scholarly journals BIOMARKER TERKINI DALAM USAHA MEMPREDIKSI PREEKLAMPSIA

2017 ◽  
Vol 13 (1) ◽  
pp. 119 ◽  
Author(s):  
Yosef Dwi Cahyadi Salan
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Gestational Age ◽  
Growth Pattern ◽  
Abnormal Placentation ◽  
Immunological Markers ◽  
Life Threatening ◽  
Early Biomarker ◽  
Main Factors ◽  
Angiogenic Markers

Abstract: Preeclampsia is a life-threatening disease and can occur in all pregnant women. Preeclampsia was defined as a disease in pregnant women that is characterized by an increase in blood pressure exceeds 140 mmHg for systolic and 90 mmHg for diastolic that occured in pregnant women with gestational age above 20 weeks. In recent decades the incidence of preeclampsia continues to rise and is caused by various factors. Factors to be considered as the most influential is the process of the growth of the placenta which is abnormal, but the main factors that trigger the growth of the placenta become abnormal is not yet certainly known, some studies tryingto find out the various factors that can trigger the growth of abnormal placentation of preeclampsia, especially the associationof the growth pattern blood vessels in the placenta are thought to have a major role in the occurrence of preeclampsia in pregnant women. From these studies are found several biomarkers that are believed to be an early marker in an attempt to prevent the occurrence of preeclampsia in pregnant women, such as angiogenic markers, immunological markers, markers of Metabolic and Endocrine marker. Keywords: Preeclampsia, Abnormal Placentation, and Early Biomarker. Abstrak: Preeklampsia merupakan salah satu penyakit yang mengancam jiwa dan dapat terjadi pada semua ibu hamil. Preeklampsia didefinisikan sebagai suatu penyakit pada ibu hamil yang ditandai dengan adanya peningkatan tekanan darah melebihi 140 mmHg untuk sistolik dan 90 mmHg untuk diastolik yang terjadi pada ibu hamil dengan usia kehamilan diatas 20 minggu. Dalam beberapa dekade terakhir angka kejadian preeklampsia terus meningkat dan disebabkan oleh berbagai macam faktor. Faktor yang dianggap paling berpengaruh yaitu adanya proses pertumbuhan plasenta yang tidak normal, akan tetapi faktor utama yang mencetuskan terjadinya pertumbuhan plasenta secara abnormal tersebut belum diketahui dengan pasti, beberapa penelitian mencoba mencari tau berbagai faktor yang dapat memicu terjadinya pertumbuhan plasenta abnormal pada preeklampsia, terutama yang berhubungan dengan pola pertumbuhan pembuluh darah pada plasenta yang diduga memiliki peranan besar dalam terjadinya preeklampsia pada ibu hamil. Dari penelitian-penelitian tersebut didapatkan beberapa biomarker yang dipercaya dapat menjadi penanda dini dalam usaha untuk mencegah terjadinya preeklampsia pada ibu hamil, seperti marker Angiogenik, marker Immunologis, marker Metabolik, dan marker Endokrin. Kata-kata Kunci: Preeklampsia, Pertumbuhan Plasenta Abnormal, dan Biomarker  Penanda Dini. 

scholarly journals Apelin 13 and Blood Pressure, Is there any Association in Pre-eclampsia? - A Case-control Study

2021 ◽  
Author(s):  
Rajeev Gandham ◽  
CD Dayanand ◽  
SR Sheela
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Gestational Age ◽  
Case Control Study ◽  
Case Control ◽  
Maternal Serum ◽  
Research Centre ◽  
Categorical Variables ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Study

