scholarly journals Therapeutic Efficacy of Entecavir and Tenofovir among the Affectees from War against Terror in the Tribal Areas of Pakistan

2021 ◽  
Author(s):  
Asim Jan ◽  
Hayat Khan ◽  
Majeed Ur Rehman ◽  
Muhammad Salman ◽  
Ijaz Ali ◽  
...  
Keyword(s):  
Antiviral Therapy ◽  
Age Groups ◽  
Active Immunization ◽  
Hbv Infection ◽  
Health Concern ◽  
Chi Square ◽  
Health Related ◽  
Chi Square Test ◽  
Male Patients ◽  
Tribal Region

Abstract BackgroundHepatitis B infection is a worldwide health concern infecting more than 400 million people worldwide. Besides the active immunization program of WHO, the role of antivirals for treating the chronic infection is inevitable. The tribal belt of Pakistan is the most affected part in war against terror. In addition to lack of basic facilities and resources, this part of country has also been neglected for various health related studies. In this study we report the efficacy of the commonly used antivirals; Entecavir (ETV) and Tenofovir Disoproxil Fumarate (TDF).MethodsA total of 2875 HBV infected patients (Male = 1500 and Female = 1375) of different age groups who were receiving either ETV as monotherapy or ETV plus TDF were followed up for 6 and 12 months. Viral DNA was extracted from serum followed by amplification and detection with MyGo Real-Time thermocycler and Gene Proof PCR kit. Response towards antivirals was analyzed statistically with Pearson’s Chi Square test. ResultsComparable response (p=0.171) was observed among the HBV patients towards both six (27%) and twelve month antiviral therapy (36%). Duration of antiviral therapy improved the rate of response in male and patients of old age (p=0.001 & <0.001 respectively). However, female were found relatively more responsive than males towards both six and twelve antiviral therapy (p=0.001 & 0.003 respectively). Furthermore, ETV plus TDF combination proved little more effective for twelve months (p=0.035). Patients of Khyber (p=0.198) and Kurrum (p=0.440) regions are equally responsive towards 6 and 12 month treatment. Compared to ETV monotherapy, ETV plus TDF improved response among the male, patients above 40 years and patients from different tribal region (Bajaur, Kurrum, Malakand and Mohmand). ConclusionOur findings demonstrate that the ETV monotherapy and ETV plus TDF combination therapy are not effective for the HBV infection because both do not achieve SVR rate even in 50% of patients following six and twelve-month follow-up. Therefore, there is a need of much more effective antiviral drugs to treat HBV infection in the study area.

scholarly journals URETHROCUTANEOUS FISTULA FOLLOWING SNODGRASS VERSUS TWO STAGE AIVAR BRACKA REPAIR OF DISTAL PENILE HYPOSPADIAS IN MALE CHILDREN: A RANDOMIZED CONTROL TRIAL

2018 ◽  
Vol 16 (2) ◽  
pp. 54-58 ◽  
Author(s):  
Habib Ullah Shah ◽  
Huma Gul ◽  
Rashid Khan ◽  
Muhammad Marwat
Keyword(s):  
Age Groups ◽  
Urethrocutaneous Fistula ◽  
Control Groups ◽  
Two Stage ◽  
Chi Square ◽  
Significant Difference ◽  
Chi Square Test ◽  
Male Patients ◽  
Randomized Control ◽  
And Control

Background: Hypospadias is the most common congenital malformation of the urethra with the prevalence of 1 in 200-300 live male births. The objective of this trial was to compare the frequency of urethrocutaneous fistula between Snodgrass and two staged Aivar Bracka repair of distal penile hypospadias in male children. Material & Methods: This RCT was conducted in Department of Plastic & Reconstructive Surgery, Hayatabad Medical Complex, Peshawar, Pakistan from 1st June 2013 to 31st May 2014. 64 male patients were randomly allocated to two surgical procedures, 32 to experimental (Snodgrass) group and 32 to control (two stage Aivar Bracka) group. Age in years, age groups and presence of urethrocutaneous fistula were variables. Age in years was analyzed by mean, SD and range and other variables by count and percentage. McNemar chi-square test was applied to see the significance of difference between the experimental and control groups in terms of frequency of urethrocutaneous fistula at alpha 0.05. Results: Mean age in experimental (Snodgross) group was 6.74 years±1.26 & in control (Aivar Bracka) group 6.71 years ±1.29. The urethrocutaneous fistula was present in three (9.38%, 80% CI 2.77-15.99%) cases in experimental (Snodgross) group and in six (18.75%, 80% CI 9.91-27.59%) cases in control (Aivar Bracka) group. McNemar chi-square test showed no significant difference between the experimental and control groups in terms of frequency of urethrocutaneous fistula. Conclusion: The results are comparable for Snodgrass repair and two stage Aivar Bracka repair for distal penile hypospadias in male children in terms of frequency of urethrocutaneous fistula in our population.

