scholarly journals ANALYSIS OF ADVERSE DRUG REACTION REPORT FORMS ON THE MEDICINES, USED FOR AIDS TREATMENT (REGISTERED IN THE REPUBLIC OF CRIMEA IN THE PERIOD FROM 2011 TO 2016)

2019 ◽  
Vol 6 (6) ◽  
pp. 568-583
Author(s):  
A. V. Matveev ◽  
A. Е. Krasheninnikov ◽  
E. A. Egorova ◽  
E. I. Konyaeva
Keyword(s):  
Quality Of Life ◽  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Antiretroviral Therapy ◽  
Adverse Reactions ◽  
Clinical Manifestations ◽  
Public Health Problem ◽  
World Health ◽  
The Republic

According to the data of the World Health Organization (WHO), human immunodeficiency virus (HIV) remains a major global public health problem.The mainmethod of treating HIV is using highly active antiretroviral therapy (HAART), which is the use of multiple medicines acting on different viral targets. The timely onset of HAART can suppress the replication of the virus in the human body and helps to strengthen its immune system and restore its ability to fight infections. At the same time, the choice of medicines to improve the quality of life and patients’ compliance during antiretroviral therapy should be based on their effectiveness and safety. The aim of this research was to analyze and study the adverse reactions that occur in patients with HIV living in the territory of the Republic of Crimea, when using HAART.Materials and methods.The objects of research were 274 report cards about the adverse reactions, registered in the regional base (registry) of spontaneous messages called ARCADe (Adverse Reactions in Crimea, Autonomic Database) for the period from 2011 to 2016.Results.The results of the study showed that the most often adverse reactions were observed when using medicines of the group of Nucleoside Reverse Transcriptase Inhibitors (NRTI). This is explained by the inclusion of NRTI medicines as the main medicine in the method of HAART. Efavirenz (EFV) and Nevirapine (NVP) were absolute leaders among these groups of antiretroviral medicines. Among the combined antiviral medicines active against HIV, the most frequently adverse reactions were associated with the use of a combination of Lamivudine (3TC) and Zidovudine (ZDV). The main clinical manifestations of adverse reactions in the use of combination medicines for treating HIV were a decrease in the level of hemoglobin and the development of anemia. At the same time, in 85% of cases, the patients needed medication in order to correct the resulting adverse drug reaction (ADR). The combination of antiretroviral therapy has often been associated with the development of serious ADR. In case of monotherapy, the main clinical manifestations of adverse reactions were disorders of the central nervous system (dizziness, hallucinations, sleep disorders) and allergic reactions of varying severity (including 1 case of angioedema to “Eferven” (Efavirenz (EFV)),600 mg). Hereby, in almost half of the cases, the usage of antiretroviral medicines of the NRTI group and protease inhibitors caused the development of serious side effects. This confirms the necessity to study and analyze adverse reactions in order to increase the safety of patients’ pharmacotherapy and improve their quality of life.Conclusion.The study of adverse reactions to the medicines used for treatment of HIV is of a paramount importance in improving the safety and compliance of HIV patients to lifelong pharmacotherapy.

scholarly journals Evaluation of the roles of HIV co-infection and socio-demographic factors as determinants of Quality of Life among Nigerians with Tuberculosis

2018 ◽  
Vol 17 (1) ◽  
pp. 21-29
Author(s):  
Peter J Olagunju ◽  
Olukemi O Odukoya ◽  
Andrew T Olagunju ◽  
Mobolanle R Balogun
Keyword(s):  
Quality Of Life ◽  
Medical Science ◽  
Demographic Factors ◽  
Public Health Problem ◽  
World Health ◽  
Physical Aspect ◽  
Global Public Health ◽  
World Health Organization Quality ◽  
Socio Demographic Factors

