scholarly journals To Study the Effect of Age, Total Cholesterol and High Density Lipoproteins in Psoriasis Subjects

2019 ◽  
Vol 7 (6) ◽  
Author(s):  
Dr Amitabh Agarwal ◽  
Keyword(s):  
Total Cholesterol ◽  
High Density ◽  
High Density Lipoproteins ◽  
Effect Of Age

scholarly journals Blood lipids in athletes depending on the orientation of the training process

2017 ◽  
Vol 8 (2) ◽  
pp. 10-14 ◽  
Author(s):  
Vladimir S Vasilenko ◽  
Evgeniya S Semenova ◽  
Yuliya B Semenova
Keyword(s):  
Total Cholesterol ◽  
Blood Lipids ◽  
Metabolic Response ◽  
High Density ◽  
High Density Lipoproteins ◽  
Control Group ◽  
Complex Nature ◽  
Training Process ◽  
Sports Activity ◽  
Men And Women

Sports form the metabolic response caused by the body’s adaptation to increased physical stress, which leads to the restructuring of metabolism for energy and plastic maintenance of sport activities. The restructuring of carbohydrate and lipid metabolism is caused primarily by the increasing energy request body, depending on type and intensity of sports activity. In this research blood serum lipids were studied depending on the orientation of the training process. A total of 108 athletes (men and women) aged 15 to 20 years of different sports qualification (I sports category, Candidate Master of Sports and Master of Sports) were examined, and a control group of 28 persons of the same age and gender. Depending of the direction of the training process there were isolated 3 groups: cyclical sport that develops mainly endurance (academic rowing); sports of complex nature (football, volleyball, handball and Nordic combined); and complex coordinated sports (artistic gymnastics). Were studied: total cholesterol, high density lipoproteins, low-density lipoproteins, atherogenic coefficient and triglycerides. The study was conducted in the preparatory period of the training cycle. The research had shown that the level of blood lipids depends on the orientation of training process and sports training. The most marked reduction of total cholesterol and high-density lipoproteins has been observed both in men and women in cyclic kinds of sports, developing mainly stamina that indicates that intense exercise in athletes who train primarily for endurance, cause the connection of lipids to the processes of energy supply of muscle activity.

scholarly journals Effects of non-surgical periodontal treatment on complete blood count, lipid and glycemic profiles of patients with an indication for surgical coronary revascularization.

2017 ◽  
Vol 74 (3) ◽  
pp. 203
Author(s):  
Sérgio Kahn ◽  
Roberta Carpes Imperial ◽  
Claudia Callegaro de Menezes ◽  
Alexandra Tavares Dias ◽  
Walmir Júnio de Pinho Reis Rodrigues ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Blood Count ◽  
Complete Blood Count ◽  
Density Lipoprotein ◽  
Test Group ◽  
High Density ◽  
Periodontal Treatment ◽  
High Density Lipoproteins ◽  
Probing Depth ◽  
Significant Difference

Objective: the aim of this study was to assess the effects of non-surgical periodontal treatment on the complete blood count, glycemic and lipid profiles in cardiopathic patients with indication for surgical revascularization. Material and Methods: this study evaluated 22 patients with chronic periodontitis, over 35 years of age (mean age 59.45 years) randomly assigned to 2 groups. The test group (n=11) received periodontal treatment before the surgical procedure and the control group (n=11) did not receive periodontal treatment prior to surgery. Results: periodontal treatment resulted in a significant reduction in probing depth in sites with periodontal probing depth >3 mm (reduction of 11.4%) and >5 mm (reduction of 6.3%) (P<0.05). The differences in clinical attachment level were not statistically significant between the groups (P>0.05). The values regarding to leukocyte count, glucose, hemocyte and hemoglobin did not differ significantly between groups (P>0.05). Total cholesterol and high density lipoprotein presented a statistically significant reduction in the test group (P<0.05). Light density lipoprotein showed no statistically significant difference between groups (P>0.05). Conclusion: non-surgical periodontal treatment was effective for controlling periodontal disease and diminished serum levels of total cholesterol and high density lipoproteins. The other blood components presented no significant alterations.

