scholarly journals The hematological parameters in clinically normal Iraqi local breed goats

2015 ◽  
Vol 39 (2) ◽  
pp. 12-16
Author(s):  
AH. H. AL-Hadithy
Keyword(s):  
Blood Cell ◽  
Cell Volume ◽  
Hematological Parameters ◽  
Hemoglobin Concentration ◽  
Mean Cell Volume ◽  
Local Breed ◽  
Clinically Normal ◽  
Significant Difference ◽  
Males And Females ◽  
Mean Cell Hemoglobin

     The aim of the present work is to determine the hematological parameters in clinically normal local breed goats. The study was conducted on 130 goats (40 males of them 20 bucks and 20 buck kids and 90 females of them 20 doe kids, 20 dry does, 25 pregnant and 25 lactating does) aged 6 months-4 years in AL-Najaf province-Iraq. Blood samples were collected from the jugular vein into EDTA tubes during October 2013 untill February 2014. Results showed that the ranges and means ±SE of blood picture were as follows; packed cell volume (PCV) 26-40% and 31.8±0.32%, Hemoglobin (Hb) 8-14.3g/dL and 10.3±0.13 g/dL, Red blood cell (RBC) 10.6-17×106/μL and 13.3±0.14×106/μL, Mean cell volume (MCV) 18.4-32.5 fL and 23.9±0.14 fL, Mean cell Hemoglobin (MCH) 5.5-8.8 and 7.7±0.05 pg, Mean cell hemoglobin concentration (MCHC) 28.3-36.9 g/dL and  32.4±0.15 g/dL, Erythrocyte sedimentation (ESR) 1-10 mm/ 24h and 4.1±0.14 mm/ 24h, White blood cell count (WBC) 5500-15900/μL and 10732±242/μL, Lymphocyte (L) 2772-10172/μL and 6080±149 /Μl, neutrophils (N) 1863-8680/μL and 4112±121/μL, monocytes 57.0-622/μL and313±11/μL, eosinophil’s 0-918/μL and 222±14/μL, basophils 0±0/μL and 0±0/μL, L/N ratio 0.4-3.8 and 1.5±0.04, respectively. There was a significant (P<0.05) increase in PCV, Hb, RBC, MCV, MCH, MCHC and no difference in ESR,WBC, DLC and L/N ratio between males and females. However, significant (P<0.05) differences in most hematological parameters of sub groups have been recorded. In conclusion the present data recorded the reference values of hematological parameters in clinically healthy local breed goats with a significant difference between males and females as well as in normal subgroups.

scholarly journals Effects of Justicia carnea Leave on Hematological Parameters in Albino Mice Carried Out in Mbingo Annex Hospital Laboratory in Bamenda, North West Region, Cameroon

2020 ◽  
pp. 43-50
Author(s):  
Asakizi Augustine Nji ◽  
Nchang Chrysanthus ◽  
Ngombe David Monyongo
Keyword(s):  
Cell Volume ◽  
Blood Cells ◽  
Hematological Parameters ◽  
Positive Control ◽  
Negative Control ◽  
Mean Cell Volume ◽  
Significant Difference ◽  
Albino Mice ◽  
Mean Cell Hemoglobin ◽  
Test Control

This study is design to ascertain the hematological status in albino mice treated with Justicia carnea leave, which could aid in the treatment of anemia. The hematological parameters investigated include Mean Cell Volume (MCV), Mean Cell Hemoglobin (MCH), Mean Cell Hemoglobin Concentration (MCHC), Platelets (PLTS), Hemoglobin (Hb), Red Blood Cells (RBCs), Pack Cell Volume (PCV) and White Blood Cells (WBCs). Nine (9) male albino mice of approximately the same weight 300 g were grouped into 3 groups that’s Negative Control (NC) Positive Control (PC) and Test Control (TC), each made up of 3 mice. Negative control mice were given normal feed moisten with water,  Positive control received diluted iron folate with normal feed, finally Test control mice were  administered powdered leaves of Justicia carnea with normal feed for 7 days, after which blood samples were collected using EDTA tubes by exsanguination and run for hematological parameters using auto-hematological analyzer. The results of various groups were found to be; as there was a significant increase in RBCs, Hb, & PCV (P=0.05), between the groups. No significant change was observed on the MCV, MCH, and MCHC. Lymphocytosis was observed in all groups with mark difference in granulocytosis. TC had granulocytosis, NC showed normal granulocyte scores and the PC show granulocytopenia with a statistical difference of P=0.0017. A significant difference was seen in platelets between the groups P=0.02. This study shows that J. carnea leaves possess anti-anemic potential, lending credence to the use of these plant leaves in folk medicine for the management of hemolytic anemia would be helpful. Further research on the various phytochemicals of the plant should be done and also its toxicological aspects.

