Effect of Serum Bisphenol A and Low T3 on Short-Term Prognosis of Young Patients with Intracerebral Hemorrhage

Abstract BackgroundBisphenol A (BPA) is an environmental chemical substance, and the widespread use of plastic products, its hazards can be said to be ubiquitous. We aimed to evaluate the relationship between serum bisphenol A (BPA), biomarkers and recent mortality in pats with young interacerebral hemorrhage (YICH) and different thyroid functions,and the cumulative consumption of plastic products.MethodsUsing a multi-center longitudinal prospective study, the research team recruited 600 YICH patients and divided them into two subgroups according to their thyroid function, of which 320 (53.3%) were in the low T3.Sub-clinical hypothyroidism(SCH) was 280 (46.6%) and control group (n = 600).All patients received serum BPA, and biomarker blood draws.ResultsEach log unit of BPA increased by 0.204 standard deviation unit (P<0.003).BPA(0.91±0.14)vs(0.765±0.13)vs(0.535±0.11)pg/ml,thrombin(1.35±0.18) vs (0.66±0.15) vs (0.66 ±0.15) ng/ml, MMP-9 (104±10 vs (53±8.1)vs(53±8.1) pg/ml,both P＜0.01. Serum BPA is positively correlated with biomarker, 24hDBPCV, and was negatively correlated LT3 and niR-451. Multiple linear regression showed that BPA was an independent risk factor affecting the percentage increase of nDBP (β = 0.286), P <0.01.Mortality rate showed 2 ,15 and 30 days of patients in the LT3 and the SCH of 4.7%vs 2.5%,6.25% vs 3.75%,4.68%vs 2.5%,P<0.01.ConclusionThus, Long-term exposure to BPA levels may be related to the occurrence of YICH, High BPA exposure strongly predicts the risk of ICH in young patients. Activation of NF-κB signaling pathway, secondary thyroid function and ABP changes, together to construct an inflammatory response program, is related to the risk of short-term death. There is a significant difference in recent mortality compared to LT3 vs SCH. Trial registrationThe trial is registered at clinical .gov (www.medresman.Chi CTR1900023626)

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Effect of serum bisphenol A and low T3 on short-term prognosis of young patients with intracerebral hemorrhage

10.21203/rs.3.rs-1058244/v1 ◽

2021 ◽

Author(s):

guoping wang ◽

Jinhua Chen ◽

Zhongdong Qiao ◽

Lili Zhao ◽

Dongxing Guo ◽

...

Keyword(s):

Intracerebral Hemorrhage ◽

Thyroid Function ◽

Young Patients ◽

Control Group ◽

Messenger Ribonucleic Acid ◽

Almost Everywhere ◽

Low T3 ◽

Plastic Bag ◽

Linear Correlation Analysis ◽

And Control

Abstract BackgroundBisphenol A (BPA) is widely present in daily necessities, and its exposure is almost everywhere. We aimed to evaluate the relationship between serum BPA levels, biomarkers and recent mortality in young patients with intracerebral hemorrhage (YICH) and low T3 .MethodsUsing a multi-center longitudinal prospective study, the research team recruited 600 YICH patients and divided into two subgroups according to their thyroid function, of which 320 (53.3%) were in the LT3, Sub-clinical hypothyroidism (SCH) was 280 (46.6%) and control group (n = 600).All patients received serum BPA, and biomarker blood draws.ResultsCalculating the cumulative quantification of plastic bag products, BPA increased by 0.204 standard deviation unit per log unit (P<0.003). Serum BPA, thrombin and matrix metalloproteinase (MMP-9) {BPA (0.91±0.14) vs (0.765±0.13) vs. (0.535±0.11) pg/ml, thrombin (1.35±0.18) vs (0.66±) 0.15) vs (0.66 ±0.15) ng/ml, MMP-9 (104±10 vs (53±8.1) vs (53±) 8.1) pg/ml, both P<0.01}. Linear correlation analysis showed that serum BPA was positively correlated with miR-388-3p and 24hDBPCV, and negatively correlated with LT3 and miR-451. Multiple linear regression showed that BPA affected the increase of nDBP Percentage of independent risk factors (β = 0.286), P <0.01. Mortality rate showed 2 ,15 and 30 days of patients in the LT3 and the SCH of 4.7%vs 2.5%,6.25% vs 3.75%,4.68%vs 2.5%, P<0.01.ConclusionHigh BPA exposure strongly predicts the risk of ICH in young patients. The activation of NF-κB signaling pathway, secondary thyroid function, ambulatory blood pressure scores, and changes in messenger ribonucleic acid construct an inflammatory response system. There are also significant differences in recent mortality between the LT3 group and the SCH group.Trial registrationThe trial is registered at clinical .gov (www.medresman.Chi CTR1900023626)

