scholarly journals Serum Apolipoprotein B/Apolipoprotein A1 Ratio In Relation To Intervertebral Disc Herniation: A Cross-Sectional Frequency-Matched Case-Control Study

2021 ◽  
Author(s):  
Fei Chen ◽  
Tongde Wu ◽  
Chong Bai ◽  
Song Guo ◽  
Junwen Huang ◽  
...  
Keyword(s):  
Serum Lipid ◽  
Density Lipoprotein ◽  
Apolipoprotein A1 ◽  
Control Group ◽  
Intervertebral Disc Herniation ◽  
Cross Sectional ◽  
Apo B ◽  
Matched Case ◽  
Control Study ◽  
Apo Ai

Abstract Study Design:A cross-sectional frequency-matched case-control studyObjective: In recent decades, the serum lipid profile of apolipoprotein(a) (Lp(a)) level and apolipoprotein B/apolipoprotein A1 ratio (Apo B/ApoA1) ratio were found more representative for serum lipid level and were recognized as the independent risk factors for various diseases. Although the serum lipid levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) were found associated with symptomatic intervertebral disc herniation (IDH), no studies have been conducted to date for the evaluation of the association of Apo AI, Apo B, Lp(a) and Apo B/Apo AI levels with symptomatic IDH.Method: A total of 1,839 Chinese patients were recruited in the present study. 918 patients were diagnosed as IDH cases and were enrolled in the experimental group. A control group of 921 patients underwent a physical examination during the same period. The serum lipid levels of TC, TG, LDL-C, HDL-C, Lp(a), Apo B and Apo B/Apo AI were examined and analyzed. The patients in the control group were collected randomly from patients who were matched with the baseline levels of the aforementioned lipid molecular.Results: The patients with IDH exhibited significantly higher TC, TG, LDL, Apo B and Lp(a) levels compared with the control subjects. The percentage of high-TC, high-TG, high-LDL, high-Apo B and high-Lp(a) were significantly higher in the IDH group. However, hyperlipidaemia was not associated with the degenerated segment of the IDH (P=0.201). The odds ratios (OR) for the incidence of IDH with an elevated LDL-C, TC, TG, Lp(a), Apo B and Apo B/Apo AI were 1.583, 1.74, 1.62, 1.58, 1.49 and 1.39, respectively. The correlation analysis revealed the correlation between elevated LDL-C, TC, TG, Apo B, Lp(a) and incidence of IDH was significant (R2LDL=0.017; R2TC=0.004; R2TG=0.015; R2Apo B=0.004; R2LP(a)=0.021) (P<0.05).Conclusion:The present study suggests that elevated levels of serum TC, TG, LDL, Apo B, Lp(a) and Apo B/Apo AI are associated with a higher risk for IDH.

scholarly journals Serum apolipoprotein B/apolipoprotein A1 ratio in relation to intervertebral disk herniation: a cross-sectional frequency-matched case–control study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Fei Chen ◽  
Tongde Wu ◽  
Chong Bai ◽  
Song Guo ◽  
Wenjun Huang ◽  
...  
Keyword(s):  
Serum Lipid ◽  
Density Lipoprotein ◽  
Intervertebral Disk ◽  
Apolipoprotein A1 ◽  
Control Group ◽  
Lipid Levels ◽  
Cross Sectional ◽  
Apo B ◽  
Intervertebral Disk Herniation ◽  
Apo Ai