scholarly journals Evaluation of female to male ratio in receiving conventional complete denture prosthesis — A retrospective study

2020 ◽  
Vol 11 (SPL3) ◽  
pp. 206-210
Author(s):  
Cibikkarthik T ◽  
Revathi Duraisamy ◽  
Jessy P
Keyword(s):  
Tooth Loss ◽  
Age Groups ◽  
Complete Denture ◽  
Test Results ◽  
Chi Square ◽  
Male Predominance ◽  
Total Data ◽  
Chi Square Test ◽  
Male Patients ◽  
Maxilla And Mandible

A complete denture is defined as a 'dental prosthesis which replaces entire dentition and associated structures of the maxilla and mandible'. Functions of complete Dentures include restoring aesthetics, mastication, and speech. When all the teeth within a jaw have been lost and need to be replaced, and it is an exclusively tissue-supported prosthesis if implants are not indicated. Tooth loss can occur due to many reasons, such as Dental caries, Periodontal disease, Trauma and Congenital disorders. So the aim of the study was to evaluate the ratio between the female and male patients in receiving the complete denture in dental college and Hospitals. Data of 423 patients records were and retrieved from total data of 86000 patients who visited between June 2019 and March 2020. The study parameters such as age, gender and patients who received complete denture were recorded and converted into excel sheets for tabulation, and the collected data were entered in SPSS and through Chi-square test. Results from the study revealed that prevalence among the males was 59.8% and among the females was 40.2%; distribution of complete denture among various age groups revealed 85.1% above 50 years and 14.9% below 50 years. The association between the age groups and the frequency of gender revealed Pearson Chi-Square Value-0.005;p&lt;0.05 Hence statistically significant. The study showed that male patients and patients above 50 years were more likely to be delivered with a complete denture. The study revealed the male predominance due to their poor oral hygiene.

The Influence of Age and Gender on Mandibular Indices among the Libyan Population

2019 ◽  
Vol 3 (2) ◽  
Keyword(s):  
Negative Correlation ◽  
Bone Mineralization ◽  
Age Groups ◽  
T Test ◽  
Chi Square ◽  
Age And Gender ◽  
Significant Difference ◽  
Chi Square Test ◽  
And Gender ◽  
Libyan Population

Radiographic Mandibular Indices serve as easy and relatively cheap tools for evaluating bone mineralization. Objectives: To examine the effect of age and gender on three mandibular indices: the panoramic mandibular index (PMI), the mandibular ratio (MR) and the mandibular cortical index (MCI), among Libyan population. Methods: The three indices were measured on 317 digital (OPGs) of adult humans (155 males, 162 females). The sample was divided into six age groups (from 18-25 years through 56-65 years). The measurements were analyzed for interactions with age and sex, using SPSS (Statistical Package for Social Studies) software version no. 22. The tests employed were two way ANOVA, the unpaired T-test and chi-square test. Results: The mean PMI fluctuated between 0.37 s.d. 0.012 and 0.38 s.d. 0.012. among the sixth age groups. One-way ANOVA statistical test revealed no significant of age on PMI. On the other hand gender variation has effect on PMI, since independent sample t-test disclosed that the difference between the male and female PMI means statistically significant. ANOVA test showed that the means of MR among age groups showed a negative correlation i.e. MR mean declined from 3.01 in 18-25 age groups to 2.7 in 55-65 age groups. In contrary, the gender showed no effect on MR according two sample t-test at p> 0.05. In regards with MCI, statistical analysis showed that it affected by age that is C1 was decreasing by age while C2 and C3 were increased by age. Using chi square test the result indicated that there is a significant difference among the different age group and the two genders in MCI readings. Conclusion: PMI was influenced significantly by age but minimally by the gender. MR is not affected by gender but has a negative correlation with age. MCI is affected by both age and gender