Introduction: Pre-eclampsia is a pregnancy specific disorder, characterised by the onset of hypertension and proteinuria. Pre-eclampsia is the leading cause of maternal, perinatal morbidity and mortality. The exact cause of pre-eclampsia is not known clearly and needs to be explored. Aim: To evaluate the maternal serum apelin 13 levels among pre-eclampsia and healthy pregnant women and also, to find the association between apelin 13 and blood pressure. Materials and Methods: A case-control study was conducted between Department of Biochemistry and Department of Obstetrics and Gynaecology, RL Jalappa Hospital and Research Centre, Kolar, Karnataka, India. After approval from the Institutional Ethics Committee and written informed consent from study subjects, a total of 270 pregnant women were recruited for this study. Among them, 135 pre-eclamptic women were considered as cases and 135 normotensive healthy pregnant women served as controls. According to the pre-eclampsia severity, cases were grouped into mild (n=47) and severe pre-eclampsia (n=88). Blood samples were collected from all the study subjects and was analysed for apelin 13 by Enzyme Linked Immunosorbent Assay (ELISA) method. Maternal and foetal adverse outcomes were recorded. Results were expressed as mean±Standard Deviation (SD). Categorical variables were expressed in percentages. Spearman’s correlation was applied and p<0.05 was considered significant. Results: The mean gestational age was 36.66±3.69 weeks which was, significantly low in pre-eclamptic women compared with healthy pregnant women. BMI (26.94±3.81 kg/m2), systolic (157.82±15.14 mmHg), diastolic (101.68±11.02 mmHg) and Mean Arterial Pressure (MAP) (120.20±11.12 mmHg), pulse rate (88.14±5.82 bpm), Aspartate Transaminase (AST) (25.25±12.49 IU/L) and Alanine Transaminase (ALT) (19.01±10.95 IU/L) were significantly increased in pre-eclamptic women when compared with control group. Mean maternal serum apelin 13 (341.44±218.63 pg/mL) concentrations were significantly lower in pre-eclampsia compared with healthy pregnant women. Maternal serum apelin 13 concentrations were negatively correlated with Systolic Blood Pressure (SBP) (r = -0.196), Diastolic Blood Pressure (DBP) (r = -0.172) and MAP (r =-0.204). Adverse maternal outcomes such as epigastric pain 75 (55.55%), oedema 62 (45.92%) and persistent headache 35 (25.92%) were higher in pre-eclamptic group. Additionally, adverse foetal outcomes were more in pre-eclamptic cases including significantly decreased birth weight (2.40±0.65), babies requiring Neonatal Intensive Care Unit (NICU) admission were 54 (40%), preterm birth (≤37 wks) in 50 (37.03%), Respiratory Distress Syndrome (RDS) 31 (22.96%), Small for Gestational Age (SGA) in 4 (2.96%) and Intra Uterine Death (IUD) in 11 (8.14%) babies. Conclusion: It was concluded from the present study that there was low maternal serum apelin 13 concentrations in pre-eclampsia and had negative correlation with blood pressure, suggesting its potential role in the pathophysiology of pre-eclampsia.

scholarly journals Association of serum neutrophil gelatinase associated lipocalin (NGAL) levels with preeclampsia

2019 ◽  
Vol 8 (2) ◽  
pp. 513
Author(s):  
M. Dhivya ◽  
Chippy Tess Mathew ◽  
G. Jeyachandran
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Gestational Age ◽  
Correlation Coefficients ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Multiple Organs ◽  
Systemic Disorder ◽  
Neutrophil Gelatinase ◽  
And Control ◽  
Control Study

Background: Preeclampsia is a systemic disorder that affects multiple organs and is characterized by the new onset of hypertension and proteinuria or end-organ dysfunction or both in the second half of pregnancy. NGAL is a 25-KDa protein of the lipocalin family and is considered to be a novel biomarker for ischemic injury. The objective of this study is to compare the levels of serum NGAL in preeclamptic patients and gestational age matched normotensive controls.Methods: The study design is case control study in which pregnant women with preeclampsia (n=40) are selected as cases. Cases were selected from pregnant women attending OG-OPD and IP satisfying the inclusion criteria and not coming under exclusion criteria. 0.5ml of blood was collected in vacutainers and was centrifuged at 3500rpm for 10 minutes. The serum thus separated was aliquoted into smaller plain containers and stored at -20 degree Celsius for analysis. The urine sample was also collected. Controls were also selected from the OP patients.Results: In present study, the serum NGAL ranged from 40-900ng/ml in cases and from 110-795ng/ml in controls. There is no difference in NGAL between cases and control. The correlation coefficients between the NGAL levels and other parameters like maternal age, gestational age, systolic Blood pressure, diastolic Blood pressure, uric acid levels, urine PCR are also not statistically significant.Conclusions: Serum NGAL levels are not significantly elevated in patients with preeclampsia when compared with the normotensive controls and also there is no significant correlation between serum NGAL levels and other assessed parameters.

scholarly journals Socioeconomic, demographic and obstetric profile of pregnant women with Hypertensive Syndrome in a public maternity

