Ekspresi Caspase-3 sebagai Petanda Apoptosis Makrofag Lesi Kulit Penderita Kusta Tipe Pausibasiler dan Multibasiler

Macrophage and Schwann cells are target cell on leprosy disease, where apoptotic is assumed as one of elimination mechanism of macrophage previously infected by M.leprae. Several study showed various result in apoptotic on leprosy disease. Apoptotic level can be evaluated by observing caspase-3 activity, an executioner caspase on cell death. This study is aimed to observe the relationship of caspase-3 expression with paucibacillary and multibacillary types of leprosy. We used observational analytic and cross sectional study with consecutive sampling method. The subject was leprosy patient which had been diagnosed on dermatovenereology division outpatient clinic Saiful Anwar Hospital, and fullfilled the inclusion-exclusion criteria. Total subject was 19 persons (11 multibacillary and 8 paucibacillary). Sampling was taken with punch biopsy on skin lession, followed by immunohistochemical staining with caspase-3 antibody, and caspase-3 expression was measured by ImmunoRatio method. Comparation test revealed significant difference (p<0.05%) between caspase-3 expression mean on paucibacillary patient (84.46%) compared to multibacillary patient (65.39%). Pearson correlation test revealed caspase-3 expression tend to be higher in paucibacillary patient than multibacillary (coefficient correlation -0.759). In conclusion, there is a significance relationship between caspase-3 expression with leprosy type.

Download Full-text

Relationship Between Finnish Diabetic Risk Score (FINDRISC) with Health-Related Quality of Life in Yogyakarta

Borneo Journal of Pharmacy ◽

10.33084/bjop.v4i1.1579 ◽

2021 ◽

Vol 4 (1) ◽

pp. 68-77

Author(s):

Ninda Sari Wahyuningtyas ◽

Dyah Aryani Perwitasari ◽

Satibi Satibi

Keyword(s):

Quality Of Life ◽

Risk Score ◽

Pearson Correlation ◽

Cross Sectional Study ◽

Utility Value ◽

Cross Sectional ◽

Significant Difference ◽

Pearson Correlation Test ◽

Related Quality

The number of people with type 2 diabetes mellitus (T2DM) in Indonesia increases every year. Control of the development of T2DM can be done by screening using Finnish Diabetic Risk Score (FINDRISC)-Indonesian. FINDRISC is a valid tool for estimating the risk of T2DM within the next 10 years. This condition can have a major impact on the estimated life span and quality of life in the future. The purpose of this research is to determine the relationship between FINDRISC-Indonesian and respondent characteristics with HRQoL from EuroQol-5 Dimension-5 Level (EQ-5D-5L) in Yogyakarta. We conducted a cross-sectional study consisting of 125 respondents who met the inclusion criteria. The risk of developing T2DM was assessed using a validated and widely used FINDRISC (range 0-26 points), and quality of life was measured by the EQ-5D-5L instrument. Overall data were analyzed using the Pearson correlation test and Independent t-test. The results showed the domain of pain was the domain that reported most respondents' most problems (28.8%). The respondent's utility value was 0.958 ± 0.69, and the VAS value was 79.4 ± 0.7. There was a significant difference in utility value based on age characteristics (p = 0.013). There is a relationship between age and utility value (p = 0.006) and FINDRISC score with utility value (p = 0.003). This study's conclusion was high FINDRISC affects the quality of life, and older age has a low quality of life.

Download Full-text

Relationship between Ratio of Second and Fourth Digit and Obesity Traits among Different Ethnic Groups in Ilorin, North Central Nigeria

Notulae Scientia Biologicae ◽

10.15835/nsb849888 ◽

2016 ◽

Vol 8 (4) ◽

pp. 396-400 ◽

Cited By ~ 2

Author(s):

Bolaji Fatai OYEYEMI ◽

John Oluwafemi ADEBAYO ◽

Abass Toba ANIFOWOSHE ◽

Oluyinka Ajibola IYIOLA

Keyword(s):

