scholarly journals Effect of serum bisphenol A and low T3 on short-term prognosis of young patients with intracerebral hemorrhage

2021 ◽  
Author(s):  
guoping wang ◽  
Jinhua Chen ◽  
Zhongdong Qiao ◽  
Lili Zhao ◽  
Dongxing Guo ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Thyroid Function ◽  
Young Patients ◽  
Control Group ◽  
Messenger Ribonucleic Acid ◽  
Almost Everywhere ◽  
Low T3 ◽  
Plastic Bag ◽  
Linear Correlation Analysis ◽  
And Control

Abstract BackgroundBisphenol A (BPA) is widely present in daily necessities, and its exposure is almost everywhere. We aimed to evaluate the relationship between serum BPA levels, biomarkers and recent mortality in young patients with intracerebral hemorrhage (YICH) and low T3 .MethodsUsing a multi-center longitudinal prospective study, the research team recruited 600 YICH patients and divided into two subgroups according to their thyroid function, of which 320 (53.3%) were in the LT3, Sub-clinical hypothyroidism (SCH) was 280 (46.6%) and control group (n = 600).All patients received serum BPA, and biomarker blood draws.ResultsCalculating the cumulative quantification of plastic bag products, BPA increased by 0.204 standard deviation unit per log unit (P<0.003). Serum BPA, thrombin and matrix metalloproteinase (MMP-9) {BPA (0.91±0.14) vs (0.765±0.13) vs. (0.535±0.11) pg/ml, thrombin (1.35±0.18) vs (0.66±) 0.15) vs (0.66 ±0.15) ng/ml, MMP-9 (104±10 vs (53±8.1) vs (53±) 8.1) pg/ml, both P<0.01}. Linear correlation analysis showed that serum BPA was positively correlated with miR-388-3p and 24hDBPCV, and negatively correlated with LT3 and miR-451. Multiple linear regression showed that BPA affected the increase of nDBP Percentage of independent risk factors (β = 0.286), P <0.01. Mortality rate showed 2 ,15 and 30 days of patients in the LT3 and the SCH of 4.7%vs 2.5%,6.25% vs 3.75%,4.68%vs 2.5%, P<0.01.ConclusionHigh BPA exposure strongly predicts the risk of ICH in young patients. The activation of NF-κB signaling pathway, secondary thyroid function, ambulatory blood pressure scores, and changes in messenger ribonucleic acid construct an inflammatory response system. There are also significant differences in recent mortality between the LT3 group and the SCH group.Trial registrationThe trial is registered at clinical .gov (www.medresman.Chi CTR1900023626)

scholarly journals Effect of Serum Bisphenol A and Low T3 on Short-Term Prognosis of Young Patients with Intracerebral Hemorrhage

2021 ◽  
Author(s):  
guoping wang ◽  
Jinhua Chen ◽  
Zhongdong Qiao ◽  
Lili Zhao ◽  
Dongxing Guo ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Thyroid Function ◽  
Young Patients ◽  
Chemical Substance ◽  
Control Group ◽  
Percentage Increase ◽  
Short Term ◽  
Environmental Chemical ◽  
Low T3 ◽  
Significant Difference

