scholarly journals Hematological Profile of Pregnant Women in Port Harcourt, Nigeria

2019 ◽  
Vol 3 (1) ◽  
pp. 1-10
Author(s):  
Chinyelu O. Mba ◽  
Ransom B. Jacob ◽  
Mercy B. Green ◽  
Loveday U. Zebedee
Keyword(s):  
Pregnant Women ◽  
Hematological Parameters ◽  
Vitamin Supplementation ◽  
White Blood Count ◽  
Mean Cell Volume ◽  
Hematological Profile ◽  
Port Harcourt ◽  
Significant Difference ◽  
Mean Cell Hemoglobin ◽  
In Pregnancy

BACKGROUND OR OBJECTIVES: Pregnant women experience a lot of changes, which often reflect in their hematological indices. The study examines the differences in the hematological profile of pregnant and nonpregnant women in Port Harcourt, in the Niger Delta region of Nigeria. METHODS: The subjects were systematically sampled, comprising of 90 pregnant and 90 non-pregnant women, with ages ranging 16 to 45 years. Five milliliters of whole blood was collected from each subject at ambient temperature using standard venepuncture techniques and three milliliters was dispensed in EDTA bottle. T-test was used to compare the mean of the parameters among the pregnant and nonpregnant women. Analysis of variance was used to compare the means for the parameters within the three trimesters. Tukey’s Post Hoc test was used to identify the trimester pairs that had significant mean difference, Hematological parameters were analyzed using Abacus380 hematological analyzer. The data obtained were coded and analysed using SPSS version 20 and data were considered significant at p≤0.05. RESULTS: Comparison of pregnant women with controls showed that Total White Blood Count TWBC), monocytes, neutrophils, Mean Cell Volume (MCV), and Mean Cell Hemoglobin (MCH) were significantly increased in pregnancy (p<0.05); while Red Blood Cell (RBC) count, hemoglobin, hematocrit and Mean Cell Hemoglobin concentration were significantly decreased (p<0.01). The following hematological parameters showed significant mean variation within the 3 trimesters: MCH (F=3.59, p=0.03) and MCHC (F=16.85, p<0.01). MCHC showed significant difference between first versus second trimesters (p=<0.01) and 1st vs. 3rd trimesters (p=<0.01). CONCLUSION AND IMPLICATIONS FOR TRANSLATION The lower hematocrit and hemoglobin level of pregnant women when compared with the non-pregnant controls implies that there is need for more emphasis on the importance of prenatal vitamin supplementation during the antenatal period, perhaps leveraging prenatal counselling sessions. Proper supplementation may avert anemia in pregnancy, and consequently, the poor birth outcomes. Key words: Hematological Profile • Pregnant Women • Nigeria • Pregnancy   Copyright © 2019 Mba et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 

scholarly journals The hematological parameters in clinically normal Iraqi local breed goats

2015 ◽  
Vol 39 (2) ◽  
pp. 12-16
Author(s):  
AH. H. AL-Hadithy
Keyword(s):  
Blood Cell ◽  
Cell Volume ◽  
Hematological Parameters ◽  
Hemoglobin Concentration ◽  
Mean Cell Volume ◽  
Local Breed ◽  
Clinically Normal ◽  
Significant Difference ◽  
Males And Females ◽  
Mean Cell Hemoglobin

