scholarly journals Cyclic loading; its impact on the orthodontic tooth movement in growing patients: in vivo study

2021 ◽  
Vol 8 (1) ◽  
pp. 1
Author(s):  
Tanushree Sharma ◽  
Ankita Gupta ◽  
Aseem Sharma ◽  
Pulkit Vaid ◽  
Kamlesh Singh ◽  
...  
Keyword(s):  
Tooth Movement ◽  
Treatment Time ◽  
Orthodontic Tooth Movement ◽  
P Value ◽  
Vibratory Stimulation ◽  
Movement Rate ◽  
Time Intervals ◽  
Tooth Movement Rate ◽  
The Impact

<p class="abstract"><strong>Background: </strong>The objective of the study was to evaluate the impact of vibratory stimulation on the orthodontic tooth movement rate in growing patients and to compare the orthodontic tooth movement rate in experimental and control sides.</p><p class="abstract"><strong>Methods: </strong>Split-mouth design study was done on 30 growing fixed appliance therapy orthodontic cases with bilateral first premolar extractions in maxillary arch. Individual canine retractions were performed in all the subjects with type-1 active tiebacks. Oral-B powered toothbrushes (125 Hz) were used to provide vibratory stimulation for 15 minutes per day (splits into 5 minutes thrice a day). The tooth movement was measured with calibrated digital vernier caliper clinically at various time intervals (T0, T1 and T2). OPG were taken at regular mentioned time intervals and grid method was used to calculate the tooth movement on OPGs.</p><p class="abstract"><strong>Results:</strong> Results were evaluated statistically and the p-value revealed significantly increased rate of tooth movement on experimental side as compared to control side.</p><p class="abstract"><strong>Conclusions: </strong>The high-frequency vibratory stimulation along with fixed orthodontic appliance can reduce treatment time expeditiously in growing patients. Powered toothbrushes can use successfully for providing vibrations to enhance the rate of tooth movement.</p>

scholarly journals Vibratory stimulation in non-growing patients and its effect on the orthodontic tooth movement

2021 ◽  
Vol 8 (1) ◽  
pp. 33
Author(s):  
Tanushree Sharma ◽  
Ankita Gupta ◽  
Aseem Sharma ◽  
Pulkit Vaid ◽  
Kamlesh Singh
Keyword(s):  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Control Group ◽  
P Value ◽  
Vibratory Stimulation ◽  
Movement Rate ◽  
Canine Retraction ◽  
And Control ◽  
Tooth Movement Rate ◽  
The Impact

<p><strong>Background:</strong> Objectives of the study were to determine the impact of vibratory stimulation in non-growing patients on the orthodontic tooth movement rate and to differentiate the orthodontic tooth movement rate in both experimental and control sides.</p><p><strong>Methods:</strong> 30 non-growing patients were selected for a split-mouth study with fixed appliance therapy orthodontic treatment undergoing bilateral first premolar extractions in maxillary arch. Type 1 active tiebacks were used to perform single canine retraction in all the patients. Vibratory stimulation was provided for 15 minutes daily with the help of Oral-B battery powered toothbrushes of 125 Hz frequency. Measurement was taken with calibrated digital vernier caliper clinically and OPG were taken at regular time intervals using grid method for the tooth movement calculation.</p><p><strong>Results:</strong> P value obtained by statistical calculation shows non-significant results in both experimental and control sides in non-growing patients.</p><p><strong>Conclusions:</strong> Cyclic loading in non-growing patients with fixed orthodontic appliance shows no change in orthodontic tooth movement in experimental and control group.</p>

scholarly journals The number of osteoblasts and osteoclasts in hypofunctional teeth during orthodontic tooth movement in rats

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 541
Author(s):  
Adibah Maulani ◽  
Cendrawasih Andusyana Farmasyanti ◽  
Darmawan Sutantyo
Keyword(s):  
Wistar Rats ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Pressure Side ◽  
Coil Spring ◽  
Movement Rate ◽  
Normal Occlusion ◽  
Male Wistar Rats ◽  
Tooth Movement Rate ◽  
Hematoxylin Eosin

