Associations between serum vitamins and serum lipids in healthy Northeast China adults

Abstract Objective In previous studies, serum vitamins were shown associated with lipid levels. However, evidence regarding the associations between various serum vitamins and serum lipids is limited. Therefore, the associations between serum vitamins and serum lipids were investigated in this cross-sectional study.Methods The study population included 131 adults (42 males and 89 females) ≥ 18 years of age who lived more than three years in Shenyang, Liaoning province, China. Serum lipids included total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). Analysis of covariance was used to explore the associations between serum vitamins and serum lipids.Results After multiple adjustments, vitamin A and vitamin C concentrations were positively associated with LDL-C level ( P for trend < 0.05). Vitamin A, vitamin B5, and vitamin C concentrations were positively associated with TG level ( P for trend < 0.05). However, vitamin B1 concentration was negatively associated with TG level ( P for trend = 0.04). Vitamin E concentration was positively associated with HDL-C level ( P for trend = 0.02). No association was observed between vitamin concentrations and TC level.Conclusion The results in the present study indicate that serum vitamin concentrations are associated with serum lipid levels. Vitamin B1 and vitamin E concentrations were associated with a better status of lipid profiles. However, vitamin A, vitamin C, and vitamin B5 concentrations were associated with a worse status of lipid profiles.

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Frizzled-related proteins 4 (SFRP4) rs1802073G allele predicts the elevated serum lipid levels during acitretin treatment in psoriatic patients from Hunan, China

PeerJ ◽

10.7717/peerj.4637 ◽

2018 ◽

Vol 6 ◽

pp. e4637 ◽

Cited By ~ 2

Author(s):

Xingchen Zhou ◽

Wu Zhu ◽

Minxue Shen ◽

Yijing He ◽

Cong Peng ◽

...

Keyword(s):

Serum Level ◽

Serum Lipid ◽

Serum Lipids ◽

Elevated Serum ◽

Density Lipoprotein ◽

Serum Triglyceride ◽

Lipoprotein Cholesterol ◽

Lipid Levels ◽

Serum Lipid Levels ◽

Related Proteins

Background Acitretin is a second-generation synthetic retinoid, and is widely used for treating the severe psoriasis vulgaris. However, it should be chosen with caution for its cardiovascular risk, and it is reported that acitretin may increase the serum lipids. The purpose of this study is to investigate the relationship between the Frizzled-related proteins 4 (SFRP4) rs1802073 polymorphism and the changes of serum lipids in Chinese psoriatic patients during the treatment with acitretin. Methods In our study, 100 psoriatic patients were recruited systematically treated with acitretin (30 mg/day) for at least eight weeks. Data of the patients’ demographic and clinical characteristics and the results of serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were collected pre- and post-treatment. Results A total of 84 psoriatic patients were enrolled and divided into three groups by SFRP4 rs1802073 genotypes. The patients who carried with TT genotype had maintained levels of TG and LDL-C after acitretin treatment, while patients with GG/GT genotypes had significantly elevated levels of serum TG and LDL-C compared to the TT genotype (ΔTG%: 27.53 ± 59.13 vs −1.47 ± 37.79, p = 0.026, ΔLDL-C%: 10.62 ± 26.57 vs −1.29 ± 17.07, p = 0.042). The association of rs1802073 with TG and LDL-C profiles remained significant after adjusting for age, gender, and body mass index. Although without significance, the pre-post change in serum level of TC across rs1802073 GG/GT genotypes demonstrated a trend similar to TG and LDL, and the serum level of HDL-C demonstrated a trend opposite to TG, TC and LDL. Conclusions Our results demonstrated that SFRP4 rs1802073 polymorphism was found to be associated with elevated serum lipid levels after acitretin treatment, and it may serve as a genetic marker of safe and precise treatment for individual psoriatic patients.