Ethnic Groups ◽

Pearson Correlation ◽

Standard Procedure ◽

Surrogate Marker ◽

Relative Length ◽

Cross Sectional Study ◽

Digit Ratio ◽

Sectional Study ◽

Cross Sectional ◽

Significant Difference

Digit ratio (2D:4D) denotes the relative length of the second and fourth digits. There are contradicting reports on its relationship with ethnicity/race, whereas convincing studies show it is related to obesity. This cross-sectional study was undertaken to demystify ethnic difference in 2D:4D ratio and to analyze its relationship with obesity among adults in Ilorin Nigeria. The cross-sectional study included 701 individuals. Finger lengths were measured with electronic calipers and other anthropometric traits were measured with standard procedure. Student t test and one-way ANOVA were used to detect differences among groups and relationship was computed with Pearson correlation. The receiver operator characteristic curves were used to detect the diagnostic effect of 2D:4D for obesity. The obtained results showed sexual dimorphism in 2D:4D ratio and other anthropometrics at p < 0.01. Obesity was associated with significantly higher mean of 2D:4D in both genders (female 0.9814 ± 0.012:0.9700 ± 0.012; male 0.9700 ± 0.010:0.9592 ± 0.010 at p < 0.001). The area under the curve was 0.753 (95% CI 0.677-0.829, p < 0.01) and 0.798 (95% CI 0.756-0.804, p < 0.01) in female and male R2D:4D respectively for obesity, implying that 2D:4D might be a surrogate marker for obesity in future. No significant difference was found in 2D:4D among different ethnic groups studied (p >0.05); this result proved that there was no ethnic specificity in 2D:4D ratio among study’ participants. Thus, it can be reported that the digit ratio was related to high 2D:4D, but this cannot be said for different ethnic groups. The results imply that 2D:4D might be a good surrogate indicator for obesity, but not ethnicity.

Download Full-text

Relation of Parasites in Soil with The Existence of Parasites on Farmer's Nails

Indonesian Journal of Medical Laboratory Science and Technology ◽

10.33086/ijmlst.v3i1.1850 ◽

2021 ◽

Vol 3 (1) ◽

pp. 47-55

Author(s):

Edza Aria Wikurendra ◽

Merry Crismiati ◽

Globila Nurika

Keyword(s):

Agricultural Land ◽

Pearson Correlation ◽

Sampling Technique ◽

Cross Sectional Study ◽

Bivariate Analysis ◽

Cross Sectional ◽

Soil Transmitted Helminths ◽

Ancylostoma Duodenale ◽

Parasitic Worms ◽

Relationship Of

Worms is an infectious disease caused by parasitic worms that can endanger health. Worms that often infect and have a very detrimental impact are soil-borne worm infections or Soil-Transmitted Helminths. Soil-Transmitted Helminths still considered insignificant because it is considered not to cause harm or cause death. This study aims to determine the relationship of parasites in the soil with the presence of parasites on the nails of farmers Sumber Urip 1 Village Wonorejo, East Java, Indonesia. The research method was used observational analytic with a cross-sectional study design which involved 18 Sumber Urip 1 farmers in Wonorejo Village. The sampling technique used was Total Sampling. The bivariate analysis uses Pearson correlation with decision making using significant <0.01. The identification of parasites using the floating method in 18 soil samples contained 12 flattering pieces of hookworm larvae and roundworm eggs. While the results of parasite identification with sedimentation method in 18 nail samples of farmers, there are 11 positive hookworm larvae samples, i.e. Ancylostoma duodenale. The correlation test result showed a relationship between parasites in the soil and nails of Sumber Urip 1 farmers in Wonorejo village (significant as P < 0.01). The use of gloves and footwear (shoes) when working on agricultural land, wash hands with soap and brush nails so that dirt is lost, and consume worm medicine can prevent worms infection.

