scholarly journals Therapy Effect of Red Dragon Fruit (Hylocereus polyrhizus) Peel Extract to Increase the Number of Sertoli Cells On BALB/c Mice (Mus musculus) Exposed to Lead Acetate

2020 ◽  
Vol 56 (2) ◽  
pp. 108
Author(s):  
Evy Wulandari ◽  
Reny I'tishom ◽  
Sri Agus Sudjarwo
Keyword(s):  
Free Radicals ◽  
Mus Musculus ◽  
Sertoli Cells ◽  
Lead Acetate ◽  
Fruit Peel ◽  
Dragon Fruit ◽  
Therapy Effect ◽  
Significant Difference ◽  
Peel Extract ◽  
Hylocereus Polyrhizus

Lead is the free radicals and heavy metals of major pollutants in the environment. Lead is toxic and cumulative. Red dragon fruit (Hylocereus polyrhizus) peel extract is a natural antioxidant. Red dragon fruit peel extract can be used to stabilize free radicals by supplementing electron deficiencies and inhibiting chain reactions. This study aimed to analyze therapy effect of red dragon fruit peel extract to increase the number of Sertoli cells on BALB/c mice (Mus musculus) exposed to lead acetate. Fourty mice were divided into 5 groups (each group consisted of 8 mice). K- group was the control group without lead acetate and dragon fruit peel extract administration, K + group was given 100 mg/KgBW lead acetate orally on the 1st day until day 14th.. P1, P2, and P3 group were continued with red dragon extract orally on the 15th day until 39th day. P1 with dose 250 mg/KgBW, P2 with dose 500 mg/KgBW, and P3 with dose 1000 mg/KgBW. The result showed significant difference (P<0.05) in the number of Sertoli cells between K+ and P1, P2, P3 group. In conclusion, dose 500 mg/kgBW of red dragon fruit peel extract can be used as the most effective therapy to increase the number of Sertoli cells on mice exposed to acetate lead.

scholarly journals Antioxidant and Anti-Hyaluronidase Activities of Dragon Fruit Peel Extract and Kaempferol-3-O-Rutinoside

2019 ◽  
Vol 30 (4) ◽  
pp. 247
Author(s):  
Liana Liana ◽  
Rizal Rizal ◽  
Wahyu Widowati ◽  
Fioni Fioni ◽  
Khainir Akbar ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Free Radicals ◽  
Human Life ◽  
Fruit Peel ◽  
Paired Samples ◽  
Dragon Fruit ◽  
Ic50 Value ◽  
Significant Difference ◽  
Ic50 Values ◽  
Peel Extract

Aging is a natural process in human life and is triggered by the presence of free radicals (ROS). The use of antioxidants from natural ingredients is one of the breakthroughs to overcome aging and counteract the harmful effects caused by the free radicals. This study aimed to determine and compare the antioxidant activity of H2O2 scavenging and hyaluronidase inhibition of red dragon fruit peel extract (DFPE) and kaempferol-3-o-rutinoside (KOR) compounds. Dragon fruit peel extract (DFPE) is obtained through extraction by maceration method using 70% ethanol solvent. The design of this study included antioxidant and anti-aging activity assay of EKBN and KOR at the series concentration of 15.63; 31.25; 62.50; 125; 250; 500 µg/mL through H2O2 scavenging, as well as the DFPE and KOR hyaluronidase inhibition assay at the series concentration of 5.21; 10.42; 20.83; 41.7; 83.33; 166.67 µg/mL. EKBN shows that the average activity of H2O2 scavenging is lower than KOR. In addition, the IC50 values of KOR for H2O2 scavenging is lower (351.46±2.30ug/mL) than DFPE (409.64±23.17ug/mL). While, KOR also has higher values of inhibitory activity than of the DFPE. However, the IC50 value of KOR for hyaluronidase inhibition activity was 84.07±10.46µg/mL, equivalent to the IC50 value of DFPE (85.32±10.24µg/mL). The presence of antioxidant and anti-aging activity in the EKBN is probably caused by betalain and the KOR compound itself contained in red dragon fruit. The results of the paired-samples T-test on antioxidant activity and anti-aging of DFPE and KOR showed non-significant difference. Thus, DFPE has an equivalent antioxidant and anti-aging through H2O2 scavenging and hyaluronidase activity as possessed by the KOR compound.