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The relationship between measures of obesity and atherogenic lipids among Nigerians with hypertension

Malawi Medical Journal ◽

10.4314/mmj.v31i3.5 ◽

2019 ◽

Vol 31 (3) ◽

pp. 193-197

Author(s):

Olamoyegun A Michael

Keyword(s):

Serum Lipid ◽

Serum Lipids ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Advanced Age ◽

Newly Diagnosed ◽

Lipid Levels ◽

Anthropometric Indices ◽

Study Population ◽

The Relationship

AimThis study aimed to determine the relationship between measures of obesity and serum lipid levels among hypertensive patients.MethodsThis was a cross-sectional study in which participants newly diagnosed with hypertension formed the study population. A range of demographic and anthropometric data was obtained, including weight, height, and waist and hip circumference. Fasting serum lipids were also measured, including total cholesterol, high density lipoprotein cholesterol (HDL-C) and triglycerides (TG). Low density lipoprotein cholesterol (LDL-C) was calculated using Friedewald formula. Statistical analysis was then carried out to determine the relationship between anthropometric indices and lipid profile levels. ResultsThe study population consisted of 124 male and 290 female subjects with a mean age of 66±16.95 years (range, 30–100 years).The female subjects were older than the male subjects (p=0.020). Our analysis showed that 85%, 58.5% and 30.7% of the study population had abnormal waist circumference (WC), abnormal waist-hip ratio (WHR) and a body mass index (BMI) >25 kg/m2, respectively. Decreased HDL-C (70.1%) was the commonest lipid abnormality detected, followed by elevated LDL (6.0%). None of the anthropometric indices were independent predictors of abnormal lipid levels. However, advanced age and female sex were independent predictors for at least one serum lipid abnormality.ConclusionNone of the measures of obesity could independently predict abnormal lipid levels in individuals newly diagnosed with hypertension. However, female sex, advanced age and systolic blood pressure were independently associated with abnormal serum lipids. Encouraging regular exercise, and the possible addition of statins, may be beneficial in addressing both obesity and dyslipidaemia.

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Effects of Sacubitril/Valsartan on Serum Lipids in Heart Failure with Preserved Ejection Fraction

Journal of the American Heart Association ◽

10.1161/jaha.121.022069 ◽

2021 ◽

Author(s):

Senthil Selvaraj ◽

Brian L. Claggett ◽

Milton Packer ◽

Faiez Zannad ◽

Inder S. Anand ◽

...

Keyword(s):

Heart Failure ◽

Ejection Fraction ◽

Serum Lipids ◽

Treatment Effects ◽

Density Lipoprotein ◽

Underlying Mechanism ◽

Guanosine Monophosphate ◽

Lipoprotein Cholesterol ◽

Preserved Ejection Fraction ◽

Lipid Levels

Abstract Background Dyslipidemia is common in heart failure with preserved ejection fraction (HFpEF). Sacubitril/valsartan improves insulin sensitivity and augments natriuretic peptide (NP) signaling, providing mechanisms by which sacubitril/valsartan may affect serum lipids. However, empiric data on these effects are lacking. Methods and Results We analyzed 4,744 participants from PARAGON‐HF with available screening lipids. During follow‐up visits, we analyzed the treatment effect on lipid levels and assessed for interaction by baseline lipid levels. At the 16‐week visit, we adjusted these treatment effects for the change in several biomarkers (including hemoglobin A1c and urinary cyclic guanosine monophosphate (cGMP)/creatinine [a biomarker of NP activation]). The average age was 73±8 years, 52% were women, 43% had diabetes mellitus, and 64% were on statin therapy. Compared with valsartan, sacubitril/valsartan reduced triglycerides ‐5.0% (‐6.6%, ‐3.5%), increased high‐density lipoprotein cholesterol (HDL‐c) +2.6% (+1.7%, +3.4%), and increased low‐density lipoprotein cholesterol (LDL‐c) +1.7% (+0.4%, +3.0%). Sacubitril/valsartan reduced triglycerides most among those with elevated baseline levels (triglycerides≥200 mg/dL) (p‐interaction<0.001), and at 16‐weeks by ‐13.0% (‐18.1%, ‐7.6%), or ‐29.9 (‐44.3, ‐15.5) mg/dL, in this group. Adjusting for the change in urinary cGMP/creatinine significantly attenuated treatment effects on triglycerides and HDL‐c, but not LDL‐c, while adjusting for other biomarkers did not significantly alter the treatment effects. Conclusions Sacubitril/valsartan significantly reduces triglycerides compared with valsartan, an effect that was substantially stronger in those with elevated baseline triglycerides. Modest increases in HDL‐c and LDL‐c cholesterol were also observed with therapy. The underlying mechanism(s) of changes in HDL‐c and triglycerides are related to sacubitril/valsartan’s effects on NP activity.