2020 ◽  
Vol 41 ◽  
Author(s):  
Lia Maristela da Silva Jacob ◽  
Artur Paiva Santos ◽  
Maria Helena Baena de Moraes Lopes ◽  
Antonieta Keiko Kakuda Shimo
Keyword(s):  
High School ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Pregnant Women ◽  
Body Mass ◽  
Gestational Age ◽  
Skin Color ◽  
High School Education ◽  
Chronic Hypertension ◽  
Elevated Blood

ABSTRACT Objective: To describe the socioeconomic, demographic and obstetric profile of pregnant women with Gestational Hypertensive Syndrome. Methods: A descriptive and correlational study, conducted in Maternity School Assis Chateaubriand, with 120 pregnant women, through a questionnaire analyzed by descriptive and analytical statistics. Results: most women had chronic hypertension (60.83%). Regarding the socioeconomic and demographic profile, most pregnant women had a mean age of 30.9 ± 6.9 years, were Catholic, brown skin color, employed, in stable unions, complete high school education, and income of up to R$ 954.00. Regarding the obstetric profile, their Body Mass Index was up to 66, slightly elevated blood pressure, an average of five prenatal consultations, two pregnancies, one delivery and no abortions. Women with chronic hypertension were older (p = 0.0024), had lower gestational age (p = 0.0219) and a higher number of abortions (p = 0.0140). Conclusions: Pregnant women are overweight/obese, with a mean age of 30.9 years and are socially vulnerable. Pregnant women with chronic hypertension are older and have a higher number of abortions.

Preeclampsia is not associated with elevated muscle sympathetic reactivity.

2020 ◽  
Author(s):  
Laura Marcela Reyes ◽  
Charlotte W. Usselman ◽  
Rshmi Khurana ◽  
Radha S. Chari ◽  
Michael K. Stickland ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Pregnant Women ◽  
Gestational Age ◽  
Cold Pressor Test ◽  
Cold Pressor ◽  
Tonic Activity ◽  
Sympathetic Nervous ◽  
Peripheral Chemoreflex

Objective: To determine whether increased chemoreflex tonic activity is associated with augmented muscle sympathetic nervous sys activity (MSNA) in women diagnosed with preeclampsia. Methods: Women with preeclampsia (n=19; 32±5 years old, 31±3 weeks gestation) were matched by age and gestational age with pregnant women (controls, n=38, 32±4 years old, 31±4 weeks gestation; 2:1 ratio). MSNA (n=9 preeclampsia) was assessed during baseline, peripheral chemoreflex de-activation (hyperoxia) and a cold pressor test (CPT). Baroreflex gain, diastolic blood pressure at which there is a 50% likelihood of MSNA occurring (T50) and plasma noradrenaline concentrations were measured. Results: Baseline mean arterial pressure (MAP: 106±11 vs. 87±10 mmHg, p<0.0001), noradrenaline concentrations (498±152 pg/mL vs. 326±147, p=0.001) and T50 (79±7 vs. 71±9 mmHg, p=0.02) were greater in women with preeclampsia compared to controls. However, baseline MSNA (burst incidence [BI]: 41±16 vs. 45±13 bursts/100hb, p=0.4) was not different between groups. Responses to hyperoxia (ΔBI -5±7 vs. -1±8 bursts/100hb, p=0.1; ΔMAP -1±3 vs. -2±3 mmHg, p=0.7) and CPT (ΔBI 15±7 vs. 12±11 bursts/100hb, p=0.6; ΔMAP 10±4 vs. 12±11 mmHg, p=0.6) were not different between groups. Conclusion: Our findings question the assumption that increased MSNA contributes to hypertension in women with preeclampsia. The chemoreflex does not appear to contribute to an increase in MSNA in women with preeclampsia.

Factors influencing foetal growth in pregnancy complicated by diabetes

2017 ◽  
Vol 4 (6) ◽  
pp. 2136
Author(s):  
Sathish Kumar S. ◽  
Anandhi A. ◽  
Luke Ravi Chelliah ◽  
Karthick A. R.
Keyword(s):  
Weight Gain ◽  
Birth Weight ◽  
Pregnant Women ◽  
Fetal Growth ◽  
Gestational Age ◽  
Growth Pattern ◽  
Abdominal Circumference ◽  
Large For Gestational Age ◽  
Maternal Weight ◽  
In Pregnancy