Download Full-text

HUBUNGAN KEBIASAAN MENGKONSUMSI KOPI DENGAN KEJADIAN HIPERTENSI

KOSALA : Jurnal Ilmu Kesehatan ◽

10.37831/kjik.v9i2.215 ◽

2021 ◽

Vol 9 (2) ◽

pp. 73-84

Author(s):

Budi Kristanto

Keyword(s):

Blood Pressure ◽

Pearson Correlation ◽

Coffee Consumption ◽

Sampling Technique ◽

World Population ◽

Cross Sectional ◽

Pearson Correlation Test ◽

Relationship Of ◽

The Relationship ◽

Consumption Habits

Latar belakang : saat ini prevalensi hipertensi secara global sebesar 22% dari total penduduk dunia. Dari sejumlah penderita tersebut, hanya kurang dari seperlima yang melakukan upaya pengendalian terhadap tekanan darah yang dimiliki. Adapun faktor yang terkait dengan tekanan darah sangat kompleks, baik yang dapat dikontrol maupun tidak dapat dikontrol. Salah satu kebiasaan yang diduga terkait dengan hipertensi adalah kebiasaan konsumsi kopi. Tujuan : mengetahui hubungan antara kebiasaan konsumsi kopi dengan kejadian hipertensi. Subjek dan Metode : responden penelitian ini adalah warga Desa Ngringo RW 22 dan 29 Kecamatan Jaten Karanganyar sejumlah 45 responden. Jenis penelitian adalah analitik observasional, desain korelasi dengan pendekatan cross sectional untuk mengetahui hubungan antara kebiasaan konsumsi kopi dengan kejadian hipertensi. Teknik sampling menggunakan total sampling, Data dianalisis menggunakan uji Pearson Corelation. Hasil : mayoritas responden memiliki kebiasaan konsumsi kopi dalam kategori ringan (1-3 cangkir perhari) sebesar 97,8%, sedangkan yang kategori sedang (4-6 cangkir perhari) sebesar 2,2%. Mayoritas responden dengan tekanan darah yang normal yaitu 82,2%, dan hipertensi 17,8%. Kesimpulan : tidak ada hubungan antara kebiasaan konsumsi kopi dengan kejadian hipertensi (p : 0,058). Kata kunci : konsumsi kopi, hipertensi THE RELATIONSHIP OF COFFEE CONSUMING HABITS WITH HYPERTENSION Budi Kristanto, Diyono Astract Background : currently the global prevalence of hypertension is 22% of the total world population. Of the number of sufferers, only less than a fifth who make efforts to control their blood pressure. The factors associated with blood pressure are very complex, both controllable and uncontrollable. One of the habits thought to be associated with hypertension is the habit of consuming coffee. The aims of the study: knowing the relationship between coffee consumption habits and the incidence of hypertension. Subject and Methods : the respondents of this research were 45 respondents in Ngringo Village RW 22 and 29, Jaten, Karanganyar District. This research used observational analytic method, correlation design with cross sectional approach to determine the relationship between coffee consumption habits and the incidence of hypertension. The sampling technique used total sampling. Data were analyzed using the Pearson Correlation test. Result : the majority of respondents have a habit of consuming coffee in the light category (1-3 cups per day) of 97.8%, while the moderate category (4-6 cups per day) is 2.2%. The majority of respondents with normal blood pressure were 82.2%, and hypertension 17.8%. Conclusion : There is no relationship between coffee consumption habits and the incidence of hypertension (p: 0.058). Keywords: coffee consumption, hypertension

Download Full-text

Normal levels of inflammatory markers in treated patients with familial hypercholesterolaemia: a cross-sectional study

JRSM Cardiovascular Disease ◽

10.1258/cvd.2012.012011 ◽

2012 ◽

Vol 1 (3) ◽

pp. 1-9 ◽

Cited By ~ 2

Author(s):

Mary Seed ◽

D John Betteridge ◽

Jackie Cooper ◽

Muriel Caslake ◽

Paul N Durrington ◽

...

