attitude Based Questions (8 Questions), 5. Practice Based Questions (11 Questions). 107 responses were collected in total. Most dental surgeons had a degree of MDS (Masters of Dental Science): 60.7%. Good knowledge and practice scores were observed among 92.7% and 79.5% of the dental surgeons. Significant association of good knowledge scores with qualifications (p = 0.04) and years of practice (p = 0.02) was found; while good practice scores were associated with qualifications only (p = 0.03). Dental surgeons in district Dehradun were found to have good knowledge and practice scores, which is important to skirmish COVID-19. They are hence advised to follow the Center of Disease Control and Prevention (CDC) World Health Organization (WHO), Ministry of Health & Family Welfare (MoHFW) guidelines in their clinics and should sensitize their staff as well. So that they themselves, their staff and patients all remain safe.

scholarly journals Clinical characteristics and outcomes of patients with Corona Virus Disease 2019 (COVID-19) at Mercy Health Hospitals, Toledo, Ohio

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0250400
Author(s):  
Muhammad Shayan Khan ◽  
Ratika Dogra ◽  
Leela K. V. Miriyala ◽  
F. N. U. Salman ◽  
Rizwan Ishtiaq ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Virus Disease ◽  
Age Groups ◽  
Primary Outcome Measure ◽  
Adverse Outcomes ◽  
The Novel ◽  
Corona Virus ◽  
Ckd Stage ◽  
Observational Cohort ◽  
Design And Methods

Importance The ongoing pandemic of the novel Corona Virus Disease 2019 (COVID-19) is an unprecedented challenge to global health, never experienced before. Objective This study aims to describe the clinical characteristics and outcomes of patients with COVID-19 admitted to Mercy Hospitals. Design and methods Retrospective, observational cohort study designed to include every COVID-19 subject aged 18 years or older admitted to Mercy Saint (St) Vincent, Mercy St Charles, and Mercy St Anne’s hospital in Toledo, Ohio from January 1, 2020 through June 15th, 2020. Primary Outcome Measure was mortality in the emergency department or as an in-patient. Results 470 subjects including 224 males and 246 females met the inclusion criteria for the study. Subjects with the following characteristics had higher odds (OR) of death: Older age [OR 8.3 (95% CI 1.1–63.1, p = 0.04)] for subjects age 70 or more compared to subjects age 18–29); Hypertension [OR 3.6 (95% CI 1.6–7.8, p = 0.001)]; Diabetes [OR 3.1 (95% CI 1.7–5.6, p<0.001)]; COPD [OR 3.4 (95% CI 1.8–6.3, p<0.001)] and CKD stage 2 or greater [OR 2.5 (95% CI 1.3–4.9, p = 0.006)]. Combining all age groups, subjects with hypertension had significantly greater odds of the following adverse outcomes: requiring hospital admission (OR 2.2, 95% CI 1.4–3.4, p<0.001); needing respiratory support in 24 hours (OR 2.5, 95% CI: 1.7–3.7, p<0.001); ICU admission (OR 2.7, 95% CI 1.7–4.4, p<0.001); and death (OR 3.6, 95% CI 1.6–7.8, p = 0.001). Hypertension was not associated with needing vent in 24 hours (p = 0.07). Conclusion Age and hypertension were associated with significant comorbidity and mortality in Covid-19 Positive patients. Furthermore, people who were older than 70, and had hypertension, diabetes, COPD, or CKD had higher odds of dying from the disease as compared to patients who hadn’t. Subjects with hypertension also had significantly greater odds of other adverse outcomes.

scholarly journals Evaluating the Novel Coronavirus infection outbreak surveillance results in a state hospital: a retrospective study

2021 ◽  
Vol 21 (3) ◽  
pp. 1107-1116
Author(s):  
Ezgi Dirgar ◽  
Betül Tosun ◽  
Soner Berşe ◽  
Nuran Tosun
Keyword(s):  
Retrospective Study ◽  
Clinical Symptoms ◽  
Clinical Status ◽  
Age Groups ◽  
World Health ◽  
Health Concern ◽  
The Novel ◽  
Global Public Health ◽  
Novel Coronavirus ◽  
Health Organization

