scholarly journals 2019-nCoV: A Possible Progenitor for SARS-CoV with Bat Origin?

2020 ◽  
Author(s):  
Yongchang Xu ◽  
Leyi Wang ◽  
Xu Jia ◽  
Youjun Feng
Keyword(s):  
Public Health ◽  
Respiratory Illness ◽  
Public Health Emergency ◽  
Evolutionary Origin ◽  
Interspecies Transmission ◽  
Wuhan City ◽  
The Past ◽  
Novel Coronavirus ◽  
Severe Respiratory Illness

A novel coronavirus (2019-nCoV) that is initially found to trigger human severe respiratory illness in Wuhan City of China, 2019, has been recognized as a public health emergency of international concern. In the past two months, this deadly agent has caused 77,785 cases with 2,666 deaths via rapid person-to-person transmission and reached at least 25 countries. However, its evolutionary origin is poorly understood. Here we show integrative evidence that 2019-nCoV is a possible progenitor for SARS-CoV with bat origin. Our finding underscores the importance of tracing origin in the efficient monitoring, and effectively preventing the interspecies transmission of such emerging/re-emerging coronaviruses.

Legal and Ethical Concerns in Critical Care Nursing to Covid-19

2021 ◽  
pp. 367-369
Author(s):  
Sneha R. Dubey
Keyword(s):  
Public Health ◽  
Respiratory Illness ◽  
Public Health Emergency ◽  
Critically Ill Patient ◽  
Critical Care Nursing ◽  
Normal Process ◽  
Ethical Concerns ◽  
Worldwide Population ◽  
Severe Respiratory Illness ◽  
Care Nursing

The devasting pandemic covid 19 that has stricken the worldwide population induced an unprecedented influx of sever ARDS patient dramatically exceeding ICU bed capacities in several areas of many countries. the devasting pandemic covid 19 that has stricken the worldwide population induced an unprecedented influx of sever ARDS patient dramatically exceeding ICU bed capacities in several areas of many countries. A public health emergency, such as a surge of person seeking health care as Wall as critically ill patient with covid 19 or another severe respiratory illness, disrupts normal process for supporting ethically sound patient care.

scholarly journals The COVID-19 variants: an overview

2021 ◽  
Vol 8 (10) ◽  
pp. 5148
Author(s):  
Anuj K. Pandey ◽  
Sidharth S. Mishra ◽  
Yogesh Wadgave ◽  
Nidhi Mudgil ◽  
Sonal Gawande ◽  
...  
Keyword(s):  
Public Health ◽  
World Health Organization ◽  
International Health ◽  
Public Health Emergency ◽  
World Health ◽  
International Health Regulations ◽  
Wuhan City ◽  
Novel Coronavirus ◽  
Health Organization ◽  
Health Regulations

The outbreak of novel coronavirus disease (COVID-19) was initially noticed in a seafood market in Wuhan city in Hubei Province of China in mid-December 2019 which has now spread to 223 countries/territories/areas worldwide. World Health Organization (WHO) under International Health Regulations (IHR) has declared this outbreak as a public health emergency of international concern (PHEIC) on 30th January 2020 subsequently declared a pandemic on 11th March 2020.

scholarly journals COVID 19 pandemic: Lesson learned by South Korea and its application with India’s perspective

2020 ◽  
Vol 32 (3) ◽  
pp. 608-609
Author(s):  
Smita Sinha ◽  
Rishita Chandra
Keyword(s):  
Public Health ◽  
South Korea ◽  
Public Health Emergency ◽  
Contact Tracing ◽  
Success Story ◽  
Wuhan City ◽  
Time Period ◽  
The World ◽  
The Republic ◽  
Novel Coronavirus

A novel coronavirus named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019, in Wuhan city of Hubei province of China, which got transmitted throughout the nation and even world. It was declared as a Public Health Emergency by WHO on January 30th 2020, due to the increase in the number of cases reported from various regions of WHO with the evidence of human to human transmission. (1) Spread of COVID-19 across the globe: China reported first COVID-19 death on January 11th 2020.  After a few weeks, 830 cases were diagnosed in China along with 26 reported deaths. By January 20, Wuhan was placed under lockdown and China alerted other nations about its spread in various provinces. (2) This contagious disease had spread to 24 nations outside China-Hong Kong-Macau, by 2nd February.  About 172 countries and regions were engulfed by this virus by March 25, 2020. (3) Globally over 3,308,643 cases have been confirmed, over 234,123 deaths have been reported, and around 1,042,981 have recovered as on 30th April 2020. (4) Controlling the Pandemic COVID 19: success story of the Republic of Korea: Initially, one country which successfully stood out from the rest of the world was South Korea. The country confirmed its first few cases in late January and then reported a surge in the cases a few weeks later. The country was exploded with cases in dozens to hundreds to thousands during late February and early March and launched drive-through testing centers and massive contact tracing. Almost 909 new cases were identified in a single day of February 29th 2020 and was reported at peak. This data brought the country with 50 million population on the verge of a deluge. But the number of new cases was halved within a time period of just a week. The number of cases reduced to half within four days, and it halved, again the following day. (5)    