Abstract Study design This was a cross-sectional frequency-matched case–control study. Background and aim The serum lipid profile of lipoprotein(a) [Lp(a)] level and apolipoprotein B/apolipoprotein A1 ratio (Apo B/Apo A1) ratio were found to be more representative for serum lipid level and were recognized as the independent risk factors for various diseases. Although the blood levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were found to be associated with symptomatic intervertebral disk herniation (IDH), no studies to date have evaluated the association of Apo AI, Apo B, Lp(a), and Apo B/Apo AI levels with symptomatic IDH. This study aimed to assess the link between blood lipid levels and symptomatic IDH. Method The study included 1839 Chinese patients. Of these, 918 patients were diagnosed with IDH and enrolled in the experimental group. A control group of 921 patients underwent a physical examination during the same period. The serum lipid levels of TC, TG, LDL-C, HDL-C, Lp(a), Apo B, and Apo B/Apo AI were examined and analyzed. The control group comprised randomly selected patients who met the baseline levels of the aforementioned lipid molecules. Results Patients with IDH exhibited significantly higher TC, TG, LDL, Apo B, and Lp(a) levels than controls. The percentage of high TC, high TG, high LDL, high Apo B, and high Lp(a) were obviously higher in the IDH group than in the control group. However, hyperlipidemia had no relationship with the degenerated segment of the IDH (P = 0.201). The odds ratio (OR) for the incidence of IDH with elevated levels of LDL-C, TC, TG, Lp(a), Apo B, and Apo B/Apo AI was 1.583, 1.74, 1.62, 1.58, 1.49, and 1.39, respectively. The correlation analysis revealed the correlation between elevated LDL-C, TC, TG, Apo B, Lp(a), and incidence of IDH was significant (R2LDL = 0.017; R2TC = 0.004; R2TG = 0.015; R2Apo B = 0.004; R2Lp(a) = 0.021) (P < 0.05). Conclusion This study suggested that elevated levels of serum TC, TG, LDL, Apo B, Lp(a), and Apo B/Apo AI were associated with a higher risk of IDH. This study provided useful information to identify a population that might be at risk of developing IDH based on elevated lipid levels.

scholarly journals Serum Apolipoprotein B/apolipoprotein A1 Ratio in Relation to Intervertebral Disc Herniation : A Cross-sectional Frequency-Matched Case-Control Study

2020 ◽  
Author(s):  
Fei Chen ◽  
Tongde Wu ◽  
Song Guo ◽  
Junwen Huang ◽  
Qiang Fu ◽  
...  
Keyword(s):  
Apolipoprotein B ◽  
Serum Lipid ◽  
Density Lipoprotein ◽  
Apolipoprotein A1 ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Lipid Levels ◽  
Apo B ◽  
Serum Lipid Levels ◽  
Apo Ai

Abstract BackgroundIn recent decades, the serum lipid profile of apolipoprotein(a) (Lp(a)) level and apolipoprotein B/apolipoprotein A1 ratio (Apo B/ApoA1) ratio were found more representative for serum lipid level and were recognized as the independent risk factors for various diseases. Although the serum lipid levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) were found associated with symptomatic IDH, no studies have been conducted to date for the evaluation of the association of Apo AI, Apo B, Lp(a) and Apo B/Apo AI levels with symptomatic IDH.MaterialsA total of 1,839 Chinese patients were recruited in the present study. 918 patients were diagnosed as IDH cases and were enrolled in the experimental group. A control group of 921 patients underwent a physical examination during the same period. The serum lipid levels of TC, TG, LDL-C, HDL-C, Lp(a), Apo B and Apo B/Apo AI were examined and analyzed.ResultsThe patients in the control group were collected randomly from patients who were matched with the baseline levels of the aforementioned lipid molecular. The patients with IDH exhibited significantly higher TC, TG, LDL, Apo B and Lp(a) levels compared with the control subjects. The percentage of high-TC, high-TG, high-LDL, high-Apo B and high-Lp(a) were significantly higher in the IDH group. However, hyperlipidaemia was not associated with the degenerated segment of the IDH (P=0.201). The odds ratios (OR) for the incidence of IDH with an elevated LDL-C, TC, TG, Lp(a), Apo B and Apo B/Apo AI were 1.583, 1.74, 1.62, 1.58, 1.49 and 1.39, respectively. The correlation analysis revealed the correlation between elevated LDL-C, TC, TG, Apo B, Lp(a) and incidence of IDH was significant (R2LDL=0.017; R2TC=0.004; R2TG=0.015; R2Apo B=0.004; R2LP(a)=0.021) (P<0.05). ConclusionsThe present study suggests that elevated levels of serum TC, TG, LDL, Apo B, Lp(a) and Apo B/Apo AI are associated with a higher risk for IDH.

scholarly journals Association Between Serum Lipid Levels and Patients With Primary Angle-Closure Glaucoma in China: A Cross Sectional, Case–Control Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Mingxi Shao ◽  
Yingzhu Li ◽  
Jisen Teng ◽  
Shengjie Li ◽  
Wenjun Cao
Keyword(s):  
Serum Lipid ◽  
Density Lipoprotein ◽  
High Serum ◽  
Angle Closure ◽  
Lipid Levels ◽  
Cross Sectional ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
Serum Lipid Levels ◽  
Control Study