Background: Coronavirus disease (COVID-19) has raised the global public health concern and has been declared a pan- demic by the World Health Organization. Objectives: This study was aimed to examine the clinical course and outcomes of the patients with COVID-19 in the south- eastern part of Turkey. Methods: This retrospective study was conducted on the files of 173 patients who were diagnosed with COVID-19. The “COVID-19 Case Information Form” in the patients’ medical records was used. Results: Of the patients with COVID-19, 64.2% were male and 16.2% had a chronic disease. Their mean age was 34.76±25.75 years. Cough and fatigue were the most common clinical symptoms at admission with 38.7%. The patients at the age of 65 and over were treated mostly in the intensive care unit, and the symptoms associated with the cardiovascular and nausea and vomiting were observed more often (p<0.05). Conclusions: It was found that the majority of the patients were male and there were differences between the age groups in terms of transmission route, the clinic where they were being followed-up, some symptoms, and clinical status outcome. It is recommended that multi-center, prospective, experimental, or observational studies with larger samples should be and the patients should be followed-up for longer periods. Keywords: COVID-19; coronavirus; surveillance; retrospective study.

SARS-COV-2: RT-PCR CYCLE THRESHOLD (CT) VALUE AT DIAGNOSIS AND ITS RELATION TO AGE AND SEX IN ASSAM, INDIA

2021 ◽  
pp. 28-30
Author(s):  
Runumi Chowdhury ◽  
Malavika Barman ◽  
Devyashree Medhi ◽  
Sumi Deka ◽  
Bandeepa Duarah ◽  
...  
Keyword(s):  
Old Age ◽  
Virus Disease ◽  
Age Groups ◽  
P Value ◽  
Age Group ◽  
Global Public Health ◽  
Rt Pcr ◽  
Corona Virus ◽  
Gender And Age ◽  
The Difference

COVID-19 (corona virus disease 2019) is a global public health emergency caused by a new corona virus with severe acute respiratory syndromelike characteristics (SARS-CoV-2). We aimed to evaluate whether gender and age are major risk factors for SARS-CoV-2 infection. For the study, 300 positive cases diagnosed during the period of July 2020 to September 2020 were included. Results showed that 69% of study samples were male of which 84% were in the >51 years old age group. And 31% of study samples were female of which 63% were in the 4-19 years old age group. ANOVAresults indicated that the means of Ct values varied signicantly between age groups (F=2.703; p-value= 0.045). The lower Ct values were recorded in males (29.01±4.35) in comparison to females (29.84±3.98) while, the difference between the means of the two groups was not signicant. Our study concluded that males have higher viral load than females and for both sexes, age was found to be a signicant risk factor for severity of COVID-19.

SARS-COV2 virus and Coronavirus disease (COVID-19)

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 977-982
Author(s):  
Mohamed J. Saadh ◽  
Bashar Haj Rashid M ◽  
Roa’a Matar ◽  
Sajeda Riyad Aldibs ◽  
Hala Sbaih ◽  
...  
Keyword(s):  
Close Contact ◽  
Antiviral Agents ◽  
Health Concern ◽  
The Novel ◽  
Global Public Health ◽  
Fatal Disease ◽  
Mild Disease ◽  
Life Threatening ◽  
Novel Coronavirus

SARS-COV2 virus causes Coronavirus disease (COVID-19) and represents the causative agent of a potentially fatal disease that is of great global public health concern. The novel coronavirus (2019) was discovered in 2019 in Wuhan, the market of the wet animal, China with viral pneumonia cases and is life-threatening. Today, WHO announces COVID-19 outbreak as a pandemic. COVID-19 is likely to be zoonotic. It is transmitted from bats as intermediary animals to human. Also, the virus is transmitted from human to human who is in close contact with others. The computerized tomographic chest scan is usually abnormal even in those with no symptoms or mild disease. Treatment is nearly supportive; the role of antiviral agents is yet to be established. The SARS-COV2 virus spreads faster than its two ancestors, the SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), but has lower fatality. In this article, we aimed to summarize the transmission, symptoms, pathogenesis, diagnosis, treatment, and vaccine to control the spread of this fatal disease.

