scholarly journals Bioengineered Scaffolds for Thermo-responsive Drug Delivery in Wound Healing

2020 ◽  
Author(s):  
Luis Castillo-Henríquez ◽  
Jose Castro-Alpízar ◽  
Mary Lopretti-Correa ◽  
José Vega-Baudrit
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Chronic Wounds ◽  
Clinical Symptoms ◽  
Solution Temperature ◽  
Thermal Stimulus ◽  
The Novel ◽  
Responsive Polymers ◽  
Biodegradable Scaffolds ◽  
Manufacturing Techniques

innate and adaptive immune responses lead to wound healing by regulating a complex series of events promoting cellular cross-talk. An inflammatory response is presented with its characteristic clinical symptoms: heat, pain, redness, and swelling. Some smart thermo-responsive polymers like chitosan can be used to create biocompatible and biodegradable scaffolds with 3D architectures similar to human structures, allowing their efficient and safe use as tissue engineering and drug delivery systems in chronic wounds. Locally heated tumors above polymer lower critical solution temperature can induce its conversion into a hydrophobic form, enhancing drug release until the thermal stimulus is gone, where a lower release is due to the swelling of the material. This paper integrates the relevant reported contributions of bioengineered scaffolds for thermo-responsive drug delivery in wound healing. Therefore, we present a comprehensive review that aims to demonstrate the capacity of these systems to provide spatially and temporally controlled release strategies for one or more drugs used in wound healing. In this sense, the novel manufacturing techniques of 3D-printing and electrospinning are explored for the tuning of their physicochemical properties to adjust therapies according to the patient’s convenience, as well as reduce drug toxicity and side effects.

scholarly journals Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

2021 ◽  
Vol 22 (3) ◽  
pp. 1408
Author(s):  
Luis Castillo-Henríquez ◽  
Jose Castro-Alpízar ◽  
Mary Lopretti-Correa ◽  
José Vega-Baudrit
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Drug Release ◽  
Inflammatory Response ◽  
Bacterial Infections ◽  
Healing Process ◽  
Solution Temperature ◽  
Wound Healing Process ◽  
Thermal Stimulus ◽  
Responsive Polymers

Innate and adaptive immune responses lead to wound healing by regulating a complex series of events promoting cellular cross-talk. An inflammatory response is presented with its characteristic clinical symptoms: heat, pain, redness, and swelling. Some smart thermo-responsive polymers like chitosan, polyvinylpyrrolidone, alginate, and poly(ε-caprolactone) can be used to create biocompatible and biodegradable scaffolds. These processed thermo-responsive biomaterials possess 3D architectures similar to human structures, providing physical support for cell growth and tissue regeneration. Furthermore, these structures are used as novel drug delivery systems. Locally heated tumors above the polymer lower the critical solution temperature and can induce its conversion into a hydrophobic form by an entropy-driven process, enhancing drug release. When the thermal stimulus is gone, drug release is reduced due to the swelling of the material. As a result, these systems can contribute to the wound healing process in accelerating tissue healing, avoiding large scar tissue, regulating the inflammatory response, and protecting from bacterial infections. This paper integrates the relevant reported contributions of bioengineered scaffolds composed of smart thermo-responsive polymers for drug delivery applications in wound healing. Therefore, we present a comprehensive review that aims to demonstrate these systems’ capacity to provide spatially and temporally controlled release strategies for one or more drugs used in wound healing. In this sense, the novel manufacturing techniques of 3D printing and electrospinning are explored for the tuning of their physicochemical properties to adjust therapies according to patient convenience and reduce drug toxicity and side effects.

scholarly journals Kinetic and Reaction Pathway Analysis in the Application of Botulinum Toxin A for Wound Healing

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Frank J. Lebeda ◽  
Zygmunt F. Dembek ◽  
Michael Adler
Keyword(s):  
Wound Healing ◽  
Botulinum Toxin ◽  
Chronic Wounds ◽  
Clinical Symptoms ◽  
Reaction Pathway ◽  
Botulinum Toxin A ◽  
Case Reports ◽  
Healing Process ◽  
Kinetic Scheme ◽  
Pharmacokinetic Data