Keyword(s):

Familial Hypercholesterolaemia ◽

Univariate Analysis ◽

Cross Sectional Study ◽

Risk Markers ◽

Sectional Study ◽

Cross Sectional ◽

Lipoprotein A ◽

Significant Difference ◽

Heterozygous Familial Hypercholesterolaemia ◽

Relationship Of

Objective To assess the relationship of levels of inflammatory risk markers to presence of clinical coronary artery disease (CAD) in patients with treated heterozygous familial hypercholesterolaemia. Design A cross-sectional study of patients on the Simon Broome Familial Hyperlipidaemia Register. Setting Six hospital outpatient clinics in the UK. Participants A total of 211 men and 199 women with heterozygous familial hypercholesterolaemia. Main outcome measures Analysis of conventional risk factors and concentrations of high-sensitivity C-reactive protein (hsCRP), lipoprotein (a), serum intercellular adhesion molecule (sICAM), interIeukin-6 (IL-6) and lipoprotein-associated phospholipase A2 (LpPLA2) mass. Results CAD was present in 104 men and in 55 women; the mean ages of onset were 43.1 and 46.5 years, respectively. On univariate analysis there was a positive relationship of CAD with age, male sex, smoking, IL-6 and sICAM, and an inverse relationship with low-density lipoprotein (LDL) and LpPLA2. On multivariate analysis, age, smoking, low LDL and low LpPLA2 were associated with CAD. When LpPLA2 values were adjusted for apoB and aspirin usage, there was no significant difference between those with and without CAD. Only age and smoking were independently associated with CAD in men, and IL-6 and lipoprotein(a) in women. Conclusions Although on univariate analysis inflammatory marker levels were associated with CAD in these patients, the majority of the associations, including that for hsCRP, disappeared when corrected for smoking and apoB. This may be because atherosclerotic plaques in these statin-treated patients were quiescent or an effect of aspirin usage. In this observational study newer risk markers were not usefully associated with the presence or absence of symptomatic CAD.

Download Full-text

Correlation of VIT D3 and serum ferritin levels in anemic patients in a hospital based study.

The Professional Medical Journal ◽

10.29309/tpmj/2020.27.11.4771 ◽

2020 ◽

Vol 27 (11) ◽

pp. 2376-2382

Author(s):

Hamzullah Khan ◽

Mohammad Basharat

Keyword(s):

Serum Ferritin ◽

Standard Error ◽

Ferritin Level ◽

Pearson Correlation ◽

Cross Sectional Study ◽

Cross Sectional ◽

Iron Deficient ◽

Significant Difference ◽

The Difference ◽

Gender Groups

Objectives: To determine the correlation of Vit D3 levels with serum ferritin in patients with anemia. Study Design: Cross Sectional study. Setting: Department of Pathology, Qazi Hussain Ahmed Medical Complex Nowshera. Period: 5th Jan 2019 to 31st Dec 2020. Material & Methods: Data entered in SPSS 25th version. Descriptive statistics was used for numerical variables. Pearson correlation was used for correlation of Vit D3 with gender. Normality of data was checked by Shapiro wilk test. Mann Whitney U test was used to show the difference of Vit D3 and ferritin levels in gender. Results: The total of 192 anemic patients with Hb<10g/dl as per definition of WHO1 were referred for ferritin level estimation with 142(74%) females and 50(26%) males. Out of total, 47 were also advised with Vit D3 level estimation with 29(61.7%) females and 18(38.3%) males. Mean with standard deviation for age was 30+9.6 years. Mean with standard Error of mean of Vit D3 was (Mean-15.5ng/ml, SE 2.19). Mean with standard Error of mean of serum ferritin was (Mean-48.2ng/ml, SE 5.90). We observed 35(74.5%) cases out of 47, as Vit D3 deficient with a count less than 20 ng/ml. We observed that 118 (61.5%) were iron deficient with serum ferritin less than 15ng/ml. Person correlation showed a statistically significant correlation of Vit D3 with ferritin (p= 0.022, r=0.7). Spearman ranked correlation showed a statistically significant correlation between the categories of Vit D3 and ferritin (p=0.022, r=0.7). Mann Whitney U Test showed no significant difference in gender groups for botht the variables (p= 0.86 &p=0.33 respectively) thus retain the null hypotheses. Conclusion: The frequency of deficiency Vit D3<20ng/ml in anemic patients was 74% while that of ferritin<15ng/ml in anemic patients was 61.5%. There is a strong statistically significant correlation of Vit D3 with serum ferritin in anemic patients with Hb<11g/dl.

