scholarly journals Various applications of platelet rich fibrin in dentistry: A literature review

2021 ◽  
Vol 3 (3) ◽  
pp. 99-101
Author(s):  
Prashanti Wahengbam ◽  
Nenavata Ravi ◽  
S Bharathesh ◽  
Dimple Budhiraja ◽  
Neha Nandal ◽  
...  
Keyword(s):  
Growth Factors ◽  
Literature Review ◽  
Human Blood ◽  
Healing Process ◽  
Platelet Concentrate ◽  
Platelet Rich Fibrin ◽  
Bio Material

Platelet rich fibrin is a part of platelet concentrate, that is derived from human blood and made through the process of centrifugation. It is an autogeneous bio material, which basically constitutes various growth factors, and cytokines that are entrapped in its matrix of fibrin. Platelet rich fibrin provides ideal environment for healing of the wound and the regeneration of the tissue. Platelet rich fibrin helps in regulating the inflammation process and increases the healing process.

scholarly journals Technology Regeneration Guided with Fibrin Rica in Platelets in Implantodontia - A Literature Review

2021 ◽  
Vol 17 (34) ◽  
pp. 252
Author(s):  
Linda Gabriele Gomes Cerqueira ◽  
Adriana Vanderlei do Amorim
Keyword(s):  
Literature Review ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Low Cost ◽  
Healing Process ◽  
Guided Tissue Regeneration ◽  
Tissue Loss ◽  
Platelet Rich Fibrin ◽  
Bone Structures ◽  
Short Time

The tissue loss is one of the consequences of damage caused by tooth loss and consequently bone tissue, one of the techniques to minimize or even correct this damage is the use of platelet-rich fibrin-guided tissue regeneration. The use of biomaterials in order to replace bone deficiencies in the regions to be implanted should provide the capacity to regenerate bone tissue, as well as make the new bone structures functional. A bibliographic survey of articles published between 2013 and 2021, articles indexed in the Databases PubMed/MEDLINE, Scielo and Google Scholar, was carried out using the keywords “Fibrin-rich platelets”, "Periodontics", "Connective Tissue" and "Guided Tissue Regeneration". We found 206 articles published in the specified period, after reading the title and abstract, 17 potential articles were identified to be part of the literature review. The technique of using platelet-rich fibrin in dentistry has shown promising results, with low cost, easy execution and accelerated healing process. The limitations of the technique were found the short time to use the material and the small amount obtained after centrifugation.

scholarly journals Platelet-Rich Fibrin as a Biofuel for Tissue Regeneration

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Sujeet Vinayak Khiste ◽  
Ritam Naik Tari
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Clinical Application ◽  
Platelet Rich Plasma ◽  
Healing Process ◽  
Vital Role ◽  
Wound Healing Process ◽  
Platelet Rich Fibrin ◽  
Fibrin Network ◽  
New Material

Wound healing is a staged process which involves the activity of leukocytes and platelets. For this process to work efficiently, the platelets play a vital role. The growth factors present in platelets are important to guide the regenerating cells to the area of healing. Platelet-rich-fibrin (PRF) is one such material that holds on to these growth factors enmeshed in the fibrin network resulting in their sustained release over a period of time that can accelerate the wound healing process. With this knowledge, research has been carried out for a past few years for the clinical application of PRF. Various platelet concentrates have been studied including the platelet-rich-plasma (PRP). However, the short duration of cytokine release and its poor mechanical properties have resulted in the search of a new material with adequate properties for clinical application and ease of preparation. PRF has found a place in the regenerative field owing to its advantages over PRP. This review focuses on the properties and various applications of PRF in the clinical practice.

scholarly journals Platelet Rich Fibrin in Periodontal Regeneration

2016 ◽  
Vol 10 (1) ◽  
pp. 174-181 ◽  
Author(s):  
Muthukumaraswamy Arunachalam ◽  
Shaju J. Pulikkotil ◽  
Nath Sonia
Keyword(s):  
Bacterial Infection ◽  
Second Generation ◽  
Healing Process ◽  
Periodontal Regeneration ◽  
Regenerative Process ◽  
Review Article ◽  
Platelet Concentrate ◽  
Platelet Rich Fibrin ◽  
Supporting Structures ◽  
Chemical Mediators

