Prevention of ARVI in newborns and their mothers under pandemic conditions of new coronavirus infection

2021 ◽  
Vol 20 (2) ◽  
pp. 66-74
Author(s):  
I.I. Bocharova ◽  
◽  
N.V. Zarochentseva ◽  
A.N. Aksenov ◽  
V.V. Malinovskaya ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Maximum Effect ◽  
Interferon Α ◽  
Study Results ◽  
Group 3 ◽  
Coronavirus Infection ◽  
Group 2 ◽  
Local Use ◽  
Key Words Prevention ◽  
Group 1

Objective. To study the prophylactic effectiveness of the intranasal application of VIFERON®, the gel for external and local use (interferon α-2b) 36,000 IU/g, against ARVI in newborns and their mothers during the COVID-19 pandemic. Patients and methods. A total of 227 mother–newborn couples were examined, randomized into three groups: Group 1 (n = 63) – the VIFERON® gel was used according to the instructions; Group 2 (n = 50) – the VIFERON® gel was used in violation of the recommended scheme; Group 3 (control, n = 114) – did not use the medication. The main criteria for the effectiveness of prevention were: the incidence of ARVI in a mother–child couple for 3 months after inclusion in the study; the duration and severity of clinical symptoms of the disease; evaluation of the frequency of adverse events associated with the use of the drug under study. Results. The use of the VIFERON® gel led to a decrease in the number of ARVI cases in mothers (11.1 and 14.9%) and newborns (7.9 and 20.2%; p = 0.034) in Group 1 compared with Group 3, respectively, as well as to a significant reduction in the duration of the disease (p = 0.001), a decrease in the severity of clinical symptoms: the level of hyperthermia (p = 0.015), the duration of febrile (p = 0.021), cough (p = 0.032), rhinitis (p = 0.033). There were no statistically significant differences between these indicators in Groups 2 and 3, which requires to follow drug instructions in order to achieve the maximum effect. The timing of onset of diseases in Group 1 in the third month of observation from the beginning of drug administration makes it possible to justify the need for repeated courses of prophylaxis at high risk of respiratory diseases. In 100% of cases, the drug was well tolerated, and there were no adverse effects. Conclusion. The high preventive efficacy and safety of interferon α-2b with antioxidants in the form of gel for external and local use (VIFERON®, gel) in newborns and their mothers against ARVI were proved, which makes it possible to recommend its use to prevent the new coronavirus infection COVID-19 in newborns and confirms the validity of its inclusion in clinical guidelines for the treatment of COVID-19 in children. Key words: prevention, ARVI, interferon α-2b with antioxidants, VIFERON® gel, mother–newborn, COVID-19

Features of postoperative period in patients with chronic venous insufficiency: phlebectomy versus thermal ablation

2020 ◽  
pp. 64-75
Author(s):  
E. Burleva ◽  
O. Smirnov ◽  
S. Tyurin
Keyword(s):  
Postoperative Period ◽  
Chronic Venous Insufficiency ◽  
Thermal Ablation ◽  
Venous Insufficiency ◽  
Clinical Symptoms ◽  
Varicose Veins ◽  
Statistical Processing ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