scholarly journals Blood Donation in Nigeria: Standard of the Donated Blood

2012 ◽  
Vol 4 (02) ◽  
pp. 094-097 ◽  
Author(s):  
Nwogoh Benedict ◽  
Awodu Omolade Augustina ◽  
Bazuaye Godwin Nosakhare
Keyword(s):  
Blood Donation ◽  
Hematological Parameters ◽  
Hemoglobin Concentration ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Hemoglobin ◽  
Mean Cell Volume ◽  
Benin City ◽  
Cell Counts ◽  
Significant Difference ◽  
The Mean

ABSTRACT Objective: The objective was to determine the basic hematological parameters of remunerated blood donors in Benin City and to compare them with those of voluntary donors. Materials and Methods: This is a prospective study conducted in a tertiary health facility in Benin City. Pretransfusion samples were obtained from blood bags after gentle mixing and analyzed for hematological parameters. Samples were analyzed using the hematology autoanalyzer MODEL SYSMEX KN21. Result: A total of 215 samples were obtained comprising 160 remunerated (paid) and 55 voluntary donor samples. In the paid donors, the mean hemoglobin concentration (Hb) and hematocrit (HCT) 7.7±2.9 and 28.8±8.5 respectively. This was significantly lower than those of voluntary donors who had 13.9±1.2 and 42.2±3.3 with P < 0.001. The mean values of the red cell counts (RBC), white cell counts (WBC), mean cell volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) were significantly lower in paid donors as P-values were <0.001. MCV was significantly low but not compared to the other parameters as P=0.04. There was no significant difference in the platelet count. Conclusion: Paid donors in Benin City have significantly lower hematological parameters than controls.

scholarly journals Haematological Alterations among Cement Loaders in Port Harcourt, Nigeria

2020 ◽  
pp. 1-8
Author(s):  
Ransom Baribefii Jacob ◽  
Chinyelu Obianuju Mba ◽  
Patience Deborah Iduh
Keyword(s):  
Blood Cell ◽  
Cell Volume ◽  
Study Design ◽  
Haemoglobin Concentration ◽  
Healthy Male Subject ◽  
Cement Dust ◽  
Cross Sectional ◽  
Mean Cell Volume ◽  
Port Harcourt ◽  
Significant Difference

Background: Exposure to cement dust without necessary precautions to prevent its inhalation is found to cause respiratory, dermatological, ocular as well as hematological problems and this is a matter of great concern to the health of cement loaders. Aim of Study: This study was aimed at determining haematological alterations among cement loaders in Port Harcourt, Nigeria. Study Design: Cross sectional study design. Methodology: A total of 100 apparently healthy male subject consisting of 50 cement loaders and 50 non cement loaders aged between the ages of 20- 45years old were recruited for the study. Four millilitres (4 mls) of blood was collected aseptically from the antecubital vein of each participant using standard venepuncture technique into ethylene diamine tetra acetic acid (EDTA) anticoagulated vacutainer bottles with proper mixing to avoid blood clotting and then analysed using Sysmex haematology autoanalyser. Graphpad prism version 6.2 was used to analyse the data obtained. Results: Results obtained showed a statistically higher value (p<0.05) in platelet count (p=0.0001), lower values (p<0.05) in haemoglobin concentration (Hb), Packed cell volume (PCV), Mean cell volume (MCV) and Mean cell haemoglobin (MCH) (p=0.0001). No significant difference (p>0.05) was observed in the mean red blood cell (RBC) count value (p=0.3110), white blood cell (WBC) count (p=0.8138) and mean cell haemoglobin concentration (MCHC) (p=0.0584) respectively. Conclusion and Recommendation: This study has confirmed that there are haematological alterations among cement loaders in Port Harcourt, Nigeria and these alterations are attributed to inhalation of cement dust during work. It is recommended that cement loaders should be mandated to use appropriate personal protective equipment during work hours and around areas where cement dust are generated.

scholarly journals Red Blood Cell Variables in Children and Adolescents regarding the Age and Sex