Objective: To evaluate the serum lipid levels of patients with primary angle-closure glaucoma (PACG) and to investigate the relationship between serum lipid levels and PACG.Methods: In this cross-sectional, case–control study, a total of 320 PACG subjects and 242 age- and sex-matched control subjects were recruited. Serum high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), small dense LDL-C (SDLDL-C), triglyceride (TRIG), and cholesterol (CHOL) levels were measured using enzymatic colorimetry. Serum apolipoprotein A (APOA), apolipoprotein B (APOB), apolipoprotein E (APOE), and lipoprotein(a) (LPa) levels were measured by immunoturbidimetry.Results: The serum LDL-C, TRIG, HDL-C, APOE, LPa, CHOL, APOB, and APOA levels were significantly higher (p &lt; 0.05) in the PACG group than in the control group. Multiple liner regression analyses revealed that there was a statistically correlation between HDL-C levels and mean deviation MD (B = 0.389, P = 0.002, 95% confidence interval [CI] = −1.249 to −0.624); LDL-C levels and MD (B = 0.190, P = 0.019, 95% CI = −5.632 to −1.306); and CHOL levels and MD (B = 0.364, P = 0.27, 95% CI = −7.727 to −1.839). Logistic regression analyses showed that high serum HDL-C (odds ratio [OR] = 11.01, 95% CI = 5.616–21.587), LDL-C (OR = 1.330, 95% CI = 1.079–1.640), SDLDL-C (OR = 1.007, 95% CI = 1.005–1.008), APOA (OR = 13.621, 95% CI = 7.251–25.591), APOB (OR = 2.243, 95% CI = 1.060–4.732), LPa (OR = 0.999, 95% CI = 0.998–1.00), and CHOL (OR = 1.131, 95% CI = 1.005–1.326) levels were significantly associated with PACG.Conclusions: High serum HDL-C, LDL-C, APOA, APOB, LPa, and CHOL levels were associated with PACG.

scholarly journals Association of Dyslipidemia With Sudden Sensorineural Hearing Loss: A Retrospective Study

2020 ◽  
Author(s):  
Dafei Li ◽  
Piao Xu ◽  
Jingya Yang ◽  
Qiongping Lin ◽  
Haiyan Zhao ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Atherogenic Index ◽  
Control Group ◽  
Lipid Levels ◽  
Apo B ◽  
The Mean ◽  
Apo Ai ◽  
Blood Lipid Levels

Abstract Background: Blood lipid levels have been widely studied in patients with sudden sensorineural hearing loss (SSNHL), but it has been unclear whether dyslipidemia associates with SSNHL. Whether there is a simple and feasible blood lipid index to predict the onset of SSNHL remains to be found.Methods: This study reviewed 100 SSNHL patients and 100 healthy subjects who received relevant clinical examination in our hospital from June 1, 2015 to June 1, 2019. The demographic, clinical characteristics, lipid levels and lipid metabolism indexes of the two groups were compared.Results: In this study, 100 patients (64 men [64%]; 36 women [36%]; mean [SD] age, 38.47 [14.36] years) were included in the SSNHL group, and 100 healthy people(60 men [60%]; 40 women [40%]; mean [SD] age, 36.52 [9.86] years) served as the control group. No significant differences between the SSNHL group and the control group in age, sex, BMI, smoking habits and alcohol drinking patterns were observed. Meanwhile, it can be seen the mean (SD) concentrations of total cholesterol (TC) (194.59 [38.22] vs 176.83 [23.55] mg/dL; MD, 17.76 mg/dL; 95% CI, 26.64-46.72 mg/dL), the mean (SD) concentrations of low density lipoprotein cholesterol (LDL-C) (116.99 [33.59] vs 96.91 [22.01] mg/dL; MD, 20.08 mg/dL; 95% CI, 32.43-48.26 mg/dL) and apolipoprotein (apo) B (89.82 [21.38] vs 81.16 [16.17] mg/dL; MD, 8.66 mg/dL; 95% CI, 12.03-23.21 mg/dL) were significantly higher than the control group. In addition, it was also observed that the median [IQR] concentrations of high density lipoprotein cholesterol (HDL-C) (1.51 [1.33-1.76] vs 1.56 [1.40-1.84] mg/dL) and the median [IQR] concentrations of apolipoprotein (apo) AI (118.50 [103.00-141.25] vs 133.00 [115.25-1.52.75] mg/dL) were lower than those in the control group. In terms of lipid metabolism indexes, the median [IQR] value of TC/HDL-C (3.31 [2.68-3.85] vs 2.72 [2.42-3.37]), the mean (SD) value of apo B/apo AI (0.76 [0.26] vs 0.63 [0.18]; MD, 0.13; 95% CI, 0.20-0.32) and the median [IQR] value of atherogenic index (ATH index) (1.61 [0.97-2.50] vs 1.01 [0.73-1.75]) were significantly higher than the control group, while the mean (SD) value of atherogenic index of plasma (AIP) (-0.24 [0.28] vs -0.25 [0.21]; MD, 0.01; 95% CI, -0.06-0.08) showed no difference between the two groups.Conclusions: There were significant differences in blood lipid levels and lipid metabolism between the SSNHL group and the control group. LDL-C, apo AI and apo B were important independent predictors of SSNHL.

