scholarly journals Zooplankton and their protective effects on cardiovascular diseases

2019 ◽  
Vol 6 (1) ◽  
Author(s):  
B Ozaltun ◽  
Z Selamoglu
Keyword(s):  
Cardiovascular Diseases ◽  
Protective Effects

Resveratrol and cardiac fibrosis prevention and treatment

2021 ◽  
Vol 22 ◽  
Author(s):  
Parinaz Zivarpour ◽  
Željko Reiner ◽  
Jamal Hallajzadeh ◽  
Liaosadat Mirsafaei
Keyword(s):  
Cardiovascular Diseases ◽  
Cardiac Fibrosis ◽  
Therapeutic Potential ◽  
Developed Countries ◽  
Clinical Results ◽  
Matrix Proteins ◽  
Protective Effects ◽  
Beneficial Effects ◽  
Laboratory Models

: Cardiovascular diseases are some of the major causes of morbidity and mortality in developed or developing countries but in developed countries as well. Cardiac fibrosis is one of the most often pathological changes of heart tissues. It occurs as a result of extracellular matrix proteins accumulation at myocardia. Cardiac fibrosis results in impaired cardiac systolic and diastolic functions and is associated with other effects. Therapies with medicines have not been sufficiently successful in treating chronic diseases such as CVD. Therefore, the interest for therapeutic potential of natural compounds and medicinal plants has increased. Plants such as grapes, berries and peanuts contain a polyphenolic compound called "resveratrol" which has been reported to have various therapeutic properties for a variety of diseases. Studies on laboratory models that show that resveratrol has beneficial effects on cardiovascular diseases including myocardial infarction, high blood pressure cardiomyopathy, thrombosis, cardiac fibrosis, and atherosclerosis. In vitro animal models using resveratrol indicated protective effects on the heart by neutralizing reactive oxygen species, preventing inflammation, increasing neoangiogenesis, dilating blood vessels, suppressing apoptosis and delaying atherosclerosis. In this review, we are presenting experimental and clinical results of studies concerning resveratrol effects on cardiac fibrosis as a CVD outcome in humans.

scholarly journals Estrogen Receptor and Vascular Aging

2021 ◽  
Vol 2 ◽  
Author(s):  
Morgane Davezac ◽  
Melissa Buscato ◽  
Rana Zahreddine ◽  
Patrick Lacolley ◽  
Daniel Henrion ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Cardiovascular Diseases ◽  
Experimental Studies ◽  
Hormonal Treatment ◽  
Protective Effects ◽  
Age Related ◽  
Nuclear Receptor Family ◽  
The Impact ◽  
Receptor Family

Cardiovascular diseases remain an age-related pathology in both men and women. These pathologies are 3-fold more frequent in men than in women before menopause, although this difference progressively decreases after menopause. The vasculoprotective role of estrogens are well established before menopause, but the consequences of their abrupt decline on the cardiovascular risk at menopause remain debated. In this review, we will attempt to summarize the main clinical and experimental studies reporting the protective effects of estrogens against cardiovascular diseases, with a particular focus on atherosclerosis, and the impact of aging and estrogen deprivation on their endothelial actions. The arterial actions of estrogens, but also part of that of androgens through their aromatization into estrogens, are mediated by the estrogen receptor (ER)α and ERβ. ERs belong to the nuclear receptor family and act by transcriptional regulation in the nucleus, but also exert non-genomic/extranuclear actions. Beside the decline of estrogens at menopause, abnormalities in the expression and/or function of ERs in the tissues, and particularly in arteries, could contribute to the failure of classic estrogens to protect arteries during aging. Finally, we will discuss how recent insights in the mechanisms of action of ERα could contribute to optimize the hormonal treatment of the menopause.