Background: Tuberculosis [TB] remains a major global public health problem, and particularly in resource-restricted settings with disproportionately high burden. This study is aimed at assessing quality of life [QoL] and the roles of HIV co-infection along with socio-demographic factors on QoL among subjects with TB.Methodology: This is a multi-center cross-sectional study among 440 participants recruited by multi-stage sampling technique across 40 Directly Observed Treatment Short-course [DOTS] centres. Interviews were done using designed questionnaire to collect information on socio-demographic and clinical details of respondents. Subsequently, the World Health Organization Quality of Life-BREF [WHOQOL-BREF] questionnaire was used to evaluate QoL.Results: Most (61.1%) of the participants was aged between 21 and 40 years, 61.6% were married and 74.5% had a paid job. Majority of the subjects reported fair QoL across all domains. Employment status and monthly income were significantly associated with participants overall QoL and their satisfaction with health (p<0.05). Also, age, gender, marital status, ethnicity and educational status were significantly associated with the social domain of QoL. The HIV co-infection was found to be significantly associated with the physical aspect of their QoL (p<0.05).Conclusion: Optimal treatment of HIV co-infection and incorporation of psychosocial medicine into TB management are indicated for improved QoL. Similarly, routine assessment of QoL is desirable.Bangladesh Journal of Medical Science Vol.17(1) 2018 p.21-29

scholarly journals INVESTIGATION OF MEDICALLY INDUCED SKIN REACTIONS BASED ON THE ANALYSIS OF REPORTS OF ADVERSE DRUG REACTIONS IN THE REPUBLIC OF CRIMEA (FROM 2009 TO 2016)

2019 ◽  
Vol 7 (1) ◽  
pp. 32-41 ◽  
Author(s):  
A. V. Matveev ◽  
А. E. Krasheninnikov ◽  
E. A. Egorova ◽  
Е. I. Konyaeva
Keyword(s):  
Adverse Reactions ◽  
Drug Hypersensitivity ◽  
Clinical Manifestations ◽  
World Health ◽  
Report Cards ◽  
Hypersensitivity Reactions ◽  
Drug Reactions ◽  
Skin Reactions ◽  
Drug Hypersensitivity Reactions ◽  
The Republic

Drug hypersensitivity reactions are among the most important problems that arise when using drugs. The occurrence of such reactions in the population is at least 7% and tends to a constant increase. The most frequent manifestations of drug hypersensitivity reactions are medically induced skin lesions.The aimof this research was to study and analyze the cases of development of skin drug reactions on the basis of the reports on the adverse reactions (ADRs) of the drugs, registered in the Republic of Crimea in the period from 2009 to 2016.Materials and methods.The objects of the research were report cards about the adverse reactions, registered in the regional base (registry) of spontaneous messages called ARCADe (Adverse Reactions in Crimea, Autonomic Database) for the period from 2009 to 2016. During the analysis of the report cards, 2,698 cases of the development of skin drug reactions arising in response to the use of drugs in patients were selected. The study of the frequency of occurrence of skin drug reactions in the application of various groups of drugs was carried out taking into account the codes of the Anatomical Therapeutic Chemical (ATC) Сlassification System of drugs of the World Health Organization (WHO).Results.Of the study showed that the development of skin drug reactions was most often associated with the use of antimicrobial agents for internal use, nonsteroidal anti-inflammatory drugs (NSAIDs), drugs for the treatment of diseases of the gastrointestinal tract and agents that affect the nervous system. Among the clinical manifestations of skin drug reactions, generalized and localized rashes prevailed, and itching and hyperemia of the skin were much less common in patients. The analysis of age categories showed that the most frequently medically induced reactions occurred in children from birth to 3 years, as well as in the age group of patients from 46 to 60 years. The risk factors identified in the course of the analysis, were female gender, early childhood and old age, as well as the presence of aggravated drug allergy history.Conclusion.Drug hypersensitivity reactions create certain difficulties in clinical practice related to the diagnosis, treatment and prophylaxis, and may also cause danger to health or life of patients. In this connection, the study of such adverse reactions is the most important task of practical health care and requires direct participation of doctors of all specialties.