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Associations between lipid profiles of adolescents and their mothers based on a nationwide health and nutrition survey in South Korea

BMJ Open ◽

10.1136/bmjopen-2018-024731 ◽

2019 ◽

Vol 9 (3) ◽

pp. e024731 ◽

Cited By ~ 1

Author(s):

Ji Hyung Nam ◽

Jaeyong Shin ◽

Sung-In Jang ◽

Ji Hyun Kim ◽

Kyu-Tae Han ◽

...

Keyword(s):

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Correlation Coefficients ◽

Lipid Profiles ◽

Lipoprotein Cholesterol ◽

Lipid Levels ◽

Nutrition Survey ◽

Cross Sectional ◽

Health And Nutrition ◽

Unit Increase

ObjectivesDyslipidaemia is a metabolic disease influenced by environmental and genetic factors. Especially, family history related to genetic background is a strong risk factor of lipid abnormality. The aim of this study is to evaluate the association between the lipid profiles of adolescents and their mothers.DesignA cross-sectional study.SettingThe data were derived from the Korea National Health and Nutrition Examination Survey (IV-VI) between 2009 and 2015.Participants2884 adolescents aged 12–18 years and their mothers were included.Primary outcome measuresOutcome variables were adolescents’ lipid levels. Mothers’ lipid levels were the interesting variables. The lipid profiles included total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). We identified partial correlation coefficients (r) between the lipids. Multiple linear regressions were performed to identify the amount of change in adolescents’ lipid levels for each unit increase of their mothers’ lipids. The regression models included various clinical characteristics and health behavioural factors of both adolescents and mothers.ResultsThe mean levels of adolescents’ lipids were 156.6, 83.6, 50.4 and 89.4 mg/dL, respectively for TC, TG, HDL-C and LDL-C. Positive correlations between lipid levels of adolescents and mothers were observed for TC, TG, HDL-C and LDL-C (r,95% CI: 0.271, 0.236 to 0.304; 0.204, 0.169 to 0.239; 0.289, 0.255 to 0.322; and 0.286, 0.252 to 0.319). The adolescent TC level was increased by 0.23 mg/dL for each unit increase of the mother’s TC (SE, 0.02; p<0.001). The beta coefficients were 0.16 (SE, 0.01), 0.24 (SE, 0.02) and 0.24 (SE, 0.02), respectively, in each model of TG, HDL-C and LDL-C (all p<0.001). The linear relationships were significant regardless of sex and mother’s characteristics.ConclusionsMothers’ lipid levels are associated with adolescents’ lipids; therefore, they can serve as a reference for the screening of adolescent’s dyslipidaemia.

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Serum Lipids are Novel Predictors for Thyroid Autoimmunity in the General Population with Normal TSH Levels From A Cross-Sectional Study

10.21203/rs.3.rs-185316/v1 ◽

2021 ◽

Author(s):

Jiarong Li ◽

Zixiao Wang ◽

He Liu ◽

Jinrong Fu ◽

Fengye Qin ◽

...

Keyword(s):

General Population ◽

Serum Lipid ◽

Serum Lipids ◽

Thyroid Autoimmunity ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Lipid Levels ◽

Thyroid Autoantibody ◽

Serum Lipid Levels ◽

Tsh Levels

Abstract Objective Serum lipids have been shown to regulate inflammatory and immune processes, but little is known about their association with thyroid autoimmunity. This study aimed to investigate the association of serum lipids with thyroid autoantibody positivity in the general population with normal thyroid-stimulating hormone (TSH) levels. Methods Data regarding the 7,688 subjects’ baseline characteristics were retrospectively collected. All subjects were categorized into four groups according to thyroid autoantibodies against thyroglobulin (TgAb) and thyroid peroxidase (TPOAb) positivity and serum lipid levels were compared. Binary logistic regression models were used to evaluate the risk of TgAb or TPOAb positivity with increasing serum lipid levels. Results In 6,456 included subjects, after adjusting for confounders, the risk of TgAb positivity was positively associated with increasing low-density lipoprotein cholesterol (LDL-C) levels (OR 1.10, 95%CI 1.02–1.19, P = 0.014) and negatively correlated with the increasing high-density lipoprotein cholesterol (HDL-C) levels (OR 0.80, 95%CI 0.67–0.96, P = 0.014). In female subjects, the association between increasing LDL-C (OR 1.15, 95%CI 1.05–1.26, P = 0.004) or HDL-C levels (OR 0.74, 95%CI 0.60–0.91, P = 0.005) and TgAb positivity become more pronounced. Moreover, there was a positive correlation between LDL-C levels and TPOAb positivity (OR 1.14, 95%CI 1.02–1.26, P = 0.016). Conclusion We have shown the associations of HDL-C and LDL-C with thyroid autoantibody positivity in the general population with normal TSH levels in a gender-dependent manner. This study highlights that serum lipids may be new predictors of thyroid autoimmunity even when TSH is within the reference range.