Abstract 106: Corticosteroid Treatment Induces Structural and Functional Changes in High-Density Lipoproteins

2012 ◽  
Vol 32 (suppl_1) ◽  
Author(s):  
Yeliz Cakan ◽  
Fatiha Tabet ◽  
Edmund Lau ◽  
David S Celermajer ◽  
Philip J Barter ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
High Density ◽  
Post Treatment ◽  
High Density Lipoproteins ◽  
High Dose ◽  
Functional Changes ◽  
Prednisone Treatment ◽  
Anti Inflammatory ◽  
Tract Infections ◽  
Lipoprotein Profiles

Rationale: We have previously shown that high-density lipoproteins (HDL) have potent anti-inflammatory properties. HDL levels are decreased in most inflammatory diseases. Corticosteroid therapy modifies lipoproteins profiles in subjects with chronic obstructive pulmonary disease (COPD) but results from these studies are inconsistent. Here, we hypothesize that in COPD subjects, prednisone treatment induces beneficial structural and functional changes in HDL thus improving HDL anti-inflammatory properties. Objectives: To elucidate the effect of prednisone on (i) HDL size, composition and subpopulation distribution (ii) the lipid and lipoprotein profiles of subjects with COPD and (iii) HDL anti-inflammatory properties. Methods: We recruited COPD subjects (n=11) treated with prednisone and people treated with antibiotics (n=6) for lower respiratory tract infections (control). Blood samples were collected on days 1, 5 of prednisone treatment and 6 weeks post-treatment. The treatment started with a high-dose (>50 mg) and was reduced over a 5-7 day treatment period. We used gel-filtration chromatography to analyse plasma lipoprotein profiles. ApoA-I, apoA-II, apoB levels were determined immunoturbidometrically; total cholesterol, HDL-C, triglyceride and phospholipid concentrations were determined colorimetrically; and size distribution and surface charge of HDL were determined by 2-D gel electrophoresis. HDL was isolated from plasma and incubated for 16h on human endothelial cells (final protein concentration 1 mg/ml). Cells were further stimulated for 5h with TNF-α (0.2 ng/ml). Adhesion molecule expression (ICAM-1 and VCAM-1) was assessed by flow cytometry. Results: Plasma from prednisone treated subjects showed increased apoA-I (36%), apo-B (51%), total cholesterol (13%) and phospholipid (37%) levels and decreased plasma triglycerides (41%) relative to 6 weeks post-treatment. HDL-C levels were higher in subjects that received high-dose prednisone (0.94±0.21 mmol/L) compared to 6 weeks post-treatment (0.65±0.06 mmol/L) and antibiotic-treated subjects (0.43±0.17 mmol/L). HDL diameter in prednisone treated subjects increased from 7.9 nm to 10 nm. HDL from prednisone-treated subjects suppressed ICAM-1 (70%) and VCAM-1 (65%) protein expression more effectively than the HDL from 6-weeks post-treatment (25% and 12% respectively) or the HDL from the antibiotics-treated subjects (36% and 24% respectively) (p<0.05 for all). Conclusions: In this study, we have shown the evidence that high-dose, short-term prednisone treatment increases HDL levels and improves their anti-inflammatory properties.

scholarly journals EFFECTS OF GROSSHEMIN AND GROSSMISIN ON THE ACUTE HYPERLIPIDEMIA MODEL INDUCED BY ETHANOL

2014 ◽  
Vol 13 (1) ◽  
pp. 67-72 ◽  
Author(s):  
A. V. Ratkin ◽  
O. A. Kaidash ◽  
V. V. Ivanov ◽  
A. I. Vengerovsky ◽  
S. M. Adekenov ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Nicotinic Acid ◽  
Blood Serum ◽  
Free Fatty Acids ◽  
Total Cholesterol ◽  
Sesquiterpene Lactones ◽  
Low Density Lipoproteins ◽  
High Density ◽  
High Density Lipoproteins ◽  
Low Density