Background: Gestational diabetes mellitus represents a metabolically altered fetal environment due to an increased maternal supply of carbohydrates. It leads to fetal hyperinsulinemia and stimulates insulin-sensitive tissue, predominantly of the abdomen, resulting in increased fetal growth and delivering large-for-gestational-age newborns. Implications of fetal hyperinsulinemia reach far beyond delivery. Children of mothers with diabetes in pregnancy are predisposed to develop obesity and glucose intolerance through a non-genetic “fuel-mediated” mechanism. The objective of the present study was to study the “fetal growth pattern at different periods of pregnancy complicated by diabetes” and to identify the factors that influence the fetal growth pattern in pregnancy complicated by diabetesMethods: 69 pregnant women with diabetes and 34 pregnant women without diabetes were included in the study by random sampling. Maternal parameters such as age, parity, height, weight at registration, and weight gain during pregnancy, BMI at the time of registration of pregnancy and at the time of delivery, detailed diabetic profile and management including meal plan, insulin administration and dosage were recorded. The fetuses were monitored for Biparietal diameter, abdomen circumference, femur length by 2 ultrasound examinations, one at 18-22 weeks and another at 28-32 weeks were performed. Soon after delivery, sex, gestational age, birth weight, length, head circumference and chest circumference of the newborn were recorded and infants were classified as LGA/SGA/AGA.Results: Maternal age, parity, BMI at the time of delivery and maternal weight gain had significant influence on the birth weight. The abdominal circumference of the fetus detected at 18-20 and 28-32 ultrasound scans had a very significant correlation with neonatal mean birth weight percentile. Conclusions: Not all babies born to diabetic mothers are macrosomic. SGA babies were not uncommon in pregnancies with diabetes especially in those who did not have significant micro vasculopathy. Maternal nutrition plays a significant key role in determining birth weight of babies even in pregnancies complicated by diabetes.

scholarly journals Association between Serum C-reactive Protein and Pre-eclampsia

2021 ◽  
Vol 15 (2) ◽  
pp. 58-61
Author(s):  
Sanjoy Kumar Das ◽  
Shafeya Khanam ◽  
Rajib Kumar Roy ◽  
Samiya Alam ◽  
Tapan Kumar Roy ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Gestational Age ◽  
Maternal Serum ◽  
Control Group ◽  
Case Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Blood Pressures ◽  
Serum Crp

Among the common disorders of pregnancy, Pre-eclampsia is important one which causes significant maternal and perinatal morbidity and mortality. Its incidence is still high in the developing countries. The triad of high blood pressure, edema and albuminuria is neither specific nor sensitive enough; therefore, a reliable biochemical marker is needed to solve the problem. C-reactive protein(CRP), a marker of tissue damage and inflammation, is elevated in serum in overt preeclampsia. The present study is aimed to explore the association of high maternal serum C-reactive protein (CRP) level with preeclampsia and correlation with the severity of pre-eclamptic process. A total of 60 pregnant women constituting 30 pre-eclamptic (case) and 30 normal (control) pregnant women in the third trimester were enrolled in this study. Both the groups were matched for their age, parity and other baseline characteristics. More than three quarters (76.70%) of the case group exhibited raised serum CRP, which was 20% in control group (p=0.001). CRP was elevated about 13 fold higher than that in the normal pregnant women. The mean systolic and diastolic blood pressure were significantly higher in case group (154±12 mm of Hg) vs (107±7 mm of Hg) in control group (p<_0.001) and serum level of CRP bears linear relationship with both systolic and diastolic blood pressures. Preeclamptic women with higher serum CRP level were at a significantly (p<0.001) lower gestational age than control. Twenty two (73.30%) cases had gestational age <37 weeks (p=0.302) and 66.70% control group had gestational age > 37 weeks. The hypothesis of the study was supported by the study findings that maternal CRP concentration was higher in women with preeclampsia and was correlated with disease progression as evidenced by the investigative analysis. Faridpur Med. Coll. J. Jan 2020;15(2): 58-61

scholarly journals Is there an association between calcium level and preeclampsia in pregnant women? A systemic review

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Melese Linger ◽  
Gedefaw Diress
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Gestational Age ◽  
Calcium Intake ◽  
Calcium Level ◽  
Case Control ◽  
Systemic Review ◽  
Dietary Calcium Intake ◽  
Pregnancy Induced Hypertension ◽  
Induced Hypertension