     The aim of the present work is to determine the hematological parameters in clinically normal local breed goats. The study was conducted on 130 goats (40 males of them 20 bucks and 20 buck kids and 90 females of them 20 doe kids, 20 dry does, 25 pregnant and 25 lactating does) aged 6 months-4 years in AL-Najaf province-Iraq. Blood samples were collected from the jugular vein into EDTA tubes during October 2013 untill February 2014. Results showed that the ranges and means ±SE of blood picture were as follows; packed cell volume (PCV) 26-40% and 31.8±0.32%, Hemoglobin (Hb) 8-14.3g/dL and 10.3±0.13 g/dL, Red blood cell (RBC) 10.6-17×106/μL and 13.3±0.14×106/μL, Mean cell volume (MCV) 18.4-32.5 fL and 23.9±0.14 fL, Mean cell Hemoglobin (MCH) 5.5-8.8 and 7.7±0.05 pg, Mean cell hemoglobin concentration (MCHC) 28.3-36.9 g/dL and  32.4±0.15 g/dL, Erythrocyte sedimentation (ESR) 1-10 mm/ 24h and 4.1±0.14 mm/ 24h, White blood cell count (WBC) 5500-15900/μL and 10732±242/μL, Lymphocyte (L) 2772-10172/μL and 6080±149 /Μl, neutrophils (N) 1863-8680/μL and 4112±121/μL, monocytes 57.0-622/μL and313±11/μL, eosinophil’s 0-918/μL and 222±14/μL, basophils 0±0/μL and 0±0/μL, L/N ratio 0.4-3.8 and 1.5±0.04, respectively. There was a significant (P<0.05) increase in PCV, Hb, RBC, MCV, MCH, MCHC and no difference in ESR,WBC, DLC and L/N ratio between males and females. However, significant (P<0.05) differences in most hematological parameters of sub groups have been recorded. In conclusion the present data recorded the reference values of hematological parameters in clinically healthy local breed goats with a significant difference between males and females as well as in normal subgroups.

scholarly journals VARIATIONS IN HEMATOLOGICAL PROFILE DURING DIFFERENT TRIMESTERS OF PREGNANCY

2020 ◽  
pp. 153-155
Author(s):  
MANISHA BAGHEL ◽  
MANPREET SAINI ◽  
MAMTA KANDWAL ◽  
SUDHIR MODALA
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Hematological Parameters ◽  
Considerable Change ◽  
Mean Corpuscular Hemoglobin ◽  
National Capital Region ◽  
Pregnant Females ◽  
Hematological Profile ◽  
Significant Difference ◽  
Hematological Values

Objectives: The present study was aimed to determine the hematological parameters in pregnant women during different trimesters. Methods: This is the case–control study, conducted to assess and compare the hematological profile among 120 pregnant (each trimester n=40) and 40 non-pregnant women attending the obstetrics and gynecology department, Santosh Medical College and Hospital, National Capital Region Delhi. SPSS software 17.0 was used for data statistical analysis. Unpaired Student’s t-test used to compare various hematological parameters between different trimesters of pregnancy and non-pregnant females. It is considered that p<0.05 is statistically significant. Analysis of variance with a post hoc test was used. Results: It has been observed in this study that significant differences found in parameters such as systolic blood pressure (SBP), pulse pressure (PP), heart rate, white blood cell (WBC), hematocrit (HCT), Hb%, mean corpuscular volume (MCV), mean corpuscular hemoglobin (Hb) (MCH), and MCH concentration (MCHC). Significant differences in mean hematological values in between the trimesters (p<0.05): 1st trimester (WBC, HB, and HCT), 2nd trimester (SBP, diastolic blood pressure [DBP], PP, WBC, HB, HCT, and MCHC), and 3rd trimester (SBP, DBP, PP, WBC, HB, HCT, MCV, MCH, and MCHC) were seen, but no significant difference in age and erythrocytes count. Conclusion: A considerable change in some hematological values between different trimesters evaluated, also decreased Hb, HCT values, and increased leukocyte values observed in the present study. These changes suggesting that it is very important to follow up hematological parameters of pregnant females during all trimesters of pregnancy so that any late complications can be avoided.

scholarly journals Hematological parameters of human immunodeficiency virus positive pregnant women on antiretroviral therapy in Aminu Kano Teaching Hospital Kano, North Western Nigeria

2018 ◽  
Vol 10 (01) ◽  
pp. 060-063
Author(s):  
Ibrahim Abdulqadir ◽  
Sagir Gumel Ahmed ◽  
Aisha Gwarzo Kuliya ◽  
Jamilu Tukur ◽  
Aminu Abba Yusuf ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Pregnant Women ◽  
Hematological Parameters ◽  
Cd4 Count ◽  
Reproductive Age ◽  
Full Blood Count ◽  
Hiv Positive ◽  
Mean Cell Volume ◽  
Significant Difference ◽  
Immunodeficiency Virus

