scholarly journals Superior sagittal sinus thrombosis in a case of beta thalassaemia major

2017 ◽  
Vol 4 (2) ◽  
pp. 585
Author(s):  
Syed Md Azad ◽  
Anwesha Mukherjee ◽  
Rohit Kapoor ◽  
Rohit Bannerji ◽  
Jaydeb Ray
Keyword(s):  
Clinical Symptoms ◽  
Sinus Thrombosis ◽  
Incidental Finding ◽  
Wide Spectrum ◽  
Clinical Manifestations ◽  
Thalassaemia Major ◽  
Beta Thalassaemia ◽  
Sagittal Sinus ◽  
Life Threatening ◽  
Transfusion Dependency

Patients with beta- thalassaemia major have a wide spectrum of clinical manifestations, from transfusion dependency to asymptomatic anaemia. Some may just have incidental finding of anaemia with splenomegaly during physical examination. Most of them require regular blood transfusion and their haemoglobin is maintained at an acceptable level. However they are at risk for multiple complications such as thrombo-embolic events which may be life threatening. We report here a case of beta- thalassaemia major complicated by cerebral sinus thrombosis, who had minimal clinical symptoms and signs at presentation. This case reiterates the importance of increased vigilance in the clinical management of this vulnerable group of patients. 

scholarly journals Sinonasal-Related Orbital Infections in Children: A Clinical and Therapeutic Overview

2019 ◽  
Vol 8 (1) ◽  
pp. 101 ◽  
Author(s):  
Sara Torretta ◽  
Claudio Guastella ◽  
Paola Marchisio ◽  
Tal Marom ◽  
Samantha Bosis ◽  
...  
Keyword(s):  
Visual Loss ◽  
Care Setting ◽  
Sinus Thrombosis ◽  
Clinical Manifestations ◽  
Urgent Care ◽  
Pediatric Diseases ◽  
Life Threatening ◽  
Infectious Disease Specialists ◽  
Urgent Care Setting ◽  
Practical Recommendations

Sinonasal-related orbital infections (SROIs) are typically pediatric diseases that occur in 3–4% of children with acute rhinosinusitis. They are characterised by various clinical manifestations, such as peri-orbital and orbital cellulitis or orbital and sub-periosteal abscesses that may develop anteriorly or posteriorly to the orbital septum. Posterior septal complications are particularly dangerous, as they may lead to visual loss and life-threatening events, such as an intracranial abscess and cavernous sinus thrombosis. Given the possible risk of permanent visual loss due to optic neuritis or orbital nerve ischemia, SROIs are considered ophthalmic emergencies that need to be promptly recognised and treated in an urgent-care setting. The key to obtaining better clinical outcomes in children with SROIs is a multi-disciplinary assessment by pediatricians, otolaryngologists, ophthalmologists, radiologists, and in selected cases, neurosurgeons, neurologists, and infectious disease specialists. The aim of this paper is to provide an overview of the pathogenesis, clinical manifestations, diagnosis, and treatment of pediatric SROIs, and to make some practical recommendations for attending clinicians.

Parvovirus Infection in a Child Presenting with Erythema Multiforme and Vasculitis after a Yellow Jacket Bee Sting

2020 ◽  
Author(s):  
Ceren Can ◽  
Mehtap Yazicioglu ◽  
Selman Gokalp ◽  
Nese Ozkayin
Keyword(s):  
Erythema Multiforme ◽  
Wide Spectrum ◽  
Parvovirus B19 ◽  
Clinical Manifestations ◽  
Yellow Jacket ◽  
Systemic Reactions ◽  
Bee Sting ◽  
Life Threatening ◽  
Insect Stings ◽  
Parvovirus B 19

Abstract Parvovirus B19 has a wide spectrum of clinical manifestations. Erythema multiforme and vasculitis are rarely reported with parvovirus B19 infections. Reactions to insect stings can range from local swelling to life-threatening systemic reactions. There have been rare reports of unusual reactions, such as vasculitis, occurring in a temporal relationship with insect stings. We report an 8-year-old patient having Parvovirus B-19-related erythema multiforme and vasculitis after a yellow jacket bee sting.

scholarly journals Acute subarachnoid hemorrhage as initial presentation of dural sinus thrombosis