Socio-Demographic Factors and Health-Related Behaviors Associated with Gerontology

GIS Business ◽  
2019 ◽  
Vol 14 (6) ◽  
pp. 359-370
Author(s):  
Dr. Ravi S. Dalawai
Keyword(s):  
Cross Sectional Study ◽  
Work Culture ◽  
Chi Square ◽  
Cross Sectional ◽  
The Social ◽  
Health Related ◽  
Chi Square Test ◽  
Current Scenario ◽  
Socio Demographic Factors ◽  
Insight Into

Indian population is in growing trend from 942.2 million in 1994 to 1.36 billion in 2019.Among this six per cent of India's population was of the age 65 and above (UNFPA, 2019). Today the work culture is totally changed. Both husband and wife are forced to work in the current scenario and unable to take care of their parents. The changing structure created increased problems for old age people leads to loneliness, psychological, physical health and financial insecurity. The study paper provides insight into the social and demographic factor and health related sickness of the oldest people. This research explained the cross-sectional study included a representative sample (n=116) of adults aged ≥60 years. The sample was chosen using a four-stage stratified random-cluster survey sampling method .The Chi Square test and ANOVA test was analyzed using SPSS20.

scholarly journals Changes in Six-Month Prevalence of Circulatory System Diseases among People Aged 20 Years and Older between 2013 and 2018 in Hunan, China

2021 ◽  
Vol 18 (5) ◽  
pp. 2599
Author(s):  
Zhenzhen Rao ◽  
Junjie Hua ◽  
Ruotong Li ◽  
Yanhong Fu ◽  
Jie Li ◽  
...  
Keyword(s):  
Age Groups ◽  
Circulatory System ◽  
Population Based ◽  
Hunan Province ◽  
Rural Residents ◽  
Chi Square ◽  
Circulatory System Diseases ◽  
Chi Square Test ◽  
Urban Rural ◽  
Socio Demographic Factors

Recent changes in population-based prevalence for circulatory system diseases (CSDs) remain unreported either nationally or locally for China. Data were from the two-round health service household interview survey of Hunan Province, China, in 2013 and 2018. A Rao–Scott chi-square test was performed to examine prevalence differences across socio-demographic variables. The overall age-standardized prevalence of CSDs increased substantially between 2013 and 2018 for inhabitants aged 20 years and older (14.25% vs. 21.25%; adjusted odds ratio (OR) = 1.59, 95% CI: 1.24–2.04). Hypertensive disease was the most prevalent type of CSD, accounting for 87.24% and 83.83% of all CSDs in 2013 and in 2018, respectively. After controlling for other socio-demographic factors, the prevalence of CSDs was significantly higher in 2018 (adjusted OR = 1.40), urban residents (adjusted OR = 1.43), females (adjusted OR = 1.12) and older age groups (adjusted OR = 5.36 for 50–59 years, 9.51 for 60–69 years, 15.19 for 70–79 years, and 12.90 for 80 years and older) than in 2013, rural residents, males and the youngest age group (20–49 years). The recent increase in the overall age-standardized CSD prevalence and the large prevalence disparities across urban/rural residents, sex and age groups merit the attention of policymakers and researchers. Further prevention efforts are needed to curb the increasing tendency and to reduce the prevalence of disparities across socio-demographic groups.