scholarly journals The Quality Life of Renal Failure Patient Undergo Hemodialysis

2016 ◽  
Vol 3 (2) ◽  
pp. 118-122
Author(s):  
Rizky Firman ◽  
Sri Mugianti ◽  
Imam Sunarno ◽  
Sri Winarni
Keyword(s):  
Quality Of Life ◽  
Renal Failure ◽  
Public Health Problem ◽  
World Health ◽  
Psychological State ◽  
World Health Organization Quality ◽  
Renal Failure Patient ◽  
Quality Life ◽  
The World

Chronic renal failure (CRF) is a public health problem in the world and is now recognized ascommon diseases with risk of hemodialysis therapy. Hemodialysis can have an impact to the patientquality of life. The aim of the research was to describe the patient quality of life with renal failure underghemodialysis at Mardi Waluyo Blitar hospital. The research used a descriptive research design. Thepopulation was all patients with renal failure which registered in Hemodialysis of Mardi Waluyo Blitarhospital on October-December 2014 as many as 84 patients. The sample was 34 patients selected byaccidental sampling. The data collection was conducted on March 30th – April 4th, 2015. The datacollecting used questionnaires of The World Health Organization Quality of Life (QoL WHO) whichdescribed physical health, psychological, social relationships, and environment. In general the qualitylife of renal failure patient underrgo hemodialysis in bad category was 55.9% (19 patients). Thiscondition was due to a chronic disease and its complications potentially stressors including renalfailure patient. Stressors that arise caused by environmental conditions, psychological state, and physicalhealth. The study recommended that health services were expected to provide comfortability, improvemaintenance functions, improve interpersonal relationships, and counseling.

scholarly journals Impact of adverse drug reaction and predictivity of quality of life status in tuberculosis

2010 ◽  
Vol 36 (1) ◽  
pp. 206-208 ◽  
Author(s):  
N. Guo ◽  
F. Marra ◽  
J. M. Fitzgerald ◽  
R. K. Elwood ◽  
C. A. Marra
Keyword(s):  
Quality Of Life ◽  
Adverse Drug Reaction ◽  
Drug Reaction

scholarly journals Atopic Dermatitis Severity, Patient Perception of the Disease, and Personality Characteristics: How Are They Related to Quality of Life?

Life ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1434
Author(s):  
Liborija Lugović-Mihić ◽  
Jelena Meštrović-Štefekov ◽  
Iva Ferček ◽  
Nives Pondeljak ◽  
Elvira Lazić-Mosler ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Atopic Dermatitis ◽  
Anxiety Disorder ◽  
Personality Traits ◽  
Clinical Manifestations ◽  
Personality Characteristics ◽  
World Health ◽  
Patient Specific ◽  
World Health Organization Quality

Introduction: Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin condition that greatly affects patients’ quality of life, psychological condition, and social relationships. Materials And Methods: To analyze different aspects of AD patients’ quality of life, we used the SCORing Atopic Dermatitis (SCORAD) index (for AD severity), the Dermatology Life Quality Index (DLQI), the World Health Organization Quality of Life Brief Version (WHOQOL-BREF), the Brief Illness Perception Questionnaire (Brief IPQ), and the Crown–Crisp Experiential Index (CCEI) to analyze personality traits. The study included 84 AD patients, 42 with clinical manifestations and 42 in remission. Results: SCORAD values correlated positively and linearly with DLQI (r = 0.551; p < 0.001) and with disease impact on life, disease control, and disease symptoms (r = 0.350–0.398; p ≤ 0.023). DLQI was also related to certain personality characteristics (free-floating anxiety disorder, obsession, somatization, and depression (p ≤ 0.032)). Symptomatic AD patients had a significantly more impaired DLQI than asymptomatic patients (p < 0.001) and the two groups differed in some IPQ dimensions, but they did not differ significantly concerning the WHOQOL-BREF dimensions and personality traits (CCEI). Conclusion: Since AD patient quality of life was dependent not only on disease severity but was also influenced by patient personality characteristics (anxiety disorder, obsession, somatization, depression), many factors need to be taken into account to create effective, patient-specific therapy regimens.