scholarly journals Identification of High Serum Apolipoprotein A1 As a Favorable Prognostic Indicator in Patients with Multiple Myeloma

Blood ◽  
2018 ◽  
Vol 132 (Supplement 1) ◽  
pp. 5589-5589
Author(s):  
Peng Liu ◽  
Lifan Liang ◽  
Jing Li
Keyword(s):  
Multiple Myeloma ◽  
Multivariate Analysis ◽  
Serum Lipid ◽  
Cox Regression ◽  
Prognostic Significance ◽  
Density Lipoprotein ◽  
Prognostic Indicator ◽  
Lipid Profiles ◽  
Apolipoprotein A1 ◽  
Apo B

Abstract Purpose To explore the prognostic significance of serum lipid profiles in patients with multiple myeloma (MM). Patients and methods The study retrospectively enrolled 307 MM patients in Zhongshan Hospital, Shanghai, China, from 2007 to 2016. We evaluated the prognostic significance of the prediagnostic serum lipid profile [cholesterol, triglyceride, low-density lipoprotein (LDL), high-density lipoprotein (HDL), Apolipoprotein A1 (Apo A1) and Apolipoprotein B (Apo B)]. Prognostic factors identified through univariate and multivariate analysis were used to construct a new model based on Lasso Cox regression. Results In our cohort, lipid levels showed significant difference between ISS stages (P<0.001 in cholesterol, P<0.001 in LDL, P=0.002 in HDL, P<0.001 in Apo A1, P<0.001 in Apo B). However, only Apo A1 showed statistically significance in overall survival (OS), progression free survival (PFS) and cause specific survival (CSS) (P=0.038, P=0.028, P=0.011) in univariate Cox regression. Patients with higher Apo A1 displayed longer OS (median OS, 67 months vs. 30 months; P<0.001). Also, Apo A1 was revealed to be independent prognostic parameters through multivariate analysis. Combining the Apo A1 level, a Zhongshan Score model was constructed with Lasso regression for prognosis prediction. This model exhibited higher accuracy than International Staging System (ISS) and Durie and Salmon (DS) system. Conclusion Among all the serum lipid profiles, serum Apo A1 is a powerful prognostic indicator for patients with MM. Disclosures No relevant conflicts of interest to declare.

Identification of six novel susceptibility loci for dyslipidemia by longitudinal exome-wide association studies in Japanese

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
M Oguri ◽  
K Kato ◽  
H Horibe ◽  
T Fujimaki ◽  
J Sakuma ◽  
...  
Keyword(s):  
Serum Lipid ◽  
Ldl Cholesterol ◽  
Association Studies ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Susceptibility Loci ◽  
Cross Sectional ◽  
Genome Wide