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Mildly Abnormal Lipid Levels, but Not High Lipid Variability, Are Associated With Increased Risk of Myocardial Infarction and Stroke in “Statin-Naive” Young Population A Nationwide Cohort Study

Circulation Research ◽

10.1161/circresaha.119.315705 ◽

2020 ◽

Vol 126 (7) ◽

pp. 824-835 ◽

Cited By ~ 4

Author(s):

Jun-Bean Park ◽

Da Hye Kim ◽

Heesun Lee ◽

In-Chang Hwang ◽

Yeonyee E. Yoon ◽

...

Keyword(s):

Myocardial Infarction ◽

Cardiovascular Disease ◽

Young Adults ◽

Total Cholesterol ◽

Density Lipoprotein ◽

Lipid Profiles ◽

Lipoprotein Cholesterol ◽

Atherosclerotic Cardiovascular Disease ◽

Young Population ◽

Lipid Levels

Rationale: In young adults, the role of mildly abnormal lipid levels and lipid variability in the risk of atherosclerotic cardiovascular diseases remains uncertain. Objective: To investigate the association of these abnormalities in lipid profiles with the risk of myocardial infarction (MI) and stroke in young population. Methods and Results: From the Korean National Health Insurance Service, a nationwide population-based cohort of 1 934 324 statin-naive adults aged 20 to 39 years, with ≥3 lipid profile measurements and without a history of MI and stroke, were followed-up until the date of MI or stroke, or December 31, 2017. The primary measure of lipid variability was variability independent of the mean. Higher baseline total cholesterol, LDL-C (low-density lipoprotein-cholesterol), and triglycerides and lower HDL-C (high-density lipoprotein-cholesterol) levels were significantly associated with increased MI risk; respective adjusted hazard ratios and 95% CIs comparing the highest versus lowest quartiles were 1.35 (1.20–1.53) for total cholesterol, 1.41 (1.25–1.60) for LDL-C, 1.28 (1.11–1.47) for triglycerides, and 0.82 (0.72–0.94) for HDL-C. Adjusted analyses for deciles of lipid profiles showed that MI risk was significantly elevated among participants with total cholesterol ≥223.4 mg/dL, LDL-C ≥139.5 mg/dL, HDL-C ≤41.8 mg/dL, and triglycerides ≥200.1 mg/dL. The associations between lipid levels and stroke risk were less prominent. Multivariable-adjusted restricted cubic spline analysis demonstrated that the increase in MI risk was not exclusively driven by extreme values of lipid profiles. Similar results were obtained on sensitivity analyses of baseline lipid levels. However, associations between lipid variability and the risk of MI and stroke varied depending on the measure of lipid variability used. Conclusions: Mildly abnormal baseline lipid levels were associated with an increased future risk of atherosclerotic cardiovascular disease events, particularly MI, whereas measures of lipid variability were not. Therefore, in young adults, achieving optimal lipid levels could be valuable in the prevention of atherosclerotic cardiovascular disease.

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ASUPAN MIKRONUTRIEN DAN RIWAYAT PENYAKIT INFEKSI PADA BALITA STUNTING DI UPTD PUSKESMAS LIMBANGAN KECAMATAN SUKARAJA KABUPATEN SUKABUMI

Journal of Nutrition College ◽

10.14710/jnc.v9i1.24647 ◽

2020 ◽

Vol 9 (1) ◽

pp. 6-11

Author(s):

Aas Asiah ◽

Gurdani Yogisutanti ◽

Asep Iwan Purnawan

Keyword(s):