The influence of varying maxillary central incisor vertical dimension on perceived smile aesthetics

2019 ◽  
Vol 46 (2) ◽  
pp. 137-142
Author(s):  
Elis Janaina Lira dos Santos ◽  
Alana Moura Xavier Dantas ◽  
Raíssa Marçal Vilela ◽  
Karina Jerônimo Rodrigues Santiago de Lima ◽  
Rejane Targino Soares Beltrão
Keyword(s):  
Age Groups ◽  
Educational Background ◽  
Cross Sectional Study ◽  
Central Incisor ◽  
Chi Square ◽  
Cross Sectional ◽  
Exact Test ◽  
Maxillary Central Incisor ◽  
Significant Difference ◽  
Chi Square Test

Objective: To evaluate patient perception of the smile focused on analysis of the upper incisors. Design: Cross-sectional study. Setting: Department of Clinical and Social Dentistry at Federal University of Paraíba, João Pessoa, Brazil. Participants: The sample consisted of 135 individuals (73 women and 62 men). Methods: Images with different characteristics associated with the incisal edges were shown at random and analysed using a Likert scale. Data were analysed using the Chi-square test or Fisher’s exact test with a statistically significant difference ( P < 0.05). Results: Smile I (difference of 1.5 mm in relation to the central incisor and lateral) was considered the most aesthetic, while Smile III (no difference in height between the central and lateral incisors) was the least aesthetic. A significant difference was found between perception of smile II (difference of 1 mm in relation to the central incisor and lateral) and age groups ( P < 0.005), with 31% (n = 13) of individuals aged 45–64 years considering smile II as not pleasant, 4.4% (n = 2) aged 15–24 years and 8.3% (n=4) aged 25–44 years and 4.4% (n = 2) aged 15–24 years considering the same. A significant difference was also found in relation to educational background of the assessor and smile perception, with smile III ( P = 0.0441) and smile IV ( P = 0.0053) considered the most aesthetic ( P = 0.0116). Conclusion: The smile considered most attractive among the sample was that with 1.5 mm steepness between the central and lateral incisors, while a flat smile arc was considered least attractive.

scholarly journals Assessment of knowledge and practice of oral health among nursing and pharmacy students

2020 ◽  
Vol 7 (11) ◽  
pp. 4339
Author(s):  
Chetanjit Baruah ◽  
Alpana P. Rabha ◽  
Hiranya Saikia
Keyword(s):  
Oral Health ◽  
Health Knowledge ◽  
Cross Sectional Study ◽  
Pharmacy Students ◽  
Chi Square ◽  
Cross Sectional ◽  
Health And Wellbeing ◽  
Health Related ◽  
Chi Square Test ◽  
Knowledge And Practice

Background: Oral health is an integral part of general health and wellbeing of an individual at every stage of life. Good oral health knowledge is a requisite criterion for good oral health related behavior. So, this study was done to assess knowledge and practice about oral health and whether there is any difference of knowledge and practice about it among nursing and pharmacy students.Methods: A cross sectional study was done among 110 nursing and 90 pharmacy students in June 2019 by stratified random sampling method using a self-administered predesigned structured questionnaire. Descriptive statistics and chi-square test were applied using SPSS software.Results: Knowledge and practice of pharmacy students was found to be better than nursing students.Conclusions: Knowledge and practice of the students should be improved through health education.

scholarly journals Perceived Level of Burden of Care and Its Association with Socio-Demographic Profile of Patients with Schizophrenia and Their Caregivers

2017 ◽  
Vol 4 (2) ◽  
Author(s):  
Dr. Shubhangi S. Dere ◽  
Dr. Bindoo S. Jadhav ◽  
Dr. Dipak C. Patil ◽  
Dr. Hemangi S. Dhavale
Keyword(s):  
Mental Health Problems ◽  
Clinical Syndrome ◽  
Older Age ◽  
Test Results ◽  
Chi Square ◽  
Demographic Profile ◽  
Perceived Burden ◽  
Chi Square Test ◽  
Male Patients ◽  
Spss Software

Background: Schizophrenia is a clinical syndrome of variable, but profoundly disruptive, psychopathology that involves cognition, emotion, perception and behaviour. Caregiver burden refers to negative response that occurs when the caregiver assumes an unpaid and unanticipated responsibility for the person with disabling mental health problems. The burden varies with socio-demographic parameters of patients and caregivers. Aims & Objectives: To study socio demographic details of schizophrenia patients and caregivers. To assess perceived level of burden in caregivers and it’s association with socio demographic profile of patients and caregivers. Materials & Methods: Ethics committee approval and informed consent was taken. 100 consecutive patients with their primary caregiver, presenting to psychiatry OPD of general hospital, satisfying inclusion criteria, were included in the study. Socio-demographic details of caregiver were collected using semi-structured proforma. Caregiver’s perceived burden was assessed with Burden Assessment Schedule. Data thus obtained, was pooled & analyzed by using SPSS software, descriptive statistics, mean, percentage, Chi- Square test. Results: The sample consisted of 52 female & 48 male patients. Prevalence of burden in caregivers was found to be 52%. The perceived burden was found to be high in caregivers of female patients, patients of older age, less educated, single, and unemployed patients. Majority of caregivers were female and of older age. The burden perceived was found to be significantly high in female caregivers, especially mother.