Abstract BackgroundBisphenol A (BPA) is an environmental chemical substance, and the widespread use of plastic products, its hazards can be said to be ubiquitous. We aimed to evaluate the relationship between serum bisphenol A (BPA), biomarkers and recent mortality in pats with young interacerebral hemorrhage (YICH) and different thyroid functions,and the cumulative consumption of plastic products.MethodsUsing a multi-center longitudinal prospective study, the research team recruited 600 YICH patients and divided them into two subgroups according to their thyroid function, of which 320 (53.3%) were in the low T3.Sub-clinical hypothyroidism(SCH) was 280 (46.6%) and control group (n = 600).All patients received serum BPA, and biomarker blood draws.ResultsEach log unit of BPA increased by 0.204 standard deviation unit (P<0.003).BPA(0.91±0.14)vs(0.765±0.13)vs(0.535±0.11)pg/ml,thrombin(1.35±0.18) vs (0.66±0.15) vs (0.66 ±0.15) ng/ml, MMP-9 (104±10 vs (53±8.1)vs(53±8.1) pg/ml,both P＜0.01. Serum BPA is positively correlated with biomarker, 24hDBPCV, and was negatively correlated LT3 and niR-451. Multiple linear regression showed that BPA was an independent risk factor affecting the percentage increase of nDBP (β = 0.286), P <0.01.Mortality rate showed 2 ,15 and 30 days of patients in the LT3 and the SCH of 4.7%vs 2.5%,6.25% vs 3.75%,4.68%vs 2.5%,P<0.01.ConclusionThus, Long-term exposure to BPA levels may be related to the occurrence of YICH, High BPA exposure strongly predicts the risk of ICH in young patients. Activation of NF-κB signaling pathway, secondary thyroid function and ABP changes, together to construct an inflammatory response program, is related to the risk of short-term death. There is a significant difference in recent mortality compared to LT3 vs SCH. Trial registrationThe trial is registered at clinical .gov (www.medresman.Chi CTR1900023626)

scholarly journals Do Statins Affect Thyroid Volume and Nodule Size in Patients with Hyperlipidemia in a Region with Mild-to-Moderate Iodine Deficiency? A Prospective Study

2018 ◽  
Vol 27 (1) ◽  
pp. 1-7
Author(s):  
Canan Demir ◽  
Cuneyd Anil ◽  
Yusuf Bozkus ◽  
Umut Mousa ◽  
Altug Kut ◽  
...  
Keyword(s):  
Prospective Study ◽  
Thyroid Function ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Thyroid Volume ◽  
Lifestyle Changes ◽  
Control Group ◽  
Nodule Size ◽  
A Prospective Study ◽  
And Control

Objective: The objective of this study was to assess the antiproliferative pleiotropic effects of statins on thyroid function, volume, and nodularity. Subjects and Methods: One hundred and six hyperlipidemic patients were included in this prospective study. The 69 patients in the statin groups received atorvastatin (16 received 10 mg and 18 received 20 mg) or rosuvastatin (20 received 10 mg and 15 received 20 mg). The 37 patients in the control group, assessed as not requiring drugs, made only lifestyle changes. Upon admission and after 6 months, all patients were evaluated by ultrasonography as well as for lipid variables (total cholesterol, high- and low-density lipoprotein cholesterol, and triglycerides) and thyroid function and structure. Results: After 6 months, no differences in thyroid function, thyroid volume, the number of thyroid nodules, or nodule size were observed in the statin and control groups. In a subgroup analysis, total thyroid volume had decreased more in patients receiving 20 mg of rosuvastatin than that in the control group (p < 0.05). Maximum nodule size had decreased more in those receiving 10 mg of rosuvastatin (p < 0.05). Conclusions: Our results suggest an association between rosuvastatin treatment and smaller thyroid volume and maximum nodule diameter; this could be attributable to the antiproliferative effects of statin therapy on the thyroid.

scholarly journals Analysis of the Effect of Cluster Nursing in Postoperative Hypertensive Cerebral Hemorrhage

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Pingxia Zheng ◽  
Jia Wang ◽  
Yan Ma ◽  
Jingjing Xu ◽  
Qianping Zhu
Keyword(s):  
Postoperative Complications ◽  
Intracerebral Hemorrhage ◽  
Treatment Compliance ◽  
Nursing Intervention ◽  
Control Group ◽  
Total Incidence ◽  
Hypertensive Intracerebral Hemorrhage ◽  
And Control ◽  
Experimental Group