2019 ◽  
Author(s):  
Jasmina PLUNCEVIC GLIGOROSKA ◽  
Serjoza GONTAREV ◽  
Beti DEJANOVA ◽  
Lidija TODOROVSKA ◽  
Daniela SHUKOVA STOJMANOVA ◽  
...  
Keyword(s):  
Blood Cell ◽  
Children And Adolescents ◽  
Red Blood Cell ◽  
Hematological Parameters ◽  
Hemoglobin Concentration ◽  
Female Group ◽  
Distribution Width ◽  
Hematological Indices ◽  
Significant Difference ◽  
Age And Sex

Background: This study aimed to assess the basic red blood cell variables and hematological indices in children and adolescents and analyze the differences regarding age and sex. Methods: Overall, 320 young participants, age 8 to 18 yr, were enrolled at Laboratory of Sport’s Medicine, Medical Faculty, Skopje, Macedonia in 2016. Capillary blood samples were drawn and following hematologic parameters were measured: the red blood cell count (RBC), hemoglobin concentration (Hb), hematocrit level (Hct) and hematological indexes: mean corpuscular volume (MCV), mean hemoglobin concentration (MCH), mean corpuscular hemoglobin concentration (MCHC) and red cell distribution width (RDW). Results: RBC variables in male group showed high statistical level of significance between age different groups (P=0.001) for all studied parameters except MCHC (P=0.423) and RDW (P=0.174). ANOVA test and multivariate tests in female group showed that there was no significant difference for all hematological parameters between age different groups. Regarding the sex differences, male participants had significantly higher red blood count (P<0.001), hemoglobin content (P<0.001) and hematocrit (P<0.001). Conclusion: Hematological parameters in adolescent as inhomogeneous population are not quantified sufficiently, especially hematological indices. RBC variables, regardless of the age, differ very much between male and female examinees, in favor of the male examinees. Hematological indices were insignificantly higher in males. Regarding the age of examinees, RBC variables showed significant inter-groups differences only within male adolescents. While with girls, ages span 8 to 18 yr, we did not find significant differences for most of the hematological variables.

scholarly journals Some hematological parameters of Wistar rats treated with Chromolaena odorata leave extracts

2017 ◽  
Vol 90 (1) ◽  
Author(s):  
Henshaw Uchechi Okoroiwu ◽  
Ifeyinwa Maryann Okafor ◽  
Emmanuel Kufre Uko ◽  
Item Justin Atangwho
Keyword(s):  
Cell Volume ◽  
Wistar Rats ◽  
Hematological Parameters ◽  
Ethanol Extract ◽  
Control Group ◽  
Chromolaena Odorata ◽  
Mean Cell Volume ◽  
Significant Difference ◽  
The Mean ◽  
Ethanol Extracts

This study was designed to investigate the effects of the different extracts of Chromolaena odorata leave on the hematopoietic system of Wistar rats. Solvent extraction was used for the ethanol and aqueous extractions while decoction method was used for the crude extraction. Fifty Wistar rats of both sexes weighing 140-180 g were used for this study. They were divided into ten groups each containing five rats. The animals were fed the extracts by oral gavage once daily for 21 days. Blood sample was collected via cardiac artery. Hematological parameters were analyzed using automation method. The ethanol extract gave the highest extract yield. The aqueous, ethanol and crude extraction had median lethal toxicity (LD50) of 2738.6 mg/kg, 1581.1 mg/kg and 224.7 mg/kg, respectively. Significant difference (P<0.05) in the total white blood cell count was observed in the 75 mg/kg ethanol and 300 mg/kg crude extracts when compared with control group. Significant difference (P<0.05) in the hemoglobin concentration was observed in the 150 mg/kg ethanol extracts when compared with the control group. Significant difference (P<0.05) in the packed cell volume was seen in the 75 mg/kg aqueous, 150 mg/kg aqueous and 75 mg/kg ethanol extracts in respect to the control group. The mean cell volume, the mean platelet volume and platelet large cell ratio of the 75 mg/kg aqueous extract were significantly different (P<0.05) when compared with the control group. The present study showed possible treatment-induced hematopoietic function of C. odorata leave extracts.

scholarly journals Hematological Profile of Pregnant Women in Port Harcourt, Nigeria

2019 ◽  
Vol 3 (1) ◽  
pp. 1-10
Author(s):  
Chinyelu O. Mba ◽  
Ransom B. Jacob ◽  
Mercy B. Green ◽  
Loveday U. Zebedee
Keyword(s):  
Pregnant Women ◽  
Hematological Parameters ◽  
Vitamin Supplementation ◽  
White Blood Count ◽  
Mean Cell Volume ◽  
Hematological Profile ◽  
Port Harcourt ◽  
Significant Difference ◽  
Mean Cell Hemoglobin ◽  
In Pregnancy

