scholarly journals Recent development in applications of nano-science in incurable diseases: A review

2021 ◽  
Vol 9 (1) ◽  
pp. 15-23
Author(s):  
Mohammed Favas M ◽  
Ahammad Rashid VK ◽  
Abdul Vajid K ◽  
Mohamed Saheer K
Keyword(s):  
Drug Delivery ◽  
Maximum Amount ◽  
Nano Materials ◽  
Therapeutic Concentration ◽  
Medical Aid ◽  
Causes Of Mortality ◽  
Nano Science ◽  
Protozoal Infection

Cancer is one amongst the key causes of mortality worldwide and advanced techniques for medical aid are desperately required. Hence, the most aim of this review is to supply info regarding the engineering in cancer medical aid. The development of novel nano materials and nanocarriers has allowed a serious drive to boost drug delivery in cancer. The major aim of most nanocarrier application has been to safeguard the drug from speedy degradation when general delivery and permitting it to achieve tumour at therapeutic concentration and avoiding drug delivery to traditional site the maximum amount as attainable to scale back ADRs. Nanotechnology is additionally employed in several incurable diseases like HIV, protozoal infection and Alzheimer apart from cancer. Hence, during this review we tend to target many nanotechnologies and improved ways in nanocarrier style for the cancer in addition as many incurable unwellness therapies.

Chitosan-Based Hydrogel Nanoparticles for Cancer Therapy

2017 ◽  
Vol 7 (04) ◽  
Author(s):  
Azadi A. ◽  
Khazaei M. ◽  
Ashrafi H.
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Recent Decade ◽  
Reticuloendothelial System ◽  
Malignant Neoplasms ◽  
Mortality And Morbidity ◽  
Hydrogel Nanoparticles ◽  
Tissue Invasion ◽  
Causes Of Mortality ◽  
Nanoparticulate Systems

Cancer, an uncontrollable growth of cells, is among the leading causes of mortality and morbidity throughout the world. Malignant neoplasms are difficult to treat diseases because of their single in kind characteristics such as tissue invasion, metastasis, evading reticuloendothelial system (RES) and so forth. In recent decade polymeric nanoparticulate systems has gained special attention in drug delivery and targeting among all biocompatible nanoforms. Among these systems, chitosan-based hydrogel nanoparticles have been wildly utilized for drug delivery purposes. The usage of chitosan nanogels in cancer therapy significantly improved in recent years. The various cancers were the target of chitosan nanogels. Also, modification of other delivery systems with chitosan were much reported. The aim of this study is the review and update of the recent studies on chitosan nanogels applications in cancer therapy by focus on cancer based classification.

Emerging areas of Nano and Smart Materials

2016 ◽  
Vol 66 (4) ◽  
pp. 289 ◽  
Author(s):  
Partha Ghosal
Keyword(s):  
Smart Materials ◽  
Science And Technology ◽  
Simple Extension ◽  
Nano Materials ◽  
International Level ◽  
The Past ◽  
The World ◽  
Nano Science

‘There’s plenty of room at the bottom’ – In 1959, one of the most brilliant physicists the world has ever seen, Richard P. Feynmann, gave us a beautiful introduction to nano-science. Today, after almost seven decades, nano-materials and related technologies are not just a simple extension of regular research and miniaturisation of materials, but have become the prime driver of advancement in science and technology all over the world. Over the past few decades, new societal requirement haveemerged atthe national and international level.

scholarly journals Cation-responsive and photocleavable hydrogels from non-canonical amphiphilic DNA nanostructures

2021 ◽  
Author(s):  
Giacomo Fabrini ◽  
Aisling Minard ◽  
Ryan A. Brady ◽  
Marco Di Antonio ◽  
Lorenzo Di Michele
Keyword(s):  
Drug Delivery ◽  
Nano Materials ◽  
Dna Nanostructures ◽  
Stimuli Responsive ◽  
Promising Candidate ◽  
One Pot ◽  
Hydrogel Particles ◽  
G Quadruplex ◽  
And Control

Thanks to its biocompatibility, versatility and programmable interactions, DNA has been proposed as a building block for functional, stimuli-responsive frameworks with applications in biosensing, tissue engineering and drug delivery. Of particular importance for in vivo applications is the possibility of making such nano-materials responsive to physiological stimuli. Here we demonstrate how combining noncanonical DNA G-quadruplex (G4) structures with amphiphilic DNA constructs yields nanostructures, which we termed "Quad-Stars", capable of assembling into responsive hydrogel particles via a straightforward, enzyme-free, one-pot reaction. The embedded G4 structures allow one to trigger and control the assembly/disassembly in a reversible fashion by adding or removing K+ ions. Furthermore, the hydrogel aggregates can be photodisassembled upon near-UV irradiation in the presence of a porphyrin photosensitiser. The combined reversibility of assembly, responsiveness and cargo-loading capabilities of the hydrophobic moieties make Quad-Stars a promising candidate for biosensors and responsive drug delivery carriers.