scholarly journals Investigating the Availability and Usage of Seatbelts in Malawi for Policy Review and Formulation

2020 ◽  
Vol 31 (3) ◽  
pp. 48-56
Author(s):  
Gibson Mpokonyoka Ngwira ◽  
Benjamin Bolaane ◽  
Bhagabat P. Parida
Keyword(s):  
Mitigation Measures ◽  
Motor Vehicles ◽  
Health Concern ◽  
Primary Data ◽  
Road Accidents ◽  
Vehicle Ownership ◽  
Chi Square ◽  
Chi Square Test ◽  
Road Fatality ◽  
Major Factors

Road fatalities remain a major public health concern as over 1.3 million people across the world die in road accidents annually, and another 20-50 million sustain injuries. Malawi, with vehicle ownership about 437,416, has not been an exception to this, with reported fatality rates of 35 crash deaths per 100,000 population, possibly due to limited understanding of factors that contribute to such high road fatality rates. This may have resulted in implementing inappropriate and ineffective mitigation measures. Thus, the overall objective of this study was to investigate the availability, including their functionality and usage of seatbelts in motor vehicles, which could possibly be one of the major factors for increase in road fatalities. To establish the rates of availability, ncluding their functionality and usage of seatbelts in motor vehicles, primary data through survey for a sample of 1,200 vehicles were investigated. The independent ariables of data were cross tabulated with the dependent variables to establish these rates. Chi-square test was also performed to establish the significance of associations between the cross tabulated variables. The analysis found that Malawi’s drivers and assengers poorly comply with seatbelt laws. The overall seatbelt usage rate was 35.8%. In this regard, where over 90% of motor vehicles in Malawi have functional seatbelts, poor enforcement of existing seatbelt laws and awareness on the dangers of not using eatbelts could account for the low usage.

scholarly journals Clinical Spectrum of Angiomatous Granuloma and Inflammatory Fibrous Hyperplasia- A Retrospective Study

2020 ◽  
Vol 11 (SPL3) ◽  
pp. 159-162
Author(s):  
Rithanya P ◽  
Archana Santhanam ◽  
Subhashree R
Keyword(s):  
Age Groups ◽  
Hospital Setting ◽  
Clinical Spectrum ◽  
Complete Analysis ◽  
P Value ◽  
Chi Square ◽  
Female Population ◽  
Gingival Enlargement ◽  
Gingival Diseases ◽  
Chi Square Test

Angiomatous granuloma is a reactive tumour-like lesion commonly seen in the oral cavity. It generally occurs due to proliferation of capillary blood vessels. Whereas, inflammatory fibrous hyperplasia (IFH) refers to gingival enlargement, which is the current terminology for an increase in the size of the gingiva and is a common feature of gingival diseases. Therefore, the aim of the current study is to analyse the clinical spectrum of angiomatous granuloma/ IFH in a private dental hospital. This study was carried out in a hospital setting (single centred study). The data of the study subjects was collected after a complete analysis of data of 86000 patients between June 2019 and March 2020. The data of the patients, including age, gender clinical diagnosis and histopathological reports, were collected and analysed using the Chi-square test to find the association between the clinical and histopathological reports in the study. In the present study, angiomatous granuloma(55%) had a higher prevalence compared to IFH (40%) with higher gender predilection among the female population (61.5%) and generally in the age group ranging from 20 to 40 years. (57.5%) [p value= 0.329] statistically not significant. Similarly, IFH was also found to be higher in the female population of about (38.4%), in the age groups between 20 to 50 years (41.3%). The knowledge of various clinical presentations and histopathological characteristics the lesion is necessary for proper identification and treatment planning.

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