The purpose of the study was to conduct a comparative assessment of the course of the postoperative period after phlebectomy and thermal ablation in patients with varicose veins of the lower extremities in the system of the great saphenous vein (GSV) with class C2 of chronic venous insufficiency (CVI) — CEAP class C2. Materials and methods: 455 patients (455 limbs) with CEAP class C2. Group 1 (n = 154) received stripping + minimally invasive phlebectomy; Group 2 — endovenous laser ablation (EVLA) of GSV trunk + sclerotherapy of varicose veins; 3 group (n = 150) — radiofrequency ablation (RFA) of the GSV + sclerotherapy. All patients were united by a single tactical solution — the elimination of pathological vertical reflux in GSV. In each group, patients were with similar hemodynamic profile were selected (Group 1 = 63; Group 2 = 61; Group 3 = 61). The course of the postoperative period (from 2 days to 2 months) was compared for pain (visual analog scale — VAS), clinical symptoms of chronic venous insufficiency, degree of satisfaction (Darvall questionnaire), and duration of disability. Statistical processing was carried out using Excel programs for Windows XP, MedCalc® (version 11.4.2.0., Mariakerke, Belgium). Results: Postoperative pain is more pronounced (during day 1 for Group 1–4.0, Group 2–3.0, Group 3–2.0) and more prolonged (up to 4 days) after open surgeries (p < 0.05). The dynamics of the clinical symptoms of CVI (including varicose syndrome and use of compression therapy) could not be fully evaluated in connection with the ongoing sclerotherapy procedures for patients of Groups 2 and 3. Satisfaction of patients with aesthetic aspects was higher than expected in all groups. Reliable statistical differences proved decrease in days of disability (Group 1–14; Group 2–4; Group 3–3) and earlier return to physical activities and work in patients after thermal ablation in comparison with phlebectomy. Conclusion: The study shows that all three methods for eliminating vertical reflux in the GSV can be proposed for a large category of patients with CEAP of class C3 and C2. Medical and social rehabilitation of patients using endovascular thermal ablation technologies proceeds faster, which is beneficial both for the patients and for society.

Contemporary aspects of pathogenetically substantiated therapy of adenomyosis

2016 ◽  
Vol 7 (3) ◽  
pp. 92-97 ◽  
Author(s):  
Arutyun F Arutyunyan ◽  
Sergey N Gaydukov ◽  
Vitaly N Kustarov
Keyword(s):  
Blood Flow ◽  
Conservative Treatment ◽  
Survey Data ◽  
Clinical Symptoms ◽  
Uterine Blood Flow ◽  
Uterine Arteries ◽  
Group 3 ◽  
Group 2 ◽  
Pathogenic Effects ◽  
Group 1

The purpose of our study was to assess the effectiveness of the use of drugs containing indole-3-carbinol and epigallocatechin-3 gallate in combination with effective natural methods (TES-therapy and hirudotherapy) depending on the degree of morphological adenomyosis. The study involved 205 women with diffuse adenomyosis. Based on survey data from 205 women surveyed in 67 verified adenomyosis first degree (Group 1), 79 - second degree adenomyosis (group 2), and 59 - third degree adenomyosis (group 3). Doppler results showed that in patients with adenomyosis first degree nizkorezistentny uterine blood flow was observed. Improvement of clinical symptoms of the disease, increasing the numerical values of R & D in the uterine arteries at the first degree adenomyosis indicates pathogenic effects of the proposed treatment. At the same time in patients with adenomyosis II-III degree was observed with highly bloodstream, indicating the deterioration of blood flow in the uterine vascular basin, as evidenced by some of hemostasis. Thus, studies have provided credible evidence pathogenesis mediated relations between the characteristics of the circulation of the uterus, the processes of neoangiogenesis, proliferation in the myometrium and the extent of spread of the disease, which will choose the appropriate methods of conservative treatment. Using drugs and Indinol epigallat affecting the basic pathogenetic mechanisms of adenomyosis, opens a new direction in the treatment of this disease, and effective natural methods - new opportunities in the treatment of adenomyosis.

scholarly journals Adherence to subcutaneous immunotherapy with aeroallergens in real-life practice during the COVID-19 pandemic