Periodontitis is a chronic bacterial infection resulting in destruction of the supporting structures of the teeth. Regeneration of the lost tissues has faced difficulties primarily due to the lack of support during the intricate healing processes. A surgical additive which can ‘jump start’ the healing process to a more predictable regenerative process is always on the wish list of any periodontist. Platelet-rich fibrin (PRF) is a second generation platelet concentrate that has been considered to be an important, easy to obtain, predictable surgical additive for periodontal regeneration. This autologous scaffold provides the much needed bio-chemical mediators which has the potential for enhancing reconstruction of the periodontium. This review article tries to understand as to why PRF would be an important link to reach predictable periodontal regeneration.

scholarly journals Platelet-Rich Fibrin and Its Emerging Therapeutic Benefits for Musculoskeletal Injury Treatment

Medicina ◽  
2019 ◽  
Vol 55 (5) ◽  
pp. 141 ◽  
Author(s):  
Alexandru Florian Grecu ◽  
Lucien Reclaru ◽  
Lavinia Cosmina Ardelean ◽  
Oliviu Nica ◽  
Eduard Mihai Ciucă ◽  
...  
Keyword(s):  
Growth Factors ◽  
Cruciate Ligament ◽  
Healing Process ◽  
Maxillofacial Surgery ◽  
Local Concentration ◽  
Muscle Injuries ◽  
Platelet Rich Fibrin ◽  
Therapeutic Benefits

New therapies that accelerate musculoskeletal tissue recovery are highly desirable. Platelet-rich fibrin (PRF) is a leukocyte- and platelet-rich fibrin biomaterial that acts as a binding site for both platelets and growth factors. Through increasing the local concentration of growth factors at specific tissues, PRF promotes tissue regeneration. PRF has been frequently used in combination with bone graft materials to reduce healing times and promote bone regeneration during maxillofacial surgery. However, its benefits during muscle repair and recovery are less well-documented. Here, we perform a narrative review on PRF therapies and muscle injuries to ascertain its beneficial effects. We reviewed the factors that contribute to the biological activity of PRF and the published pre-clinical and clinical evidence to support its emerging use in musculoskeletal therapy. We include in vitro studies, in vivo animal studies and clinical articles highlighting both the success and failures of PRF treatment. PRF can promote the healing process when used in a range of orthopaedic and sports-related injuries. These include cartilage repair, rotator cuff surgery and anterior cruciate ligament surgery. However, conflicting data for these benefits have been reported, most likely due to inconsistencies in both PRF preparation protocols and dosing regimens. Despite this, the literature generally supports the use of PRF as a beneficial adjuvant for a range of chronic muscle, tendon, bone or other soft tissue injuries. Further clinical trials to confirm these benefits require consistency in PRF preparation and the classification of a successful clinical outcome to fully harness its potential.

scholarly journals Skin Grafts Associated with Platelet Rich Plasma and Surgical Sponge - Literature Review

2017 ◽  
Vol 9 (4) ◽  
pp. 51
Author(s):  
Josiane M. Pazzini ◽  
Eduardo L. Serafim ◽  
Ricardo R. A. Uscategui ◽  
Vivian T. Almeida ◽  
Carlos A. C. Oliva ◽  
...  
Keyword(s):  
Growth Factors ◽  
Literature Review ◽  
Platelet Rich Plasma ◽  
Healing Process ◽  
Skin Grafts ◽  
Vascular Pedicle ◽  
Surgical Sponge ◽  
Donor Region ◽  
Tissue Healing ◽  
Surgical Wounds

Skin graft is one of the techniques used to reconstruct surgical wounds. The graft is composed of epidermal and dermal segments that are completely removed from the donor region and transferred to the recipient bed. After its implantation it’s recommended to make compressive dressing in the receiver bed. Since the grafts do not have a vascular pedicle, it’s important to make the compressive dressing to improve graft contact with the wound and allow adequate angiogenesis. The compressive dressing is made with a sponge or foam, which offers adequate protection and reduces the discomfort of the patient in the postoperative period. The use of platelet-rich plasma (PRP) is the objective of several studies associated with the reduction of postoperative surgical complications, especially necrosis. This product is a result of the centrifugation of the patient’s blood that promotes the separation of its constituents and allows the extraction of plasma with higher concentration of platelets. PRP improves the tissue healing process by releasing biological mediators and growth factors at the site of application. Researches on platelet-rich plasma used in reconstructive surgery are important because this product has therapeutic characteristics to promote healing. When it’s used in skin grafts, platelet-rich plasma is able to improve graft integration in the recipient bed, and reduce necrosis after the surgical procedure. The use of postoperative surgical sponges associated with platelet-rich plasma is indicated to improve the healing of the graft and to avoid its displacement of the recipient bed.