Hypertensive intracerebral hemorrhage is a common condition in clinic. Due to the improvement of minimally invasive technology, its therapeutic effect is good, but there are still postoperative complications. The corresponding routine nursing intervention is not effective in the rehabilitation of postoperative patients with hypertensive intracerebral hemorrhage. In this paper, cluster nursing was applied to the treatment of postoperative patients with hypertensive intracerebral hemorrhage. For this purpose, a retrospective study or experiment was conducted on 150 patients with hypertensive intracerebral hemorrhage in the hospital specifically from January 2019 to December 2020. According to the nursing strategy, patients were divided into experimental (n = 75) and control groups (n = 75), respectively. The control group adopted routine nursing mode, whereas the experimental group adopted cluster nursing mode. The treatment compliance of patients in the experimental group was 86.67%, while that in the control group was 73.33% ( P  < 0.05). The total incidence of postoperative complications in the experimental group was 3.2%, which was lower than 25% in the control group ( P  < 0.05). The motor function score of the experimental group was better than that of the control group ( P  < 0.05). The application of cluster nursing in postoperative patients with hypertensive intracerebral hemorrhage is feasible, and its nursing effect is significant, which can not only reduce the incidence of postoperative complications but also improve patients’ compliance and quality of life. It has good application value.

scholarly journals Clinical Features of First-episode Psychoses During the COVID-19 Pandemic

10.17816/cp85 ◽  
2021 ◽  
Vol 2 (3) ◽  
pp. 27-33
Author(s):  
Vladimir A. Zyablov ◽  
Mikhail A. Gusev ◽  
Vasilyi S. Chizhikov
Keyword(s):  
Psychotic Disorders ◽  
Statistical Significance ◽  
Young Patients ◽  
Mental Healthcare ◽  
Health Clinic ◽  
First Episode ◽  
Psychotic Episode ◽  
Control Group ◽  
Icd 10 ◽  
And Control

INTRODUCTION: The pandemic of the new coronavirus infection has become one of the most significant global social shocks in the past decade. It influenced the lifestyle of many people, including those with mental disorders. AIM: To compare the psychopathological structure of psychotic states in young patients (up to 40 years old) with first-episode psychosis before the COVID-19 pandemic and during the COVID-19 pandemic. METHODS: The research was conducted at the First psychotic episode clinic of the Mental-health clinic No. 1 n.a. N.A. Alexeev, Moscow, Russia. In total, 66 patients were enrolled, who met the inclusion criteria: first-in-life admission to a mental healthcare unit that occurred during the spring of 2019 (control group) or spring 2020 (experimental group), diagnosis on admission that belonged to the group Acute and transient psychotic disorders (F23.XX) of ICD-10. Patients with a disability or concurrent somatic or neurologic conditions were excluded from the study. Assessment of clinical and psychopathological characteristics with the allocation of the leading syndrome within the psychotic state, psychometric assessment according to the PANSS scale was carried out, the above indicators were compared between the experimental and control group. RESULTS: We observed statistically insignificant increase in the rates of affective and catatonic subtypes of psychoses, a decrease in the rate of the delusional subtype of paranoid syndrome. PANSS scores differed significantly for different clinical subtypes of psychoses, although the differences between the experimental and control groups showed no statistical significance. Additionally, in spring 2020, a considerable decrease in the total number of hospitalizations was revealed. CONCLUSIONS: The differences in the clinical and psychopathological structure of psychotic states revealed during the COVID-19 pandemic were statistically insignificant. Additional results of the study may indicate a decrease in the availability of mental healthcare for patients with psychoses, which requires further investigation.