Abstract Background The circulating concentrations of triglycerides, high density lipoprotein (HDL)-cholesterol, and low density lipoprotein (LDL)-cholesterol have a substantial genetic component. Although previous genome-wide association studies identified various genes and loci related to plasma lipid levels, those studies were conducted in a cross-sectional manner. Purpose The purpose of the study was to identify genetic variants that confer susceptibility to hypertriglyceridemia, hypo-HDL-cholesterolemia, and hyper-LDL-cholesterolemia in Japanese. We have now performed longitudinal exome-wide association studies (EWASs) to identify novel loci for dyslipidemia by examining temporal changes in serum lipid profiles. Methods Longitudinal EWASs (mean follow-up period, 5 years) for hypertriglyceridemia (2056 case, 3966 controls), hypo-HDL-cholesterolemia (698 cases, 5324 controls), and hyper-LDL-cholesterolemia (2769 cases, 3251 controls) were performed with Illumina Human Exome arrays. The relation of genotypes of 24,691 single nucleotide polymorphisms (SNPs) that passed quality control to dyslipidemia-related traits was examined with the generalized estimating equation (GEE). To compensate for multiple comparisons of genotypes with each of the three conditions, we applied Bonferroni's correction for statistical significance of association. Replication studies with cross-sectional data were performed for hypertriglyceridemia (2685 cases, 4703 controls), hypo-HDL-cholesterolemia (1947 cases, 6146 controls), and hyper-LDL-cholesterolemia (1719 cases, 5833 controls). Results Longitudinal EWASs revealed that 30 SNPs were significantly (P&lt;2.03 × 10–6 by GEE) associated with hypertriglyceridemia, 46 SNPs with hypo-HDL-cholesterolemia, and 25 SNPs with hyper-LDL-cholesterolemia. After examination of the relation of identified SNPs to serum lipid profiles, linkage disequilibrium, and results of the previous genome-wide association studies, we newly identified rs74416240 of TCHP, rs925368 of GIT2, rs7969300 of ATXN2, and rs12231744 of NAA25 as a susceptibility loci for hypo-HDL-cholesterolemia; and rs34902660 of SLC17A3 and rs1042127 of CDSN for hyper-LDL-cholesterolemia. These SNPs were not in linkage disequilibrium with those previously reported to be associated with dyslipidemia, indicating independent effects of the SNPs identified in the present study on serum concentrations of HDL-cholesterol or LDL-cholesterol in Japanese. According to allele frequency data from the 1000 Genomes project database, five of the six identified SNPs were monomorphic or rare variants in European populations. In the replication study, all six SNPs were associated with dyslipidemia-related phenotypes. Conclusion We have thus identified six novel loci that confer susceptibility to hypo-HDL-cholesterolemia or hyper-LDL-cholesterolemia. Determination of genotypes for these SNPs at these loci may prove informative for assessment of the genetic risk for dyslipidemia in Japanese. Funding Acknowledgement Type of funding source: None

scholarly journals Lipoprotein Profile in Populations from Regions of the Russian Federation: ESSE-RF Study

2022 ◽  
Vol 19 (2) ◽  
pp. 931
Author(s):  
Victoria A. Metelskaya ◽  
Svetlana A. Shalnova ◽  
Elena B. Yarovaya ◽  
Vladimir A. Kutsenko ◽  
Sergey A. Boytsov ◽  
...  
Keyword(s):  
Russian Federation ◽  
Rural Areas ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Risk Modeling ◽  
Lipoprotein Profile ◽  
Apo B ◽  
The Russian Federation ◽  
Ascvd Risk ◽  
Apo Ai

This study aimed to describe the dyslipidemia prevalence and pattern among adult populations from different regions (n = 13) of the Russian Federation (RF). Randomly selected samples (n = 22,258, aged 25–64) were studied according to the ESSE-RF protocol. Lipoprotein parameters were estimated by routine methods. Statistical analyses were performed using R software (v.3.5.1). The overall dyslipidemia prevalence was 76.1% (76.9/75.3% for men/women). In women, total cholesterol (TC) and low-density lipoprotein (LDL)-C levels gradually increased with age (from 4.72 to 5.93 and from 2.76 to 3.79 mmol/L, respectively); in men, they reached a maximum by 45–54 (5.55 and 3.55 mmol/L, respectively) and then decreased. No differences in high-density lipoprotein (HDL)-C in men of different ages were found, but slight decreases in HDL-C and apo AI were observed in women by 55–64 years. No pronounced associations between education and lipid levels in men were observed; higher-educated women showed significantly better lipoprotein profiles. Similar associations between lipids and income level were detected. Women from rural areas had higher TC and triglycerides than urban residents. Regardless of sex, rural residents had higher HDL-C and apo AI, and reduced apo B/apo AI. Conclusion: Information on the peculiarities of dyslipidemia prevalence and lipoprotein profile depending on sex, age, residential place, and socioeconomic status is useful for assessing the global ASCVD risk, and for risk modeling based on national data.