Objective: study sesquiterpene lactones grosshemin and grossmisin lipid-lowering properties on the model of acute hyperlipidemia induced by ethanol in rats.Materials and methods. Rats during 7 days injected into the stomach grosshemin and grossmisin in a dose 10 mg/kg or reference drug nicotinic acid in a dose 25 mg/kg. Hyperlipidemia caused by single introduction of ethanol into the stomach in a dose 5 g/kg. In blood serum of tail vein measured the triacylglycerols, total cholesterol, high density and low density lipoproteins cholesterol, also the level of free fatty acids. Calculated the ratio of high density lipoproteins cholesterol to the amount of low density lipoproteins cholesterol and the index of atherogenicity.Results. A single dose of ethanol increased serum level of triacylglycerols in 1.9 times, free fatty acids – in 3.2 times, low density lipoproteins – on 44% in comparison with the intact animals indices. It shows the development of acute hyperlipidemia. Serum total cholesterol, high density lipoproteins cholesterol and the index of atherogenicity were not changed. Course sesquiterpene lactones grosshemin and grossmisin introduction against the background of acute hyperlipidemia was accompanied by a decrease in the serum of triacylglycerols levels respectively by 19.8% and 34.1%. Nicotinic acid lowered the content of triacylglycerols by 42.4%. Grosshemin and nicotinic acid reduced the increased level of free fatty acids in the blood serum by 60.7–67.9%. Grossmisin and nicotinic acid decreased by 14.6–17.2% of total cholesterol in the blood serum. In acute hyperlipidemia grosshemin and grossmisin reduced low density lipoproteins cholesterol by 17.6% and 20%, respectively, nicotinic acid – by 15.7%. Both of sesquiterpene lactone and nicotinic acid did not modify the content of high density lipoproteins cholesterol. When introduction grosshemin, grossmisin and nicotinic acid ratio of high density lipoproteins cholesterol to the amount of low density lipoproteins cholesterol significantly increased by 42.8%, 38,6% and 22.1% respectively.Conclusion. Sesquiterpene lactones grosshemin and grossmisin posses hypolipidemic effect in acute experimental hyperlipidemia caused by the ethanol introduction. Lactones normalize many indices of lipid metabolism, which can be caused by different biochemical targets of these molecules. Lactones, as nicotinic acid, in the model of acute hyperlipidemia decrease in blood serum triacylglycerols, total cholesterol, and low density lipoproteins cholesterol content. Grosshemin and nicotinic acid also reduce the free fatty acids level.

scholarly journals LIPID SYNTHESIS FUNCTION OF LIVER IN PREGNANT WOMEN WITH CYTOMEGALOVIRUS INFECTION

2017 ◽  
Vol 1 (66) ◽  
pp. 54-59
Author(s):  
Игорь Гориков ◽  
Igor Gorikov ◽  
Наталия Ишутина ◽  
Nataliya Ishutina
Keyword(s):  
Total Cholesterol ◽  
Cytomegalovirus Infection ◽  
Lipid Synthesis ◽  
High Density ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Igg Antibodies ◽  
Avidity Index ◽  
Pregnancy And Delivery ◽  
Antibody Titers