scholarly journals Dysregulation of RNA interference components in COVID-19 patients

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Seyyed Reza Mousavi ◽  
Maryam Sadat Sajjadi ◽  
Farinaz Khosravian ◽  
Sara Feizbakhshan ◽  
Sharareh Salmanizadeh ◽  
...  
Keyword(s):  
Rna Interference ◽  
Defense Mechanisms ◽  
Respiratory Illness ◽  
Transcriptional Gene Silencing ◽  
The Novel ◽  
Wuhan City ◽  
Post Transcriptional Gene Silencing ◽  
Essential Components ◽  
Novel Coronavirus ◽  
Severe Respiratory Illness

Abstract Objective Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the novel coronavirus causing severe respiratory illness (COVID-19). This virus was initially identified in Wuhan city, a populated area of the Hubei province in China, and still remains one of the major global health challenges. RNA interference (RNAi) is a mechanism of post-transcriptional gene silencing that plays a crucial role in innate viral defense mechanisms by inhibiting the virus replication as well as expression of various viral proteins. Dicer, Drosha, Ago2, and DGCR8 are essential components of the RNAi system, which is supposed to be dysregulated in COVID-19 patients. This study aimed to assess the expression level of the mentioned mRNAs in COVID-19patients compared to healthy individuals. Results Our findings demonstrated that the expression of Dicer, Drosha, and Ago2 was statistically altered in COVID-19 patients compared to healthy subjects. Ultimately, the RNA interference mechanism as a crucial antiviral defense system was suggested to be dysregulated in COVID-19 patients.

A flexible, multi-faceted profession: Supporting frontline practitioners in the fight against COVID-19

2020 ◽  
Vol 8 (5) ◽  
pp. 204-206
Author(s):  
Sharin Baldwin ◽  
Patricia Kelly
Keyword(s):  
Public Health ◽  
Health Professionals ◽  
Public Health Emergency ◽  
World Health ◽  
Wuhan City ◽  
Health Visitors ◽  
The World ◽  
Novel Coronavirus ◽  
Health Organization

Novel coronavirus was first identified in Wuhan City, China and was reported to the World Health Organization (WHO) in China on 31 December, 2019. On 30 January, WHO declared the outbreak of COVID-19 a ‘public health emergency of international concern’. Since then, the virus has spread rapidly across the world, with the WHO declaring it a pandemic on 11 March 2020. This article describes a case study where two health visitors were able to adapt and use their wide-ranging skills to support frontline health professionals in acute settings to meet the demands placed on them during these unprecedented times.

The application of WeChat App with “group function” in emergency management and treatment of COVID-19 (Preprint)

2020 ◽  
Author(s):  
Jing Liu ◽  
Hong Shan ◽  
Changli Tu ◽  
Meizhu Chen ◽  
Xiujuan Qu ◽  
...  
Keyword(s):  
Public Health ◽  
Group Communication ◽  
Public Health Emergency ◽  
Diagnosis And Treatment ◽  
Labor Costs ◽  
Wuhan City ◽  
Group Function ◽  
The Public ◽  
Communication Method ◽  
Tertiary Hospitals

UNSTRUCTURED Background: Since December 2019, Coronavirus Disease 2019 (COVID-19) emerged in Wuhan city and rapidly spread throughout China. Facing this kind of public health emergency, an efficient, fast and group communication method is needed. Method: As a director of the department Pulmonary and Critical Care Medicine in a tertiary hospitals, which is the only designated one for diagnosis and treatment of COVID-19 in a medium-sized city, I analyzed and summarized the “group function” of WeChat (Weixin, micro-message) App in working about COVID-19. Results: By February 16, 2020, we have completed 1,526 citywide consultations and treatment of 322 inpatients, including 97 patients diagnosed with COVID-19, with the help of 12 WeChat groups by handy. The advantages of WeChat group are as follows: 1. Work efficiency can be improved greatly, saving labor costs. 2. Accurate and intuitive information can be gotten fast and timely, avoiding close contacting with COVID-19 patients. 3. Data and message in WeChat groups can be saved, arranged and reviewed at any time. Conclusions: The “group function” in WeChat App plays a greater role in the public health emergent work about management, diagnosis and treatment of COVID-19.

