Efficiency of surgical treatment of multidrug-resistant Pulmonary Tuberculosis within the DOTS-PLUS program

Efficiency of the surgical treatment of pulmonary tuberculosis for multidrug-resistant (MDR TB) tuberculosis patients was analyzed. Seventy DOTS-PLUS patients with various clinical forms of pulmonary tuberculosis and Mycobacterium resistance from 3 to 8 antituberculosis drugs have been operated. Positive clinical results have been achieved for 65 (92,8%) patients. Indications for surgical treatment for patients with MDR TB have been developed. To ensure positive outcomes of the surgical interventions, main objective is the development of so-called a favorable preoperative environment during the preoperative phase. It includes switching on intensive chemotherapy and pathogenetic methods of treatment.

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High Prevalence of Fluoroquinolone Resistance among Non-Multidrug-Resistant Pulmonary Tuberculosis Patients Attending a Tertiary Care Hospital: An Imminent Threat

Indian Journal of Medical Microbiology ◽

10.1016/j.ijmmb.2021.08.315 ◽

2021 ◽

Vol 39 ◽

pp. S91

Author(s):

Aitihya Chakraborty ◽

Banya Chakraborty ◽

Anindita Rakshit

Keyword(s):

Pulmonary Tuberculosis ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Multidrug Resistant ◽

Fluoroquinolone Resistance ◽

Care Hospital ◽

Tuberculosis Patients ◽

High Prevalence ◽

Imminent Threat

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Surgical treatment of pulmonary tuberculosis in patients with concurrent parenteral viral hepatitis

Tuberculosis and lung diseases ◽

10.21292/2075-1230-2020-98-6-22-26 ◽

2020 ◽

Vol 98 (6) ◽

pp. 22-26

Author(s):

S. N. Shugаevа ◽

А. E. Suzdаlnitskiy ◽

E. D. Sаvilov ◽

S. I. Mаlov ◽

I. V. Mаlov

Keyword(s):

Drug Resistance ◽

Surgical Treatment ◽

Viral Hepatitis ◽

Hepatitis Virus ◽

Small Scale ◽

Surgical Interventions ◽

Tuberculosis Patients ◽

Continuous Sampling ◽

Extensive Drug Resistance ◽

Chronic Course

The objective: to assess the effect of parenteral viral hepatitis on the manifestations of respiratory tuberculosis and the nature of surgical interventions for tuberculosis.Subjects and methods. An ambispective observational study was conducted with a continuous sampling of 475 respiratory tuberculosis patients over 18 years old who underwent surgical interventions. The patients are divided into two groups: the group of RTB+PVH consisted of 92 patients with concurrent respiratory tuberculosis and chronic parenteral viral hepatitis; the group of RTB included 383 patients with respiratory tuberculosis and no parenteral viral hepatitis.Results. It was found that compared with RTB group, in RTB+PVH group (regardless of the type of hepatitis virus), a chronic course of tuberculosis was registered significantly more often (42.4%; p = 0.005; OS = 2.0); more often bacillary excretion was documented (68.5%; p = 0.035; OR = 1.7), including those with multiple and extensive drug resistance (52.4% of cases with positive sputum tests, p = 0.048; OR = 1.8). Radical (69.6%; p = 0.05; OS = 1.7) and small-scale surgical interventions (64.1%; p = 0.037; OS = 1.8) were significantly less frequently performed in RTB+PVH patients; and such patients often developed postoperative complications (8.7%; p = 0.009; OS = 2.9).

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EXPERIENCE OF SURGICAL TREATMENT OF MULTIDRUG RESISTANT PULMONARY TUBERCULOSIS IN CHILDREN АND TEENAGERS

Ukrainian Pulmonology Journal ◽

10.31215/2306-4927-2018-102-4-48-52 ◽

2018 ◽

Vol 102 (4) ◽

pp. 48-52

Author(s):

М. S. Opanasenko ◽

◽

О. V. Tereshkovуch ◽

O. І. Belogortseva ◽

Т.V. Kyrylova ◽

...

Keyword(s):

Surgical Treatment ◽

Pulmonary Tuberculosis ◽

Multidrug Resistant ◽

Tuberculosis In Children

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Prevalence of tuberculosis, multidrug resistant tuberculosis and associated risk factors among smear negative presumptive pulmonary tuberculosis patients in Addis Ababa, Ethiopia

BMC Infectious Diseases ◽

10.1186/s12879-019-4241-7 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 7

Author(s):

Waganeh Sinshaw ◽

Abebaw Kebede ◽

Adane Bitew ◽

Ephrem Tesfaye ◽

Mengistu Tadesse ◽

...