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Comparative study of episiotomy repair: absorbable synthetic versus chromic catgut suture material

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20172042 ◽

2017 ◽

Vol 6 (6) ◽

pp. 2186

Author(s):

Devika Perumal ◽

Divya Selvaraju

Keyword(s):

Comparative Study ◽

Suture Material ◽

Statistical Significance ◽

Wound Dehiscence ◽

Chromic Catgut ◽

Control Group ◽

Absorbable Suture ◽

Perineal Laceration ◽

Short Term ◽

Significant Difference

Background: The choice of suture material for repair of episiotomy or perineal laceration is largely of one’s personal preference. Chromic catgut was widely used in most institutions. It now appears that chromic catgut is associated with more postpartum discomfort and hence chromic catgut has been largely replaced by synthetic absorbable materials like polyglactin and polyglycolic acid.Methods: The study was conducted in Institute of Social Obstetrics and Government Kasturba Gandhi Hospital, Chennai. This is a prospective, comparative study involving two groups. The use of a rapidly absorbing form of synthetic absorbable suture material, in the repair of episiotomy or perineal laceration in 100 patients during the study period February 2012 to July 2012, were simultaneously compared with the traditional natural absorbable suture material.Results: With the use of rapidly absorbing polyglactin 910, there was a significant reduction (p=0.000) in the short-term pain, 19 compared to 80 in the control group. With regard to wound dehiscence and the need for resuturing, there was statistically significant difference in the control group (15%) compared to the study group (0%). There was no statistical significance between the two groups in terms of dyspareunia (12.4% vs 10.7%).Conclusions: Fast-absorbing form of Polyglactin seems to be effective in reducing some of the morbidity associated with perineal repair following childbirth. There was significant reduction in the short-term pain and the need for analgesia. The incidence of wound dehiscence was markedly reduced.

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Effect of Carnatic Music Listening Training on Speech in Noise Performance in Adults

Journal of Audiology & Otology ◽

10.7874/jao.2020.00255 ◽

2021 ◽

Vol 25 (1) ◽

pp. 22-26

Author(s):

Raksha Amemane ◽

Archana Gundmi ◽

Kishan Madikeri Mohan

Keyword(s):

Repeated Measures ◽

Functional Organization ◽

Control Group ◽

Music Listening ◽

Noise Performance ◽

Short Term ◽

Speech In Noise ◽

Carnatic Music ◽

Significant Difference ◽

And Control

Background and Objectives: Music listening has a concomitant effect on structural and functional organization of the brain. It helps in relaxation, mind training and neural strengthening. In relation to it, the present study was aimed to find the effect of Carnatic music listening training (MLT) on speech in noise performance in adults.Subjects and Methods: A total of 28 participants (40-70 years) were recruited in the study. Based on randomized control trial, they were divided into intervention and control group. Intervention group underwent a short-term MLT. Quick Speech-in-Noise in Kannada was used as an outcome measure.Results: Results were analysed using mixed method analysis of variance (ANOVA) and repeated measures ANOVA. There was a significant difference between intervention and control group post MLT. The results of the second continuum revealed no statistically significant difference between post training and follow-up scores in both the groups.Conclusions: In conclusion short-term MLT resulted in betterment of speech in noise performance. MLT can be hence used as a viable tool in formal auditory training for better prognosis.

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Efficacy of Surgery Combined with Autologous Bone Marrow Stromal Cell Transplantation for Treatment of Intracerebral Hemorrhage

Stem Cells International ◽

10.1155/2015/318269 ◽

2015 ◽

Vol 2015 ◽

pp. 1-7 ◽

Cited By ~ 6

Author(s):

Jianxin Zhu ◽

Yilei Xiao ◽

Zhongmin Li ◽

Fabin Han ◽

Taiwu Xiao ◽

...