scholarly journals Post corona virus Disease-19 (COVID-19): Hyper inflammatory syndrome-associated bilateral anterior uveitis and multifocal serous retinopathy secondary to steroids

2021 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
Srinivasan Sanjay ◽  
VijayK R. Rao ◽  
Deepashri Mutalik ◽  
Padmamalini Mahendradas ◽  
Ankush Kawali ◽  
...  
Keyword(s):  
Anterior Uveitis ◽  
Virus Disease ◽  
Corona Virus ◽  
Inflammatory Syndrome

Clinical cases of eculizumab use as a part of complex therapy in patients with severe COVID-19.

2021 ◽  
Author(s):  
Р.А. Майер ◽  
Б.А. Бакиров ◽  
А.А. Набиева ◽  
Д.А. Кудлай
Keyword(s):  
Virus Disease ◽  
Membrane Attack Complex ◽  
Lung Ventilation ◽  
Blood Analysis ◽  
The Novel ◽  
Reactive Protein ◽  
Corona Virus ◽  
Complex Therapy ◽  
Novel Coronavirus ◽  
Clinical Cases

Введение. В последние 2 года серьезной проблемой для всего мирового сообщества стало распространение новой коронавирусной (CoV) инфекции COVID-19 (COrona VIrus Disease-2019). Ввиду сложившихся событий в лечении COVID-19 активно стали применяться новые молекулы и уже зарегистрированные лекарственные препараты, доказавшие свою эффективность при других заболеваниях. Цель исследования: оценить эффективность применения препарата экулизумаб у пациентов с тяжелой формой течения COVID-19. Материалы и методы. Проанализированы 3 клинических случая применения препарата экулизумаб в составе комплексной терапии у пациентов с тяжелой формой течения COVID-19. Для оценки эффективности лечения проводился мониторинг основных клинико-лабораторных показателей, а также показателей, характеризующих воспалительный процесс при коронавирусной инфекции: общий анализ крови, биохимический анализ крови, проанализированы уровни таких показателей как ферритин, С-реактивный белок, интерлейкин-6, лактатдегидрогеназа и мембраноатакующий комплекс. Результаты. На фоне проводимой терапии выявлено снижение концентрации основных маркеров воспаления относительно исходных значений. Заключение. Комплексная терапия, включающая экулизумаб, облегчает течение заболевания, позволяет сократить длительность пребывания пациентов в отделении реанимации и интенсивной терапии, укорачивает срок их пребывания на искусственной вентиляции легких, тем самым снижая процент летальности. Background. In the past two years, the incidence of the novel coronavirus (CoV) infection COVID-19 (COrona Virus Disease-2019) has been a serious problem for the global community. Considering these circumstances, new molecules and already registered drugs that have proven their effectiveness in other diseases, began to be actively used in COVID-19 treatment. Objectives: to assess the effi cacy of eculizumab in patients with severe COVID-19. Patients/Methods. Three clinical cases of eculizumab use as a part of complex therapy in patients with severe COVID-19 have been analyzed. To assess the treatment efficacy, the main clinical and laboratory parameters and indicators of inflammatory process in coronavirus infection were monitored (clinical blood analysis, biochemical blood test, levels of ferritin, C-reactive protein, interleukin-6, lactate dehydrogenase and membrane attack complex). Results. Under the therapy we found the reduction of concentration of the main inflammation markers relative to the initial values. Conclusions. Complex therapy with eculizumab facilitates the course of the disease, reduces the stay duration of patients in the intensive care unit, shortens the period of artificial lung ventilation, thereby reducing the mortality rate.

scholarly journals Analyzing and Visualizing the Impact of Covid19 on the World

2020 ◽  
pp. 265-268
Keyword(s):  
World Health ◽  
The Novel ◽  
Global Public Health ◽  
Corona Virus ◽  
Johns Hopkins University ◽  
Large Numbers ◽  
The World ◽  
Open Datasets ◽  
Health Organization ◽  
The Impact

