scholarly journals The trajectory of high sensitivity C-reactive protein is associated with incident diabetes in Chinese adults

2020 ◽  
Author(s):  
Ren-ying Xu ◽  
Xiaomin Jiang ◽  
Zhuping Fan ◽  
Yanping Wan ◽  
Xiang Gao
Keyword(s):  
Fasting Blood Glucose ◽  
Heart Association ◽  
High Sensitivity ◽  
Incident Diabetes ◽  
Chinese Adults ◽  
Low Level ◽  
Reactive Protein ◽  
Secondary Analyses ◽  
Hs Crp ◽  
High Level

Abstract Background We performed a cohort study to evaluate the association between the CRP trajectory and incident diabetes in Chinese adults. Methods Included were 6,439 adults (4,111 men and 2,249 women; aged 46.6±11.9 years). The concentration of high sensitivity CRP (hs-CRP) was measured in 2013 (baseline), 2014, and 2015. The hs-CRP trajectory was identified based the above three measurements by latent mixture modeling. Incident diabetes cases were diagnosed by fasting blood glucose (≥126mg/dl) or Hb A1c (≥6.5%) during subsequent three years (2016-2018). Results Hs-CRP level during 2013 -2015 was classified into 3 levels: low (<1.0 mg/L), moderate (1.0–3.0 mg/L), and high (≥3.0 mg/L) based on a statement by American Heart Association. We named four hs-CRP trajectories as following: “low-stable” (low in 2013 and maintained at low level in 2014 and 2015), “moderate-fluctuated” (moderate in 2013, then increased to high level in 2014, and decreased to low level in 2015), “high-decreased” (high in 2013 but decreased to moderate level in 2014 and 2015), and “moderate-increased (moderate in 2013 and increased to high level in 2014 and 2015)”. We identified 235 incident diabetes during subsequent three years. The adjusted HR for incident diabetes was 1.71 (95% CI: 1.02, 2.87) comparing the moderate-increased and the low-stable group, after adjusting for potential confounders. In the secondary analyses, baseline hs-CRP level and the average of hs-CRP were associations between higher hs-CRP concentration and higher diabetes risk were observed (P-trend<0.01 for both). Conclusions The hs-CRP trajectory pattern was associated with altered incident diabetes in Chinese adults.

scholarly journals The trajectory of high sensitivity C-reactive protein is associated with incident diabetes in Chinese adults

2020 ◽  
Author(s):  
Ren-ying Xu ◽  
Xiaomin Jiang ◽  
Zhuping Fan ◽  
Yanping Wan ◽  
Xiang Gao
Keyword(s):  
Fasting Blood Glucose ◽  
Heart Association ◽  
High Sensitivity ◽  
Incident Diabetes ◽  
High Concentration ◽  
Chinese Adults ◽  
Low Concentration ◽  
Reactive Protein ◽  
Secondary Analyses ◽  
Hs Crp

Abstract Background: We performed a cohort study to evaluate the association between the CRP trajectory and incident diabetes in Chinese adults. Methods: Included were 6,439 adults (4,111 men and 2,249 women; aged 46.6±11.9 years). The concentration of high sensitivity CRP (hs-CRP) was measured in 2013 (baseline), 2014, and 2015. The hs-CRP trajectory was identified based the above three measurements by latent mixture modeling. Incident diabetes cases were diagnosed by fasting blood glucose (³126mg/dl) or Hb A1c (³6.5%) during subsequent three years (2016-2018). Results: Hs-CRP concentration during 2013 -2015 was classified into 3 levels: low (<1.0 mg/L), moderate (1.0–3.0 mg/L), and high (³3.0 mg/L) based on a statement by American Heart Association. We named four hs-CRP trajectories as following: “low-stable” (low in 2013 and maintained at low concentration in 2014 and 2015), “moderate-fluctuated” (moderate in 2013, then increased to high concentration in 2014, and decreased to low concentration in 2015), “high-decreased” (high in 2013 but decreased to moderate concentration in 2014 and 2015), and “moderate-increased (moderate in 2013 and increased to high concentration in 2014 and 2015)”. We identified 235 incident diabetes during subsequent three years. The adjusted HR for incident diabetes was 1.71 (95% CI: 1.02, 2.87) comparing the moderate-increased and the low-stable group, after adjusting for potential confounders. In the secondary analyses, two single-measured hs-CRP concentration (in 2013 or in 2015) and the average of hs-CRP were associated with high risk of diabetes (P-trend<0.01 for all). Conclusions: The hs-CRP trajectory pattern was associated with altered incident diabetes in Chinese adults.