2021 ◽  
Author(s):  
Osman Ozan Yeğit ◽  
semra demir ◽  
Derya Erdoğdu ◽  
Muge Olgac ◽  
Kadriye Terzioğlu ◽  
...  
Keyword(s):  
Public Transportation ◽  
Clinical Symptoms ◽  
Real Life ◽  
Delay Group ◽  
Subcutaneous Immunotherapy ◽  
Asthmatic Patients ◽  
Symptom Scores ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Background: The success of subcutaneous immunotherapy (SCIT) mostly depends on regular injections. Our aim was to investigate adherence to SCIT with aeroallergens during the COVID-19 pandemic and demonstrate clinical consequences of treatment disruptions in real-life. Methods: Visual analogue scale for quality of life (VAS-QoL), VAS for symptom scores (VAS-symptom), medication scores (MSs) and total symptom scores (TSS-6) were recorded during the pandemic in 327 adult allergic rhinitis and/or asthmatic patients receiving maintenance SCIT and these scores were compared with the pre-pandemic data. Patients were grouped according to SCIT administration intervals; no delay (Group 1), <2 months (Group 2), and ≥2 month intervals (Group 3). Results: 104 (31.8%) patients (Group 3) were considered as non-adherent which was mostly related to receiving SCIT with HDMs and using public transportation for reaching the hospital. Median MS, VAS-symptom and TSS-6 scores of Group 3 patients during the pandemic were higher than the pre-pandemic scores (p=0.005, p<0.001, p<0.001, respectively) whereas median VAS-QoL scores of Group 3 during the pandemic were lower than the pre-pandemic scores (p<0.001). Median TSS-6 and VAS-symptom scores were the highest in Group 3 compared to other groups (p<0.001 for each comparison). Median VAS-QoL scores were the lowest in Group 3 compared to Group 1 and Group 2 (p<0.001, p=0.043, respectively). Conclusion: When precautions in allergy clinics are carefully applied, adherence to SCIT can be high during a pandemic. Patients must be warned about adhering to SCIT injections since delays in SCIT administration can deteriorate clinical symptoms.

scholarly journals Analysis of the bactericidal effect of ozone pneumoperitoneum

2009 ◽  
Vol 24 (2) ◽  
pp. 124-127 ◽  
Author(s):  
Rodrigo Altenfelder Silva ◽  
José Eduardo Rosseto Garotti ◽  
Renata Santos Bittencourt Silva ◽  
Alessandra Navarini ◽  
Adhemar Monteiro Pacheco Jr
Keyword(s):  
Wistar Rats ◽  
Bactericidal Effect ◽  
Bactericidal Action ◽  
Co2 Pneumoperitoneum ◽  
E Coli ◽  
Carbon Dioxide Gas ◽  
Study Results ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

PURPOSE: To assess the bactericidal action of ozone pneumoperitonium, and to compare the results with CO2. METHODS: It was used 36 Wistar rats. The animals, under anesthesia, were inoculated with 2ml of E. coli ATCC at a concentration of 10(10)UFC, and 1ml of BaSO4, into the peritoneal cavity. They were divided into three groups: Group 1, CO2 pneumoperitoneum was performed for 15 minutes; Group 2, ozone pneumoperitoneum was performed for 5 minutes at a concentration of 42µg/ml, and Group 3, ozone pneumoperitoneum was performed for 5 minutes at a concentration of 62µg/ml. Six animals from each group were sacrificed after the experiment, and the remaining 6 observed for 24 hours. Material was collected from the cavity of all animals for microbiological study. RESULTS: Ozone presented a greater bactericidal effect than CO2 in those animals sacrificed immediately after pneumoperitoneum. In the animals studied 24 hours after pneumoperitoneum evidenced no difference in bactericidal effect between the two gases. Moreover, no difference in mortality was observed. CONCLUSION: Ozone has a more potent bactericidal effect than carbon dioxide gas, although this did not influence survival of the animals.

RETROSPECTIVE ANALYSIS OF FEATURES OF DETECTION OF NEW CORONOVIRAL INFECTION COVID-19 IN PATIENTS WITH SURGICAL PROFILE ARRIVING IN A EMERGENCY

2021 ◽  
pp. 139-148
Author(s):  
Дмитрий Валериевич Судаков ◽  
Евгений Владимирович Белов ◽  
Олег Валериевич Судаков ◽  
Ольга Игоревна Гордеева ◽  
Оксана Александровна Андросова
Keyword(s):  
Clinical Symptoms ◽  
Positive Impact ◽  
Clinical Manifestations ◽  
Reactive Protein ◽  
Group 4 ◽  
Group 3 ◽  
Ct Data ◽  
Group 2 ◽  
Group 1