Background: When moved orthodontically, hypofunctional teeth will have a decreased tooth movement rate compared to normal teeth. This study aimed to determine the number of osteoblasts in the tension side and the number of osteoclasts in the pressure side of the hypofunctional teeth during orthodontic tooth movement. Method: 18 male Wistar rats were given a palatal coil spring application on the maxillary incisors. Rats were divided into two groups, the orthodontic group with normal occlusion (NO) and hypofunctional occlusion (HO). The number of osteoblasts on the tension side and osteoclasts on the pressure side on days zero (D0), five (D5), and 10 (D10) were tested with two-way ANOVA. Observations were made by hematoxylin eosin staining. Result: The results showed that the number of osteoblasts on the tension side of the HO group was the same at the NO group (p> 0.05). The number of osteoblasts on the tension side in the NO and HO groups at D5 was the same at D10 (p = 0.99), but significantly higher (p = 0.002), than D0. The number of osteoclasts on the pressure side in the HO group was significantly lower than the NO group (p <0.05). The number of osteoclasts in the NO D5 group was significantly higher than the other groups (p <0.05). Conclusions: The number of osteoblasts on the tension side was not affected by the hypofunctional state but decreased the number of osteoclasts on the pressure side during orthodontic tooth movement.

scholarly journals Effects of pentagamavunon-0 (PGV-0) as alternative analgesics on orthodontic tooth movement in rats

2019 ◽  
Vol 31 (3) ◽  
pp. 152
Author(s):  
Cendrawasih Andusyana Farmasyanti ◽  
Anne Marie Kuijpers-Jagtman ◽  
Heni Susilowati ◽  
Edy Meiyanto
Keyword(s):  
Orthodontic Treatment ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Positive Control ◽  
Analgesic Drug ◽  
Movement Rate ◽  
Treatment Groups ◽  
Male Wistar Rats ◽  
Post Hoc ◽  
Tooth Movement Rate

Introduction: Some analgesic drugs may have adverse effects on bone remodelling and, thus, on orthodontic tooth movement rate (OTM). GV-0 is synthesized by reacting vanillin and cyclopentanone catalyzed in acidic condition, and it has been revealed as a selective COX-2 inhibitor. This study was aimed to investigate the effect of pentagamavunon-0 (PGV-0), one of the curcumin analogues, on OTM. Methods: This study was conducted on 50 male Wistar rats (350-450 g) which were randomly divided into five groups (n = 10 each): 1) no treatment group (NT), 2) orthodontic treatment only (ORT), 3) ORT plus 0.4% sodium carboxymethyl cellulose (Na-CMC) analgesic carrier, 4) ORT plus 200 mg/kg BW Paracetamol (PCT) as the positive control, and 5) ORT plus PGV-0 (50 mg/kg BW (PGV-0). Results: Drug and day interaction was statistically significant on two-way ANOVA. Post-hoc analyses showed that OTM increased from day 3 to 7 in all orthodontic groups over the same distance (p>0.05). Maximum OTM was found on day 6, which was significantly farther than the distance on day 4. On day 7, OTM was less than on day 6. OTM in all orthodontic groups, including in the PGV-0 group, was higher than in the NT group (p<0.05). No differences was seen in OTM between PGV-0 group and other orthodontic groups (p>0.05). Post-hoc analysis (intra days) revealed that OTM in PGV-0 and other orthodontic treatment groups increased. Conclusion: After a single orthodontic force, PGV-0 does not inhibit tooth movement in rats from day 1 to day 7. Therefore, it is possible to develop PGV-0 as an alternative analgesics during orthodontic therapy.Keywords: Analgesic drug, orthodontics, tooth movement, curcumin.

scholarly journals Effect of Drugs on Orthodontic Tooth Movement in Human Beings: A Systematic Review of Randomized Clinical Trials

2019 ◽  
Vol 13 (1) ◽  
pp. 22-32
Author(s):  
Khaled Khalaf ◽  
Mahmoud Mando
Keyword(s):  
Clinical Trials ◽  
Randomized Clinical Trials ◽  
Tooth Movement ◽  
Treatment Time ◽  
Orthodontic Tooth Movement ◽  
Final Analysis ◽  
Human Beings ◽  
Level Of Evidence ◽  
Hand Search ◽  
The Impact