scholarly journals BMI, high-sensitivity C-reactive protein and the conversion from metabolically healthy to unhealthy phenotype in Chinese adults: a cohort study

2020 ◽  
pp. 1-8
Author(s):  
Renying Xu ◽  
Peixiao Shen ◽  
Chunhua Wu ◽  
Yanping Wan ◽  
Zhuping Fan ◽  
...  
Keyword(s):  
Cohort Study ◽  
Serum Uric Acid Level ◽  
Fasting Blood Glucose ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Chinese Adults ◽  
Reactive Protein ◽  
Metabolically Healthy ◽  
Hs Crp

Abstract Objective: We performed the cohort study to evaluate the association between BMI, high-sensitivity C-reactive protein (hs-CRP) and the conversion from metabolically healthy to unhealthy phenotype in Chinese adults. Design: Metabolically healthy was defined as participants without history of metabolic diseases and with normal fasting blood glucose level, glycated Hb A1c level, blood pressure, lipid profile, serum uric acid level and liver ultrasonographic findings at baseline. Participants were either classified into normal weight (18·5 ≤ BMI < 24·0 kg/m2) and overweight (BMI ≥ 24·0 kg/m2) based on baseline BMI, or low (<1 mg/l) and high (≥1 mg/l) groups based on baseline hs-CRP. The conversion from metabolically healthy to unhealthy phenotype was deemed if any of the metabolic abnormalities had been confirmed twice or more during 5 years of follow-up. Results: Included were 4855 (1942 men and 2913 women, aged 36·0 ± 8·9 years) metabolically healthy Chinese adults. We identified 1692 participants who converted to metabolically unhealthy phenotype during the follow-up. Compared with their counterparts, the adjusted hazards ratio of the conversion was 1·19 (95 % CI 1·07, 1·33) for participants with overweight, while it was 1·15 (95 % CI 1·03, 1·29) for those with high hs-CRP level (≥1 mg/l). Further adjustment of hs-CRP did not materially change the association between BMI and the conversion. However, the association between hs-CRP and the conversion was not significant after further adjustment of BMI. The sensitivity analysis generated similar results to main analysis. Conclusion: BMI was associated with the risk of the conversion from metabolically healthy to unhealthy status in Chinese adults.

scholarly journals The trajectory of high sensitivity C-reactive protein is associated with incident diabetes in Chinese adults

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Renying Xu ◽  
Xiaomin Jiang ◽  
Zhuping Fan ◽  
Yanping Wan ◽  
Xiang Gao
Keyword(s):  
High Sensitivity ◽  
Incident Diabetes ◽  
C Reactive Protein ◽  
Chinese Adults ◽  
Reactive Protein

Mediation effect of C-reactive protein in the relationship between abdominal obesity and intermediate hyperglycemia in Kuwaiti adolescents

2020 ◽  
Vol 14 (15) ◽  
pp. 1427-1437
Author(s):  
Hend Alqaderi ◽  
Ebaa Al-Ozairi ◽  
Saadoun Bin-Hasan ◽  
Mary Tavares ◽  
Jo M Goodson ◽  
...  
Keyword(s):  
Abdominal Obesity ◽  
Fasting Blood Glucose ◽  
High Sensitivity ◽  
Mediating Effect ◽  
Mediation Effect ◽  
Multilevel Regression ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
The Relationship

Aim: This study aimed to investigate the mediating effect of C-reactive protein (CRP) on obesity and hyperglycemia. Materials & methods: Fasting blood glucose, high-sensitivity CRP (hs-CRP) levels and waist circumference (WC) were measured on 353 participants. Multilevel regression modeling and mediation analyses were used to investigate the link between abdominal obesity, hs-CRP and hyperglycemia. Results: Elevation in hs-CRP was predictive of hyperglycemia in nonobese individuals (OR = 1.3, p = 0.03). With every 1-mg/l increase in hs-CRP, there was a 1-cm increase in WC (B = 0.87, p = 0.001). hs-CRP was a full mediator in the relationship between WC and hyperglycemia. Conclusion: hs-CRP predicts hyperglycemia development in nonobese individuals and the effect of increased WC on hyperglycemia was fully mediated by hs-CRP.