В статье рассматриваются особенности своевременного выявления новой короновирусной инфекцией (НКИ) у пациентов хирургического профиля на уровне приемного отделения областной клинической больницы. Представленная работа является в настоящее время крайне актуальной, в виду продолжающейся в мире пандемии НКИ - Covid-19. Важное значение данному исследованию придает то, что оно направлено на как можно более раннюю диагностику Covid-19, уже на уровне нахождения в приемном отделении при поступлении в многопрофильный стационар. Подобные меры могут существенно помочь в сохранении здоровья медицинских работников и могут оказать положительное влияние на эпидемиологическую обстановку в целом. Интересной составляющей данного исследования является и то, что диагностика Covid-19 основывается лишь на тех лабораторных анализах, которые можно быстро определить в условиях приемного отделения. Объектами исследования послужило 200 пациентов, поступающих в приемное отделение БУЗ ВО ВОКБ №1 исключительно с хирургической патологией. Все больные были подразделены на 4 группы по 50 человек, всем им был поставлен сопутствующий диагноз Covid-19. В 1 группу вошли пациенты, поступающие в приемное отделение без сознания, сбор анамнеза и сбор жалоб у которых был невозможен. 2 группу составили пациенты, у которых НКИ была диагностирована непосредственно после оперативного вмешательства. В 3 группу вошли пациенты, у которых была выявлена НКИ, но объем оперативного вмешательства и объем поражения легких позволял им дальнейшее амбулаторное лечение. 4 группу составили пациенты, у которых Covid-19 выявлялся в течение 3 дней после оперативного вмешательства. У всех больных подробно собирался анамнез жизни и эпидемиологический анамнез (за исключением 1 группы), анализировались наиболее частые клинические проявления и показатели общего и биохимического анализа крови, обрабатывались данные КТ легких. Были определены основные клинические симптомы НКИ, такие как: повышенная температура тела, кашель, слабость и утомляемость. Наиболее важными лабораторными показателями стало определение уровня лейкоцитоза, с уровнем нейтрофилов и лимфоцитов, а также СОЭ, D-димера, С-реактивного белка. Представленная статья представляет большой интерес для врачей, работающих в условиях приемных отделений многопрофильных стационаров. По результатам работы планируется продолжение исследования с большей выборкой пациентов и большим количеством изучаемых параметров The article discusses the features of the timely detection of a new coronavirus infection (NCI) in surgical patients at the level of the admission department of a regional clinical hospital. The presented work is currently extremely relevant, in view of the ongoing NСI pandemic in the world - Covid-19. The importance of this study is attached to the fact that it is aimed at the earliest possible diagnosis of Covid-19, already at the level of being in the admission department upon admission to a multidisciplinary hospital. Such measures can significantly help preserve the health of medical workers and can have a positive impact on the epidemiological situation in general. An interesting component of this study is the fact that the diagnosis of Covid-19 is based only on those laboratory tests that can be quickly determined in the conditions of the admission department. The objects of the study were 200 patients admitted to the admission department of BUZ VO VOKB № 1 exclusively with surgical pathology. All patients were divided into 4 groups of 50 people, all of them were diagnosed with a concomitant Covid-19 diagnosis. Group 1 consisted of patients admitted to the emergency department unconscious, and it was impossible to collect anamnesis and collect complaints. Group 2 consisted of patients in whom NCI was diagnosed immediately after surgery. Group 3 included patients who had NCI, but the volume of surgery and the volume of lung lesions allowed them further outpatient treatment. Group 4 consisted of patients in whom Covid-19 was detected within 3 days after surgery. In all patients, a detailed life history and epidemiological history were collected (except for group 1), the most frequent clinical manifestations and indicators of general and biochemical blood tests were analyzed, and CT data of the lungs were processed. The main clinical symptoms of NCI were identified, such as: fever, cough, weakness and fatigue. The most important laboratory indicators were the determination of the level of leukocytosis, with the level of neutrophils and lymphocytes, as well as ESR, D-dimer, C-reactive protein. The presented article is of great interest to doctors working in the admission departments of multidisciplinary hospitals. Based on the results of the work, it is planned to continue the study with a larger sample of patients and a large number of studied parameters

scholarly journals Lateral cephalometric diagnosis of asymmetry in Angle Class II subdivision compared to Class I and II