DDR1 may be a good biomarker for brain tumors.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e13557-e13557
Author(s):  
Dilek Erdem ◽  
Mahmut Büyüksimsek ◽  
Meral Gunaldi ◽  
Nilgun Sahin
Keyword(s):  
Brain Tumor ◽  
Control Group ◽  
Tyrosine Kinase Receptor ◽  
Blood Levels ◽  
Blood Samples ◽  
Messenger Ribonucleic Acid ◽  
Central Nerve System ◽  
Tumor Tissues ◽  
Nerve System ◽  
And Control

e13557 Background: There are two important hardness in the treatment of central nerve system tumors; first of it is tumor heterogenity while the second is biomarker deficiency which can be target in the tumor tissue. For the reason we aimed to examine discoidin domain receptor (DDR1), a tyrosine kinase receptor , which may be thought to be effective in cell adhesion. Methods: 38 brain tumor were evaluated for tissue DDR1 messenger ribonucleic acid and blood DDR1 levels. We compared these with 10 control group tissue and blood levels of DDR1. Results: All brain tumor and control group tissues and blood samples were found DDR1 value positive. DDR1 levels of brain tumor tissues and blood samples were statistically higher when compared with DDR1 levels of control group tissue and blood samples. Conclusions: DDR1, found statistically higher among brain tumor tissues and blood samples may be a useful biomarker for the therapy and management of these patients.

scholarly journals A novel finding related to bulla and bleb formation in patients with primary spontaneous pneumothorax

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Akira Iyoda ◽  
Yoko Azuma ◽  
Takashi Sakai ◽  
Satoshi Koezuka ◽  
Hajime Otsuka ◽  
...  
Keyword(s):  
Clinical Finding ◽  
Spontaneous Pneumothorax ◽  
Smoking Status ◽  
Young Patients ◽  
Primary Spontaneous Pneumothorax ◽  
Control Group ◽  
The Novel ◽  
Clinical Factors ◽  
Bleb Formation ◽  
And Control

Abstract Background Spontaneous pneumothorax is a common problem globally. Bullas and blebs have been implicated in this problem, but the etiology of their formation is unknown. We aim to show the relation between a novel clinical finding, the pulmonary delayed inflation (PDI) sign, and the etiology of bulla and bleb formation in young patients. Methods We retrospectively analyzed data from 111 patients with pneumothorax and a control group of 27 patients. We evaluated the relation between the PDI sign and other clinical factors. Results The PDI sign was observed in 78 patients. Of these, 75 exhibited the PDI sign in only the upper lobe. Regardless of smoking status, patients 34 years of age or younger had a significantly higher incidence of the PDI sign than, patients 55 years of age or older and control patients. The inflation time in patients 34 years of age or younger, regardless of smoking status, was significantly longer than in patients 55 years of age or older and patients in the control group. There was no significant association between inflation time and the presence of asthma. Conclusions The novel PDI sign is seen in patients 34 years of age or younger. Because this sign may indicate a peripheral bronchial abnormality and may be related to the formation of blebs and bullae in young patients with spontaneous pneumothorax, it is possible that it can be used to develop effective treatments for pneumothorax in young patients.

scholarly journals Thyroid Dysfunction and Autoantibodies Association with Hypertensive Disorders during Pregnancy

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Azin Alavi ◽  
Khadijeh Adabi ◽  
Sepideh Nekuie ◽  
Elham Kazemi Jahromi ◽  
Mehrdad Solati ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Thyroid Dysfunction ◽  
Gestational Hypertension ◽  
Previous History ◽  
Reproductive Age ◽  
Control Group ◽  
Thyroid Function Tests ◽  
Hypertensive Patients ◽  
Hypertensive Disorders ◽  
Low T3

Background. Thyroid dysfunction and autoimmunity are relatively common in reproductive age and have been associated with adverse health outcomes for both mother and child, including hypertensive disorders during pregnancy.Objective. To survey the relation between thyroid dysfunction and autoimmunity and incidence and severity of pregnancy-induced hypertensive disorders.Method. In this case control study 48 hypertensive patients in 4 subgroups (gestational hypertension, mild preeclampsia, severe preeclampsia, eclampsia) and 50 normotensive ones were studied. The samples were nulliparous and matched based on age and gestational age and none of them had previous history of hypertensive or thyroid disorders and other underlying systemic diseases or took medication that might affect thyroid function. Their venous blood samples were collected using electrochemiluminescence and ELISA method and thyroid hormones and TSH and autoantibodies were measured.Results. Hypertensive patients had significant lower T3 concentration compared with normotensive ones with mean T3 values152.5±48.93 ng/dL,175.36±58.07 ng/dL respectively. Anti-TPO concentration is higher in control group6.07±9.02 IU/mL compared with2.27±2.94 IU/mL in cases.Conclusion. The severity of preeclampsia and eclampsia was not associated with thyroid function tests. The only significant value was low T3 level among pregnancy, induced hypertensive patients.