scholarly journals EFFECTS OF RED DRAGON FRUIT PEEL EXTRACT ADMINISTRATION ON NEUTROPHIL COUNTS FOLLOWING PERIAPICAL RADIOGRAPHY EXPOSURE

2021 ◽  
Vol 6 (2) ◽  
pp. 154
Author(s):  
Maydina Izzatul Yazidah ◽  
Didit Aspriyanto ◽  
Renie Kumala Dewi
Keyword(s):  
Free Radicals ◽  
Radiation Exposure ◽  
Cell Damage ◽  
Control Group ◽  
Fruit Peel ◽  
X Ray ◽  
Dragon Fruit ◽  
Significant Difference ◽  
Peel Extract ◽  
Periapical Radiography

Background: Radiation exposure from periapical imaging can cause cell damage in various tissues due to the formation of free radicals. Cell damage in the tissue can be observed from the number of neutrophils which are immune cells. Free radicals can be suppressed by administering exogenous antioxidants. One source of natural antioxidants is red dragon fruit, especially on its peel. Objective: To analyze the effect of periapical imaging x-ray radiation exposure after the administration of red dragon fruit peel extract on absolute neutrophil counts in mice. Method: This research was a true experimental study with a post-test only and control group design using 24 mice that were divided into 6 groups. The control group was not given any treatment while P1 to P5 group were given red dragon fruit peel extract at a dose of 100 mg/kg BW and exposed to radiation with different exposures. P1 group was exposed 1 time (0.63 mGy), P2 group was exposed 4 times (1.66 mGy), P3 group was exposed 8 times (4.37 mGy), P4 group was exposed 12 times (8.19 mGy), and group P5 was given no exposure. Results: There were changes in the number of neutrophils in all groups. The LSD Posthoc test results showed a significant difference between the control group (12.470 / mm3) and the P5 group (12.470 / mm3) compared to P3 group with 8 times exposure (40.348 / mm3). Conclusion: There is an effect of periapical radiographic x-ray radiation exposure by red dragon fruit peel extract on the absolute neutrophil count in mice. Keywords: Antioxidants, Neutrophils, Periapical Radiography, Radiation, Red Dragon Fruit Peel.

scholarly journals In vitro Test of Macrophage Phagocytic Activity of Extracts and Fractions of Red Dragon Fruit Peel [Hylocereus polyrhizus (F.A.C.Weber) Britton and Rose]

2018 ◽  
Vol 17 (2) ◽  
pp. 161-165
Author(s):  
Sri Wahdaningsih ◽  
Subagus Wahyuono ◽  
Sugeng Riyanto ◽  
Retno Murwanti
Keyword(s):  
Phagocytic Activity ◽  
Phagocytic Index ◽  
In Vitro Test ◽  
Fruit Peel ◽  
Media Control ◽  
Dragon Fruit ◽  
Significant Difference ◽  
Vitro Test ◽  
Hylocereus Polyrhizus

The peel of red dragon fruit [Hylocereus polyrhizus (F.A.C.Weber) Britton and Rose] can be used to treat various diseases and to improve immune system of body. This study was aimed to investigate the in vitro macrophage phagocytic activity of extracts and fractions of red dragon fruit peel (Hylocereus polyrhizus). The in vitro test was conducted based on the method of Leijh et al. The parameters of phagocytic activity were based on the macrophages capacity to phagocytose latex beads using the calculation of phagocytic capacity and phagocytic index. The test results indicated significant difference (p < 0.05). The petroleum benzene extract showed higher phagocytic activity of macrophages than methanol extract of the fruit peel, sediment, and media control (-). The LSD test showed that macrophage phagocytic activity using fractions (500 and 100 μg/ml) was significantly different from macrophage phagocytic activity using fractions (20 μg/ml), sediment (500, 100 and 20 μg/ml), extracts (500, 100 and 20 μg/ml), and media control. Dhaka Univ. J. Pharm. Sci. 17(2): 161-165, 2018 (December)

scholarly journals Pengaruh Penambahan Ekstrak Kulit Buah Naga (Hylocereus polyrhizus) terhadap Karakteristik Krim Kunyit dan Daun Asam