2014 ◽  
Vol 19 (4) ◽  
pp. 80-88 ◽  
Author(s):  
Aparecida Fernanda Meloti ◽  
Renata de Cássia Gonçalves ◽  
Ertty Silva ◽  
Lídia Parsekian Martins ◽  
Ary dos Santos-Pinto
Keyword(s):  
Class Ii ◽  
Diagnostic Methods ◽  
Class I ◽  
Linear Measurements ◽  
Morphological Alterations ◽  
Mandibular Asymmetry ◽  
Study Results ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

INTRODUCTION: Lateral cephalometric radiographs are traditionally required for orthodontic treatment, yet rarely used to assess asymmetries. OBJECTIVE: The objective of the present study was to use lateral cephalometric radiographs to identify existing skeletal and dentoalveolar morphological alterations in Class II subdivision and to compare them with the existing morphology in Class I and II relationship. MATERIAL AND METHODS: Ninety initial lateral cephalometric radiographs of male and female Brazilian children aged between 12 to 15 years old were randomly and proportionally divided into three groups: Group 1 (Class I), Group 2 (Class II) and Group 3 (Class II subdivision). Analysis of lateral cephalometric radiographs included angular measurements, horizontal linear measurements and two indexes of asymmetry that were prepared for this study. RESULTS: In accordance with an Index of Dental Asymmetry (IDA), greater mandibular dental asymmetry was identified in Group 3. An Index of Mandibular Asymmetry (IMA) revealed less skeletal and dental mandibular asymmetry in Group 2, greater skeletal mandibular asymmetry in Group 1, and greater mandibular dental asymmetry in Group 3. CONCLUSION: Both IDA and IMA revealed greater mandibular dental asymmetry for Group 3 in comparison to Groups 1 and 2. These results are in accordance with those found by other diagnostic methods, showing that lateral cephalometric radiography is an acceptable method to identify existing skeletal and dentoalveolar morphological alterations in malocclusions.

scholarly journals A TEN-YEAR ANALYSIS OF CHANGES IN THE SENSITIVITY OF THE LEADING UROPATHOGEN TO ANTIBACTERIAL AGENTS IN CHILDREN WITH URINARY TRACT INFECTION IN THE NEPHROLOGY DEPARTMENT

2020 ◽  
Vol 73 (7) ◽  
pp. 1360-1364
Author(s):  
Tetiana V. Budnik ◽  
Tetiana B. Bevzenko
Keyword(s):  
Relative Risk ◽  
High Sensitivity ◽  
Study Groups ◽  
E Coli ◽  
The Past ◽  
Study Results ◽  
Sensitivity Level ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