Keyword(s):

Risk Factors ◽

Pulmonary Tuberculosis ◽

Addis Ababa ◽

Multidrug Resistant ◽

Tuberculosis Patients ◽

Resistant Tuberculosis ◽

Multidrug Resistant Tuberculosis ◽

Smear Negative ◽

Associated Risk Factors

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Analysis of Smear Microscopy and Culture Conversion Results in Multidrug-Resistant Tuberculosis Patients with and without Type 2 Diabetes Mellitus

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY ◽

10.24293/ijcpml.v26i3.1590 ◽

2020 ◽

Vol 26 (3) ◽

Author(s):

Henny Fauziah ◽

Aprianti S. ◽

Handayani I. ◽

Kadir NA

Keyword(s):

Diabetes Mellitus ◽

Multidrug Resistant ◽

World Health ◽

Smear Microscopy ◽

Tuberculosis Patients ◽

Resistant Tuberculosis ◽

Multidrug Resistant Tuberculosis ◽

Significant Difference ◽

Mdr Tb ◽

Culture Conversion

The World Health Organization (WHO) recommended microscopic AFB smear examination and culture as follow-ups to the response of MDR TB therapy. Analyzed the results of microscopic AFB smear and culture conversion as well as treatment outcome in Multidrug-Resistant Tuberculosis (MDR-TB) patients with and without Diabetes Mellitus (DM). This is a retrospective study involved 70 MDR-TB patients with (27 patients) with DM and without DM (43 patients) who had microscopic AFB smear and culture results at the start of the follow-up therapy. This research was conducted at Labuang Baji Regional Public Hospital, Makassar, from June to July 2019, used medical records of MDR-TB patients the period of June 2016 to December 2017. The results showed that 52 out of 70 MDR-TB patients had microscopic AFB smear and culture conversion in MDR-TB with DM (21 patients) and without DM (31 patients). The duration of microscopic AFB smear conversion in MDR TB patients with DM (3.33±0.54 months) was longer than patients without DM (2.07±0.05 months), p=0.001. While in culture conversion, there was no significant difference between MDR-TB with DM (1.28±0.64 months) and without DM (1.25±0.59), p=0.648. The recovery outcome between MDR-TB with (48.1%) and without DM (48.8%) was not significantly different. However, the output of treatment failure was greater in DM (11.2%) than without DM (2.3%), although statistically, there was no significant difference (p=0.568). Multidrug-resistant tuberculosis patients with DM experienced slower microscopic AFB smear conversion than MDR-TB patients without DM. However, in culture, there was no significant difference in the conversion period between the two groups. MDR-TB patients, both of with and without DM, had the same chance of recovery.

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Rifampicin and isoniazid drug resistance among patients diagnosed with pulmonary tuberculosis in southwestern Uganda

PLoS ONE ◽

10.1371/journal.pone.0259221 ◽

2021 ◽

Vol 16 (10) ◽

pp. e0259221

Author(s):

Lisa Nkatha Micheni ◽

Kennedy Kassaza ◽

Hellen Kinyi ◽

Ibrahim Ntulume ◽

Joel Bazira

Keyword(s):

Drug Resistance ◽

Pulmonary Tuberculosis ◽

Multidrug Resistant ◽

Bivariate Analysis ◽

Newly Diagnosed ◽

High Resolution Melt ◽

Significant Control ◽

Mdr Tb ◽

Previously Treated ◽

Southwestern Uganda

Multidrug-resistant tuberculosis (MDR-TB) has become a major threat to the control of tuberculosis globally. Uganda is among the countries with a relatively high prevalence of tuberculosis despite significant control efforts. In this study, the drug resistance of Mycobacterium tuberculosis to rifampicin (RIF) and isoniazid (INH) was investigated among patients diagnosed with pulmonary tuberculosis in Southwestern Uganda. A total of 283 sputum samples (266 from newly diagnosed and 17 from previously treated patients), collected between May 2018 and April 2019 at four different TB diagnostic centres, were assessed for RIF and INH resistance using high-resolution melt curve analysis. The overall prevalence of monoresistance to INH and RIF was 8.5% and 11% respectively, while the prevalence of MDR-TB was 6.7%. Bivariate analysis showed that patients aged 25 to 44 years were at a higher risk of developing MDR-TB (cOR 0.253). Furthermore, among the newly diagnosed patients, the prevalence of monoresistance to INH, RIF and MDR-TB was 8.6%, 10.2% and 6.4% respectively; while among the previously treated cases, these prevalence rates were 5.9%, 23.5% and 11.8%. These rates are higher than those reported previously indicating a rise in MTB drug resistance and may call for measures used to prevent a further rise in drug resistance. There is also a need to conduct frequent drug resistance surveys, to monitor and curtail the development and spread of drug-resistant TB.