Download Full-text

Perbedaan arus puncak ekspirasi antara anak asma dengan obesitas dan anak asma tanpa obesitas

Jurnal Gizi Klinik Indonesia ◽

10.22146/ijcn.18839 ◽

2013 ◽

Vol 10 (1) ◽

pp. 19

Author(s):

Nurul Hadi ◽

Madarina Julia ◽

Roni Naning

Keyword(s):

Peak Flow ◽

Pearson Correlation ◽

Cross Sectional Study ◽

Growth Chart ◽

Z Score ◽

Flow Meter ◽

Cross Sectional ◽

Asthmatic Children ◽

Increased Risk ◽

Significant Difference

Background: Obesity in children is associated with impairment of pulmonary function and increased risk of asthma. Obesity in asthmatic children may reduce lung function, that can be assessed by peak flow meter, a practical and an inexpensive tool.Objectives: To compare the peak expiratory flow (PEF) between obese and non-obese asthmatic children.Method: We conducted a cross sectional study in Yogyakarta during March 2010-September 2012. Fifty obese asthmatic patients and 50 non obese asthmatic control subjects participated in this study. Inclusion criteria were asthmatic patient, according to Pedoman Nasional Asma Anak (PNAA), and 6-18 years of age. Exclusion criteria were asthmatic attack, respiratory disease, heart disease and congenital chest malformation. Obesity is defined as body mass index (BMI) for age more than +3 SD WHO growth chart standards BMI for age 2007 z-score. Z-score is calculated with WHO AnthroPlus for Personal Computers. Data PEF is taken with electrical peak flow meter when the patient was not suffering from asthma attack. Normal PEF was defined as PEF ≥80% average (predicted) value for height.Results: The mean of age of asthmatic children in this study was 9.38 years and 9.50 years for non obese and obese respectively. The PFR was not different between obese asthmatic children and non obese asthmatic children (p=0,83). Pearson correlation of PFR and z-score BMI for age was positive weak correlation (r=0.12). There was significant difference of PFR between z-score BMI for age <3,20 and z-score BMI for age ≥3.20 (p=0.03). Significant difference of PFR also appears in duration of illness (p<0.001).Conclusion: There is no PFR difference between obese asthmatic children and non-obese asthmatic children. The difference of PFR emerges when statistic analysis performed using z-score BMI ≥3.20.

Download Full-text

Correlation of serum uric acid with renal function parameters in preeclampsia.

The Professional Medical Journal ◽

10.29309/tpmj/2020.27.12.4267 ◽

2020 ◽

Vol 27 (12) ◽

pp. 2703-2707

Author(s):

Muddasir Zia ◽

Rukhshan Khurshid ◽

Uzma Jabbar ◽

Adnan Riaz ◽

Roohi Jabbar ◽

...

Keyword(s):

Renal Function ◽

Uric Acid ◽

Serum Creatinine ◽

Serum Uric Acid ◽

Cross Sectional Study ◽

Urinary Protein ◽

Estimation Of Parameters ◽

Cross Sectional ◽

Significant Difference ◽

Relationship Of

Objectives: Study was designed to find out the Correlation of serum uric acid with renal function parameters in Preeclampsia. Study Design: Cross Sectional study. Setting: Sir Ganga Ram Hospital Lahore. Period: July 2016 to July 2017. Material & Methods: Level of serum uric acid, serum creatinine and blood urea of 40 Preeclamptic women and 30 gestation-matched normotensive controls were estimated. Their Demographic and clinical characteristics were noted. The blood sample was analyzed for biochemical parameters, blood urea, serum uric acid, serum creatinine and urinary protein. Result: Mean age and gestational age of women was 25 weeks with BMI 29 Kg/m2. Level of serum uric acid and blood urea and serum creatinine were increased, but significant difference only observed with serum uric acid and blood urea with marked proteinuria. An inverse relationship of serum uric acid with urinary protein was observed. A direct relationship, of serum uric acid with serum creatinine was observed. Conclusion: it is concluded that estimation of parameters of renal function of preeclamptic women are important along with hyperuicaemia.