The aim: To study the prevalence of ABR among children with UTI over the past 10 years, with an assessment of the sensitivity of E. Coli to common antibiotics in dynamics. Materials and methods: The study involved 1,044 children with UTI aged from 1 month to 18 years. Examination of patients and interpretation of the results was performed in accordance with the provisions of the Declaration of Helsinki of Human Rights. According to the design, the study included 3 comparison groups: Group 1 — children of the 2009 follow-up year (n = 337), Group 2 — of 2014 (n = 328) and Group 3 — of 2019 (n = 379). Results: Escherichia coli is recognized as the leading uropathogen in all study groups: its percentage in Group 1 was 47 % (158/337), in Group 2 — 64 % (210/328) and in Group 3 — 66.5 % (252/379). The prevalence of antibacterial resistance of E. coli strains and the high dynamics of its growth are shown. So the level of resistance of E. Coli in 2019 was 70 ± 4.06 % (176/252). This was 11 % more compared to 2014 and 18.8 % more compared to 2009. The percentage of multiresistant strains tended to increase and amounted to 28 ± 9.97 % (70/252) among patients with UTI and 40 ± 9.12 % (70/176) in the structure of resistance in 2019. The relative risk of ABR increased by 1.6 times in 2019 compared to 2014 (RR2019 = 2.208 ± 0.207 [1.473;3.310], р < 0.05 vs RR2014 = 1.375 ± 0.209 [0.913;2.063]) and by 3 times compared to 2009 (RR2009 = 0.727 ± 0.209 [0.483;1.095]). Ampicillin and amoxicillin showed an equally low sensitivity level (3.5 ± 32.14 % (9/252)). Only every second child confirmed sensitivity to cefuroxime (53.6 ± 5.76 (135/252)). Ceftazidime and ciprofloxacin showed a relatively high sensitivity level — 77.4 ± 3.34 (195/252) and 83 ± 2.81 (209/252), and at the same time the rapidly growing resistance rates — almost twice as high over the past 5 years. Furazidin K showed a high sensitivity level of 85.7 ± 2.53% (216/252), the lowest level of overall resistance of 14.3 ± 15.15 % (36/252) and a slow rate of its formation. An unfavourable prognosis of an increase in the relative risk of ABR by 2.9-3.7 times in the next 5–10 years was determined among patients with UTI, provided that the existing diagnostic and treatment approaches are maintained. Conclusions: The study results are important for understanding the clinical decision on the benefits of antibacterial therapy and optimizing its empirical choice for a patient with UTI.

scholarly journals HISTOLOGICAL STRUCTURE OF PROXIMAL METAPHYSEAL CARTILAGE OF HUMERUS IN RATS AFTER 60-DAY TARTRAZINE ADMINISTRATION

2020 ◽  
pp. 150-157
Author(s):  
V.I. Luzin ◽  
O.N. Fastova ◽  
V.N. Morozov ◽  
E.N. Morozova ◽  
S.V. Zabolotnaya
Keyword(s):  
Body Weight ◽  
Male Rats ◽  
Control Group ◽  
Histological Structure ◽  
Total Width ◽  
Adult Rats ◽  
Study Results ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