Vitamin E ◽

Vitamin A ◽

Vitamin C ◽

Random Sampling ◽

Vitamin B1 ◽

Chi Square ◽

Cross Sectional ◽

X 24

Latar belakang: Anak stunting beresiko mudah sakit, untuk itu diperlukan asupan zat gizi yang dapat meningkatkan respon imun tubuh agar dapat meningkatkan kekebalan tubuhnya. Zat gizi tersebut bisa didapatkan dalam vitamin dan mineral yang seimbang;Tujuan: Mengetahui hubungan antara asupan mikronutrien dengan riwayat penyakit infeksi pada balita stunting;Metode: : Penelitian observasional dengan pendekatan cross sectional di UPTD Puskesamas Limbangan Sukaraja Sukabumi, jumlah sampel 74 balita stunting usia 12-59 bulan, dipilih dengan proportional random sampling dari 4 desa. Data yang dikumpulkan meliputi: asupan mikronutrien yang diperoleh dari formulir recall 2 x 24 jam dan kuesioner riwayat penyakit infeksi, seperti: diare, ISPA dan kecacingan. Data dianalisis dengan uji analisis univariat, analisis bivariate menggunakan uji chi-square;Hasil: Hasil penelitian menunjukkan bahwa asupan mikronutrien pada balita stunting termasuk dalam kategori kurang. Balita yang menderita infeksi sebesar 78,4%. Hasil analisis statistik disimpulkan bahwa terdapat hubungan antara asupan vitamin A, vitamin C, zat besi, zinc dan tembaga (p<0,05) dan tidak ada hubungan antara asupan vitamin B1, B6, B9 dan vitamin E dengan kejadian infeksi balita stunting (p>0,05). Semakin baik asupan mikronutrien pada balita stunting, maka kejadian infeksi semakin menurun. Simpulan: Kejadian infeksi pada balita stunting berhubungan dengan intake mikronutrien yang diperlukan untuk mempertahankan kekebalan tubuh.

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The Effect of Helicobacter pylori Eradication on Lipid Levels: A Meta-Analysis

Journal of Clinical Medicine ◽

10.3390/jcm10050904 ◽

2021 ◽

Vol 10 (5) ◽

pp. 904

Author(s):

Jun Watanabe ◽

Masato Hamasaki ◽

Kazuhiko Kotani

Keyword(s):

Helicobacter Pylori ◽

Cardiovascular Diseases ◽

Meta Analysis ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Lipid Levels ◽

Pubmed Database ◽

H Pylori ◽

Meta Analyses

Introduction: Helicobacter pylori (H. pylori) infection is positively associated with cardiovascular diseases, but the involvement of lipids in this association remains unclear. The present study reviewed the changes in circulating lipid levels following H. pylori eradication. Methods: A PubMed database was searched until December 2020 to identify randomized control trials (RCTs) and non-RCTs investigating the effect of H. pylori eradication on the lipid levels in inverse variance-weighted, random-effects meta-analyses. Results: A total of 24 studies (four RCTs and 20 non-RCTs) with 5270 participants were identified. The post-eradication levels were increased for high-density lipoprotein cholesterol (HDL-C; mean difference (MD) 2.28 mg/dL, 95% confidence interval (CI) 1.90 to 2.66) and triglyceride (TG; MD 3.22 mg/dL, 95% CI 1.13 to 5.31) compared with the pre-eradication levels. H. pylori eradication resulted in little to no difference in the low-density lipoprotein-cholesterol levels (MD −2.33 mg/dL, 95% CI −4.92 to 0.26). In the analyses of RCTs only, the findings for elevated HDL-C levels, but not TG, were robust. Conclusions: H. pylori eradication increases the HDL-C levels. Further studies are needed to elucidate the effects of lipid changes following H. pylori eradication on cardiovascular diseases.

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Abstract P102: Variability In Lipid Levels And Risk For Cardiovascular Disease: An Electronic Health Record-based Population Cohort Study

Circulation ◽

10.1161/circ.143.suppl_1.p102 ◽

2021 ◽

Vol 143 (Suppl_1) ◽

Author(s):

Sheila M Manemann ◽

Suzette J Bielinski ◽

Ethan D Moser ◽

Jennifer L St. Sauver ◽

Paul Y Takahashi ◽

...