Anthocyanins from red cabbage extract — evidence of protective effects on blood platelets

2012 ◽  
Vol 7 (4) ◽  
pp. 655-663 ◽  
Author(s):  
Joanna Saluk ◽  
Michał Bijak ◽  
Joanna Kołodziejczyk-Czepas ◽  
Małgorzata Posmyk ◽  
Krystyna Janas ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Platelet Activation ◽  
Blood Platelets ◽  
Protective Effects ◽  
Platelet Activity ◽  
Red Cabbage ◽  
Arachidonate Cascade ◽  
Wide Range ◽  
Antioxidative Effects

AbstractRed cabbage belongs to cruciferous vegetables recognized as a rich source of anthocyanins. Anthocyanins have a wide range of therapeutic advantages without adverse effects, including cardiovascular protective properties. For development of cardiovascular diseases, platelet activation is crucial; therefore compounds which inhibit platelet activation are sought after. The anti-platelet activity of anthocyanins has only been described and is still unclear. In our study, the extract of anthocyanins, obtained from fresh leaves of red cabbage, was used in vitro to examine their antioxidative effects on platelets under oxidative stress conditions which are responsible for hyperactivity of these cells. The antiplatelet and antioxidative activities were determined by platelet aggregation and specific markers of the arachidonate cascade with O2−· generation, and oxidative changes (carbonyl groups and 3-nitrotyrosine). Extracts (5–15 μM) protected platelet proteins and lipids against oxidative damage, and diminished platelet activation. Anthocyanins from red cabbage provided beneficial anti-platelet effects and might help prevent cardiovascular diseases.

scholarly journals The Effects of Guizhi Gancao Decoction on Pressure Overload-Induced Heart Failure and Posttranslational Modifications of Tubulin in Mice

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Hui-hua Chen ◽  
Pei Zhao ◽  
Jing Tian ◽  
Wei Guo ◽  
Ming Xu ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiovascular Diseases ◽  
Posttranslational Modifications ◽  
Volume Fraction ◽  
Pressure Overload ◽  
Therapeutic Effects ◽  
Protective Effects ◽  
Immunofluorescent Analysis ◽  
Traditional Chinese Medical ◽  
Hemodynamic Measurements

Guizhi Gancao Decoction (GGD), a traditional Chinese medical recipe, has been widely used in the treatment of cardiovascular diseases in China for centuries. The present study was carried out to determine whether GGD exerts direct protective effects against pressure overload-induced heart failure. Moreover, we investigated whether GGD affects tubulin expression and posttranslational modifications. We demonstrated that GGD ameliorated TAC caused cardiac hypertrophy by gravimetric and echocardiography analysis in C57BL/6 mice. We found that GGD abrogated TAC-induced myocardium fibrosis by Masson’s staining and collagen volume fraction (CVF) analysis. By using pressure-volume hemodynamic measurements, we found that GGD prevented TAC-induced cardiac systolic and diastolic dysfunction. Immunoblotting and immunofluorescent analysis revealed that GGD abrogated TAC-induced detyrosination and acetylation abnormalities on microtubules. Our present study demonstrated potential therapeutic effects of GGD against pressure overload-induced heart failure.

scholarly journals Mechanisms of protective effects of moderate alcohol consumption on the cardiovascular system

2004 ◽  
Vol 132 (9-10) ◽  
pp. 334-339
Author(s):  
Branko Jakovljevic ◽  
Katarina Paunovic ◽  
Goran Belojevic ◽  
Vesna Stojanov
Keyword(s):  
Cardiovascular Diseases ◽  
Alcohol Consumption ◽  
Molecular Mechanisms ◽  
Blood Clot ◽  
Alcoholic Beverage ◽  
Significant Risk ◽  
Population Level ◽  
Epidemiological Studies ◽  
Alcoholic Beverages ◽  
Protective Effects

Consumption of alcoholic beverages has been known in many cultures since the ancient civilizations, so harmful consequences of excessive alcohol intake have been well explained. Many epidemiological studies confirmed lower morbidity and mortality rates of cardiovascular diseases in persons who drink alcohol "moderately" (1-2 drinks a day), independently of the kind of alcoholic beverage. This paper presents the review of molecular mechanisms that are believed to explain cardioprotective effect of moderate drinking-alcohol effects on lipoproteins, endothelial cells, blood clot formation and dissolution, as well as genetic and gender variances modifying the relation. A simple recommendation regarding the increase of alcohol consumption cannot be made on population level. The professionals must therefore concentrate on other preventive methods in order to reduce other significant risk factors of cardiovascular diseases.