The aim of the research is to study the histological structure of proximal metaphysial cartilage of the humerus in adult rats after 60 days of tartrazine administration (750 mg/kg and 1500 mg/kg body weight). Materials and Methods. The study was carried out on 90 white male rats, divided into 3 groups. In Group 1 (control), animals daily intragastrically received 1ml of 0.9 % isotonic sodium chloride solution for 60 days. Rats of Groups 2 and Group 3 received intragastrically 1ml of tartrazine solution (750 mg/kg and 1500 mg/kg body weight respectively) for 60 days. The readaptation period after the last tartrazine administration was 3, 10, 15, 24, or 45 days. The area of the proximal humerus metaphysis underwent treatment according to the standard histological protocol. The obtained sections were stained with hematoxylin-eosin and subjected to a subsequent histomorphometric study. Results. On the 3rd day of the readaptation period, the total width of the proximal metaphysial cartilage of the humerus in animals of Group 2, was by 8.59 % less than the values of the control group; the width of the indifferent, proliferating and definitive cartilage was by 6.11 %, 8.85 % and 7.15 % less; the width of the destruction zone was by 11.55 % less; and the width of the osteogenesis zone was by 9.92 % less. The content of primary spongiosis in the osteogenesis zone and the number of cells on the trabeculae surface were lower than the values of Group 1 by 8.45 % and 8.42 % respectively. During the readaptation period, the authors observed similar dynamics of changes in the histomorphometric parameters of the metaphysical cartilage of the humerus with levelling by the 45th day of the experiment. In rats of Group 3, during the entire readaptation period, the histomorphometric parameters changed more significantly and their recovery to control values was slower than in animals of Group 2. Conclusion. 60-day tartrazine administration to adult rats is accompanied by inhibition of the bone formation function of the proximal metaphysial cartilage of the humerus. It is confirmed by a decrease in the width of all its zones and components of the osteogenesis zone. More pronounced in amplitude and duration changes in the parameters studied were recorded in animals treated with tartrazine, 1500 mg/kg body weight. Keywords: humerus, metaphysial cartilage, tartrazine, histomorphometry. Цель исследования. Установить, оказывает ли влияние 60-дневное введение тартразина в дозах 750 и 1500 мг/кг массы тела на гистологическое строение проксимального метафизарного хряща плечевой кости у половозрелых крыс. Материалы и методы. Исследование проведено на 90 белых крысах-самцах, распределенных на 3 группы: 1-я – контрольная, в которой животные ежедневно в течение 60 дней получали физиологический раствор через желудочный зонд; 2-ю и 3-ю группы составили крысы, которые на протяжении 60 дней получали внутрижелудочно 1 мл раствора тартразина в дозах 750 и 1500 мг/кг массы тела соответственно. Сроки периода реадаптации после окончания введения тартразина составляли 3, 10, 15, 24, 45 сут. Проксимальный метафиз плечевой кости подвергался обработке по стандартному гистологическому протоколу. Полученные срезы окрашивались гематоксилин-эозином и подвергались последующему гистоморфометрическому исследованию. Результаты. У животных 2-й группы на 3-й день периода реадаптации общая ширина проксимального метафизарного хряща плечевой кости была меньше значений контрольной группы на 8,59 %, ширина зон индифферентного, пролиферирующего и дефинитивного хряща – на 6,11, 8,85 и 7,15 % меньше, ширина зоны деструкции – на 11,55 %, а ширина зоны остеогенеза – на 9,92 %. Содержание первичной спонгиозы в зоне остеогенеза и количество клеток на поверхности трабекул были меньше значений контрольной группы на 8,45 и 8,42 %. В ходе периода реадаптации сходная динамика изменений гистоморфометрических параметров метафизарного хряща плечевой кости сохранялась с тенденцией к сглаживанию к 45-м сут эксперимента. У крыс 3-й группы в ходе всего периода реадаптации изучаемые параметры изменялись более значимо и их восстановление до контрольных величин происходило медленнее, чем во 2-й группе. Выводы. 60-дневное введение тартразина половозрелым крысам сопровождается угнетением костеобразовательной функции проксимального метафизарного хряща плечевой кости, что подтверждается снижением ширины всех его зон и объемных компонентов зоны остеогенеза. Более выраженные по амплитуде и длительности изменения изучаемых параметров зафиксированы у животных, получавших тартразин в дозе 1500 мг/кг массы тела. Ключевые слова: плечевая кость, метафизарный хрящ, тартразин, гистоморфометрия.

scholarly journals Benefits of treatment with favipiravir in hospitalized patients for COVID-19: a retrospective observational case–control study

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Anıl Ucan ◽  
Pamir Cerci ◽  
Serdar Efe ◽  
Hakan Akgun ◽  
Ahmet Ozmen ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Specific Treatment ◽  
Reactive Protein ◽  
Study Results ◽  
New Finding ◽  
Group 3 ◽  
Group 2 ◽  
Positive Effect ◽  
Control Study ◽  
Group 1

Abstract Background Although more than a year past since COVID-19 was defined, there is no specific treatment yet. Since COVID-19 management differs over time, it is hard to determine which therapy is more efficacious. In this study, we aimed to evaluate the efficacy of the regimen with Favipiravir (FPV) and determine if the timing of FPV addition offers any improvement. Methods A retrospective observational case-controlled cohort study was performed between March and September 2020, including adults with COVID-19 in a single-center in Turkey. We categorized patients into age-sex matched three groups, group 1 (n = 48) and group 2 (n = 48) included patients treated with the combination of FPV plus Hydroxychloroquine (HQ) early and late, respectively. Group 3 (n = 48) consisted of patients on HQ monotherapy. In Group 2, if the respiratory or clinic condition had not improved sufficiently, FPV was added on or after day 3. Results We found that starting FPV early had an impact on PCR negativity and the progression of the disease. 'No progression' was defined as the absence of a new finding in the control radiological examination and the absence of accompanying clinical deterioration. Also, the decrease in C-reactive protein (CRP) was greater in Group 1 than Group 3 (p < 0.001). However, we found that early initiation of FPV treatment did not have a positive effect on the estimated survival time. Conclusions According to this retrospective study results, we believe that for better clinical outcomes, FPV treatment should be started promptly to enhance antiviral effects and improve clinical outcomes.