2020 ◽  
Vol 8 (4) ◽  
pp. 569
Author(s):  
Yohanes Wiliam Pagur ◽  
Sri Mulyani ◽  
Lutfi Suhendra
Keyword(s):  
Antioxidant Capacity ◽  
Water Extract ◽  
Fruit Peel ◽  
Color Test ◽  
Separation Ratio ◽  
Randomized Design ◽  
Dragon Fruit ◽  
Completely Randomized Design ◽  
Peel Extract ◽  
Hylocereus Polyrhizus

The purpose of this study was to determine the effect of dragon fruit peel extract (Hylocereus polyrhizus) on the characteristics of turmeric cream and tamarind leaves. The concentration of dragon fruit peel extract treatment consisted of 6 levels, namely 0, 5, 10, 15, 20 and 25%. Each treatment was repeated 3 times, so that 18 experimental units were obtained. The variables observed in turmeric cream and tamarind leaves were homogeneity, viscosity, pH, dispersibility, adhesion, and separation ratio, antioxidant capacity, LAB color test. Data were observed and analyzed using a completely randomized design. The results showed that the extract of dragon fruit peel did not affect homogeneous separation ratio, viscosity, spread power, pH and antioxidant capacity, while color testing affected the brightness level of the cream and the yellowish value b. All treatments adding water extract of dragon fruit peel produce turmeric cream and tamarind leaves that are homogeneous, there is no separation, viscosity 6766-6850cP, spread ability 5.9-6.27 cm, adhesion 54.67-72.33s, pH 5.37-5.57, nalia color test values L 38.72 – 46.08, values A 27.41-34.98 values B 31.56-44.65 and antioxidant capacity 91,67-112,17. Keywords: Dragon fruit, turmeric and tamarind leaves, cream characteristics.

scholarly journals Pengaruh Ekstrak Kulit Buah Naga Merah (Hylocereus Polyrhizus) terhadap Waktu Perdarahan (Bleeding Time) Pada Mencit Strain Balb-C

2021 ◽  
Vol 18 (2) ◽  
pp. 61
Author(s):  
Dwi Mukti Kusumastuti ◽  
Zainul Cholid ◽  
Winny Adriatmoko
Keyword(s):  
Bleeding Time ◽  
The Body ◽  
Bleeding Complications ◽  
Control Group ◽  
Fruit Peel ◽  
Dragon Fruit ◽  
Whatman Paper ◽  
Natural Medicines ◽  
Peel Extract ◽  
Hylocereus Polyrhizus

Tooth extraction causes prolonged bleeding complications and the body will respond with hemostasis. Currently developing natural medicines to help the process of hemostasis. Red dragon fruit peel, which is generally a waste containing tannins, flavonoids, and saponins to stop bleeding. Purpose was to find out the effect of red dragon fruit peel extract on bleeding time in the tail of Balb-C strain mice. 16 mice samples were adapted for one week. Mice were divided into 2 groups subsquently fasted for 7 hours. The first group as a control (0.5% Na-CMC). The second group was given red dragon fruit peel extract which was divided into three sub-groups at a dose of 0.5 mg / g BW, mg / g BW, and 1.5 mg / g BW. All samples were waited for 45 minutes and cut along 2 cm from the tip of the tail. Blood is spilled on Whatman paper which has 30 seconds in each box. The number of blood spots on the box was calculated and multiplied by 30 seconds. The result showed that bleeding time in the group given red dragon fruit peel extract was significantly lower (p <0.05) than in the control group. The conclusion was red dragon fruit peel extract (Hylocereus Polyrhizus) has an effect on shortening the bleeding time in cutting the tail of bulb-c strain mice and the dose of red dragon fruit peel extract (Hylocereus Polyrhizus) which has the most significant effect is 1 mg / BB mice.

