scholarly journals Dietary Intakes and Plasma Polyunsaturated Fatty Acid Levels in Parkinson’s Disease

2020 ◽  
Author(s):  
Dallah Yoo ◽  
Yunsook Lim ◽  
Yiseul Son ◽  
Hyunkyung Rho ◽  
Chaewon Shin ◽  
...  
Keyword(s):  
Dietary Intake ◽  
Plasma Levels ◽  
Case Control Study ◽  
Plasma Concentrations ◽  
Clinical Effects ◽  
Dietary Intakes ◽  
Lower Plasma ◽  
Pufa Supplementation ◽  
Non Motor Symptoms ◽  
Control Study

Abstract The study aims to determine the correlation between dietary intakes and plasma concentrations of PUFA and their associations with clinical severities in PD. We designed a case-control study to assess dietary fat intakes and disease severity in 38 PD patients and 33 healthy volunteers. Plasma levels of five PUFAs including α-linolenic acid (ALA), eicosapentaenoic acid, docosahexaenoic acid, linoleic acid (LA), and arachidonic acid (AA) were measured using gas chromatography. No differences were observed in dietary total energy and lipid intakes including PUFAs between two groups. PD patients had lower plasma levels of ALA, LA, and AA than controls. The associations between dietary intake and plasma concentrations of PUFAs were insignificant, whereas the association between dietary intake and plasma concentration of AA was exceptionally significant in controls. Plasma levels of ALA and LA were inversely associated with motor rating scores in PD patients, while that of AA was positively associated with non-motor symptoms.Plasma levels of ALA, LA, and AA were lower in PD patients than those in healthy controls, suggesting absorption problems in PD or expedited utilization of PUFAs. Contradictory relations on motor and non-motor symptoms imply conflicting clinical effects of PUFAs, raising questions about the usefulness of PUFA supplementation.

scholarly journals Dietary Intake and Plasma Levels of Choline and Betaine in Children with Autism Spectrum Disorders

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Joanna C. Hamlin ◽  
Margaret Pauly ◽  
Stepan Melnyk ◽  
Oleksandra Pavliv ◽  
William Starrett ◽  
...  
Keyword(s):  
Dietary Intake ◽  
Plasma Levels ◽  
Plasma Concentrations ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Research Network ◽  
Control Group ◽  
Lower Plasma ◽  
One Carbon Metabolism ◽  
Positive Correlations

Abnormalities in folate-dependent one-carbon metabolism have been reported in many children with autism. Because inadequate choline and betaine can negatively affect folate metabolism and in turn downstream methylation and antioxidant capacity, we sought to determine whether dietary intake of choline and betaine in children with autism was adequate to meet nutritional needs based on national recommendations. Three-day food records were analyzed for 288 children with autism (ASDs) who participated in the national Autism Intervention Research Network for Physical Health (AIR-P) Study on Diet and Nutrition in children with autism. Plasma concentrations of choline and betaine were measured in a subgroup of 35 children with ASDs and 32 age-matched control children. The results indicated that 60–93% of children with ASDs were consuming less than the recommended Adequate Intake (AI) for choline. Strong positive correlations were found between dietary intake and plasma concentrations of choline and betaine in autistic children as well as lower plasma concentrations compared to the control group. We conclude that choline and betaine intake is inadequate in a significant subgroup of children with ASDs and is reflected in lower plasma levels. Inadequate intake of choline and betaine may contribute to the metabolic abnormalities observed in many children with autism and warrants attention in nutritional counseling.

Relationship between nutrients intake and the risk of prostate cancer

2018 ◽  
Vol 48 (4) ◽  
pp. 689-700 ◽  
Author(s):  
Amir Bagheri ◽  
Seyed Mostafa Nachvak ◽  
Hadi Abdollahzad ◽  
Peshawa Arzhang ◽  
Mansour Rezaei ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vitamin E ◽  
Dietary Intake ◽  
Design Methodology ◽  
Case Control Study ◽  
Dietary Vitamin ◽  
Vitamin B ◽  
Dietary Intakes ◽  
Content Type ◽  
Control Study

Purpose It has been suggested that there is a link between the dietary intake of certain nutrients and the risk of prostate cancer. The aim of this study is to examine the associations between dietary intakes of all nutrients and the risk of prostate cancer in Kermanshah. Design/methodology/approach This case-control study was conducted in Kermanshah, a province in the west of Iran in November of 2016. The sample consisted of 50 patients with confirmed prostate cancer, and 150 healthy men who matched in age with these cases and did not have any symptoms of prostate disorder were chosen as controls. Dietary intakes were collected by a semi-quantitative food frequency questionnaire that contained 147 food items and were then analyzed by Nutritionist 4 software. Findings After adjustment for potential confounding factor, highest tertile compared to lowest tertile of dietary vitamin E intake [odds ratio (OR) = 0.21; 95% confidence interval (CI) = 0.05-0.89], lycopene intake (OR = 0.11; 95% CI = 0.01-0.86) and magnesium intake (OR = 0.02; 95% CI = 0.01-0.55) had a protective effect on the incidence of prostate cancer. However, there were no associations between dietary intakes of fiber, vitamin A, vitamin D, vitamin B12, folate and calcium with prostate cancer. Originality/value The finding suggests that the dietary intakes of vitamin E, lycopene and magnesium could decrease the risk of prostate cancer. Nevertheless, dietary intake of other nutrients such as fiber, calcium, vitamins D, A, B12 and folate was not associated with prostate cancer.