2010 ◽  
Vol 01 (01) ◽  
pp. 23-25 ◽  
Author(s):  
Shriram Sharma ◽  
Nalini sharma ◽  
M. E. Yeolekar
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Magnetic Resonance ◽  
Sinus Thrombosis ◽  
Wide Spectrum ◽  
Venous Pressure ◽  
Clinical Manifestations ◽  
Venous Sinus ◽  
Vascular Lesions ◽  
Dural Sinus ◽  
Lateral Sinus

ABSTRACTSubarachnoid hemorrhage (SAH) in the older is most often due to aneurismal rupture. Other vascular lesions are known to rarely cause SAH. Cerebral venous thrombosis (CVT) can be diffi cult to diagnose because of its wide spectrum of clinical manifestations. Its diagnosis can be further complicated when patients initially present with acute SAH. We report a case of dural venous sinus thrombosis with SAH, most probably, due to raised venous pressure draining venous tributaries. A 59-year-old man presented with severe headache. Computerized tomography (CT) scan head was normal. Magnetic resonance imaging (MRI) suggested right parasagittal fronto-parietal hemorrhage. No aneurysm was detected on magnetic resonance angiography (MRA) or digital subtraction angiography (DSA). MRV revealed superior sagittal sinus (SSS) and lateral sinus thrombosis. DSA showed occlusion of intracranial SSS and lateral venous sinus. The patient improved with anticoagulant therapy. This case highlights the fact that SAH may reveal a CVT, and emphasizes on the inclusion of MRV in the diagnostic workup of SAH, particularly in cases in which aneurysm is not detected.

scholarly journals Cerebral Venous Sinus Thrombosis with an Intracranial Haemorrhage: A Case Report

2019 ◽  
Vol 7 (6) ◽  
pp. 1029-1031 ◽  
Author(s):  
Abdullah M. Al Zahrani ◽  
Reem Al Sheikh
Keyword(s):  
Sinus Thrombosis ◽  
Signs And Symptoms ◽  
Cerebral Venous Sinus Thrombosis ◽  
Pregnant Female ◽  
Venous Sinus ◽  
Diagnostic Challenge ◽  
Venous Sinus Thrombosis ◽  
Sagittal Sinus ◽  
Life Threatening ◽  
Acute Headache

BACKGROUND: Cerebral venous sinus thrombosis (CVST) is a rare, life-threatening disorder. It has an annual incidence of approximately two to four per million people per year. Nearly 70–80% of all cases of CVST are located in the superior sagittal sinus (SSS). CVST presents a diagnostic challenge due to different presentations. CASE PRESENTATION: We describe the case of a young pregnant female who presented to the emergency room with an acute headache attributed to multifactorial causes. CONCLUSION: This report highlights the importance of including CVST in the differential diagnosis when treating a pregnant female with headaches. Although the symptoms of CVST are varied, the most common occlusion is in the SSS. In such cases, the patient may present with signs and symptoms that include headaches, intracranial hypertension and papilloedemas.

scholarly journals Faciocranial complications of sinusitis

New Medicine ◽  
2019 ◽  
Vol 23 (1) ◽  
Author(s):  
Michał Michalik ◽  
Adrianna Podbielska-Kubera
Keyword(s):  
Sinus Thrombosis ◽  
Nasal Congestion ◽  
Empirical Therapy ◽  
Nasal Discharge ◽  
Anatomical Location ◽  
Fungal Sinusitis ◽  
Sagittal Sinus ◽  
Intracranial Complications ◽  
Life Threatening ◽  
Orbital Complications

Sinusitis is one of the most common conditions. The aetiology of sinusitis has not been fully discovered; however, viruses and bacteria are usually the dominant causes. The chief symptoms include nasal congestion, profuse nasal discharge and a compromised sense of smell. Inflammation of any sinus can be the source of complications. Complications develop usually as a result of exacerbation of chronic sinusitis. Sinusitis may result in inflammation spreading inside the cranium and to the orbital area and in the development of osteomyelitis or superior sagittal sinus thrombosis. Due to the anatomical location and proximity of important structures, sphenoid sinusitis may lead to meningitis or subdural empyemas, temporal lobe abscesses and cavernous sinus thrombosis. Fungal sinusitis is very dangerous since it is characterised by a rapid course often complicated by intracranial and orbital spread. Invasive fungal paranasal sinusitis with orbital complications is a life-threatening emergency. If there is concern about possible orbital or intracranial complications of sinusitis or if there is no improvement after initial empirical therapy, the use of diagnostic imaging is necessary, including computed tomography and magnetic resonance imaging. Early diagnosis of sinusitis and multidisciplinary management involving a combination of antibiotic therapy and surgical treatment, including neurosurgery and maxillofacial procedures can be effective in the prevention of complications and may significantly reduce morbidity and mortality.