Pre-Engraftment Syndrome After Myeloablative Umbilical Cord Blood Transplantation: Risk Factors and How To Stratify

Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 5482-5482
Author(s):  
Zimin Sun ◽  
Maojing Guan ◽  
Huilan Liu ◽  
Liangquan Geng ◽  
Xingbing Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Clinical Symptoms ◽  
Cord Blood Transplantation ◽  
Group 4 ◽  
Significant Difference ◽  
Engraftment Syndrome ◽  
Group 3 ◽  
Group 2 ◽  
One Year ◽  
Group 1

Abstract Introduction Pre-engraftment syndrome (PES) is a group of symptoms occurred after hematopoietic stem cell transplantation especially unrelated cord blood transplantation(UCBT) before the engraftment, including unexplained fever higher than 38.3°CAunexplained erythematous skin rashAdiarrheaAhepatic dysfunction Anon-cardiogenic edemaApulmonary infiltrates and weight gain. Severe PES can be fatal, however there’s no criteria to define it. We retrospectively analyzed the incidence, risk factors, manifestations and clinical outcomes of PES in CBT recipients, who had been treated for hematologic malignancies. All patients received TBI(12GY)/Ara-c(8g/ m2)/CY(120mg/kg) without ATG or Flu(120mg/ m2)/Ara-c(8g/ m2)+BU(12.8mg/kg)+CY (120mg/kg) myeloablative conditioning. Methods From April 2010 to July 2011, 61 patients underwent UCBT at our transplantation center and 40 patients(65.6%) developed PES at a median of 7 d (range 5–13) post-transplant. We analyze 8 factors related to treatment-related mortality (TRM) within 180 days : occurrence timeAthe maximum temperatureAclinical symptomsAconcentration of CyclosporinAthe initial dose of MPAmethylprednisolone (MP) effective daysAdays till MP reduced and reoccurrence after symptoms under control. Univariate analysis identified early occurrence time( day +5 or +6 ) AMP effective days and clinical symptoms as significant risk factors for higher TRM. In a multivariate analysis, we found these three factors are independent and have no interactions. We retrospectively analyze all the patients who developed PES from April 2010 to December 2012. Results There were 94 cases and we scored them based on these three factors. The patient got one score for each factor if he/she got a fever on day 5-6 after UCBT or had more than two clinical symptoms or not under control after 7 days of MP. We added the three scores together and divide the patients into four groups according to the total score(zero for Group 1Aone score for Group 2Atwo score for Group 3Athree for Group 4). The number of patients for Group 1-4 was 32A32A18 and 12. There is a significant difference for the TRM within 180 days between Group 4(58%) and Group 1(18.7%)AGroup 2(22.2%) (P<0.01). The TRM of Group 4 in one year is 66.7%, which is significantly higher than Group 1( 22.7%), Group 3(22.2%) (P<0.01), but shows less significant difference compared with TRM of group 2, which is 33%. The relapse rate of one year for each group from 1 to 4 was 9%A16.7%A5.5%A8.3%. The probability of one-year disease-free survival (DFS) was much higher in Group 1 (71.7%) and 3(72.2%) than Group 4(25%) (P<0.01). The difference was apparent as to the probability of one-year overall survival (OS) between Group 1 (74.8%) and 4(25%), the same is true whith Group 3 (71.3%) and 4(25%). The difference between Group 2(55.4%) and Group 4 was not clearly significant (P=0.06). Conclusions Recognizing and treating immediately severe PES will significantly reduce the TRM of UCBT. Our analyze confirmed that these three factors are crucial to define severe PES .We therefore put forward this ranking method to help to diagnosis and take effective treatment. Disclosures: No relevant conflicts of interest to declare.

Sign in / Sign up

Export Citation Format

Share Document