scholarly journals Lower Plasma Levels of Antioxidant Vitamins in Patients with Metabolic Syndrome: A Case Control Study

2016 ◽  
Vol 25 (4) ◽  
pp. 689-700 ◽  
Author(s):  
Małgorzata Godala ◽  
Izabela Materek-Kuśmierkiewicz ◽  
Dariusz Moczulski ◽  
Maciej Rutkowski ◽  
Franciszek Szatko ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Plasma Levels ◽  
Case Control Study ◽  
Case Control ◽  
Antioxidant Vitamins ◽  
Lower Plasma ◽  
Control Study

Dietary Intake and Plasma Levels of Antioxidant Vitamins in Health and Disease: A Hospital-based Case-control Study

1995 ◽  
Vol 5 (3) ◽  
pp. 235-242 ◽  
Author(s):  
Ram B Singh ◽  
Mohammad A Niaz ◽  
Saraswati Ghosh ◽  
Raheena Beegum ◽  
Indira Bishnoi ◽  
...  
Keyword(s):  
Dietary Intake ◽  
Plasma Levels ◽  
Case Control Study ◽  
Case Control ◽  
Antioxidant Vitamins ◽  
Health And Disease ◽  
Control Study

scholarly journals Dietary intake and plasma levels of polyunsaturated fatty acids in early-stage Parkinson’s disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Dallah Yoo ◽  
Yunsook Lim ◽  
Yiseul Son ◽  
Hyunkyung Rho ◽  
Chaewon Shin ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Fatty Acids ◽  
Parkinson's Disease ◽  
Polyunsaturated Fatty Acids ◽  
Dietary Intake ◽  
Plasma Levels ◽  
Early Stage ◽  
Plasma Concentrations ◽  
Clinical Severity ◽  
Non Motor Symptoms

AbstractPolyunsaturated fatty acids (PUFA) are important for neuronal function and may contribute to the development of neurodegenerative diseases. Here, we investigated the correlation between dietary intake and plasma concentrations of PUFA and their associations with clinical severity in early-stage Parkinson’s disease (PD). In a case–control study with 38 patients with PD and 33 controls, we assessed dietary intake using food frequency questionnaires and simultaneously measured the plasma levels of five PUFA. No differences were observed in dietary total energy and lipid intake, including PUFA, between patients with PD and controls. However, α-linolenic acid (ALA), linoleic acid (LA), and arachidonic acid (AA) plasma levels were lower in patients with PD. The association between dietary intake and plasma PUFA concentrations was not significant in patients with PD. ALA and LA plasma levels were inversely correlated with motor severity in patients with PD, while docosahexaenoic acid and AA plasma levels were positively correlated with non-motor symptoms after controlling for age and sex.

scholarly journals Study of cognitive impairment and genetic polymorphism of SLC41A1 (rs11240569 allele) in Parkinson’s disease in Upper Egypt: case-control study

2021 ◽  
Vol 57 (1) ◽  
Author(s):  
Hamdy N. El-Tallawy ◽  
Tahia H. Saleem ◽  
Wafaa M. Farghaly ◽  
Heba Mohamed Saad Eldien ◽  
Ashraf Khodaery ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Motor Symptoms ◽  
And Control ◽  
Non Motor Symptoms ◽  
Control Study

Abstract Background Parkinson’s disease is one of the neurodegenerative disorders that is caused by genetic and environmental factors or interaction between them. Solute carrier family 41 member 1 within the PARK16 locus has been reported to be associated with Parkinson’s disease. Cognitive impairment is one of the non-motor symptoms that is considered a challenge in Parkinson’s disease patients. This study aimed to investigate the association of rs11240569 polymorphism; a synonymous coding variant in SLC41A1 in Parkinson’s disease patients in addition to the assessment of cognitive impairment in those patients. Results In a case -control study, rs11240569 single nucleotide polymorphisms in SLC41A1, genes were genotyped in 48 Parkinson’s disease patients and 48 controls. Motor and non-motor performance in Parkinson's disease patients were assessed by using the Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS). The genotype and allele frequencies were compared between the two groups and revealed no significant differences between case and control groups for rs11240569 in SLC41A1 gene with P value .523 and .54, respectively. Cognition was evaluated and showed the mean ± standard deviation (SD) of WAIS score of PD patients 80.4 ± 9.13 and the range was from 61 to 105, in addition to MMSE that showed mean ± SD 21.96 ± 3.8. Conclusion Genetic testing of the present study showed that rs11240569 polymorphism of SLC41A1 gene has no significant differences in distributions of alleles and genotypes between cases and control group, in addition to cognitive impairment that is present in a large proportion of PD patients and in addition to the strong correlation between cognitive impairment and motor and non-motor symptoms progression.