scholarly journals Sigmoid Sinus Thrombosis as a Complication of Acute Otitis Media in a 6-Year-Old Male

2021 ◽  
pp. 014556132110157
Author(s):  
Alexandros Poutoglidis ◽  
Nikolaos Tsetsos ◽  
Stergiani Keramari ◽  
Ioannis Skoumpas ◽  
Konstantinos Vlachtsis ◽  
...  
Keyword(s):  
Otitis Media ◽  
Pediatric Patients ◽  
Sinus Thrombosis ◽  
Wide Spectrum ◽  
Acute Otitis Media ◽  
Sigmoid Sinus ◽  
Cortical Mastoidectomy ◽  
Life Threatening ◽  
Life Threatening Complication ◽  
High Index Of Suspicion

Sigmoid sinus thrombosis (SST) is a potentially life-threatening complication of otitis media which is nowadays rare due to the widespread use of antibiotics. A high index of suspicion is necessary to allow for a timely diagnostic and therapeutic intervention. Intravenous wide-spectrum antibiotics and a cortical mastoidectomy are the mainstay of treatment. There is no consensus regarding the necessity of anticoagulants in pediatric patients. We present a 6-year-old boy who presented with an SST as a result of acute otitis media.

scholarly journals ECMO Rescues Patients With Acute Respiratory Failure Related to GPA

2021 ◽  
Vol 8 ◽  
Author(s):  
Rongjun Wan ◽  
Wenzhe Yang ◽  
Xinhua Ma ◽  
Wei Yang ◽  
Pinhua Pan ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Acute Respiratory Failure ◽  
Granulomatosis With Polyangiitis ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Systemic Involvement ◽  
Online Databases ◽  
Appropriate Treatment ◽  
Wide Range ◽  
Life Threatening

Granulomatosis with polyangiitis (GPA) is a subtype of anti-neutrophil cytoplasmic antibody-associated vasculitis with a wide range of clinical symptoms related to the systemic involvement of small blood vessels. The respiratory system is one of the most frequently involved, and life-threatening acute respiratory failure could occur due to diffusive alveolar hemorrhage and tracheal stenosis. When maximum mechanical ventilation is unable to maintain oxygenation, extracorporeal membrane oxygenation (ECMO) should be considered as the final respiratory supportive method, if available. Here we present a 32-year-old male patient with acute respiratory failure (ARF) related to GPA, who was rescued by winning time for accurate diagnosis and appropriate treatment. Additionally, we reviewed more than 60 GPA-related ARF cases on multiple online databases, summarized the clinical manifestations of these patients, and concluded that ECMO plays an important role in further respiratory support for ARF patients with GPA and assists in accurate and timely diagnosis and appropriate treatment, thus helping them recuperate.

scholarly journals Is COVID-19 infection triggering oral herpes zoster? A case report

2021 ◽  
Vol 9 ◽  
pp. 2050313X2110657
Author(s):  
Wafaa Saleh ◽  
Fatma Ata ◽  
Mohamed M Elashry
Keyword(s):  
Case Report ◽  
Herpes Zoster ◽  
Clinical Symptoms ◽  
Oral Care ◽  
Clinical Manifestations ◽  
Oral Lesion ◽  
System A ◽  
Oral Herpes ◽  
Life Threatening ◽  
Rapid Appearance

Patients affected with COVID-19 are at risk of developing serious and life-threatening conditions. The clinical manifestations of COVID-19 were detected in asymptomatic cases to severe clinical symptoms with a major impact on the respiratory system. A few cases of cutaneous as well as an oral lesion of herpes zoster in patients with COVID-19 were reported in the literature. We present a case of the rapid appearance of the oral lesion as a manifestation of herpes zoster associated with COVID-19 infection. Our case highlights the importance of oral examination as well as oral care in patients with COVID-19 infection.