The Effect of Early Warm Plastic Bag Application on Postoperative Pain after Hemorrhoidectomy: A Prospective Randomized Controlled Trial

2015 ◽  
Vol 81 (2) ◽  
pp. 182-186 ◽  
Author(s):  
Ahmet Ziya Balta ◽  
Yavuz Ozdemir ◽  
Ilker Sucullu ◽  
Aliilker Filiz ◽  
Ergun Yucel ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Resting State ◽  
Controlled Trial ◽  
Postoperative Pain Management ◽  
Control Group ◽  
Early Application ◽  
Significant Difference ◽  
Plastic Bag ◽  
Vas Scores ◽  
And Control

Hemorrhoidectomy is used for the surgical treatment of high-grade hemorrhoids. The most prominent complaint after hemorrhoidectomy is pain. Postoperative pain management is still a big problem after surgery in patients with hemorrhoidectomy. The aim of the study was to assess the effect of early application of warm bag on postoperative pain after hemorrhoidectomy. All patients were randomly divided into warm plastic bag and control groups by using sealed envelopes, which were prepared preoperatively. After standard spinal anesthesia, all patients underwent standard Milligan-Morgan hemorrhoidectomy using Ligasure™. Although the study group received the warm bag application, the control group did not receive such a treatment. Two separate visual analog scale (VAS) measurements were performed for postoperative pain assessments on postoperative days, one during the resting state and the other one during the straining phase after the onset of peristaltic bowel movement. Postoperative VAS scores were significantly lower among the warm plastic bag group as compared with the control group on Days 1 and 3 for the resting state and on Day 3 for defecation. Additionally, a significant difference existed between the two groups in terms of the need for additional anesthesia. Local thermal application appears to be a safe and effective method for pain relief after hemorrhoidectomy.

scholarly journals Hyperthyroidism in Pregnancy: The Delicate Balance between too Much or too Little Antithyroid Drug

2021 ◽  
Vol 10 (16) ◽  
pp. 3742
Author(s):  
Monica Livia Gheorghiu ◽  
Roxana Georgiana Bors ◽  
Ancuta-Augustina Gheorghisan-Galateanu ◽  
Anca Lucia Pop ◽  
Dragos Cretoiu ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Antithyroid Drug ◽  
Antithyroid Drugs ◽  
Premature Delivery ◽  
Control Group ◽  
Neonatal Hypothyroidism ◽  
Fetal Complications ◽  
Neonatal Hyperthyroidism ◽  
And Control