Quality of life and adverse drug reaction measured in patients undergoing cancer chemotherapy.

2014 ◽  
Vol 32 (31_suppl) ◽  
pp. 214-214
Author(s):  
Harminder Singh ◽  
Raja Banipal ◽  
Ritu Bala
Keyword(s):  
Quality Of Life ◽  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Symptom Scale ◽  
Appetite Loss ◽  
Financial Difficulties ◽  
Patient Reported ◽  
Eortc Qlq C30 ◽  
Eortc Qlq

214 Background: Cancer prevalence in India is estimated around 2.0-2.5 million, 0.7- 0.8 million new cases identified every year, and cancer deaths reported per year is 0.4-0.5 Million. The objective of this study was to analyze and compare patient-reported QoL (quality of life), and their physical/psychosocial symptom and adverse drug reaction in cancer patients. Methods: Study done by questionnaire EORTC QLQ-C30. Comparison among 3 distinctive groups (G) (varied number of Chemotherapy cycles) was done. ADR measured appropriately Results: 131 patients were recruited and QoL scoring GHS (global health status) and 4 items of symptom scale i.e. insomnia, pain, appetite loss, constipation, and financial difficulties attained a significance difference. GHS significantly improved in G3 as compared to G1, indicating that the patient overall health improved as the chemotherapy sessions progressed. Female patients had more ADR (mean 3.2/person) and G3 had more ADR (mean 3.96). Conclusions: QoL score didn’t show significant improvement in all areas (except insomnia, pain, appetite loss, constipation & financial difficulties), a judicious diagnosis with an appropriate treatment including chemotherapy may lessen the negative perception of cancer. [Table: see text]

scholarly journals CTNI-28. A PROSPECTIVE, OBSERVATIONAL STUDY EVALUATING THE SAFETY AND QUALITY OF LIFE OF TUMOR TREATING FIELDS IN CHINESE GLIOBLASTOMA PATIENTS

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii48-ii48
Author(s):  
Kevin Wong ◽  
Tao Jiang
Keyword(s):  
Quality Of Life ◽  
Adverse Reactions ◽  
Clinical Manifestations ◽  
Treatment Compliance ◽  
Symptomatic Treatment ◽  
Chinese Patients ◽  
Published Data ◽  
Newly Diagnosed ◽  
Tumor Treating Fields

Abstract OBJECTIVES Glioblastoma (GBM) is the most common and aggressive primary brain tumor with a median survival of 15 months. Adding Tumor Treating Fields (TTFields) to first-line therapy in GBM demonstrated improved survival in the EF-14 trial. This prospective study was designed to investigate the safety and effect on QoL of TTFields in Chinese patients with GBM. METHODS A total of 44 patients (29 newly diagnosed GBM, 15 recurrent GBM, median age 51.0 [24.0 - 81.0] years) who underwent TTFields following surgery, concurrent chemoradiotherapy were enrolled into the study. The primary endpoint was the incidence of TTFields-related skin adverse events; the secondary endpoint included quality of life (QoL), treatment adherence. RESULTS Of the 44 patients followed up for at least 3 months, 24 (54.5%) had skin adverse reactions, all of which were grade 1–2. Median time to skin AE was 1.2 months. The common skin AE were dermatitis (53.8%), ulcer (19.2%), infection (19.2%), and most of them could be resolved by symptomatic treatment (topical corticosteroid/antibiotics). In terms of QoL, noticeable improvement in overall health and clinical manifestations such as fatigue, nausea and vomiting were observed. The overall average treatment compliance was 91%: compliance (mean±SD), in newly diagnosed patients, 0.89±0.14, median 0.91; in recurrent patients, 0.86±0.13, median 0.93. CONCLUSIONS The incidence of skin adverse reactions (which could be effectively alleviated with treatment) in GBM patients treated with TTFields was acceptable. From our short follow up, TTFields appear to improve QoL and compliance in Chinese patients comparable to published data.