The Novel Corona virus is emerging as a Global public health threat. The outbreak initially emerged in Wuhan, China, large numbers of patients were getting sick because of Pneumonia and later it was found that they were nfected with the Novel Corona virus this emphasizes the importance of analyzing the data of this virus and predicting their risks of infecting people all around the globe. In this study, we present an effort to compile and analyze the outbreak information on COVID19 based on the open datasets on 2019 nCoV provided by the Johns Hopkins University, World Health Organization. An exploratory data analysis with visualizations has been made to understand the number of different cases reported (confirmed, death, and re-covered) in the World. Overall, at the outset of an outbreak like this, it is highly important to readily provide information to begin the evaluation necessary to understand the risks and begin containment activities.

scholarly journals A Review on Automatic Covid-19 Lung Infection Detection from Different Imaging Techniques

2021 ◽  
Vol 9 (VII) ◽  
pp. 3850-3856
Author(s):  
Sangeeta Singh
Keyword(s):  
World Health Organization ◽  
Virus Disease ◽  
Imaging Techniques ◽  
World Health ◽  
The Novel ◽  
Corona Virus ◽  
The World ◽  
Health Organization ◽  
High Level ◽  
Precision Rate

Corona Virus Disease-2019 commonly known as COVID-19 which has been defined by the Novel Corona Virus. It is a family of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) and was first detected during respiratory outbreak. It was first reported to the World Health Organization on December 31, 2019. On January 30, 2020, the World Health Organization declared the COVID-19 eruption a global health emergency. As of 27-May-2021 169,095,283 confirmed cases have been reported in the world and 2, 73, 67, 935 cases in India. It is required to identify the infection with high precision rate but there are lots of deficiency in the diagnosing system that may resulted false alarm rate. Initially it could be detected through throat saliva but now it can also be identified thought the impairment in lungs from computerized tomographical imaging technique. This paper reviewed various researches over COVID-19 diagnosis approach as well as the syndrome in respiratory organs. There are so many imaging techniques through which lungs impairments can be detected that may diagnose COVID-19 with high level of accuracy. CT scan image is the best alternative for diagnosing COVID-19.

scholarly journals COVID-19: The Pandemic Situation in the Context of India

2021 ◽  
pp. 456-463
Author(s):  
Daksh Hardaswani
Keyword(s):  
Virus Disease ◽  
The Novel ◽  
Physical And Mental Health ◽  
Health Crisis ◽  
Animal Virus ◽  
Therapeutic Drugs ◽  
Corona Virus ◽  
Hand Wash ◽  
The World ◽  
Financial Impacts

The novel corona virus disease (COVID-19) is a pandemic due to the global health crisis it has created in the world and greatest challenges that it has introduced in this 21ST century. COVID-19 is the the 5th pandemic which was first reported in Wuhan, China and gradually spread into the other parts of the world. This virus is a spillover of an animal virus and then also adapted the ability of transferring human to human. The virus is highly contagious due to rapid spread and constantly evolves in the human population.  COVID-19 pandemic is a lot more than just a health emergency, but it is also socio-economic because people are losing jobs and income. The COVID-19 disease affects physical and mental health due to isolation. Moreover, more and more countries are affecting the cases of COVID-19 which are rising very rapidly day by day. Therefore, every country needs to several actions which accelerates their safety health, balance between the protection of health, prevent economic and social disruption due to this pandemic. In the spirit of the solidarity, we all need to be contributing our self to protect this situation. However, every country is equally responsible for determining the measures to prevent or decrease the viral transmission. Government authorizes also trying to act for reduce disease’s trajectory and they focus on develop the vaccination and therapeutic drugs.  Aim: To find causes, symptoms, awareness, Prevention, and treatment of COVID-19. Conclusion: The world is going by the critical situation and that is COVID-19 pandemic which is originated due to corona virus. Shortness of breath, fever and dry cough are most common symptoms of the novel corona virus. COVID-19 is highly contagious, so we must keep safe distance from other people and wear a mast hand wash our hands frequently. As it were together can we overcome the interwoven wellbeing and social and financial impacts of the widespread and anticipate its acceleration into an extended compassionate and nourishment security catastrophe, with the potential misfortune of as of now accomplished advancement picks up. 

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