Abstract CONTEXT: Human immunodeficiency virus (HIV) scourge continues to affect young women within the reproductive age group and pregnancy is a recognized indication for the use antiretroviral (ARV) drugs among HIV-positive women. AIMS: The aim is to determine the combined effect of pregnancy, HIV and ARV drugs on the hematological parameters of the pregnant women. SETTINGS AND DESIGN: This was a comparative cross-sectional study conducted among 70 each of HIV-positive and negative pregnant women. SUBJECTS AND METHODS: Bio-demographic and clinical data were extracted from the client folder and 4 ml of blood sample was obtained from each participant. Full blood count was generated using Swelab automatic hematology analyzer while reticulocyte count and erythrocyte sedimentation rate (ESR) were conducted manually. STATISTICAL ANALYSIS USED: Data analysis was performed using SPSS version software 16 while P < 0.05 was considered statistically significant. RESULTS: Pregnant women with HIV had statistically significant lower hematocrit and white blood cell (WBC) and higher ESR than pregnant women without HIV (P < 0.000). There was no statistically significant difference between the two groups in terms of platelet and reticulocyte (P > 0.05). However, among HIV positive pregnant women, those with CD4 count <350/μL had statistically significant lower WBC and lymphocyte count than those with CD4 count ≥350/μL (P < 0.05), whereas, those on zidovudine (AZT)-containing treatment had statistically significant lower hematocrit and higher mean cell volume than those on non-AZT-containing treatment (P < 0.05), but there was no statistically significant difference in any of the hematological parameters (P > 0.050) between women on first- and second-line ARV regimens. CONCLUSIONS: There is a significant difference in terms of hematological parameters between HIV-positive and HIV-negative pregnant women in this environment.

scholarly journals Effects of Justicia carnea Leave on Hematological Parameters in Albino Mice Carried Out in Mbingo Annex Hospital Laboratory in Bamenda, North West Region, Cameroon

2020 ◽  
pp. 43-50
Author(s):  
Asakizi Augustine Nji ◽  
Nchang Chrysanthus ◽  
Ngombe David Monyongo
Keyword(s):  
Cell Volume ◽  
Blood Cells ◽  
Hematological Parameters ◽  
Positive Control ◽  
Negative Control ◽  
Mean Cell Volume ◽  
Significant Difference ◽  
Albino Mice ◽  
Mean Cell Hemoglobin ◽  
Test Control

This study is design to ascertain the hematological status in albino mice treated with Justicia carnea leave, which could aid in the treatment of anemia. The hematological parameters investigated include Mean Cell Volume (MCV), Mean Cell Hemoglobin (MCH), Mean Cell Hemoglobin Concentration (MCHC), Platelets (PLTS), Hemoglobin (Hb), Red Blood Cells (RBCs), Pack Cell Volume (PCV) and White Blood Cells (WBCs). Nine (9) male albino mice of approximately the same weight 300 g were grouped into 3 groups that’s Negative Control (NC) Positive Control (PC) and Test Control (TC), each made up of 3 mice. Negative control mice were given normal feed moisten with water,  Positive control received diluted iron folate with normal feed, finally Test control mice were  administered powdered leaves of Justicia carnea with normal feed for 7 days, after which blood samples were collected using EDTA tubes by exsanguination and run for hematological parameters using auto-hematological analyzer. The results of various groups were found to be; as there was a significant increase in RBCs, Hb, & PCV (P=0.05), between the groups. No significant change was observed on the MCV, MCH, and MCHC. Lymphocytosis was observed in all groups with mark difference in granulocytosis. TC had granulocytosis, NC showed normal granulocyte scores and the PC show granulocytopenia with a statistical difference of P=0.0017. A significant difference was seen in platelets between the groups P=0.02. This study shows that J. carnea leaves possess anti-anemic potential, lending credence to the use of these plant leaves in folk medicine for the management of hemolytic anemia would be helpful. Further research on the various phytochemicals of the plant should be done and also its toxicological aspects.

scholarly journals Differences in pregnancy and perinatal outcomes among symptomatic versus asymptomatic COVID-19-infected pregnant women: a systematic review and meta-analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Durray Shahwar A. Khan ◽  
La-Raib Hamid ◽  
Anna Ali ◽  
Rehana A. Salam ◽  
Nadeem Zuberi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Pregnant Women ◽  
Low Birthweight ◽  
Meta Analysis ◽  
Perinatal Outcomes ◽  
Respiratory Disorder ◽  
Significant Difference ◽  
The Mean ◽  
In Pregnancy