Overt hyperthyroidism (HT) during pregnancy is associated with a risk of maternal–fetal complications. Antithyroid drugs (ATD) have a potential risk for teratogenic effects and fetal–neonatal hypothyroidism. This study evaluated ATD treatment and thyroid function control during pregnancy, and pregnancy outcome in women with HT. Patients and methods: A retrospective analysis of 36 single fetus pregnancies in 29 consecutive women (median age 30.3 ± 4.7 years) with HT diagnosed before or during pregnancy; a control group of 39 healthy euthyroid pregnant women was used. Results: Twenty-six women had Graves’ disease (GD, 33 pregnancies), 1 had a hyperfunctioning autonomous nodule, and 2 had gestational transient thyrotoxicosis (GTT). Methimazole (MMI) was administered in 22 pregnancies (78.5%), Propylthiouracil (PTU) in 2 (7.1%), switch from MMI to PTU in 4 (14.2%), no treatment in 8 pregnancies (3 with subclinical HT, 5 euthyroid with previous GD remission before conception). In the 8 pregnancies of GD patients diagnosed during gestation or shortly before (<6 weeks), i.e., with fetal exposure to uncontrolled HT, there was 1 spontaneous abortion at 5 weeks (3.4% of all ATD-treated pregnancies), and 1 premature delivery at 32 weeks with neonatal death in 24 h (3.4%); 1 child had neonatal hyperthyroidism (3.3% of live children in GD women) and a small atrial sept defect (4% of live children in ATD treated women). In women treated more than 6 months until conception (20 pregnancies): (a) median ATD doses were lower than those in women diagnosed shortly before or during pregnancy; (b) ATD was withdrawn in 40% of pregnancies in trimester (T)1, all on MMI < 10 mg/day (relapse in 14.2%), and in up to 55% in T3; (c) TSH level was below normal in 37%, 35% and 22% of pregnancies in T1, T2 and T3 respectively; FT4 was increased in 5.8% (T1) and subnormal in 11.75% in T2 and T3; (d) no fetal birth defects were recorded; one fetal death due to a true umbilical cord knot was registered. Mean birth weight was similar in both ATD-treated and control groups. Hyperthyroidism relapsed postpartum in 83% of GD patients (at median 3 ± 2.6 months). Conclusion: In hyperthyroid women with long-term ATD treatment before conception, drugs could be withdrawn in T1 in 40% of them, the thyroid function control was better, and pregnancy and fetal complications were rarer, compared to women diagnosed during pregnancy. Frequent serum TSH and FT4 monitoring is needed to maintain optimal thyroid function during pregnancy.

scholarly journals CIRCADIAN-RELATED ECTOPIC RHYTHMS IN YOUNG PATIENTS: ETHIOPATHOLOGICAL FEATURES AND PRINCIPLES OF THERAPY

2019 ◽  
Vol 19 (2) ◽  
pp. 9-12
Author(s):  
V.M. Zhdan ◽  
О.І. Katerenchuk
Keyword(s):  
Young Patients ◽  
Test Group ◽  
Heart Rhythm ◽  
Control Group ◽  
Time Interval ◽  
Young Generation ◽  
Night Time ◽  
Ventricular Extrasystoles ◽  
Working Day ◽  
And Control

The autonomic nervous system plays a key role in the processes of adaptation, regulating the functioning of the whole organism. And a disturbance of the heart rhythm is typically one of the first manifestations of autonomic circadian maladaptation. The aim of this study was to assess the relationship between circadian rhythm disorders and autonomic misbalance with the occurrence of arrhythmic events in young patients with the further development of treatment strategy. Materials and methods: the study was performed at the Medical Centre «MEDION». 34 patients aged 18-35 years were enrolled to the study, divided into the test and control groups. Results: despite a significantly higher frequency of supraventricular arrhythmias in the test group compared to the control group, the supraventricular extrasystoles occurred in the control group predominantly at night time (with peak from 3 to 6 a.m.). In the test group, atrial ectopic beats were observed predominantly from 5 to 12 a. m. In the group of patients with the number of ventricular ectopic complexes over 500 / day, no time interval was found, during which the number of ventricular extrasystoles was statistically significantly predominant. The most important factors of ventricular ectopic events occurrence included: sleeping less than 6 hours, job lasting over 10 hours a day, and too little time spent outdoors. All individuals were recommended to modify their lifestyle and take when necessary autonomic normalization agents and antiarrhythmics. Conclusion: the modern lifestyle of the young generation leads to the disturbance of circadian biorhythms as a result of the unbalanced autonomic regulation and the subsequent occurrence of ectopic arrhythmic events. The most unfavourable factors in this case are sleeping less than 6 hours, a working day lasting over 10 hours, and outdoor-spent time lasting less than 2 hours a day.

Sign in / Sign up

Export Citation Format

Share Document