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Resistance patterns of Mycobacterium tuberculosis isolates from pulmonary tuberculosis patients in Nairobi

The Journal of Infection in Developing Countries ◽

10.3855/jidc.2281 ◽

2011 ◽

Vol 6 (01) ◽

pp. 33-39 ◽

Cited By ~ 13

Author(s):

Perpetual Wangui Ndung'u ◽

Samuel Kariuki ◽

Zipporah Ng'ang'a ◽

Gunturu Revathi

Keyword(s):

Mycobacterium Tuberculosis ◽

Pulmonary Tuberculosis ◽

Small Businesses ◽

Drug Susceptibility ◽

Multidrug Resistant ◽

First Line ◽

Tuberculosis Patients ◽

Control Programs ◽

Solid Media ◽

Resistance Patterns

Introduction: In Kenya, which ranks thirteenth of 27 high tuberculosis burden countries, diagnosis is based on Ziehl-Neelsen staining alone and patients are treated without information on sensitivity patterns. This study aimed to determine resistance patterns of Mycobacterium tuberculosis isolated from pulmonary samples.Methodology: Pulmonary tuberculosis patients in Nairobi were randomly sampled after informed consent and recruited into the study using a structured questionnaire. Specimens were cultured in liquid and solid media, and drug susceptibility tests were performed for first-line drugs including (isoniazid, rifampin, streptomycin, ethambutol and pyrazinamide). Results: Eighty-six (30%) of 286 isolates were resistant to at least one of five antibiotics tested. Thirty-seven (30.2%) isolates were resistant to isoniazid; 15 (11.6%) to streptomycin; 13 (4.5%) to ethambutol; four (1.4%) to rifampin ; and 30 (10.4%) to pyrazinamide. Double resistance was seen as follows: four (1.4%) isolates were resistant to both isoniazid and pyrazinamide; four (1.4%) to streptomycin and isoniazid; and one (0.3%) to rifampin and streptomycin. Two isolates (0.7%) were multidrug resistant, and one was triple resistant with an additional resistance to ethambutol. Results also showed 88.7% of patients were below the age of 40 years, while 26.3% were HIV positive. The majority of the patients (66.5%) were unemployed or self-employed in small businesses, with 79.4% earning less than 100 USD per month.Conclusion: The high resistance observed in isoniazid, which is a first-line drug, could result in an increase in multidrug resistance unless control programs are strengthened. Poverty should be addressed to reduce infection rates.

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Multidrug-resistant strains of Mycobacterium complex species in Egyptian farm animals, veterinarians, and farm and abattoir workers

Veterinary World ◽

10.14202/vetworld.2020.2150-2155 ◽

2020 ◽

Vol 13 (10) ◽

pp. 2150-2155

Author(s):

Hossam A. Abdelsadek ◽

Hassan M. Sobhy ◽

Kh. F. Mohamed ◽

Sahar H. A. Hekal ◽

Amany N. Dapgh ◽

...

Keyword(s):

Mycobacterium Tuberculosis ◽

Lymph Nodes ◽

Raw Milk ◽

Multidrug Resistant ◽

Farm Animals ◽

Economic Losses ◽

Second Line ◽

Rt Pcr ◽

Antituberculosis Drugs ◽

Mdr Tb

Background and Aim: Mycobacterium tuberculosis complex (MTBC) is a group of mycobacteria that are important human pathogens. Mycobacterium tuberculosis and Mycobacterium bovis cause serious chronic life-threatening disease and also significant economic losses in both production and remedication. Recently, emergence of multidrug-resistant tuberculosis (MDR-TB) complex has generated global recognition of the need for rapid and sensitive diagnosis and development of new treatments. The current study illustrates the isolation/identification of MTBC strains in specimens obtained from cows and humans by conventional and real-time polymerase chain reaction (RT-PCR) techniques. Further, the study assesses sensitivity to antituberculosis drugs in isolated MDR strains. Materials and Methods: A total of 1464 samples from cattle (1285 raw milk and 179 lymph node), and 149 human sputum samples, were collected from farms and abattoirs in Delta Egypt. Conventional methods (culture and Ziehl–Neelsen staining) were implemented as were RT-PCR using MTBC universal DNA. The effect of some antituberculosis drugs on obtained isolates was assayed using drug susceptibility proportion and qualitative suspension techniques. Results: The MBTC detection rate using the culture method was higher than for Ziehl–Neelsen staining; raw cow milk (2.56 vs. 1.63%), lymph nodes (51.59 vs. 48.04%), and human sputum (5.36 vs. 4.02%). A total of 135 isolates were obtained. Application of RT-PCR detected 138 isolates from the same set of samples. MBTC isolates were resistant to first-line antituberculosis drugs, such as pyrazinamide, isoniazid, rifampicin, and ethambutol by 78.5, 59.3, 40.7, and 31.8%, respectively, and could be highly resistant to kanamycin (82.3%) and amikacin (80.7%). However, isolates remained sensitive to ciprofloxacin (71.1%) and clarithromycin (73.3%) as second-line drugs. Conclusion: There is a growing risk for isolation of MDR-TB from raw milk and lymph nodes of field tuberculin positive cattle as well as sputum of veterinarians and workers existed in farms and abattoirs. PCR-based techniques have become the gold standard for the identification of mycobacterial species, showing high efficiency compared to bacteriological and microscopic examination. Application of the first- and second-line antituberculosis drugs in combination could counter the MDR-TB concern once infections are identified.

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