scholarly journals Effects of a vocational rehabilitation programme on return to work among sick-listed primary health care patients A population-based matched, case-control study

2019 ◽  
Author(s):  
Anna-Sophia von Celsing ◽  
Per Kristiansson ◽  
Kurt Svärdsudd ◽  
Thorne Wallman
Keyword(s):  
Sick Leave ◽  
Intervention Group ◽  
Population Based ◽  
Control Group ◽  
Primary Health ◽  
Matched Case ◽  
Vocational Programme ◽  
Matched Case Control Study ◽  
Control Study

Abstract Background: To evaluate the efficacy of a multidisciplinary vocational programme in sick-listed, primary health care patients as compared to matched non-programme patients. Methods: The design was a 3-year prospective population-based, matched case-control study. It was set in a large primary healthcare centre in the city of Eskilstuna, Sweden. The subjects were 943 sickness-certified patients (482 women and 461 men). Intervention: 170 high-risk patients and a matched control group (n = 340) with similar risk for not returning to work within expected time, based on propensity score was created. The intervention group passed a multidisciplinary medical assessment and a coordinated vocational programme, while the control group received usual care by their general practitioner. Main outcome measures: Sick leave conclusion and the day when it occurred. Results: The follow-up time was subdivided into four periods. During the first two periods, days 1–14 and days 15–112 after baseline, the intervention group had a significantly lower sick leave conclusion rate than the control group (hazard ratios, (HR) 0.32, 95% CI 0.20–0.51, p < 0.0001 and 0.47, 95% CI 0.35–0.64). During the third period, days 113–365, the intervention group had an insignificantly lower conclusion rate (HR 0.70, 95% CI 0.46–1.08, p = 0.10), and during the fourth follow-up period, days 366–1096, the intervention group had an insignificantly higher conclusion rate than the control group (HR 1.16, 95% CI 0.69–1.96, p = 0.58). Across the total follow-up period, the intervention group had a lower conclusion rate than the control group (HR 0.55, 95% CI 0.45–0.66, p < 0.0001). Conclusions: No positive significant effects of the rehabilitation programme on time to sick leave conclusion were found.

scholarly journals Effects of Hamo NK hard capsule on serum lipid profiles in dyslipidemia experimental animals

2021 ◽  
Vol 141 (5) ◽  
pp. 10-18
Author(s):  
Pham Thuy Phuong ◽  
Pham Quoc Binh ◽  
Dinh Thi Hong Minh ◽  
Tran Thi Thu Hien ◽  
Nguyen Trong Thong ◽  
...  
Keyword(s):  
Serum Lipid ◽  
Therapeutic Strategy ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Poloxamer 407 ◽  
Control Group ◽  
Cholesterol Levels ◽  
Daily Dose ◽  
Previously Treated ◽  
Cholesterol Control

Dyslipidemia is a major risk factor for cardiovascular disease. Polyherbal formulation is a traditional therapeutic strategy used to treat dyslipidemia over many years of tradition. The aim of this study was designed to evaluate the effects of Hamo NK hard capsule on endogenous dyslipidemia and exogenous dyslipidemia experimental animal model. In endogenous hyperlipidemia model, mice were previously treated by Hamo NK hard capsule, and intraperitoneally injected by poloxamer - 407 to induce hyperlipidemia. Rats were oral administration of oil - cholesterol mixture and Hamo NK for 4 consecutive weeks (exogenous dyslipidemia). Parameters of serum lipid were determined. Hamo NK ameliorated the elevation of serum total cholesterol, Non - HDL - cholesterol at the daily dose of 1.5g/kg b.w (p < 0.05). Also, there was no signicant difference in increase on high - density lipoprotein cholesterol levels and decrease triglyceride levels between the groups. Hamo NK at two doses of 0.25g/kg b.w and 0.75g/kg b.w significantly reduced serum LDL - C levels compared to the cholesterol control group. Hamo NK hard capsule affected on serum lipid modulations in dyslipidemia models.

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