BACKGROUND OR OBJECTIVES: Pregnant women experience a lot of changes, which often reflect in their hematological indices. The study examines the differences in the hematological profile of pregnant and nonpregnant women in Port Harcourt, in the Niger Delta region of Nigeria. METHODS: The subjects were systematically sampled, comprising of 90 pregnant and 90 non-pregnant women, with ages ranging 16 to 45 years. Five milliliters of whole blood was collected from each subject at ambient temperature using standard venepuncture techniques and three milliliters was dispensed in EDTA bottle. T-test was used to compare the mean of the parameters among the pregnant and nonpregnant women. Analysis of variance was used to compare the means for the parameters within the three trimesters. Tukey’s Post Hoc test was used to identify the trimester pairs that had significant mean difference, Hematological parameters were analyzed using Abacus380 hematological analyzer. The data obtained were coded and analysed using SPSS version 20 and data were considered significant at p≤0.05. RESULTS: Comparison of pregnant women with controls showed that Total White Blood Count TWBC), monocytes, neutrophils, Mean Cell Volume (MCV), and Mean Cell Hemoglobin (MCH) were significantly increased in pregnancy (p<0.05); while Red Blood Cell (RBC) count, hemoglobin, hematocrit and Mean Cell Hemoglobin concentration were significantly decreased (p<0.01). The following hematological parameters showed significant mean variation within the 3 trimesters: MCH (F=3.59, p=0.03) and MCHC (F=16.85, p<0.01). MCHC showed significant difference between first versus second trimesters (p=<0.01) and 1st vs. 3rd trimesters (p=<0.01). CONCLUSION AND IMPLICATIONS FOR TRANSLATION The lower hematocrit and hemoglobin level of pregnant women when compared with the non-pregnant controls implies that there is need for more emphasis on the importance of prenatal vitamin supplementation during the antenatal period, perhaps leveraging prenatal counselling sessions. Proper supplementation may avert anemia in pregnancy, and consequently, the poor birth outcomes. Key words: Hematological Profile • Pregnant Women • Nigeria • Pregnancy   Copyright © 2019 Mba et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 

scholarly journals Red blood cell profile in patients with mild, moderate and severe COVID-19

2021 ◽  
Vol 15 (2) ◽  
pp. 26-31
Author(s):  
Khushbhun Nahar Layla ◽  
Shahanara Yeasmin ◽  
Afrina Binte Azad ◽  
Masba Uddin Chowdhury ◽  
Nasrin Sultana ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Hematological Parameters ◽  
Hemoglobin Concentration ◽  
Significant Negative Correlation ◽  
Mean Corpuscular Hemoglobin ◽  
Rt Pcr ◽  
Distribution Width ◽  
Significant Difference ◽  
Bonferroni Test

Background and objectives: Coronavirus disease 2019 (COVID-19) pandemic has affected millions of people world-wide. It is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Increasing evidence has shown abnormalities of different hematological parameters with the severity of the diseases. The present study was undertaken to determine the red blood cell (RBC) profile in different categories of COVID-19 patients. Materials and methods: The study was conducted from January 2020 to December 2020. Reverse transcriptase-polymerase chain reaction (RT-PCR) positive COVID-19 patients were enrolled. Patients were categorized into mild, moderate and severe COVID-19 cases. Blood samples were analyzed by Automated Hematology Analyzer for hemoglobin concentration, total erythrocyte count and RBC indices. ANOVA followed by Bonferroni test, Chi square test, Spearman’s rho correlation coefficient test were performed as applicable using SPSS version 25.0. Results: A total of 100 RT-PCR positive COVID-19 patients were included in the study. There were 25, 38 and 37 mild, moderate and severe cases respectively. The mean age of the study participants was 44.68 + 13.16 years (range: 18 to 65 years). There were 67 (67%) males and 33 (33%) females. No significant difference in hemoglobin (Hb), hematocrit (HCT), total RBC count, red blood cell distribution width (CDW) was observed among the three groups. Significant negative correlation of mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH); rs-0.362 & -0.255 respectively) was observed with disease severity. Conclusion: The study showed low MCV and MCH were significantly related with the severity of the COVID-19 illness. Therefore, comprehensive analysis of the RBC profile would be helpful to understand the disease course. Ibrahim Med. Coll. J. 2021; 15(2): 26-31

Inflammatory cytokine inhibition of erythropoiesis in patients implanted with a mechanical circulatory assist device