scholarly journals The study of adverse drug reactions of antihypertensive medicines in essential hypertension patients in Hi-Tech Medical College and Hospital, Bhubaneswar, Odisha, India

2019 ◽  
Vol 8 (5) ◽  
pp. 886 ◽  
Author(s):  
Bikash Roy ◽  
Srikanta Mohanty ◽  
Anju Prasad ◽  
Chaitali Pattanayak ◽  
Ratna Palit ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Health Care ◽  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Antihypertensive Drugs ◽  
Antihypertensive Agents ◽  
General Medicine ◽  
Drug Reactions ◽  
Medical College

Background: Every drug has the potentiality to cause an adverse drug reaction (ADR). ADRs are a major problem in drug therapy .The aim of this study was to assess the incidence and causality of ADRs to antihypertensive agents used for the essential hypertensive patients attending at the general medicine out patients departments of Hi-Tech Medical College and Hospital, Bhubaneswar Odisha, during the time period of November 2016 to October 2018.Methods: This prospective-observational study was carried out in general medicine outpatient department of Hi-Tech Medical College and Hospital, Bhubaneswar, Odisha.Results: Out of 254 patients, 78 (30.71%) patients were developed ADRs to antihypertensive drugs. 51 (65.38%) were female and 27 (34.62%) were male. Calcium channel blockers were the commonest therapeutic class of antihypertensive drugs associated with ADRs (n = 50, 64.10%). According to WHO causality assessment scale most of the ADRs were “probable” 41 (52.56%), followed by “possible” 21 (26.92%), unclassifiable 13 (16.67%) and unlikely 3 (3.85%).Conclusions: The results of this study concluded that antihypertensive drugs able to induce the development of adverse drug reactions, which were significant cause of increase burden on health care system and decrease the quality of life, the health care professionals should take care about the rational use of antihypertensive agents. Thus, to minimize the incidence of adverse drug reaction and to increase the quality of life.

scholarly journals Assessment of quality of life among HIV infected people on antiretroviral therapy in a tertiary hospital, Karnataka

2021 ◽  
Author(s):  
Anjan Sreeranga ◽  
P. Pavithra ◽  
Anand D. Meundi
Keyword(s):  
Quality Of Life ◽  
Antiretroviral Therapy ◽  
Rural Areas ◽  
World Health ◽  
Cross Sectional ◽  
Infected People ◽  
Significant Difference ◽  
Patient Reported ◽  
The Impact

Background: With the availability of highly effective antiretroviral treatment, HIV is transforming into a chronic condition, whose management is now experiencing problems of other chronic diseases, where quality of life (QOL) has become an important component of overall assessment of health care and management. This study was conducted with the objective of assessing the QOL and factors influencing it in HIV infected people on antiretroviral therapy (ART).Methods: A cross-sectional study was conducted at district ART center, Hassan. Purposive sampling was used to identify 148 HIV infected people on antiretroviral therapy, who were interviewed using a pretested questionnaire, assessing QOL with the World Health Organization (WHOQOL) HIV‑BREF.Results: The average age of the study population was 37.69 years. Majority of them were males 54.7% compared to 45.3% of females. Most of them resided in rural areas (87.8%). The educational status of the subjects was poor with 33.8% of them being illiterates. The mean score was highest for spirituality and social relationships domain and least for psychological domain. Age, education and socioeconomic status did not have any influence on the QOL. There was significant difference between QOL scores and clinical stages. Individuals in stage I and II had better scores compared to stage 3 and 4. QOL scores decreased with decreasing CD4 count.Conclusions: Our findings suggest that patient-reported measures of health status and related concepts may help provide a feasible, reliable and valid method to assess the impact of HIV/AIDS improve patient outcomes. 

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