Background: Pregnancy-induced hypertension is a diagnosis used to describe a wide spectrum of patients who may have only mild elevations in blood pressure or severe hypertension with various organ dysfunctions. Preeclampsia is a form of pregnancy-induced hypertension which is defined as the new onset of hypertension and proteinuria after 20 weeks of gestation in a previously normotensive woman. Preeclampsia has been identified as the leading reason for maternal admission to the intensive care unit in the puerperal period. Trends of pregnancy-induced hypertension in low- and middle-income countries were increasing. The WHO recommend calcium supplementation as part of the antenatal care for the prevention of preeclampsia in pregnant women, particularly among those population where calcium intake low and at higher risk of developing hypertension. Methods: The data were searched electronically From Pub Med, Google Scholar, Cochrane database reviews and Google. Case-control, retrospective and prospective cohort and clinical trial and papers published in the English language was included. Out of 460 pieces of literature searched electronically, only 23 pieces of literature were used in this study. The other 435 references were not reviewed based on exclusion criteria. In this review 14 case-control studies, 2 cross-sectional studies, 1 longitudinal study, 2 clinical trials, and 4 reviews were included. Results: The age of the study participant’s ranges from 18-41, all study participant’s gestational age was greater than 12 wk. All studies used a diagnostic criteria for preeclampsia based on the following criteria: Blood pressure (BP) more than 140/90 and proteinuria >300 mg/do in 24 hr or 1+ in dipstick urine sample Low levels of calcium have a significant association to preeclampsia as indicated in most studies. Conclusion: Most studies explored that calcium level was low among preeclampsia women. Inconsistencies of recruitment (for example some researcher recruit at 20 weeks of gestational age others in 28 weeks of gestational age) of participant's leads to inconclusive and biased findings in this review. For future researcher should focus on pathophysiology calcium and hypertension. And also it is better the country should give special attention to improve the dietary calcium intake of pregnant women. In the future scientists should better assess calcium level through multiple methods like dietary, clinical and biochemical method and also the impact of calcium on neonatal and maternal should be assessed

scholarly journals Serum Homocystine Level in Women with Severe Preeclampsia

2017 ◽  
Vol 5 (1-2) ◽  
pp. 54-60
Author(s):  
Shahnaz Akter Jahan ◽  
Nahid Reaz ◽  
Shafeya Khanam ◽  
Mirza Md Asaduzzaman ◽  
Zebunnessa Parvin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Gestational Age ◽  
Roc Curve ◽  
Predictor Variable ◽  
Severe Preeclampsia ◽  
Control Group ◽  
Case Group ◽  
History Of ◽  
And Control

Objective: Though preeclampsia (PE) is an age-old disease, its pathology still remains obscure. Available epidemiological evidences suggest that PE is a disease of multiple theories. Recently serum homocystine level is considered as factor to be associated with preecampsia and the higher the level the greater is the severity of preeclampsia. The present study is aimed at investigating this hypothesized association. Methodology: This case-control study was conducted over a period of 24 months from January 2012 to December 2013 in the Department of Obstetrics & Gynaecology, Dhaka Medical College, Dhaka. Pregnant women admitted with severe preeclampsia were the case, while pregnant women attending at the antenatal clinic without preeclampsia were the controls. Severe preeclampsia was diagnosed by blood pressure > 160/110 mm of Hg with proteinuria 3+ or more in dipstick test. The control group comprised of women of 24 - 40 weeks gestation, with blood pressure (both diastolic and systolic) remaining within normal limits without having any medical or obstetric complications. Data were analysed using software SPSS (Statistical Package for Social Sciences) version 16.0. The test statistics used to analyse the data were descriptive statistics, Chi-square (χ2) Test, Student’s t-Test and Receiver-operating characteristic (ROC) curve analysis. Result: Around two-thirds of the patients in both groups were in the age range of 21-30 years with mean age of the cases and control being 25.8 ± 5.2 and 24.1 ± 3.7 years respectively (p = 0.108). Over three-quarters (77.5%) of the patients in case group and 60.0% in control group belonged to middle class (p = 0.091). Majorities of the cases (85.0%) and controls (90.0%) were preterm (gestational age < 37 weeks) with mean gestational age being 33.2 ± 3.3 and 32.3 ± 3.5 weeks in case and control groups respectively (p > 0.05). The patients in either group were predominantly primigravida. Seven (17.5%) patients in the case group gave the history of past preeclampsia as opposed to none in the control group (p = 0.005). Family history of preeclampsia was reported by the case group alone (p = 0.027). Majority (95.0%) of the cases had 3+ proteinuria. Serum homocystine concentration was significantly raised (15.7 ± 8.3 μmol/L) in case group than that in the control group (6.7 ± 1.3 μmol/L) (p < 0.001). Based on the receiver-operator characteristic (ROC) curve, serum homocysteine levels in pregnant women had the best area under the curve (0.975 or 97.5%) with sensitivity and specificity of the predictor variable being 92.5 and 77.5% respectively. Conclusion: The study concluded that homocysteine levels are significantly elevated in patients with preeclampsia compared to the pregnant women without preeclampsia. Homocysteine may be of value in the monitoring of pregnancies to be complicated by preeclampsia. Ibrahim Card Med J 2015; 5 (1&2): 54-60

scholarly journals Studies of Some Haemostatic Variables in Preeclamptic Women in Owerri, Imo State, Nigeria