Background:Orthodontic tooth movement represents a series of events at both cellular and molecular levels which in turn stimulates inflammatory pathway to induce tooth movement. Some drugs taken by patients have a negative effect which can block this pathway, on the other hand, others may influence these events and reduce treatment time.Search Methods:A search strategy was implemented using both manual hand search and electronic databases, including Cochrane database of clinical trials, PubMed, ScienceDirect and Scopus. The risk of biased eligible studies to be included in the final analysis was assessed independently by two authors using Cochrane risk of bias tool.Results:A total of 491 articles were identified in both manual and electronic searches as well as by checking the reference lists of articles to be included in the study. After reviewing the titles, abstracts and full-text articles, only 8 RCTs met the inclusion criteria, and thus, were included in the final analysis. Six out of the 8 RCTs were assessed as of low quality. No statistical methods were employed to combine the studies due to the heterogeneities of the studies and the low level of evidence.Conclusion:Acetylsalicylic acid and ibuprofen reduced orthodontic tooth movement whereas paracetamol, Rofecoxib and tenoxicam had no impact on orthodontic tooth movement. Due to the low quality of the studies included, therefore to base our practice on scientific evidence, better-controlled RCTs are needed to investigate the impact of common medications on orthodontic tooth movement.

scholarly journals Dietary Salt Accelerates Orthodontic Tooth Movement by Increased Osteoclast Activity

2021 ◽  
Vol 22 (2) ◽  
pp. 596
Author(s):  
Agnes Schröder ◽  
Joshua Gubernator ◽  
Alexandra Leikam ◽  
Ute Nazet ◽  
Fabian Cieplik ◽  
...  
Keyword(s):  
Bone Density ◽  
Bone Loss ◽  
Bone Metabolism ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Dietary Salt ◽  
Osteoclast Activity ◽  
Salt Uptake ◽  
Periodontal Bone Loss ◽  
The Impact

Dietary salt uptake and inflammation promote sodium accumulation in tissues, thereby modulating cells like macrophages and fibroblasts. Previous studies showed salt effects on periodontal ligament fibroblasts and on bone metabolism by expression of nuclear factor of activated T-cells-5 (NFAT-5). Here, we investigated the impact of salt and NFAT-5 on osteoclast activity and orthodontic tooth movement (OTM). After treatment of osteoclasts without (NS) or with additional salt (HS), we analyzed gene expression and the release of tartrate-resistant acid phosphatase and calcium phosphate resorption. We kept wild-type mice and mice lacking NFAT-5 in myeloid cells either on a low, normal or high salt diet and inserted an elastic band between the first and second molar to induce OTM. We analyzed the expression of genes involved in bone metabolism, periodontal bone loss, OTM and bone density. Osteoclast activity was increased upon HS treatment. HS promoted periodontal bone loss and OTM and was associated with reduced bone density. Deletion of NFAT-5 led to increased osteoclast activity with NS, whereas we detected impaired OTM in mice. Dietary salt uptake seems to accelerate OTM and induce periodontal bone loss due to reduced bone density, which may be attributed to enhanced osteoclast activity. NFAT-5 influences this reaction to HS, as we detected impaired OTM and osteoclast activity upon deletion.

scholarly journals Effects of Vitrification on the Blastocyst Gene Expression Profile in a Porcine Model

2021 ◽  
Vol 22 (3) ◽  
pp. 1222
Author(s):  
Cristina Cuello ◽  
Cristina A. Martinez ◽  
Josep M. Cambra ◽  
Inmaculada Parrilla ◽  
Heriberto Rodriguez-Martinez ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Analysis ◽  
Survival Rates ◽  
Control Group ◽  
P Value ◽  
Transcriptome Profile ◽  
Embryo Viability ◽  
The Impact

This study was designed to investigate the impact of vitrification on the transcriptome profile of blastocysts using a porcine (Sus scrofa) model and a microarray approach. Blastocysts were collected from weaned sows (n = 13). A total of 60 blastocysts were vitrified (treatment group). After warming, vitrified embryos were cultured in vitro for 24 h. Non-vitrified blastocysts (n = 40) were used as controls. After the in vitro culture period, the embryo viability was morphologically assessed. A total of 30 viable embryos per group (three pools of 10 from 4 different donors each) were subjected to gene expression analysis. A fold change cut-off of ±1.5 and a restrictive threshold at p-value < 0.05 were used to distinguish differentially expressed genes (DEGs). The survival rates of vitrified/warmed blastocysts were similar to those of the control (nearly 100%, n.s.). A total of 205 (112 upregulated and 93 downregulated) were identified in the vitrified blastocysts compared to the control group. The vitrification/warming impact was moderate, and it was mainly related to the pathways of cell cycle, cellular senescence, gap junction, and signaling for TFGβ, p53, Fox, and MAPK. In conclusion, vitrification modified the transcriptome of in vivo-derived porcine blastocysts, resulting in minor gene expression changes.

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