Lipid synthesis function of the liver was studied by the contents of total cholesterol, lipoproteins of high density, lipoproteins of low density and triglycerides in 270 women in the second trimester of pregnancy. The first group (control) included 30 women with a physiological course of pregnancy. The main group consisted of the patients of the second, third, fourth and fifth groups with chronic cytomegalovirus infection (CMVI). Each of them were divided into two subgroups: subgroup A included the women with progressing pregnancy which terminated with the delivery in term; subgroup B - the patients with miscarriage threat whose treatment led to prolongation of the pregnancy and delivery at the 38-40th weeks of gestation. The second group included 60 women with latent chronic CMVI. The third group included patients with reactivation of chronic CMVI (antibody titers of IgM to CMV were 1:200-1:400, antibody titers of IgG to CMV were 1:200-1:400, avidity index of IgG antibodies was more than 65%). The fourth group included 60 patients with acute phase of chronic CMVI (antibody titers of IgM to CMV were 1:200-1:400, antibody titers of IgG to CMV were 1:200-1:800, avidity index of IgG to CMV was more than 65%), the fifth group had 60 patients with reactivation of chronic CMVI (antibody titers of IgM to CMV were 1:200-1:400, antibody titers of IgG to CMV were 1:400-1:1600, avidity index of IgG antibodies was more than 65%). When comparing the parameters of the first group with such-like ones of 2A and 2B subgroups there were not found any changes in the contents of total cholesterol, lipoproteins of high density and lipoproteins of low density and triglycerides; whereas in 3A subgroup there were revealed lower values of lipoproteins of low density (3.55±0.09 mmole/L; p<0.01), and in subgroup 3B there was a decrease of concentration of total cholesterol till 6.33±0.14 mmole/L (in control it was 6.7±0.09 mmole/L; p<0.05) and lipoproteins of low density till 3.43±0.10 mmole/L (in control it was 3.93±0.09 mmole/L; p<0.001). In the patients of subgroup 4B in comparison with the first group there were registered lower values of total cholesterol (6.20±0.15 mmole/L; p<0.01) and there was a growth of lipoproteins of high density till 2.04±0.13 mmole/L (p<0.05). In subgroup 5B there was a drop of concentration of total cholesterol till 5.93±0.14 mmole/L (p<0.001 in comparison with the first group; p<0.05 in comparison with subgroup 2B); there was a decrease of lipoproteins of low density in comparison with the first group till 2.73±0.09 mmole/L (p<0.001), as well as the increase of concentration of lipoproteins of high density till 2.06±0.10 mmole/L (p<0.01) and triglycerides till 1.96±0.05 mmole/L (p<0.01). The changes in the concentration of lipids in the serum of peripheral blood proved a very important role of the acute virus infection with 4-time growth of antibodies of IgG to CMVI in the suppression of lipid synthesis function of the liver and development of miscarriage.

scholarly journals Haplotype Analysis of Genomic Prediction Using Structural and Functional Genomic Information for Seven Human Phenotypes

2020 ◽  
Vol 11 ◽  
Author(s):  
Zuoxiang Liang ◽  
Cheng Tan ◽  
Dzianis Prakapenka ◽  
Li Ma ◽  
Yang Da
Keyword(s):  
Body Mass Index ◽  
Total Cholesterol ◽  
Genomic Prediction ◽  
Prediction Accuracy ◽  
Haplotype Analysis ◽  
Low Density Lipoproteins ◽  
High Density ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Genomic Information

Genomic prediction using multi-allelic haplotype models improved the prediction accuracy for all seven human phenotypes, the normality transformed high density lipoproteins, low density lipoproteins, total cholesterol, triglycerides, weight, and the original height and body mass index without normality transformation. Eight SNP sets with 40,941-380,705 SNPs were evaluated. The increase in prediction accuracy due to haplotypes was 1.86-8.12%. Haplotypes using fixed chromosome distances had the best prediction accuracy for four phenotypes, fixed number of SNPs for two phenotypes, and gene-based haplotypes for high density lipoproteins and height (tied for best). Haplotypes of coding genes were more accurate than haplotypes of all autosome genes that included both coding and noncoding genes for triglycerides and weight, and nearly the same as haplotypes of all autosome genes for the other phenotypes. Haplotypes of noncoding genes (mostly lncRNAs) only improved the prediction accuracy over the SNP models for high density lipoproteins, total cholesterol, and height. ChIP-seq haplotypes had better prediction accuracy than gene-based haplotypes for total cholesterol, body mass index and low density lipoproteins. The accuracy of ChIP-seq haplotypes was most striking for low density lipoproteins, where all four haplotype models with ChIP-seq haplotypes had similarly high prediction accuracy over the best prediction model with gene-based haplotypes. Haplotype epistasis was shown to be the reason for the increased accuracy due to haplotypes. Low density lipoproteins had the largest haplotype epistasis heritability that explained 14.70% of the phenotypic variance and was 31.27% of the SNP additive heritability, and the largest increase in prediction accuracy relative to the best SNP model (8.12%). Relative to the SNP additive heritability of the same regions, noncoding genes had the highest haplotype epistasis heritability, followed by coding genes and ChIP-seq for the seven phenotypes. SNP and haplotype heritability profiles showed that the integration of SNP and haplotype additive values compensated the weakness of haplotypes in estimating SNP heritabilities for four phenotypes, whereas models with haplotype additive values fully accounted for SNP additive values for three phenotypes. These results showed that haplotype analysis can be a method to utilize functional and structural genomic information to improve the accuracy of genomic prediction.