Protective Effects of Pomegranate in Endothelial Dysfunction

2020 ◽  
Vol 26 (30) ◽  
pp. 3684-3699 ◽  
Author(s):  
Nathalie T.B. Delgado ◽  
Wender N. Rouver ◽  
Roger L. dos Santos
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Diseases ◽  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Common Factor ◽  
Blood Lipid ◽  
Punica Granatum ◽  
Protective Effects ◽  
Beneficial Effects ◽  
Anti Inflammatory

Background: Punica granatum L. is an infructescence native of occidental Asia and Mediterranean Europe, popularly referred to as pomegranate. It has been used in ethnomedicine for several applications, including the treatment of obesity, inflammation, diabetes, and the regulation of blood lipid parameters. Thus, pomegranate has been linked to the treatment of cardiovascular diseases that have endothelial dysfunction as a common factor acting mainly against oxidative stress due to its high polyphenol content. Its biocomponents have antihypertensive, antiatherogenic, antihyperglycemic, and anti-inflammatory properties, which promote cardiovascular protection through the improvement of endothelial function. Methods: Different electronic databases were searched in a non-systematic way to uncover the literature of interest. Conclusion: This review article presents updated information on the role of pomegranate in the context of endothelial dysfunction and cardiovascular diseases. We have shown that pomegranate, or rather its components (e.g., tannins, flavonoids, phytoestrogens, anthocyanins, alkaloids, etc.), have beneficial effects on the cardiovascular system, improving parameters such as oxidative stress and the enzymatic antioxidant system, reducing reactive oxygen species formation and acting in an anti-inflammatory way. Thus, this review may contribute to a better understanding of pomegranate's beneficial actions on endothelial function and possibly to the development of strategies associated with conventional treatments of cardiovascular diseases.

Potential protective effects of Aloe vera gel on cardiovascular diseases: A mini‐review

2021 ◽  
Author(s):  
Saeideh Sabbaghzadegan ◽  
Haide Golsorkhi ◽  
Mohammad Hossein Soltani ◽  
Mohammad Kamalinejad ◽  
Mohsen Bahrami ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Aloe Vera ◽  
Protective Effects ◽  
Aloe Vera Gel

scholarly journals Effects of strength training on blood lipoprotein concentrations in postmenopausal women

2014 ◽  
Vol 13 (4) ◽  
pp. 312-317
Author(s):  
Cleiton Silva Correa ◽  
Bruno Costa Teixeira ◽  
Aline Bittencourt ◽  
Álvaro Reischak-Oliveira
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Diseases ◽  
Strength Training ◽  
Postmenopausal Women ◽  
Pharmacological Treatment ◽  
Metabolic Disorders ◽  
Lipoprotein Metabolism ◽  
Protective Effects ◽  
Large Numbers ◽  
The Subject

Strength training is often identified as a contributing factor in prevention of diseases and as a non-pharmacological treatment for metabolic disorders and for control of body mass. Its protective effects and utility for management of disease are amplified in people at risk of diabetes mellitus and dyslipidemias, and cardiovascular diseases (CVD). Recently the benefits of strength training have been used to reduce the risk of these diseases emerging in postmenopausal women, who are at greater risk of CVD than men of the same age. Notwithstanding, little is known about the effects of strength training on metabolism of blood lipoproteins. The objective of this review was to compare the results of articles that have investigated the effects on lipoprotein concentrations of strength training in postmenopausal women. Current articles dealing with the subject, with publication dates from 1979 to 2012 and large numbers of citations by well-known researchers were identified on the Pubmed, Scopus and EBSCO databases. It was concluded that strength training possibly has an action that affects lipoprotein metabolism and concentrations in postmenopausal women.

scholarly journals Protective Effects of Dietary Polyphenols on Arterial Stiffness

Proceedings ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 40
Author(s):  
Nina Hermans ◽  
Bieke Steenput ◽  
Lynn Roth ◽  
Guido De Meyer ◽  
Claudia Nunes dos Santos ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Arterial Stiffness ◽  
Protective Effects ◽  
Dietary Polyphenols ◽  
The Eu

Cardiovascular diseases are the major cause of mortality, with 17.9 million deaths/year worldwide and 3.9 million deaths/year in Europe, representing a cost to the EU economy of €210 billion/year [1,2]. [...]

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