A relatively new approach in the treatment of specific wounds in animal models and in patients with type A botulinum toxin is the focus of this paper. The indications or conditions include traumatic wounds (experimental and clinical), surgical (incision) wounds, and wounds such as fissures and ulcers that are signs/symptoms of disease or other processes. An objective was to conduct systematic literature searches and take note of the reactions involved in the healing process and identify corresponding pharmacokinetic data. From several case reports, we developed a qualitative model of how botulinum toxin disrupts the vicious cycle of muscle spasm, pain, inflammation, decreased blood flow, and ischemia. We transformed this model into a minimal kinetic scheme for healing chronic wounds. The model helped us to estimate the rate of decline of this toxin's therapeutic effect by calculating the rate of recurrence of clinical symptoms after a wound-healing treatment with this neurotoxin.

Lipid Nanoparticles as a Skin Wound Healing Drug Delivery System: Discoveries and Advances

2020 ◽  
Vol 26 (36) ◽  
pp. 4536-4550
Author(s):  
Myla Lôbo de Souza ◽  
Widson Michael dos Santos ◽  
André Luiz Moreira Domingues de Sousa ◽  
Victor de Albuquerque Wanderley Sales ◽  
Fernanda Pontes Nóbrega ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Chronic Wounds ◽  
Synergistic Effects ◽  
Skin Permeation ◽  
Skin Barrier ◽  
Lipid Nanoparticles ◽  
Dosage Forms ◽  
Skin Wound Healing ◽  
Activity Increase

Chronic wounds are a remarkable cause of morbidity, requiring long-time treatments with a significant impact on the quality of life and high costs for public health. Although there are a variety of topical skin preparations commercially available, they have several limitations that frequently impair wound healing, such as drug instability, toxicity, limited time of action and ineffective skin permeation. In recent years, researchers have focused on the development of new effective treatments for wound healing and shown frequent interest in nanometric drug delivery systems to overcome such obstacles. In dermatology, lipid nanoparticles (LNPs) have received great attention from researchers due to their great functionalities, greater adhesion to the skin and film formation, enabling the hydration and maintenance of skin integrity, as well as present a more effective penetration through the skin barrier. This review provides an update on topical formulations based on Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs) as wound healing treatments. Both SLNs and NLCs are able to increase solubility and stability of active pharmaceutical ingredients and increase skin penetration compared to the free drugs. Additionally, SLNs and NLCs can increase pharmacological activity, increase the release profile of the drugs, promote synergistic effects and improve the sensory properties of the final formulation. Topical dosage forms containing nanoparticles have been extensively evaluated for wound healing activity, mainly the dressings, films and scaffolds. Therefore, lipid nanoparticles have contributed in improving wound healing therapies when incorporated into other dosage forms with better efficacy and lesser adverse effects than conventional formulations.

scholarly journals Growth factor functionalized biomaterial for drug delivery and tissue regeneration

2017 ◽  
Vol 32 (6) ◽  
pp. 568-581 ◽  
Author(s):  
Alex Leonard ◽  
Piyush Koria
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Tissue Regeneration ◽  
Chronic Wounds ◽  
Biologically Active ◽  
Application Site ◽  
Epidermal Growth ◽  
And Migration

Elastin-like polypeptides are a class of naturally derived and non-immunogenic biomaterials that are widely used in drug delivery and tissue engineering. Elastin-like polypeptides undergo temperature-mediated inverse phase transitioning, which allows them to be purified in a relatively simple manner from bacterial expression hosts. Being able to genetically encode elastin-like polypeptides allows for the incorporation of bioactive peptides, thereby functionalizing them. Here, we report the synthesis of a biologically active epidermal growth factor–elastin-like polypeptide fusion protein that could aid in wound healing. Epidermal growth factor plays a crucial role in wound healing by inducing cell proliferation and migration. The use of exogenous epidermal growth factor has seen success in the treatment of acute wounds, but has seen relatively minimal success in chronic wounds because the method of delivery does not prevent it from diffusing away from the application site. Our data show that epidermal growth factor–elastin-like polypeptide retained the biological activity of epidermal growth factor and the phase transitioning property of elastin-like polypeptide. Furthermore, the ability of the epidermal growth factor–elastin-like polypeptide to self-assemble near physiological temperatures could allow for the formation of drug depots at the wound site and minimize diffusion, increasing the bioavailability of epidermal growth factor and enhancing tissue regeneration.