Abstract Background There is dearth of information on COVID-19’s impact on pregnant women. However, literature reported trends of COVID-19 differ, depending on the presence of clinical features upon presentation. Objective This systematic review aimed to assess differences in risk factors, management, complications, and pregnancy and perinatal outcomes in symptomatic vs. asymptomatic pregnant women with confirmed SARS-CoV-2 infection. Methods A search was run on electronic databases to identify studies reporting COVID-19 in pregnancy. Meta-analysis was performed and odds ratios and mean difference with 95% confidence intervals were calculated using Review Manager 5.4. Review Prospero registration number CRD42020204662. Results We included ten articles reporting data from 3158 pregnancies; with 1900 symptomatic and 1258 asymptomatic pregnant women. There was no significant difference in the mean age, gestational age, and body mass index between the two groups. The meta-analysis suggested that pregnant women who were obese (OR:1.37;95%CI:1.15 to 1.62), hypertensive (OR:2.07;95%CI:1.38 to 3.10) or had a respiratory disorder (OR:1.64;95%CI:1.25 to 2.16), were more likely to be symptomatic when infected with SARS-CoV-2. Pregnant women with Black (OR:1.48;95%CI:1.19 to 1.85) or Asian (OR:1.64;95%CI:1.23 to 2.18) ethnicity were more likely to be symptomatic while those with White ethnicity (OR:0.63;95%CI:0.52 to 0.76) were more likely to be asymptomatic. Cesarean-section delivery (OR:1.40;95%CI:1.17 to 1.67) was more likely amongst symptomatic pregnant women. The mean birthweight(g) (MD:240.51;95%CI:188.42 to 293.51), was significantly lower, while the odds of low birthweight (OR:1.85;95%CI:1.06 to 3.24) and preterm birth (< 37 weeks) (OR:2.10;95%CI:1.04 to 4.23) was higher amongst symptomatic pregnant women. Symptomatic pregnant women had a greater requirement for maternal ICU admission (OR:13.25;95%CI:5.60 to 31.34) and mechanical ventilation (OR:15.56;95%CI:2.96 to 81.70) while their neonates had a higher likelihood for Neonatal Intensive Care Unit admission (OR:1.96;95%CI:1.59 to 2.43). The management strategies in the included studies were poorly discussed, hence could not be analyzed. Conclusion The evidence suggests that the presence of risk factors (co-morbidities and ethnicity) increased the likelihood of pregnant women being symptomatic. Higher odds of complications were also observed amongst symptomatic pregnant women. However, more adequately conducted studies with adjusted analysis and parallel comparison groups are required to reach conclusive findings.

scholarly journals Blood Donation in Nigeria: Standard of the Donated Blood

2012 ◽  
Vol 4 (02) ◽  
pp. 094-097 ◽  
Author(s):  
Nwogoh Benedict ◽  
Awodu Omolade Augustina ◽  
Bazuaye Godwin Nosakhare
Keyword(s):  
Blood Donation ◽  
Hematological Parameters ◽  
Hemoglobin Concentration ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Hemoglobin ◽  
Mean Cell Volume ◽  
Benin City ◽  
Cell Counts ◽  
Significant Difference ◽  
The Mean

ABSTRACT Objective: The objective was to determine the basic hematological parameters of remunerated blood donors in Benin City and to compare them with those of voluntary donors. Materials and Methods: This is a prospective study conducted in a tertiary health facility in Benin City. Pretransfusion samples were obtained from blood bags after gentle mixing and analyzed for hematological parameters. Samples were analyzed using the hematology autoanalyzer MODEL SYSMEX KN21. Result: A total of 215 samples were obtained comprising 160 remunerated (paid) and 55 voluntary donor samples. In the paid donors, the mean hemoglobin concentration (Hb) and hematocrit (HCT) 7.7±2.9 and 28.8±8.5 respectively. This was significantly lower than those of voluntary donors who had 13.9±1.2 and 42.2±3.3 with P < 0.001. The mean values of the red cell counts (RBC), white cell counts (WBC), mean cell volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) were significantly lower in paid donors as P-values were <0.001. MCV was significantly low but not compared to the other parameters as P=0.04. There was no significant difference in the platelet count. Conclusion: Paid donors in Benin City have significantly lower hematological parameters than controls.