Keyword(s):

Bone Marrow ◽

Barthel Index ◽

Autologous Bone Marrow ◽

Control Group ◽

Short Term ◽

System Disease ◽

Therapeutic Benefits ◽

Neurologic Impairment ◽

Significant Difference

Bone marrow stromal cells (BMSCs) may differentiate into nerve cells under a certain condition; however, the clinical application for treating nervous system disease remains unclear. The aim is to assess the safety profile, feasibility, and effectiveness of surgery combined with autologous BMSCs transplantation for treating ICH. 206 ICH patients who had received surgical procedure were divided into transplantation (n=110) or control group (n=96). For transplantation group, BMSCs were injected into the perihemorrhage area in the base ganglia through an intracranial drainage tube 5.5 (3.01–6.89) days after surgery, followed by a second injection into the subarachnoid space through lumbar puncture 4 weeks later. Neurologic impairment and daily activities were assessed with National Institute Stroke Scale (NIHSS), Barthel index, and Rankin scale before transplantation and 6 months and 12 months after transplantation. Our results revealed that, compared with control group, NIHSS score and Rankin scale were both significantly decreased but Barthel index was increased in transplantation group after 6 months. Interestingly, no significant difference was observed between 12 months and 6 months. No transplantation-related adverse effects were investigated during follow-up assessments. Our findings suggest that surgery combined with autologous BMSCs transplantation is safe for treatment of ICH, providing short-term therapeutic benefits.

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EFFECTS OF TRAINING SIDE HOP OVER BARRIER WITH DUMBELL AND HEXAGON WITH DUMBELL ON LEG STRENGTH AND LEG POWER

JOSSAE Journal of Sport Science and Education ◽

10.26740/jossae.v2n2.p46-50 ◽

2018 ◽

Vol 2 (2) ◽

pp. 46

Author(s):

Nur Akbari ◽

Oce Wiriawan ◽

Nining Widyah Kusnanik

Keyword(s):

Control Group ◽

Percentage Increase ◽

Design Data ◽

Group Iii ◽

Strength Group ◽

Leg Strength ◽

Group I ◽

Significant Difference ◽

Quasi Experimental ◽

Group Ii

This study was conducted at 45 students of SMAN 1 Cerme with aged between 15-16 years old. Students were divided into 3 groups. the type of research used quantitative with quasi-experimental approach. Instruments of this study were test of leg strength and leg power using Leg Dynamometer and Jump MD. The research design used matching only design. Data was anlyzed using ANOVA. The results of the research was found that training program side hop over barrier with dumbell and hexagon with dumbbell significantly increase at leg strength and leg power (Sig. 0.000 <α = 0.05). Group I, Group II and Group III had significant difference (Sig. 0.000 α = 0.005). Percentage increase in leg strength group 1 of 1,80% and leg power of 15,49%. Percentage increase in leg strength group II of 1,68% and a power of 14,27% and whereas in the control group increase in leg strength was 1.67% power at 12.32%.It can be concluded that There was an increase in leg strength and leg power in each group after the training was given. In addition, there were differences among the three groups effects seen improved in leg strength and leg power through ANOVA, where the training side hop over barrier with dumbbell and hexagon with dumbell had increased in leg strength and leg power. But side hop over barrier with dumbbell had more significant increased than hexagon with dumbbell. Key words: Side hop over with barrier dumbell, hexagon with dumbell, leg strength and leg power.

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Effect of Different Media on Short Term Storage of Leaping Mullet (Liza saliens (Risso, 1810)) Sperm

Turkish Journal of Agriculture - Food Science and Technology ◽

10.24925/turjaf.v8i4.996-1000.3262 ◽

2020 ◽

Vol 8 (4) ◽

pp. 996-1000

Author(s):

Serhat Engin ◽

Muammer Kürşat Fırat ◽

Osman Özden ◽

Cüneyt Suzer ◽

Müge Hekimoğlu ◽

...

Keyword(s):

Sperm Quality ◽

Control Group ◽

Natural Seawater ◽

Short Term ◽

Liza Saliens ◽

Seawater Salinity ◽

Significant Difference ◽

Term Storage ◽

Quality Variation ◽

Motility Rate

The present study aimed to evaluate the activation characteristics of the leaping mullet spermatozoa and diluted with four different media (D1, D2, D3, D4) for 250 h at 4±2°C. The semen was collected from nine wild fish in Homa Lagoon, İzmir, Turkey in July, during reproductive season. In each trial (n = 9), semen samples were collected and mixed to reduce sperm quality variation to obtain the required gametes for the experiment. The semen was activated with natural seawater (salinity of 34, pH 7.9 and 4±2°C) to determine: motility time, motility rate and viability of sperm. Dilution with inactivation media 1:3 increased motility time of diluted semen than control group. At the end of the experiment, no significant difference was found for the duration of survival in the D2 and D4 groups. The highest survival rate was found in D2 group.