Keyword(s):

Cardiovascular Disease ◽

Electronic Health Record ◽

Total Cholesterol ◽

Index Date ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Health Record ◽

Lipid Levels ◽

Population Cohort ◽

Increased Risk

Background: Larger within-patient variability of lipid levels has been associated with an increased risk of cardiovascular disease (CVD). However, measures of lipid variability are not currently used clinically. We investigated the feasibility of calculating lipid variability within a large electronic health record (EHR)-based population cohort and assessed associations with incident CVD. Methods: We identified all individuals ≥40 years of age who resided in Olmsted County, MN on 1/1/2006 (index date) without prior CVD. CVD was defined as myocardial infarction, coronary artery bypass graft surgery, percutaneous coronary intervention or stroke. Patients with ≥3 measurements of total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and/or triglycerides during the 5 years before the index date were retained in the analyses. Lipid variability was calculated using variability independent of the mean (VIM). Patients were followed through 9/30/2017 for incident CVD (including CVD death). Cox regression was used to investigate the association between quintiles of lipid VIMs and incident CVD. Results: We identified 18,642 individuals (mean age 60; 55% female) who were free of CVD at baseline and VIM calculated for at least one lipid measurement. After adjustment, those in the highest VIM quintiles of total cholesterol had a 25% increased risk of CVD (Q5 vs. Q1 HR: 1.25, 95% CI: 1.08-1.45; Table). We observed similar results for LDL-C (Q5 vs. Q1 HR: 1.20, 95% CI: 1.04-1.39) and HDL-C (Q5 vs. Q1 HR: 1.25, 95% CI: 1.09-1.43). There was no association between triglyceride variability quintiles and CVD risk. Conclusion: In a large EHR-based population cohort, high variability in total cholesterol, HDL-C and LDL-C was associated with an increased risk of CVD, independently of traditional risk factors, suggesting it may be a target for intervention. Lipid variability can be calculated in the EHR environment but more research is needed to determine its clinical utility.

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PERBAIKAN KADAR ALBUMIN PASIEN POST AMPUTASI ET CAUSA LUKA BAKAR LISTRIK 25% DERAJAT III DAN STATUS GIZI KURANG DENGAN PEMBERIAN ASUPAN TINGGI PROTEIN

IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN) ◽

10.54773/ijcnp.v1i1.27 ◽

2018 ◽

Vol 1 (1) ◽

pp. 18-25

Author(s):

Diane Paparang ◽

Nurpudji A. Taslim ◽

Haerani Rasyid ◽

A. Yasmin Syauki

Keyword(s):

Vitamin A ◽

Vitamin C ◽

Vitamin B12 ◽

Vitamin B6 ◽

Vitamin B1

Pendahuluan Proses penyembuhan luka post amputasi dan luka bakar dengan luas 25% dan kedalaman derajat III serta hipoalbuminemia sedang (albumin 2,6g/dL) dan status gizi kurang memerlukan terapi gizi spesifik tinggi protein. Laporan Kasus Tn.I, laki-laki, 28 tahun dikonsul oleh bagian bedah dengan luka post amputasi dan luka bakar listrik derajat III luas 25%. Keluhan utama asupan makan kurang sejak 16 hari terakhir karena nafsu makan kurang akibat nyeri pada luka post amputasi dan luka bakar. Ada nyeri ulu hati dan demam menggigil. Asupan 24 jam 1000kkal. Pasien didiagnosis dengan status gizi kurang (LLA=80,7%), status metabolik anemia normositik normokrom (Hb 9.7 g/dl), deplesi sedang sistem imun (TLC 940/µL), hipoalbuminemia (albumin 2,6g/dL) dan status gastrointestinal fungsional. Terapi nutrisi dengan energi 2500 kkal, protein 2 gr/kgBBI/hari (23%), karbohidrat 57% dan lemak 20 %, melalui oral berupa makanan biasa 1250 kkal, ONS glutamine 2.5g/hari, suplementasi 6 butir putih telur (protein 31,5g/hari), vitamin C 1g/24jam, vitamin A 6.000IU/12jam, vitamin B1-100mg, vitamin B6-200mg, vitamin B12-200mg, Zinc 50mg/24jam, selenium 55µg, Curcuma 400mg/8jam dan ekstrak ikan gabus 2 kapsul/8 jam. Setelah perawatan 30 hari, terjadi perbaikan dalam penyembuhan luka, peningkatan LLA menjadi 23,5cm, peningkatan hemoglobin 9.3g/dl, peningkatan sistem imun (TLC 2064/µL), peningkatan albumin 3.9g/dL. Kesimpulan Terapi nutrisi spesifik dengan protein 2 gr/kgBBI dapat meningkatkan kadar albumin dan mempercepat penyembuhan luka pada pasien luka bakar.

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