scholarly journals High-Sensitivity CRP (C-Reactive Protein) Is Associated With Incident Carotid Artery Plaque in Chinese Aged Adults

Stroke ◽  
2019 ◽  
Vol 50 (7) ◽  
pp. 1655-1660 ◽  
Author(s):  
Renying Xu ◽  
Yanan Zhang ◽  
Xiang Gao ◽  
Yanping Wan ◽  
Zhuping Fan
Keyword(s):  
Blood Pressure ◽  
High Risk ◽  
Risk Group ◽  
Fasting Blood Glucose ◽  
High Sensitivity ◽  
Carotid Artery Plaque ◽  
Reactive Protein ◽  
Hs Crp ◽  
Prospective Analyses

Background and Purpose— CRP (C-reactive protein) is an inflammatory biomarker which predicts the risk of cardiovascular diseases. However, whether CRP is associated with carotid artery plaque (CAP) remains unclear. Methods— The current retrospective study was performed in 8229 Chinese aged adults (aged 65–99 years; 4677 men and 3552 women). hs-CRP (high-sensitivity CRP) concentrations were measured at baseline (2013), and further classified into 3 groups: low risk (<1.0 mg/L), intermediate risk (1.0–3.0 mg/L), and high risk (≥3.0 mg/L). Ultrasound B-mode imaging was repeatedly performed annually to detect CAP during 5-year follow-up (2013–2018). Potential confounders, including body mass index, blood pressure, fasting blood glucose, alanine transferase, aspartate transferase, alkaline phosphatase, gamma-glutamyl transferase, total bilirubin, direct bilirubin, blood urea nitrogen, creatinine, and uric acid, lipid profiles, were also collected at baseline. White blood cell was collected as well. We used a logistic regression model for the cross-sectional relation between CRP concentration and CAP status and proportional hazardous Cox model for prospective analyses. Results— Comparing to the low-risk group, the adjusted odds ratios for CAP was 1.66 (95% CI, 1.43–1.92) in the intermediate-risk group and 1.72 (95% CI, 1.39–2.13) in the high-risk group, after adjustment for potential confounders. We identified 512 incident CAP cases during 5-year follow-up. Each mg/L increase of hs-CRP was associated with a hazard ratio of 1.1 (95% CI, 1.03–1.17) to developing CAP. Sensitivity analysis generated similar results with prospective analyses after excluding participants with overweight and obesity, with elevated fasting blood glucose, LDL (low-density lipoprotein) cholesterol, and white blood cell. The association lost significant when we excluded participants with elevated blood pressure, however, few cases of CAP (n=41) was recruited in participants with normal blood pressure during follow-up. Conclusions— High hs-CRP concentration was associated with the high risk of developing CAP in Chinese aged adults.

scholarly journals Prevalence of cardiometabolic risk factors among Malaysian obese adults

2016 ◽  
Vol 15 (1) ◽  
Author(s):  
Siti Zuhaidah Shahadan ◽  
Azlina Daud ◽  
Muhammad Lokman Md Isa ◽  
Samsul Deraman ◽  
Muhammad Ibrahim
Keyword(s):  
Risk Factors ◽  
Cardiometabolic Risk ◽  
Fasting Blood Glucose ◽  
High Sensitivity ◽  
Obese Adults ◽  
Mean Values ◽  
Reactive Protein ◽  
High Prevalence ◽  
The Mean ◽  
Hs Crp