Enzymatic determinations of cholesterol in high-density-lipoprotein fractions prepared by a precipitation technique.

1976 ◽  
Vol 22 (1) ◽  
pp. 98-101 ◽  
Author(s):  
B W Steele ◽  
D F Koehler ◽  
M M Azar ◽  
T P Blaszkowski ◽  
K Kuba ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
Convenient Method ◽  
Density Lipoprotein ◽  
High Density ◽  
High Density Lipoproteins ◽  
Lipid Research ◽  
Enzymatic Method ◽  
Fine Precipitate

Abstract An enzymatic method for cholesterol in serum [Clin. Chem. 20, 470 (1974)] was initially found to be unsatisfactory for measuring cholesterol in high-density-lipoprotein fractions prepared by precipitation with Mn2+. A fine precipitate formed in the cuvette and cholesterol values were falsely increased. We describe a simple, convenient method for circumventing these problems. An ethylenediaminetetraacetate solution is used to reconstitute the enzymatic reagent. Cholesterol values by this procedure correlated with those obtained by the Lipid Research Clinic's procedure for the same lipoprotein fraction preparations (regression slope, .998; Y-intercept, 8.9 mg/liter; correlation coefficient, .984; standard error of the estimate, 16.8 mg/liter). Precision of the assay, including the precipitation step, was calculated. The SDwithin day was 9.7 mg/liter and SDoverall was 23.7 mg/liter. Results for total cholesterol with the modified reagent were linearly related to concentrations exceeding 4 g/liter, thereby permitting determination of high-density-lipoproteins and total cholesterol in a single run.

scholarly journals Influence of Functional Sweet White Lupin Biscuits on Lipid Profile and Food Efficiency of Induced Hyperlipidemia Rats

2015 ◽  
Vol 4 (3) ◽  
pp. 14 ◽  
Author(s):  
Rasha Mousa Ahmed Mousa
Keyword(s):  
Weight Gain ◽  
Total Cholesterol ◽  
Low Density Lipoproteins ◽  
High Density ◽  
The Body ◽  
Atherogenic Index ◽  
White Lupin ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Food Efficiency

<p>In recent years, functional foods have attracted much interest to prevent nutrition-related diseases such as hyperlipidemia and weight gain. In this regard, this study was designed to examine the effect of use sweet white lupin (SWL) oil and flour with/without germination as a source of active healthy components to prepare functional biscuits for lowering blood lipids and growth. Functional biscuits were formulated by replacing wheat flour and butter in biscuit formulae by SWL extracted flour and SWL oil in the range of 20-30% (w/w) and 30-40% (v/w), respectively. Results indicated that the feed of hyperlipidemic rats on diets supplemented with different functional SWL biscuits for 6 weeks significantly (P &lt; 0.05) reduced serum total cholesterol, triglycerides, low density lipoproteins, very low density lipoproteins, ratio of total cholesterol/high density lipoproteins cholesterol, ratio of low density lipoproteins/high density lipoproteins cholesterol and atherogenic index. Furthermore, the feed of functional SWL biscuits significantly reduced the body weight gain of rats and their food efficiency compared to that of rats fed on hyperlipidemic diet. On the other hand, there was an increase in the value of high density lipoproteins cholesterol and its ratio with total cholesterol. All these findings supported that the addition of 25% germinated SWL flour and 35% or 40% germinated SWL oil in biscuits gave interested results compared to the common wheat biscuits. Therefore, the proposed functional SWL biscuits could be able to regulate the blood cholesterol and the body growth levels of individuals and patients.</p>

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