scholarly journals Development and Characterization of Eucalyptus Oil Loaded Poly Lactic Co-Glycolic Acid - Albumin Nanocapsules

2021 ◽  
Vol 68 (1) ◽  
Author(s):  
C.Sadak Vali ◽  
Abdullah Khan ◽  
M. Prathibha Bharathi ◽  
S. Siva Prasad ◽  
A. Srikanth
Keyword(s):  
Drug Delivery ◽  
Essential Oils ◽  
Bacterial Infections ◽  
Fungal Infections ◽  
Protein Complexes ◽  
Uv Spectroscopy ◽  
Drug Carrier ◽  
Nano Materials ◽  
Medical Problems ◽  
Eucalyptus Oil

Nano materials such as nanoparticles, nano capsules, nano emulsions, nano suspensions, nano spheres, solid lipid nanoparticles, dendrimers, nano tubes, nano shells, nano wires, nano pores, and quantum dots have been used extensively for delivery of therapeutic agents. Protein nanocapsules have gained significance as vehicles for targeted drug delivery due to improved ease of administration, medical imaging, gene delivery, and increased half-life of drug. Nano materials and devices are used for addressing medical problems and have established enormous potential for, subcutaneous imaging without surgical incisions. They are used in imaging of liver, lymph nodes, bone marrow, monitoring of many serious illnesses, including cancer, CVS disorders, neurological disorders, HIV/AIDS, and diabetes. They are employed as solubilizing agent for water-insoluble drugs by emulsification and designing of essential oil protein complexes which paved the path for using nano materials in drug delivery with prolonged blood circulation times. PLGA and albumin nanoparticles are considered to be a potential drug carrier with good biodegradability, biocompatibility, and non toxic nature. Eucalyptus oil contains 1,8-Cineol and ?-pinene as chief ingredients. Eucalyptus oil is known for healing of inflammation, pruritus, abscesses, sepsis, bacterial infections, blisters, boils, chicken pox, congestion, fungal infections, herpes (cold sores) and ulcers. However, these essential oils are unstable, volatile, which limits their use for new formulations. Therefore, this study focuses on developing a PLGA- Albumin nano carrier for the encapsulation of essential oils. The effects of process parameters such as the effect of heat and the concentrations of polymers were investigated. Various physicochemical characterizations such as SEM, FTIR, EE, and UV spectroscopy, Invitro drug release studies were performed.2 Formulation F4 containing 0.6 mg/ mL of PLGA and AL loaded eucalyptus loaded nanocapsules p

Applications of Micro/Nanotechnology in Ultrasound-Based Drug Delivery and Therapy for Tumors

2020 ◽  
Vol 27 ◽  
Author(s):  
Suhui Sun ◽  
Ping Wang ◽  
Sujuan Sun ◽  
Xiaolong Liang
Keyword(s):  
Drug Delivery ◽  
Focused Ultrasound ◽  
Tumor Therapy ◽  
High Intensity Focused Ultrasound ◽  
Nano Materials ◽  
Invasive Treatment ◽  
Sonodynamic Therapy ◽  
Non Invasive ◽  
Recent Developments

: Ultrasound has been broadly used in biomedicine for both tumor diagnosis as well as therapy. The applications of recent developments in micro/nanotechnology promote the development of ultrasound-based biomedicine, especially in the field of ultrasound-based drug delivery and tumor therapy. Ultrasound can activate nano-sized drug delivery systems by different mechanisms for ultrasound-triggered on-demand drug release targeted only at the tumor. Ultrasound targeted microbubble destruction (UTMD) technology can not only increase the permeability of vasculature and cell membrane via sonoporation effect but also achieve in situ conversion of microbubbles into nanoparticles to promote cellular uptake and therapeutic efficacy. Furthermore, high intensity focused ultrasound (HIFU), or sonodynamic therapy (SDT), is considered to be one of the most promising and representative non-invasive treatment for cancer. However, their application in the treatment process is still limited due to their critical treatment efficiency issues. Fortunately, recently developed micro/nanotechnology offer an opportunity to solve these problems, thus improving the therapeutic effect of cancer. This review summarizes and discusses the recent developments in the design of micro- and nano- materials for ultrasound-based biomedicine applications.

Ionic Liquid-Based Nano-Materials for Drug Delivery

2019 ◽  
pp. 1-5 ◽  
Author(s):  
Zeanat Zara ◽  
Saurabh K. Pandey ◽  
Babak Minofar
Keyword(s):  
Drug Delivery ◽  
Ionic Liquid ◽  
Nano Materials

Biomembrane-Active Molecular Switches as Tools for Intracellular Drug Delivery

2005 ◽  
Vol 58 (6) ◽  
pp. 411 ◽  
Author(s):  
Volga Bulmus
Keyword(s):  
Drug Delivery ◽  
Vaccine Development ◽  
Molecular Switches ◽  
Synthetic Polymers ◽  
Ph Responsive ◽  
Cellular Membranes ◽  
Therapeutic Concentration ◽  
Transport Barrier ◽  
Intracellular Drug Delivery ◽  
Biological Organisms