scholarly journals Temperature and pH Responsive Microfibers for Controllable and Variable Ibuprofen Delivery

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Toan Tran ◽  
Mariana Hernandez ◽  
Dhruvil Patel ◽  
Ji Wu
Keyword(s):  
Drug Delivery ◽  
Solution Temperature ◽  
Pharmaceutical Sciences ◽  
Electrospinning Technique ◽  
Critical Solution Temperature ◽  
Practical Applications ◽  
Responsive Polymers ◽  
Ph Values ◽  
Higher Temperature ◽  
Diffusion Rates

Electrospun microfibers (MFs) composed of pH and temperature responsive polymers can be used for controllable and variable delivery of ibuprofen. First, electrospinning technique was employed to prepare poly(ε-caprolactone) (PCL) and poly(N-isopropylacrylamide-co-methacrylic acid) (pNIPAM-co-MAA) MFs containing ibuprofen. It was found that drug release rates from PCL MFs cannot be significantly varied by either temperature (22–40°C) or pH values (1.7–7.4). In contrast, the ibuprofen (IP) diffusion rates from pNIPAM-co-MAA MFs were very sensitive to changes in both temperature and pH. The IP release from pNIPAM-co-MAA MFs was highly linear and controllable when the temperature was above the lower critical solution temperature (LCST) of pNIPAM-co-MAA (33°C) and the pH was lower than thepKaof carboxylic acids (pH 2). At room temperature, however, the release rate was dramatically increased by nearly ten times compared to that at higher temperature and lower pH. Such a unique and controllable drug delivery system could be naturally envisioned to find many practical applications in biomedical and pharmaceutical sciences such as programmable transdermal drug delivery.

Innovations in drug delivery for chronic wound healing

2021 ◽  
Vol 27 ◽  
Author(s):  
Erfan Rezvani Ghomi ◽  
Mohamadreza Shakiba ◽  
Ali Saedi Ardahaei ◽  
Mahsa Akbari ◽  
Mehdi Faraji ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Drug Delivery Systems ◽  
Chronic Wounds ◽  
Chronic Wound ◽  
Healing Process ◽  
Skin Structure ◽  
Physical Problems ◽  
Complex Process ◽  
Chronic Ulcers

: Wound healing is a varied and complex process designed to promptly restore standard skin structure, function, and appearance. To achieve this goal, different immune and biological systems participate in coordination through four separate steps, including homeostasis, inflammation, proliferation, and regeneration. Each step involves the function of other cells, cytokines, and growth factors. However, chronic ulcers, which are classified into three types of ulcers, namely vascular ulcers, diabetic ulcers, and pressure ulcers, cannot heal through the mentioned natural stages. It causes mental and physical problems for these people and, as a result, imposes high economic and social costs on society. In this regard, using a system that can accelerate the healing process of such chronic wounds, as an urgent need in the community, should be considered. Therefore, in this study, the innovations of drug delivery systems for the healing of chronic wounds using hydrogels, nanomaterial, and membranes are discussed and reviewed.

Electrospun nanofibers provide a good platform to treat chronic wounds like diabetic foot ulcers

2021 ◽  
Author(s):  
Moataz Dowaidar
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Diabetic Foot ◽  
Wound Closure ◽  
Chronic Wounds ◽  
Electrospun Nanofibers ◽  
Wound Management ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers

Chronic foot ulceration is one of the major comorbid challenges associated with the manifestation of Type-2 Diabetic Mellitus and is responsible for high mortality rates, requiring the development of a localized drug delivery system (DDS) that can deliver the drug payload while also facilitating wound closure. Although nanofibers may be produced in many ways, electrospinning is one of the most versatile methods. Nanofiber-based DDSs show a substantial influence on targeted drug delivery, faster wound healing, and chronic wound closure. Electrospun nanofibers have evolved over time from simple nanofibers to new generations of nanofibers such as blend, composite, core-shell electrospun, and hybrid nanofibers, each with unique physicochemical and mechanochemical properties, giving distinct advantages to the respective nanofibers for better diabetic wound management. Optimizing the parameters involved in the preparation of nanofibers, which can be classified as static, processing and environmental parameters, is critical for process reproducibility, ensuring the desired properties of nanofibers, maintaining uniformity and maximizing the performance of electrospinning. Electrospun nanofibers are a suitable platform for treating chronic wounds such as diabetic foot ulcers. However, clinically using nanofiber-based DDSs as a localized wound therapy platform requires comprehensive physicochemical and mechanochemical characterization, as well as rigorous in-vitro and in-vivo drug release and wound healing efficacy testing.

scholarly journals Ca-Alginate-PEGMA Hydrogels for In Situ Delivery of TGF-β Neutralizing Antibodies in a Mouse Model of Wound Healing

2021 ◽  
Vol 11 (3) ◽  
pp. 1164
Author(s):  
Jahaziel Gasperin-Bulbarela ◽  
Ana B. Castro-Ceseña ◽  
Tanya Camacho-Villegas ◽  
Pavel H. Lugo-Fabres ◽  
Nestor Emmanuel Díaz-Martínez ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Transforming Growth Factor Beta ◽  
Calcium Alginate ◽  
Neutralizing Antibodies ◽  
Chronic Wounds ◽  
Transforming Growth Factor ◽  
Topical Administration ◽  
Wound Model

Hydrogels provide effective alternatives for drug delivery when therapeutics cannot be applied directly to a wound, or if adverse effects are associated with systemic administration. However, drug delivery vehicles need to be biocompatible and biodegradable and exhibit sufficient mechanical strength to withstand handling and different physiological conditions, such as those encountered during topical administration of a therapeutic. Wound healing can be divided into three phases stimulated by transforming growth factor-beta (TGF-β) and, subsequently, targeted therapeutics have been developed to inhibit this cytokine for the treatment of chronic wounds and to prevent scarring. In this study, the capacity of calcium alginate hydrogels plasticized with poly(ethylene glycol) methyl ether methacrylate (PEGMA) to deliver anti-TGF-β antibodies (1D11.16.8) to a wound was investigated in situ. Three levels of antibodies, 10, 50, and 100 μg, were loaded into calcium-alginate-PEGMA hydrogels and evaluated in an excisional wound model in mice. Hydrogels containing 50 and 100 μg 1D11.16.8 produced less inflammation, accompanied by a marked reduction in collagen deposition and cell infiltration. These findings demonstrate the capacity of calcium-alginate-PEGMA hydrogels to deliver larger proteins, such as antibodies, to the site of a wound.

scholarly journals Exploring Dendrimer Nanoparticles for Chronic Wound Healing

2021 ◽  
Vol 3 ◽  
Author(s):  
Samuel Tetteh-Quarshie ◽  
Eric R. Blough ◽  
Cynthia B. Jones
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Drug Delivery Systems ◽  
Chronic Wounds ◽  
Chronic Wound ◽  
Treatment Options ◽  
The United States ◽  
Delivery Systems ◽  
Infection Age ◽  
Nanoparticle Drug Delivery

The United States spends billions of dollars to treat chronic wounds each year. Wound healing is complex in nature which involves several intricate multiphase processes that can be delayed for a number of reasons leading to the development of chronic wounds. Wound healing therapies range from topical preparations to surgical repair with treatment options that vary based on other underlying factors like co-infection, age, or co-morbidities such as diabetes. Historically, micelles and liposomes are some of the nanoparticle drug delivery systems explored to treat chronic wounds; however, recent data suggests that dendrimers have shown potential to rival these systems in treating chronic wounds as well as other diseases. This mini review examines advances in dendrimer nanoparticle drug delivery systems to treat chronic wounds.

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