scholarly journals COVID-19 Pandemic: A Global Disaster

2021 ◽  
Vol 1 (1) ◽  
pp. 7-8
Author(s):  
Solomon Arigwe Joseph ◽  
Abuhuraira Ado Musa ◽  
Faisal Muhammad ◽  
Tijjani Muhammad Ahmad
Keyword(s):  
Public Health ◽  
World Health Organization ◽  
Signs And Symptoms ◽  
Viral Disease ◽  
Hubei Province ◽  
Public Health Emergency ◽  
World Health ◽  
Novel Coronavirus ◽  
Health Organization

People began to become ill in late December 2019 in Wuhan, Hubei Province, China, and the illness was revealed to be a kind of pneumonia with unusual signs and symptoms. It was eventually discovered as a novel coronavirus, a virus that causes widespread sickness in animals and birds. World Health Organization (WHO) named this new viral disease coronavirus disease 2019 (COVID-19) and declared a Public Health Emergency of International Concern in January 2020.

COVID 19 and its management

2021 ◽  
pp. 117-121
Author(s):  
Subhashis Debnath ◽  
Runa Chakravorty ◽  
Donita Devi
Keyword(s):  
Public Health ◽  
Acute Respiratory Distress Syndrome ◽  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
The Elderly ◽  
Public Health Emergency ◽  
Novel Coronavirus

In December 2019, severe acute respiratory syndrome-coronavirus-2, a novel coronavirus, initiated an outbreak of pneumonia from Wuhan in China, which rapidly spread worldwide. The outbreak was declared as “a public health emergency of international concern” by the WHO on January 30, 2020, and as a pandemic on March 11, 2020. The disease is transmitted by inhalation or contact with infected droplets and the incubation period ranges from 2 to 14 d. The symptoms are usually fever, cough, sore throat, breathlessness, fatigue, malaise among others. The disease is mild in most people; in some (usually the elderly and those with comorbidities), it may progress to pneumonia, acute respiratory distress syndrome (ARDS) and multi organ dysfunction. Many people are asymptomatic. The virus spreads faster than its two ancestors the SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), but has lower fatality.

scholarly journals Nanobiosensors for the Detection of Novel Coronavirus 2019-nCoV and Other Pandemic/Epidemic Respiratory Viruses: A Review

Sensors ◽  
2020 ◽  
Vol 20 (22) ◽  
pp. 6591
Author(s):  
Badriyah Alhalaili ◽  
Ileana Nicoleta Popescu ◽  
Olfa Kamoun ◽  
Feras Alzubi ◽  
Sami Alawadhia ◽  
...  
Keyword(s):  
Public Health ◽  
Vaccine Development ◽  
Respiratory Viruses ◽  
Public Health Emergency ◽  
Detection Methods ◽  
Origin And Evolution ◽  
The World ◽  
Human Coronaviruses ◽  
Novel Coronavirus ◽  
Made In

The coronavirus disease 2019 (COVID-19) pandemic is considered a public health emergency of international concern. The 2019 novel coronavirus (2019-nCoV) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that caused this pandemic has spread rapidly to over 200 countries, and has drastically affected public health and the economies of states at unprecedented levels. In this context, efforts around the world are focusing on solving this problem in several directions of research, by: (i) exploring the origin and evolution of the phylogeny of the SARS-CoV-2 viral genome; (ii) developing nanobiosensors that could be highly effective in detecting the new coronavirus; (iii) finding effective treatments for COVID-19; and (iv) working on vaccine development. In this paper, an overview of the progress made in the development of nanobiosensors for the detection of human coronaviruses (SARS-CoV, SARS-CoV-2, and Middle East respiratory syndrome coronavirus (MERS-CoV) is presented, along with specific techniques for modifying the surface of nanobiosensors. The newest detection methods of the influenza virus responsible for acute respiratory syndrome were compared with conventional methods, highlighting the newest trends in diagnostics, applications, and challenges of SARS-CoV-2 (COVID-19 causative virus) nanobiosensors.

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