Many therapeutic strategies, such as gene therapy and vaccine development require the delivery of polar macromolecules (e.g. DNA, RNA, and proteins) to intracellular sites at a therapeutic concentration. For such macromolecular therapeutics, cellular membranes constitute a major transport barrier that must be overcome before these drugs can exert their biological activity inside cells. A number of biological organisms, e.g. viruses and toxins, efficiently destabilize the cellular membranes upon a trigger, such as low pH, and facilitate the delivery of their biological cargo to the cytoplasm of host cell. pH-responsive synthetic peptides and polymers have been designed to mimic the function of membrane-destabilizing natural organisms and evaluated as a part of drug delivery systems. In this Review, pH-dependent membrane activity of natural and synthetic systems is reviewed, focussing on fundamental and practical aspects of pH-responsive, membrane-disruptive synthetic polymers in intracellular drug delivery.

scholarly journals To Study the causes of Industrial Sickness in Nanded District (Maharashtra)

2017 ◽  
Vol 4 (37) ◽  
Author(s):  
Balaji S. Mudholkar
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Recent Decade ◽  
Reticuloendothelial System ◽  
Malignant Neoplasms ◽  
Mortality And Morbidity ◽  
Tissue Invasion ◽  
The World ◽  
Causes Of Mortality ◽  
Nanoparticulate Systems

Cancer, an uncontrollable growth of cells, is among the leading causes of mortality and morbidity throughout the world. Malignant neoplasms are difficult to treat diseases because of their single in kind characteristics such as tissue invasion, metastasis, evading reticuloendothelial system (RES) and so forth. In recent decade polymeric nanoparticulate systems has gained special attention in drug delivery and targeting among all biocompatible nanoforms. Among these systems, chitosan-based hydrogel nanoparticles have been wildly utilized for drug delivery purposes. The usage of chitosan nanogels in cancer therapy significantly improved in recent years. The various cancers were the target of chitosan nanogels. Also, modification of other delivery systems with chitosan were much reported. The aim of this study is the review and update of the recent studies on chitosan nanogels applications in cancer therapy by focus on cancer based classification.

scholarly journals Forgotten coindex of some non-toxic dendrimers structure used in targeted drug delivery

2020 ◽  
Vol 44 (1) ◽  
pp. 22-31
Author(s):  
Yasir Ali ◽  
Zainab Bibi ◽  
Quanita Kiran
Keyword(s):  
Drug Delivery ◽  
Network Theory ◽  
New Technologies ◽  
Chemical Properties ◽  
Topological Descriptors ◽  
Nano Materials ◽  
Dynamic Therapy ◽  
Conventional Drug ◽  
Great Attraction ◽  
Photo Dynamic Therapy

Abstract In recent past, porphyrin-based dendrimers have gained great attraction due to their usefulness in nano devices and photo-dynamic therapy. New technologies based upon nano-materials or dendrimers have potential to overcome the problems due to conventional drug delivery, like toxicity, poor solubility and poor release pattern of drugs. The chemical and physical properties of these highly branched nanometer sized dendrimers depend on their structure. In chemical network theory, various topological indices are used to predict chemical properties of molecules(dendrimers). Among many useful topological descriptors forgotten coindex is relatively less explored but is found very useful in material engineering, pharmaceutical and chemical industries. In this article, we consider some special dendrimers, like poly(propyl) ether imine, porphyrin, and zinc-porphyrin, and nanostars like D 1[k] and D 2[k] and compute forgotten coindex for these important structures.

Graphene Family of Nanomaterials: Reviewing Advanced Applications in Drug delivery and Medicine

2019 ◽  
Vol 16 (3) ◽  
pp. 195-214 ◽  
Author(s):  
Kumud Joshi ◽  
Bhaskar Mazumder ◽  
Pronobesh Chattopadhyay ◽  
Nilutpal Sharma Bora ◽  
Danswrang Goyary ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Single Atom ◽  
Nano Materials ◽  
Cancer Gene ◽  
Physical Strength ◽  
Potential Applications ◽  
Targeted Drug ◽  
Safety And Toxicity ◽  
Advanced Applications

Graphene in nano form has proven to be one of the most remarkable materials. It has a single atom thick molecular structure and it possesses exceptional physical strength, electrical and electronic properties. Applications of the Graphene Family of Nanomaterials (GFNs) in different fields of therapy have emerged, including for targeted drug delivery in cancer, gene delivery, antimicrobial therapy, tissue engineering and more recently in more diseases including HIV. This review seeks to analyze current advances of potential applications of graphene and its family of nano-materials for drug delivery and other major biomedical purposes. Moreover, safety and toxicity are the major roadblocks preventing the use of GFNs in therapeutics. This review intends to analyze the safety and biocompatibility of GFNs along with the discussion on the latest techniques developed for toxicity reduction and biocompatibility enhancement of GFNs. This review seeks to evaluate how GFNs in future will serve as biocompatible and useful biomaterials in therapeutics.

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