scholarly journals Efisiensi Mikroenkapsulasi Ekstrak Kulit Buah Naga Super Merah (Hylocereus costaricensis) Tersalut Maltodekstrin Berdasarkan Kecepatan Pengadukan

KOVALEN ◽  
2020 ◽  
Vol 6 (1) ◽  
pp. 1-8
Author(s):  
Jaya Hardi ◽  
Dian Citra ◽  
Syamsuddin ◽  
Dwi Juli Pusptasari
Keyword(s):  
Antioxidant Activity ◽  
Particle Size ◽  
Free Radicals ◽  
Freeze Drying ◽  
Fruit Peel ◽  
Coating Efficiency ◽  
Dragon Fruit ◽  
Before And After ◽  
Ic50 Values ◽  
Peel Extract

Extract of super red dragon fruit peel has an antioxidant activity that can prevent free radicals from outside and its activity can be maintained by the coating of super red dragon fruit peel extract with maltodextrin The coating efficiency of super red dragon fruit peel extract with maltodextrin can be controlled with the speed of stirring during microencapsulation experiment. In order to obtain the highest microencapsulation efficiency and compare the antioxidant activity of super red dragon fruit peel extract before and after microencapsulation experiment. The study of coating efficiency has been done with microencapsulation that was carried out using the freeze-drying technique. During the microencapsulation of super red dragon fruit peel extract with freeze-drying technique, stirring speed in the microencapsulation process was 600 rpm, 800 rpm, 1000 rpm, 1200 rpm, and 1400 rpm respectively. From the microencapsulation process of super red dragon fruit peel extract coated with maltodextrin, it was obtained the highest microencapsulation efficiency at stirring speed of 800 rpm, which was 66.85% and had a particle size of 14.24 µm. It can be concluded that the antioxidant activity before and after encapsulation included a very weak category with IC50 values of 205.42 ppm for extracts and 246.32 ppm for microcapsules. Keywords: Super red dragon fruit peel, freeze-drying, microencapsulation, maltodextrin

scholarly journals Hylocereus polyrhizus Peel Extract Increase Testosteron Levels of Balb/C Mice (Mus musculus) Exposed Lead Acetate

2020 ◽  
Vol 1 (1) ◽  
pp. 1-6
Author(s):  
Reny I’tishom ◽  
Evy Wulandari ◽  
Sri Agus Sudjarwo
Keyword(s):  
Oxidative Stress ◽  
Mus Musculus ◽  
Lead Acetate ◽  
The Body ◽  
Control Group ◽  
Control Group Design ◽  
Post Test ◽  
Acetate Lead ◽  
Peel Extract ◽  
Hylocereus Polyrhizus

Lead is a heavy metal, the main polluting material in the environment, which comes from gasoline, batteries, paint, pipes, soil, cosmetics, household appliances, and decorations. Lead is a free radical causing oxidative stress. Lead can accumulate in the body due to its slow elimination process. Lead increases oxidative stress by forming reactive oxygen species (ROS) such as superoxide ion (O2-), hydroxil radical (OH-), and nitric oxide (NO), and direct suppression of antioxidant reserves such as Superoxide Dismutase (SOD), Catalase, and Glutathione Peroxide (GPx). Hylocereus polyrhizus peel is a natural antioxidant that can overcome the toxic effects of lead. The aim of this study was to analyze the treatment of Hylocereus polyrhizus peel extract orally once in a day for 40 days to increase testosteron levels of Balb/C mice (Mus musculus) exposed to lead acetate. The type of this study was true experimental study with Post Test Only Control Group design. Forty mice aged 8-10 weeks and the range of the body weight 30-40 grams were divided into 5 groups (each group of 8 mice). K- group was the control group without lead acetate and Hylocereus polyrhizus peel extract. K+, P1, P2 and P3 group was given 100 mg/kgBW lead acetate orally on the 1st day until day 14th. P1, P2 and P3 group was continued by giving Hylocereus polyrhizus peel extract orally on the 15th day until 39th day. P1 with dose 250 mg/KgBW, P2 with dose 500 mg/KgBW, and P3 with dose 1000 mg/KgBW. The results showed significant differences in testosterone levels between the K+ groups with P1 and P2. The conclusion of this study is Hylocereus polyrhizus peel extract can increase the testosteron levels of mice exposed to acetate lead.