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Investigation of sub-acute levels of zinc oxide nanoparticles on the filtration rate of Mytilaster lineatus and Dressina polymorpha in the short term

Nusantara Bioscience ◽

10.13057/nusbiosci/n100108 ◽

2018 ◽

Vol 10 (1) ◽

pp. 53-57

Author(s):

AMIR QADERMARZI ◽

MOJTABA POULADI ◽

ALI REZAMAND ◽

SEYED HOSSEIN HOSEINIFAR ◽

ALI AKBAR HEDAYATI

Keyword(s):

Zinc Oxide ◽

Zinc Oxide Nanoparticles ◽

Filtration Rate ◽

Infiltration Rate ◽

Control Group ◽

Oxide Nanoparticles ◽

Short Term ◽

The Third ◽

Significant Difference ◽

Mytilaster Lineatus

Qadermarzi A, Pouladi M, Rezamand A, Hoseinifar SH, Hedayati AA. 2018. Investigation of sub-acute levels of zinc oxide nanoparticles on the filtration rate of Mytilaster lineatus and Dressina polymorpha in the short term. Nusantara Bioscience 10: 53-57. The filtration rate is one of the physiological indices in the bivalves which indicate the degree of efficacy of the filtration function in the exposure to contaminants. In this study, changes in the filtration rate of freshwater bivalves (D. polymorpha and M. lineatus) were investigated after exposure periods of 5 and 10 days with nanoparticles. Bivalves were transferred from the natural environment to the laboratory. The distribution of nanoparticles was measured by differential light scattering (DLS). Bivalves were exposed to 2.5, 25 and 50 ppm nanoparticles for ten days in water reservoirs. The filtration rates were significantly different in the treatments compared to the control samples, with the highest filtration rate was observed in the control group. On the fifth day, the highest filtration rate was obtained in the first treatment of M. lineatus and the lowest filtration rate was obtained in the third treatment of D. polymorphia. The highest filtration rates were observed in the first and second treatments and the lowest filtration rate was observed in the third treatment. Also, there was no significant difference in the filtration rate of M. lineatus in the 1st treatment with control (P> 0.05) on the 5th day, but filtration rate was significantly (P <0.05) less than other concentrations and control group in the third treatment. On the other hand, the filtration rates on the 10th day showed similar differences compared to the 5th day. It could be concluded that the changes infiltration rate are an appropriate indicator for the measurement of contamination in nanoparticles.

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Intensity modulated radiotherapy in combination with endocrinotherapy in the treatment of middle and advanced Prostatic Cancer

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.35.5.591 ◽

2019 ◽

Vol 35 (5) ◽

Author(s):

Sumei Zhang ◽

Shufen Zhao ◽

Xinzhen Fu

Keyword(s):

Prostate Cancer ◽

Prostatic Cancer ◽

Advanced Prostate Cancer ◽

Intensity Modulated Radiotherapy ◽

Control Group ◽

Observation Group ◽

Short Term ◽

Advanced Prostatic Cancer ◽

Intensity Modulated ◽

Significant Difference

Objective: To evaluate the clinical efficacy of intensity modulated radiation therapy and endocrinotherapy for middle and advanced prostate cancer. Methods: Total 104 elderly patients with middle and advanced prostate cancer who were admitted to our hospital from November 2014 to August 2015 were selected using random number table method. They were divided into intensity-modulated radiotherapy combined with endocrinotherapy group (observation group) and conventional radiotherapy combined with endocrinotherapy group (control group), 52 each. The serum levels of prostate specific antigen (PSA) and free prostate antigen (f PSA) were measured three months after treatment. The short-term efficacy and toxic and side effects of the patients were observed, and the survival rate was recorded through three-year follow up. Results: The clinical effective rate of the observation group was 92.68%, and that of the control group was 70.73%; there was a significant difference between the two groups (P<0.05). The serum PSA and f PSA levels of the two groups were similar before treatment, but there was no significant difference (P>0.05). The serum PSA and f PSA levels after treatment were significantly lower than before treatment. The incidence of adverse reactions in the observation group was lower than that in the control group (P<0.05). The one-year and three-year survival rates of the two groups were significantly different (90.0 vs. 80.0%, 60.0 vs. 43.3%, P>0.05). Conclusion: Intensity modulated radiotherapy combined with endocrinotherapy was safe and well tolerated in the treatment of middle and advanced prostate cancer. It can improve the short-term efficacy and effectively reduce the serum oncological index concentration of patients. It can be promoted in clinics. doi: https://doi.org/10.12669/pjms.35.5.591 How to cite this:Zhang S, Zhao S, Fu X. Intensity modulated radiotherapy in combination with endocrinotherapy in the treatment of middle and advanced Prostatic Cancer. Pak J Med Sci. 2019;35(5):---------. doi: https://doi.org/10.12669/pjms.35.5.591 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Weight and Glycemic Control Outcomes of Bariatric Surgery and Pharmacotherapy in Patients With Melanocortin-4 Receptor Deficiency