Dietary and serum vitamin D and preeclampsia risk in Chinese pregnant women: a matched case–control study

2021 ◽  
pp. 1-26
Author(s):  
Xue-min Huang ◽  
Yan-hua Liu ◽  
Han Zhang ◽  
Yuan Cao ◽  
Wei-feng Dou ◽  
...  
Keyword(s):  
Vitamin D ◽  
Dietary Intake ◽  
Pregnant Women ◽  
Case Control Study ◽  
Serum Levels ◽  
Case Control ◽  
Serum Concentrations ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

Abstract The effect of vitamin D (VD) on the risk of preeclampsia (PE) is uncertain. Few of previous studies focused on the relationship between dietary VD intake and PE risk. Therefore, we conducted this 1:1 matched case-control study to explore the association of dietary VD intake and serum VD concentrations with PE risk in Chinese pregnant women. A total of 440 pairs of participants were recruited during March 2016 to June 2019. Dietary information was obtained using a 78-item semi-quantitative food frequency questionnaire. Serum concentrations of 25(OH)D2 and 25(OH)D3 were measured by liquid chromatography–tandem mass spectrometry. Multivariate conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic splines (RCS) were plotted to evaluate the dose-response relationship of dietary VD intake and serum VD concentrations with PE risk. Compared with the lowest quartile, the ORs of the highest quartile were 0.45 (95%CI: 0.29-0.71, Ptrend = 0.001) for VD dietary intake and 0.26 (95%CI: 0.11-0.60, Ptrend = 0.003) for serum levels after adjusting for confounders. In addition, the RCS analysis suggested a reverse J-shaped relationship between dietary VD intake and PE risk (P-nonlinearity = 0.02). A similar association was also found between serum concentrations of total 25(OH)D and PE risk (P-nonlinearity = 0.02). In conclusion, this study provides evidence that higher dietary intake and serum levels of VD are associated with the lower risk of PE in Chinese pregnant women.

Dietary intake of vegetables, fruit, and antioxidants and risk of ulcerative colitis: a case-control study in Japan

Nutrition ◽  
2021 ◽  
pp. 111378
Author(s):  
Yoshihiro Miyake ◽  
Keiko Tanaka ◽  
Chisato Nagata ◽  
Shinya Furukawa ◽  
Akira Andoh ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Dietary Intake ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

scholarly journals Dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and risk of Parkinson's disease: a case–control study in Japan

2010 ◽  
Vol 104 (5) ◽  
pp. 757-764 ◽  
Author(s):  
Kentaro Murakami ◽  
Yoshihiro Miyake ◽  
Satoshi Sasaki ◽  
Keiko Tanaka ◽  
Wakaba Fukushima ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dietary Intake ◽  
Case Control Study ◽  
Case Control ◽  
B Vitamins ◽  
Vitamin B ◽  
Increased Risk ◽  
The Uk ◽  
Control Study

Increased homocysteine levels might accelerate dopaminergic cell death in Parkinson's disease (PD) through neurotoxic effects; thus, increasing intake of B vitamins involved in the regulation of homocysteine metabolism might decrease the risk of PD through decreasing plasma homocysteine. However, epidemiological evidence for the association of dietary B vitamins with PD is sparse, particularly in non-Western populations. We conducted a hospital-based case–control study in Japan to examine associations between dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and the risk of PD. Patients with PD diagnosed using the UK PD Society Brain Bank criteria (n 249) and controls without neurodegenerative diseases (n 368) were recruited. Dietary intake during the preceding month was assessed at the time of study recruitment using a validated, self-administered, semi-quantitative, comprehensive diet history questionnaire. After adjustment for potential dietary and non-dietary confounding factors, intake of folate, vitamin B12 and riboflavin was not associated with the risk of PD (P for trend = 0·87, 0·70 and 0·11, respectively). However, low intake of vitamin B6 was associated with an increased risk of PD, independent of potential dietary and non-dietary confounders. Multivariate OR (95 % CI) for PD in the first, second, third and fourth quartiles of vitamin B6 were 1 (reference), 0·56 (0·33, 0·94), 0·69 (0·38, 1·25) and 0·48 (0·23, 0·99), respectively (P for trend = 0·10). In conclusion, in the present case–control study in Japan, low intake of vitamin B6, but not of folate, vitamin B12 or riboflavin, was independently associated with an increased risk of PD.

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