scholarly journals Pemanfaatan Jagung Manis Dan Kulit Buah Naga Untuk Olahan Mie Kering Kaya Nutrisi

2017 ◽  
Vol 16 (2) ◽  
Author(s):  
Analianasari Analianasari ◽  
Muhammad Zaini
Keyword(s):  
Sweet Corn ◽  
Test Results ◽  
Fruit Peel ◽  
Dragon Fruit ◽  
Significant Difference ◽  
Two Factors ◽  
Unit Unit ◽  
Peel Extract ◽  
Test Treatment ◽  
Better Than

The research was aimmed at studying (1) Determine the percentage of wheat flour,sweet corn and skin dragon fruit right in the manufacture of dry noodles that can beaccepted by consumers, and (2) Determine the influence of addition of sweet corn andrind of a dragon on the content of moisture, ash, protein, and preferences ofconsumers towards the parameters of color, flavor, elasticity, and sensory overall.The method used in this study is a factorial experimental design with two factors,namely the substitution treatment of sweet corn pasta and red dragon fruit skinextracts of the flour. Substitution of sweet corn used is 10%, 20% and 30%. Mediumaddition of dragon fruit peel extract of 5%, 10% and 15%. Each experiment carriedrepeat 3 times, so it will be acquired unit (unit) trial were 9 units trial. The dataobtained were tested with the test Barlett diversity and additional data with Tuckeytest. Furthermore, to see the value of the middle test treatment Significant Difference(LSD) at 5% level. The resulting dried noodles then analyzed the water content, ashprotein, the overall sensory test. Results from the study if seen from the test sensorypreferences overall, generally panelists prefer the treatment of sweet corn and dragonfruit with a concentration of 20%, 15% better than the taste, color and elasticity ofnoodles, while from the nutritional content of dried noodles sweet corn and dragonfruit SNI is in conformity with dry noodles.Keywords: Sweet corn, dragon fruit peel, dried noodles

scholarly journals 2. Antibacterial Test of Red Dragon Fruit Extract Peel (Hylocereus polyrhizus) Against Bacteria Salmonella pullorum

2018 ◽  
Vol 12 (1) ◽  
pp. 9-14
Author(s):  
Ichsan Maulana ◽  
Abdul Harris ◽  
Fakhrurrazi Fakhrurrazi ◽  
Maryulia Dewi ◽  
Safika Safika ◽  
...  
Keyword(s):  
Inhibition Zone ◽  
Fruit Peel ◽  
Mueller Hinton ◽  
Dragon Fruit ◽  
Salmonella Pullorum ◽  
Mueller Hinton Agar ◽  
Veterinary Faculty ◽  
Peel Extract ◽  
Hylocereus Polyrhizus ◽  
Positive Controls

The purpose of this study is to determine the effect of the red dragon fruit peels (Hylocereus polyrhizus) extract on the growth of Salmonella pullorum. This research was conducted at the Laboratory of Microbiology, Veterinary Faculty, University of Syiah Kuala, Banda Aceh. Red dragon fruit peels that used in this study is obtained from  ripe fruit and Salmonella pullorum cultures is  obtained from  Microbiology Laboratory of Veterinary Faculty Unsyiah. Salmonella pullorum culture added evenly on the surface of Mueller Hinton Agar, the number of the bacteria have been standarized using Mc Farland'1 method. Discs soaked in the red dragon fruit peels extracts at different concentrations (20 mg/ml, 40 mg/mL, and 60 mg/ml). Ampicillin is used as positive controls and DMSO (dimethyl sulfoxide) was placed on the surface of Mueller Hinton Agar. The parameters in this study is the inhibition zone diameter. Data were analyzed descriptively. The results showed that the red dragon fruit peel extract is able to inhibit the growth of Salmonella  pullorum and the average of  inhibition diameter zone at a concentration 60 mg / ml is 9.6 mm, 40 mg / ml is 9.4 mm and 20 mg / ml is 9.3 mm

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