Frontiers in Endocrinology ◽

10.3389/fendo.2021.792354 ◽

2022 ◽

Vol 12 ◽

Author(s):

Esphie Grace Fodra Fojas ◽

Saradalekshmi Koramannil Radha ◽

Tomader Ali ◽

Evan P. Nadler ◽

Nader Lessan

Keyword(s):

Bariatric Surgery ◽

Weight Loss ◽

Glycemic Control ◽

Therapeutic Interventions ◽

Control Group ◽

Short Term ◽

Melanocortin 4 Receptor ◽

Significant Difference

BackgroundMelanocortin-4 receptor (MC4R) mutations are the most common of the rare monogenic forms of obesity. However, the efficacy of bariatric surgery (BS) and pharmacotherapy on weight and glycemic control in individuals with MC4R deficiency (MC4R-d) is not well-established. We investigated and compared the outcomes of BS and pharmacotherapy in patients with and without MC4R-d.MethodsPertinent details were derived from the electronic database among identified patients who had BS with MC4R-d (study group, SG) and wild-type controls (age- and sex-matched control group, CG). Short- and long-term outcomes were reported for the SG. Short-term outcomes were compared between the two groups.ResultsSeventy patients were screened for MC4R-d. The SG [six individuals (four females, two males); 18 (10–27) years old at BS; 50.3 (41.8–61.9) kg/m2 at BS, three patients with homozygous T162I mutations, two patients with heterozygous T162I mutations, and one patient with heterozygous I170V mutation] had a follow-up duration of up to 10 years. Weight loss, which varied depending on mutation type [17.99 (6.10–22.54) %] was stable for 6 months; heterogeneity of results was observed thereafter. BS was found superior to liraglutide on weight and glycemic control outcomes. At a median follow-up of 6 months, no significant difference was observed on weight loss (20.8% vs. 23.0%, p = 0.65) between the SG and the CG [eight individuals (four females, four males); 19.0 (17.8–36.8) years old at BS, 46.2 (42.0–48.3) kg/m2 at BS or phamacotherapeutic intervention]. Glycemic control in patients with MC4R-d and Type 2 diabetes improved post-BS.ConclusionOur data indicate efficacious short-term but varied long-term weight loss and glycemic control outcomes of BS on patients with MC4R-d, suggesting the importance of ongoing monitoring and complementary therapeutic interventions.

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Efficacy of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in the Management of Malignant Ascites

10.21203/rs.2.23958/v2 ◽

2020 ◽

Author(s):

Jie Jiao ◽

Chengzhen Li ◽

Guanying Yu ◽

Lei Zhang ◽

Xiaoyan Shi ◽

...

Keyword(s):

Intraperitoneal Chemotherapy ◽

Adverse Reactions ◽

Total Effective Rate ◽

Malignant Ascites ◽

Effective Rate ◽

Control Group ◽

Observation Group ◽

Short Term ◽

Significant Difference ◽

The Difference

Abstract Objective: The purpose of this study is to compare the difference of clinical efficacy between conventional intraperitoneal chemotherapy and HIPEC, so as to explore the clinical application value and advantages of HIPEC.Design: A retrospective analysis was conducted on 80 patients with malignant ascites admitted to our hospital from June 2017 to June 2019. The general clinical data and qualitative data of the treatment results of 80 patients with malignant ascites were processed by SPSS19.0 using χ2 test and quantitative data were processed by t test. P <0.05, statistical data can be considered statistically significant.Results: 1. There was no significant change in vital signs and temperature in the observation group during the treatment, and the difference was not statistically significant 2. The short-term total effective rate of patients in the observation group was 91.11%, and the short-term total effective rate of the patients in the control group was 40%.3. There was no significant difference in the incidence of adverse reactions between the two groups of patients.Conclusion: Intraperitoneal hyperthermic chemotherapy combined with intravenous chemotherapy can significantly control malignant ascites, and has small adverse reactions, which is worthy of clinical promotion and application.

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