Effects of Novel Coronavirus 2019 Infection on Antenatal Hematological Parameters in Pregnant Women

2021 ◽  
Vol 15 (11) ◽  
pp. 3279-3284
Author(s):  
Monika . ◽  
Israt Saba Mari ◽  
Monika Maheshwari ◽  
Shahida Shaikh ◽  
Qararo Shah Syed ◽  
...  
Keyword(s):  
Antenatal Care ◽  
Pregnant Women ◽  
Urban Areas ◽  
Research Evaluation ◽  
Hematological Parameters ◽  
Haematological Parameters ◽  
Maternal Complications ◽  
Cross Sectional ◽  
Group I ◽  
In Pregnancy

Background: Disturbance of haematological parameters is prevalent in pregnancy globally leading to a range of feto-maternal complications. Covid-19 infection has potential to enhance the severity of and complications impending due to anaemia in pregnancy. Objective: To determine the effects of Covid-19 infection on haematological parameters during antenatal care among pregnant women in rural Sindh. Study Design: Cross sectional study. Setting: Shaikh Zaid Institute, Chandka Medical College, Larkana. Duration: From March 1, 2021, and May 31, 2021. Materials and Method: A sample of 110 pregnant women, of 18-50 years of age, presenting in first through third trimester with single alive pregnancy, were included in the study after taking a valid written consent. The Research Evaluation Committee of SMBBMU- Larkana granted approval. Women having any haemoglobinopathy were excluded. Covid-19 test conducted through rt-PCR method. A standard questionnaire was used to collect data of two groups. Analysis was performed through SPSS Version-23. Descriptive and inferential statistics were calculated. Results: Mean ± SD age was 30.3 ± 6.99 (Range: 19 to 45) years. Both groups were identical in age. Mean ± SD gestational age was 28.12 ± 4.66 weeks (Range: 20-38). Covid-19 positive women had lower mean Hb (9.7 ± 2.11) than the covid-19 negative (10.54 ± 2.51; P = 0.158). Other haematological parameters like MCV, serum ferritin, TIBC, TLC & platelets were statistically different between groups. Women of eldest group i-e; in 41-50 years, from urban areas, second trimester (gest. age 13-24 weeks), and nulliparous had been affected more from covid-19 (P = 0.271, 0.748, 0.290 & 0.053). Frequency and severity of anaemia was more among Covid-19 positive women. Conclusion: Covid‐19 demands maternal healthcare to be extra vigilant to the haematological parameters of pregnant women during antenatal care till delivery. Keywords: Antenatal care, pregnancy, anaemia, haemoglobin, Covid‐19.

Competence of medical and obstetric registrars in the management of systemic lupus erythematosus in pregnancy

2020 ◽  
pp. 1753495X2096467
Author(s):  
Jarrod Zamparini ◽  
Stuart Pattinson ◽  
Kavita Makan
Keyword(s):  
South Africa ◽  
Systemic Lupus Erythematosus ◽  
Pregnant Women ◽  
Lupus Erythematosus ◽  
Pass Rate ◽  
Childbearing Age ◽  
Systemic Lupus ◽  
Significant Difference ◽  
General Physicians ◽  
In Pregnancy

Introduction Systemic lupus erythematosus has a predilection for women of childbearing age. Globally a shortage of rheumatologists exists resulting in general physicians and obstetricians treating systemic lupus erythematosus in pregnancy. Methods We conducted a survey amongst medical and obstetric registrars in South Africa to assess their subjective and objective competence in managing pregnant women with systemic lupus erythematosus. Results The pass rate for the objective section was 70.8% with no statistically significant difference in the pass rate between medical and obstetric registrars. Participants felt unprepared to manage pregnant women with systemic lupus erythematosus, with a mean overall score of 3.4 out of 7 for the subjective section, based on four Likert scale type questions. Conclusion Trainees are not able to accurately assess their own levels of competence in order to identify their learning needs. Due to the shortage of rheumatologists and lack of obstetric physicians in South Africa, general physicians and obstetricians must be equipped to provide adequate care to pregnant women with systemic lupus erythematosus.

scholarly journals Hematological parameters of the blood count in a healthy population of pregnant women in the Northwest of Morocco (Tetouan-M'diq-Fnideq provinces)