Some Clinical Manifestations and Laboratory Findings of Human Gigantica Fascioliasis in Pregnant Women and Children in Central-Coastal Provinces, Vietnam, 2003-2017

2019 ◽  
Vol 4 (3) ◽  
Keyword(s):  
Pregnant Women ◽  
Clinical Symptoms ◽  
Wide Spectrum ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Fasciola Gigantica ◽  
World Health ◽  
Laboratory Findings ◽  
Laboratory Parameters ◽  
Women And Children

Introduction: Fascioliasis is a disease of the hepatobiliary system, caused by Fasciola spp that are increasing and threating of public health in the tropic areas, including of Central coastal of Vietnam. World Health Organisation estimates that at least 2.4 million people are infected in more than 70 countries worldwide, with several million at risk, and particularly, no continent is free from fascioliasis. This study carried out to evaluate several typical clinical and paracinical aspects in the pregnant women and children groups with fascioliasis. Methods: With the descriptive cross-sectional study design, and sample size in line with hospital based data. Results: the data post-analysis showed that total of 94 pregnant women and 212 child with gigantica fascioliasis were enrolled:- In the pregnant women group: the major clinical symptoms of epigastric and Chauffard Rivet triangle pain (95.74%), subshoulder muscle pain (97.87%), gastrointestinal disturbances as abdominal pain plus constipation (14.89%), loosed stool (22.34%), nausea and/or vomit (29.78%), mild fever (68%), allergic reaction with pruritis and urticaria (64.89%), mild anemia (4.26%), rare symptoms may be hepatomegaly (6.38%), chest pain, dyspnoea (43.62%), jaundice (2.13%); Laboratory parameters were positive ELISA test with Fasciola gigantica antigen (95.74%), hepatobiliary lesions by ultrasound (97.87%), majority in right liver (90.32%), eosinophilia is the predominant indicator (90.42%), In the children group: the clinical manifestations included of epigastric and Chauffard-Rivet area pain (94.34%), flatuence, nausea and intermittent vomiting (76.41%), digestive disoders (40.57%), allergy (30.66%), fatigue plus weight loss (12.74%); laboratory findings included of hepatobiliary lesions by US (100%), positive ELISA with Fasciola gigantica antigen (96.70%), eosinophil of 93.39% and 1.90% positive copro-examination with Fasciolae eggs. Conclusions: In pregnant women, symptoms are indistinguishable from hepatobiliary, digestive tract diseases or overlap with gestation terrains, and clinical signs of paediatric fascioliasis may mimic a wide spectrum of hepatobiliary disorders laboratory parameters and imaging diagnostics, especially in FasELISA, hypereosinophilia and liver lesions by ultrasound were very useful in positive diagnosis.

scholarly journals Immunoglobulin M Paraproteinaemias

Cancers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1688
Author(s):  
Louis-Pierre Girard ◽  
Cinnie Yentia Soekojo ◽  
Melissa Ooi ◽  
Li Mei Poon ◽  
Wee-Joo Chng ◽  
...  
Keyword(s):  
B Cell ◽  
Incidental Finding ◽  
Clinical Manifestations ◽  
Vital Role ◽  
Immunoglobulin M ◽  
Diagnostic Process ◽  
Large Molecular Weight ◽  
Life Threatening ◽  
Plasma Cell Dyscrasias ◽  
Monoclonal Proteins

Monoclonal paraproteinaemia is an increasingly common reason for referral to haematology services. Paraproteinaemias may be associated with life-threatening haematologic malignancies but can also be an incidental finding requiring only observation. Immunoglobulin M (IgM) paraproteinaemias comprise 15–20% of monoclonal proteins but pose unique clinical challenges. IgM paraproteins are more commonly associated with lymphoplasmacytic lymphoma than multiple myeloma and can occur in a variety of other mature B-cell neoplasms. The large molecular weight of the IgM multimer leads to a spectrum of clinical manifestations more commonly seen with IgM paraproteins than others. The differential diagnosis of B-cell and plasma cell dyscrasias associated with IgM gammopathies can be challenging. Although the discovery of MYD88 L265P and other mutations has shed light on the molecular biology of IgM paraproteinaemias, clinical and histopathologic findings still play a vital role in the diagnostic process. IgM secreting clones are also associated with a number of “monoclonal gammopathy of clinical significance” entities. These disorders pose a novel challenge from both a diagnostic and therapeutic perspective. In this review we provide a clinical overview of IgM paraproteinaemias while discussing the key advances which may affect how we manage these patients in the future.

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