2021 ◽  
pp. 39-48
Author(s):  
Obioma Raluchukwu Emeka-Obi ◽  
Nancy C. Ibeh ◽  
Emmanuel Ifeanyi Obeagu ◽  
Hope M. Okorie
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Demographic Data ◽  
Test Group ◽  
Peripheral Circulation ◽  
Control Group ◽  
Imo State ◽  
Significant Difference ◽  
Life Threatening ◽  
Abnormal Pattern

Preeclampsia is a serious and life-threatening pregnancy complication. In this study, the levels of haemostatic parameters were measured in preeclamptic women in Owerri, Imo State. A total of 120 pregnant women aged 18-45 years at 20-40 weeks of pregnancy were recruited; 60 were preeclamptic women (test group) while 60 were normotensive pregnant women (control group). Preeclampsia was determined by the presence of ≥2+ protein in the urine using combi 2 dipstick for urinalysis and sphygmomanometer blood pressure reading of ≥ 140/90 mmHg. From the demographic data obtained in the studied subject through questionnaire, it showed that nulliparity and family history of high blood pressure were the most dominant risk factor of preeclampsia. The mean haemostatic parameters (PT, APTT, Fibrinogen, D-dimer and t-PA) of the test group were 12.3±0.94sec, 32.17±3.38sec, 627.31±106.93mg/ld, 2.23±0.50mg/l, 2.65±0.57ng/ml respectively, while the control group were 11.76±0.97sec, 28.69±2.64sec, 554±124.81 mg/dl, 1.89±0.44mg/l and 2.37±0.66 ng/ml respectively. There was a significant difference between the haemostatic parameter of the test group when compared with the control group. The results indicated that although anaemia and activation of coagulation and fibrinolysis occur within the peripheral circulation of both preeclamptic and normotensive pregnancy, an abnormal pattern of haemostasis occurs more in preeclamptic women.

HIPEREMESIS GRAVIDARUM PADA IBU HAMIL DI KLINIK BIDAN SUPRIYATI SRIBIT BERBAH SLEMAN

2019 ◽  
Vol 14 (1) ◽  
pp. 51
Author(s):  
Pramukti Dian Setianingrum ◽  
Farah Irmania Tsani
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Hyperemesis Gravidarum ◽  
Unwanted Pregnancy ◽  
The Body ◽  
Nausea And Vomiting ◽  
Daily Activities ◽  
World Health ◽  
The World

Backgroud: The World Health Organization (WHO) explained that the number of Hyperemesis Gravidarum cases reached 12.5% of the total number of pregnancies in the world and the results of the Demographic Survey conducted in 2007, stated that 26% of women with live births experienced complications. The results of the observations conducted at the Midwife Supriyati Clinic found that pregnant women with hyperemesis gravidarum, with a comparison of 10 pregnant women who examined their contents there were about 4 pregnant women who complained of excessive nausea and vomiting. Objective: to determine the hyperemesis Gravidarum of pregnant mother in clinic. Methods: This study used Qualitative research methods by using a case study approach (Case Study.) Result: The description of excessive nausea of vomiting in women with Hipermemsis Gravidarum is continuous nausea and vomiting more than 10 times in one day, no appetite or vomiting when fed, the body feels weak, blood pressure decreases until the body weight decreases and interferes with daily activities days The factors that influence the occurrence of Hyperemesis Gravidarum are Hormonal, Diet, Unwanted Pregnancy, and psychology, primigravida does not affect the occurrence of Hyperemesis Gravidarum. Conclusion: Mothers who experience Hyperemesis Gravidarum feel nausea vomiting continuously more than 10 times in one day, no appetite or vomiting when fed, the body feels weak, blood pressure decreases until the weight decreases and interferes with daily activities, it is because there are several factors, namely, hormonal actors, diet, unwanted pregnancy, and psychology.

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