2018 ◽  
Vol 29 ◽  
Author(s):  
Saad Bakrim ◽  
Youssef Motiaa ◽  
Ali Ouarour ◽  
Azlarab Masrar
Keyword(s):  
Pregnant Women ◽  
Reference Values ◽  
Blood Count ◽  
Complete Blood Count ◽  
Hematological Parameters ◽  
Control Group ◽  
Mean Corpuscular Hemoglobin ◽  
Healthy Population ◽  
Corpuscular Hemoglobin ◽  
Significant Difference

Introduction: numerous biological parameters are physiologically modified during normal pregnancy, in particular hematology. The knowledge of these modifications of the maternal body by biologists and clinicians allows the screening of possible anomalies. In Morocco, the reference values of the complete blood count test for pregnant woman are missing, as are those specific to different trimesters of pregnancy. The aim of this study is to look for the reference values for healthy pregnant women of the Northwest region of Morocco, to compare them to those of non-pregnant women (control) and to those of the literature. Methods: blood samples were taken voluntarily from 3898 healthy pregnant women from 18 to 46 years old who presented themselves at the center of health Kalaa and at the service of gynecology obstetrics of the Provincial Hospital Center of M'diq (Morocco), for prenatal care. To establish the reference intervals of the CBC for non-pregnant women, a control group was constituted by 7035 healthy women from 18 to 50 years old selected according to the Moroccan law of blood donation. The CBC was measured on a Sysmex KX21N® analyzer. For each sample a systematic blood smear was done to determine the leukocyte differential. Results: a statistically significant difference between the pregnant women and control group was noted (p < 0.05) for all the hematological parameters: red blood cells, hematocrit, hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, leukocytes, neutrophils, basophils, eosinophils, lymphocytes, monocytes, platelets and mean platelet volume. So, the comparison of the averages established between the first, second and third trimester of pregnancy showed the existence of a significant variation with regard to all the parameters of the CBC test looked for (p < 0.001). Conclusion: the present study provides additional baseline data for basic hematological parameters in healthy pregnant Moroccan women and concluded that pregnancy in women has the tendency to alter some hematological indices. For these reasons, there is an interest to take these modifications into account for optimal maternal and fetal medical care.

scholarly journals Serum and urine vitamin D metabolite analysis in early preeclampsia

2018 ◽  
Vol 7 (1) ◽  
pp. 199-210 ◽  
Author(s):  
J A Tamblyn ◽  
C Jenkinson ◽  
D P Larner ◽  
M Hewison ◽  
M D Kilby
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Reproductive Age ◽  
Vitamin D Metabolites ◽  
Serum Concentrations ◽  
Control Serum ◽  
Significant Difference ◽  
Paired Serum ◽  
In Pregnancy ◽  
Serum And Urine

Vitamin D deficiency is common in pregnant women and may contribute to adverse events in pregnancy such as preeclampsia (PET). To date, studies of vitamin D and PET have focused primarily on serum concentrations vitamin D, 25-hydroxyvitamin D3 (25(OH)D3) later in pregnancy. The aim here was to determine whether a more comprehensive analysis of vitamin D metabolites earlier in pregnancy could provide predictors of PET. Using samples from the SCOPE pregnancy cohort, multiple vitamin D metabolites were quantified by liquid chromatography–tandem mass spectrometry in paired serum and urine prior to the onset of PET symptoms. Samples from 50 women at pregnancy week 15 were analysed, with 25 (50%) developing PET by the end of the pregnancy and 25 continuing with uncomplicated pregnancy. Paired serum and urine from non-pregnant women (n = 9) of reproductive age were also used as a control. Serum concentrations of 25(OH)D3, 25(OH)D2, 1,25(OH)2D3, 24,25(OH)2D3 and 3-epi-25(OH)D3 were measured and showed no significant difference between women with uncomplicated pregnancies and those developing PET. As previously reported, serum 1,25(OH)2D3 was higher in all pregnant women (in the second trimester), but serum 25(OH)D2 was also higher compared to non-pregnant women. In urine, 25(OH)D3 and 24,25(OH)2D3 were quantifiable, with both metabolites demonstrating significantly lower (P < 0.05) concentrations of both of these metabolites in those destined to develop PET. These data indicate that analysis of urinary metabolites provides an additional insight into vitamin D and the kidney, with lower urinary 25(OH)D3 and 24,25(OH)2D3 excretion being an early indicator of a predisposition towards developing PET.

Sign in / Sign up

Export Citation Format

Share Document