Download Full-text

What Do Our Nurses Know about Managing Patient with Permanent Pacemakers?

Jurnal NERS ◽

10.20473/jn.v15i2.18925 ◽

2020 ◽

Vol 15 (2) ◽

pp. 157

Author(s):

Muhamad Al Muizz Ismail ◽

Nor Marini Ibrahim ◽

Muhammad Kamil Che Hasan

Keyword(s):

Clinical Laboratory ◽

Pearson Correlation ◽

Demographic Data ◽

Descriptive Analysis ◽

Pacemaker Implantation ◽

Cross Sectional Study ◽

Cross Sectional ◽

Number Of Patients ◽

Significant Difference ◽

Level Of Knowledge

Introduction: The number of patients with pacemaker implant is increasing in the health services sector in Malaysia, which requires nurses to have expertise in patient care with pacemaker implantation. Therefore, this study was conducted to analyse the level of knowledge among nurses regarding the management of patients with pacemaker implantation.Methods: A cross-sectional study was conducted through purposive sampling among all nurses working at the critical care unit, intensive care unit, cardiac rehabilitation ward, investigation clinical laboratory, and non-invasive clinical laboratory in a public hospital in Kelantan. A questionnaire consisted of demographic data and nurses’ knowledge was distributed. Data were analysed for descriptive analysis and using Pearson correlation test.Results: Results from all respondents (n=70), show 48.6 % of the respondents had moderate knowledge about patient management with pacemaker implantation, 32.9 % had a low level of knowledge and only 13.6% had high knowledge regarding management of patient with pacemaker implantation. There is a significant difference between the level of knowledge and demographic data, that is between the level of education (p=0.027), age (p=0.011) and length of service (p=0.015). There is no significant relationship between knowledge and demographic data, such as gender (p=0.481), marital status (p=0.315), and post-basic (p=0.067).Conclusion: Level of knowledge among nurses about the management of patient with pacemaker implantation is low to moderate. Additional education and exposure among nurses are needed to enhance the knowledge of nurses and improve the quality of care among patients with pacemaker implant.

Download Full-text

The Relation Between IGF-1 Levels and Fasting Blood Glucose in Obese Women

STRADA JURNAL ILMIAH KESEHATAN ◽

10.30994/sjik.v9i1.276 ◽

2020 ◽

Vol 9 (1) ◽

pp. 140-146

Author(s):

Zakaria Sendy Wardana ◽

Gadis Meinar Sari ◽

Damayanti Tinduh

Keyword(s):

Pearson Correlation ◽

Fasting Blood Glucose ◽

Physiological Mechanism ◽

Cross Sectional Study ◽

Obese Women ◽

Elisa Method ◽

Cross Sectional ◽

Percentage Body Fat ◽

Analysis Techniques ◽

Pearson Correlation Test

This study used a cross sectional study method using 39 obese women aged 19-22 years old, Body Mass Index (BMI) 25-35 kg / m2 and Percentage Body Fat (PBF) above 30%, normal blood pressure, heart rate normal rest and normal Hemoglobin (Hb). IGF-1 levels were measured using the Enzym Link Immunosorbent Assay (ELISA) method, while the FBG measurements used ACCU-CHEK® Performance. Data analysis techniques used the Pearson Correlation test with the Statistical Package for Social Science (SPSS). The results obtained an average level of IGF-1 (11,530 ± 4,397) ng / mL and an average FBG (90,153 ± 6,659) mg / dL (r = 0.379) and (p = 0.017). Based on the results of the study, it’s concluded that there is a positive correlation of IGF-1 levels with FBG in obese women. Further research is needed to explain the physiological mechanism of the relation between IGF-1 and FBG in more detail

Download Full-text