Factors associated with differential community prevalence of hepatitis E in two sub-counties in Kitgum District in Northern Uganda: A comparative cross-sectional study
Abstract Background: Hepatitis E is one of the leading causes of acute viral hepatitis worldwide. During 2009, an epidemic of hepatitis E resulted in 10,437 infections and 167 deaths in Kitgum district.Objective: To investigate factors associated with the differential community prevalence of hepatitis E in two sub-counties in Kitgum District.Methods: We conducted a community survey during the 4th-31st of May 2012 in two Sub Counties in Kitgum District in Northern Uganda. A total of 474 heads of household were recruited using a probability proportional to size through multistage and random sampling methods. Two hundred thirty-four (49.26%) heads of household were from Mucwini, and 241 (50.74%) were from Kitgum Matidi Sub Counties. The questionnaire had an internal validity of Cronbach’s α=0.85. The study was approved by a local IRB. STATA version 10.0 was used for data analysis, and a p-value less than 0.05 was considered significant.Results: The prevalence of hepatitis E was significantly higher in Mucwini Subcountry 97 (41.99%) than in Kitgum Matidi 63 (26.47%); χ2=12.6; p=0.000. Factors associated with differential prevalence were hand washing after latrine use with Adjusted Odds Ratio (AoR)=0.23,95%CI:0.110-0.646; p=0.003; frequency of communal hand washing AoR=0.53,95%CI:0.330-0.860; p=0.01; patients’ handling by health workers AoR=1.91,95%CI:1.410-2.610; p<0.001; frequency of village health meetings held AoR=0.69,95%CI:0.56-0.85; p<0.001 and awareness of the cause of Hepatitis E AoR=1.42, 95%CI:0.710-1.880; p=0.015.Conclusions: Factors associated with the differential community prevalence of hepatitis E in the two communities were poor personal hygiene, poor community practices and a low level of community awareness about the virus. District and health authorities should put in place measures to improve personal and household hygiene and strengthen community health education on hepatitis E.