Perfusion ◽  
2005 ◽  
Vol 20 (2) ◽  
pp. 83-90 ◽  
Author(s):  
Christopher N Pierce ◽  
Douglas F Larson
Keyword(s):  
Inflammatory Cytokine ◽  
Hematological Parameters ◽  
Hemoglobin Concentration ◽  
Mean Cell Volume ◽  
Distribution Width ◽  
Normal Limits ◽  
Circulatory Assist Devices ◽  
Cytokine Inhibition ◽  
Normal Measure ◽  
The University

Mechanical circulatory assist devices (MCADs) are increasingly utilized independently of cardiac transplantation in the management of heart failure. Though MCAD use incorporates inherent mechanical risks, the inevitable onset of chronic anemia, with its associated morbidity and mortality, is also a significant concern. MCAD support has been correlated with elevated plasma levels of inflammatory cytokines TNF-α, IL-1b, and IL-6, which have separately been found to inhibit erythropoietin (Epo)-induced erythrocyte (RBC) maturation. Previous analysis of hematological parameters for MCAD-sup-ported patients concluded that an amplified inflammatory response impedes RBC proliferation and recovery from hemolytic anemia. Additional analysis may bolster this assertion. Hemoglobin concentration (HC), RBC distribution width (RDW), mean cell volume (MCV), and cardiac index were retrospectively analysed for 78 MCAD-supported patients implanted for greater than 30 days at the University of Arizona Health Sciences Center from 1996 to 2002. Analysis confirms that the HC, a conventional marker for anemia, declines with MCAD placement and remains below the clinically defined, minimum normal value. Inversely, the RDW rises above maximum normal measure, signifying an increased fraction of juvenile RBCs. The MCV remains unchanged and within normal limits, demonstrating adequate substrate for RBC formation. MCAD performance also stabilizes as adequate perfusion returns. These results further support our previously published conclusion that a sufficient response of erythropoiesis occurs in reaction to the onset of anemia by an increased production of immature RBCs. However, the cells never fully mature and join circulation. The patient’s inflammatory cytokine response to the implanted device most likely mediates the chronic MCAD-induced anemia by inhibition of Epo effects.

Blood Profile and Selected Organ Histopathology of Balami Sheep Fed Shea Cake (Vitellaria paradoxa) Meal

2021 ◽  
pp. 46-56
Author(s):  
D. O. Okunlola ◽  
M. D. Shittu ◽  
O. O. Olatunji ◽  
A. J. Amuda ◽  
B. O. Olateju ◽  
...  
Keyword(s):  
Blood Cell ◽  
Control Diet ◽  
Average Weight ◽  
Blood Profile ◽  
Significant Difference ◽  
Randomized Experimental Design ◽  
Inclusion Level ◽  
Males And Females ◽  
Dietary Treatments ◽  
Representative Samples

The blood profile and histology of selected tissues (kidney, lungs, intestine, and epididymis) of Balami Sheep fed Shea Cake meal supplement was investigated. A total of thirty-two (32) sheep of the average weight range of 11.75-14.75kg comprising an equal number (16) of males and females were randomly allotted to four dietary treatments in a completely randomized experimental design with eight sheep per treatment for twelve weeks duration. Treatment 1 (T1) was a control diet and had zero inclusion level of Shea cake meal (SCM), while treatments 2,3, and 4 had 10%,15%, and 20%  inclusion of SCM, respectively. At the twelfth week of the experiment, two blood samples of 5ml each were taken from each animal from the jugular vein. The first set was preserved in Ethylene Diamine Tetra Acetic Acid (EDTA) bottle for haematological parameters, while the second samples were preserved without EDTA for serum examination. Representative samples of tissues were randomly selected and slaughtered for gross microscopic examination. There was a significant difference (P<0.05) at various levels of inclusion for parameters investigated. The white blood cell (WBC), Red blood cell (RBC), and Packed cell volume (PCV) recorded the highest values at T3 (15% inclusion level) (13.42 x109/L), 2.92x1012/L, 3.75%, respectively). The serum parameters were significantly(p <0.05)different among the treatments. Total protein ranges from 54.78(mg/dl) (T1) - 60.51(mg/dl) (T2), Cholesterol70.15(mg/dl) (T1) - 78.00(mg/dl) (T4). Iron ranges from 58.15(ug/dl) (T1) - 62.88(ug/dl) (T3).The histopathology of tissues (kidney, lungs, intestine, and epididymis) showed no alteration across the treatments (P= .05) in the gross microscopic examinations. No lesion was observed in the lungs, kidney, epididymis, and intestine. The results showed that shea cake meal posed no health risk to Balami sheep and as such recommended as a good supplement in the diets of the sheep.

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