Natural, Synthetic and their Combinatorial Nanocarriers Based Drug Delivery System in the Treatment Paradigm for Wound Healing Via Dermal Targeting

2020 ◽  
Vol 26 (36) ◽  
pp. 4551-4568
Author(s):  
Mohammad Kashif Iqubal ◽  
Sadaf Saleem ◽  
Ashif Iqubal ◽  
Aiswarya Chaudhuri ◽  
Faheem Hyder Pottoo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Photodynamic Therapy ◽  
Growth Factors ◽  
Combination Therapy ◽  
Healing Process ◽  
Wound Healing Process ◽  
Wound Site ◽  
Synthetic Drugs ◽  
Treatment Paradigm

A wound refers to the epithelial loss, accompanied by loss of muscle fibers collagen, nerves and bone instigated by surgery, trauma, frictions or by heat. Process of wound healing is a compounded activity of recovering the functional integrity of the damaged tissues. This process is mediated by various cytokines and growth factors usually liberated at the wound site. A plethora of herbal and synthetic drugs, as well as photodynamic therapy, is available to facilitate the process of wound healing. Generally, the systems used for the management of wounds tend to act through covering the ruptured site, reduce pain, inflammation, and prevent the invasion and growth of microorganisms. The available systems are, though, enough to meet these requirements, but the involvement of nanotechnology can ameliorate the performance of these protective coverings. In recent years, nano-based formulations have gained immense popularity among researchers for the wound healing process due to the enhanced benefits they offer over the conventional preparations. Hereupon, this review aims to cover the entire roadmap of wound healing, beginning from the molecular factors involved in the process, the various synthetic and herbal agents, and combination therapy available for the treatment and the current nano-based systems available for delivery through the topical route for wound healing.

scholarly journals Multi-Functional Core-Shell Nanofibers for Wound Healing

Nanomaterials ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1546
Author(s):  
Zhen Li ◽  
Shunqi Mei ◽  
Yajie Dong ◽  
Fenghua She ◽  
Puwang Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Drug Release ◽  
Release Rate ◽  
Healing Process ◽  
Wound Healing Process ◽  
Core Shell ◽  
High Production Rate ◽  
Centrifugal Spinning ◽  
Multiple Drugs

Core-shell nanofibers have great potential for bio-medical applications such as wound healing dressings where multiple drugs and growth factors are expected to be delivered at different healing phases. Compared to monoaxial nanofibers, core-shell nanofibers can control the drug release profile easier, providing sustainable and effective drugs and growth factors for wound healing. However, it is challenging to produce core-shell structured nanofibers with a high production rate at low energy consumption. Co-axial centrifugal spinning is an alternative method to address the above limitations to produce core-shell nanofibers effectively. In this study, a co-axial centrifugal spinning device was designed and assembled to produce core-shell nanofibers for controlling the release rate of ibuprofen and hEGF in inflammation and proliferation phases during the wound healing process. Core-shell structured nanofibers were confirmed by TEM. This work demonstrated that the co-axial centrifugal spinning is a high productivity process that can produce materials with a 3D environment mimicking natural tissue scaffold, and the specific drug can be loaded into different layers to control the drug release rate to improve the drug efficiency and promote wound healing.

scholarly journals The Role of the Extracellular Matrix Components in Cutaneous Wound Healing

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Pawel Olczyk ◽  
Łukasz Mencner ◽  
Katarzyna Komosinska-Vassev
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Growth Factors ◽  
Wound Repair ◽  
Structural Integrity ◽  
Healing Process ◽  
Cellular Functions ◽  
Extracellular Matrix Components ◽  
Essential Components ◽  
Matrix Components

Wound healing is the physiologic response to tissue trauma proceeding as a complex pathway of biochemical reactions and cellular events, secreted growth factors, and cytokines. Extracellular matrix constituents are essential components of the wound repair phenomenon. Firstly, they create a provisional matrix, providing a structural integrity of matrix during each stage of healing process. Secondly, matrix molecules regulate cellular functions, mediate the cell-cell and cell-matrix interactions, and serve as a reservoir and modulator of cytokines and growth factors’ action. Currently known mechanisms, by which extracellular matrix components modulate each stage of the process of soft tissue remodeling after injury, have been discussed.

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