Introduction: Obese adults are associated with increased cardiometabolic risk (CMR). The study aims to investigate the prevalence of CMR factor abnormalities in obese adults in Kuantan. Methods: Seventy-six obese adults with a mean (standard deviation) age of 33.7 years (9.8 years) participated in this study. All participants had a waist circumference (WC) measured, blood pressure (BP) taken, and assessment of fasting blood glucose (FBG), lipid profile (LP) and high-sensitivity C-reactive protein (hs-CRP) level. Results: For CMR factors, the mean values for WC was 97.2 ± 9.6 cm, mean overall BP was 119 ± 15/76 ± 11 mmHg, mean FBG level was 4.8 ± 0.5 mmol/L and the mean of total cholesterol (TC) and triglyceride (TG) was 5.4 ± 1.0 mmol/L and 1.4 ± 0.7 mmol/L, respectively. Lastly, the mean of hs-CRP was 6.0 ± 6.1 mg/L. The CMR factors with the highest prevalence of abnormal values included WC (male 100%; female 98%) and TC (male 73.1%; female 52%) for both genders, systolic BP (50%) and TG level (61.5%) for male, and hs-CRP level (68%) for female. Out of the nine CMR factors measured, five CMR risk factors were shown to have a high prevalence of abnormalities. Conclusions: The present study suggests that obese adults in Kuantan have multiple CMR factor abnormalities. A larger trial, sensibly informed of this trial, can now build upon and confirm these results.

scholarly journals Serum miR-222 is independently associated with atrial fibrillation in patients with degenerative valvular heart disease

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hualan Zhou ◽  
Sen Lin ◽  
Xia Li ◽  
Dianxuan Guo ◽  
Yun Wang ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Heart Disease ◽  
Valvular Heart Disease ◽  
Fasting Blood Glucose ◽  
High Sensitivity ◽  
Serum Levels ◽  
Reactive Protein ◽  
Hs Crp ◽  
Medical University ◽  
Control Study

Abstract Background Inflammation is involved in the progression of degenerative valvular heart disease (DVHD). microRNA-222 (miR-222) contributes to inflammation-mediated vascular remodeling, but its involvement in DVHD in relation to atrial fibrillation (AF) is unknown. This study aimed to investigate the changes in miR-222, interleukin (IL)-6, high-sensitivity C-reactive protein (hs-CRP), and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with DVHD complicated with AF. Methods This was a case control study of patients with DVHD who were hospitalized at the Geriatrics Department of the Affiliated Huai’an Hospital of Xuzhou Medical University between 01/2017 and 08/2018. The participants were grouped according to the presence of AF, and serum miR-222, IL-6, hs-CRP, and NT-proBNP levels were compared. Results There were fifty-two participants (28 males) in the DVHD with AF group, aged 60–80 years (73.0 ± 5.9 years). Sixty participants (31 males) were included in the DVHD without AF group, aged 60–80 years (71.9 ± 6.92 years). There were no significant differences in age, sex, body mass index, fasting blood glucose, triglycerides, cholesterol, and blood pressure between the two groups. The serum levels of miRNA-222, IL-6, hs-CRP, and NT-proBNP in DVHD patients were significantly higher in those with AF compared with the non-AF group (all P < 0.05). Correlation analyses revealed that IL-6, hs-CRP, and NT-proBNP levels were positively correlated with miR-222 levels in all patients (IL-6: r = 0.507, P < 0.01; hs-CRP: r = 0.390, P < 0.01; NT-proBNP: r = 0.509, P < 0.01). Conclusions Serum miR-222 was independently associated with AF in patients with DVHD.

scholarly journals High Sensitivity C-Reactive Protein Increases the Risk of Carotid Plaque Instability in Male Dyslipidemic Patients

Diagnostics ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 2117
Author(s):  
Manuel Scimeca ◽  
Manuela Montanaro ◽  
Marina Cardellini ◽  
Rita Bonfiglio ◽  
Lucia Anemona ◽  
...  
Keyword(s):  
Carotid Plaque ◽  
Smoking Habit ◽  
Density Lipoprotein ◽  
Heart Association ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Plaque Instability ◽  
Reactive Protein ◽  
Asymptomatic Patients ◽  
Hs Crp

Background: The aim of this study was to evaluate how the high sensitivity C-reactive protein (hs-CRP) values influence the risk of carotid plaque instability in association with other cardiovascular risk factors. Methods: One hundred and fifty-six carotid plaques from both symptomatic and asymptomatic patients requiring surgical carotid endarterectomy were retrospectively collected. According to the modified American Heart Association, atherosclerosis plaques have been histologically distinguished into unstable and stable. The following anamnestic and hematochemical data were also considered: age, gender, hypertension, diabetes mellitus, smoking habit, therapy, low-density lipoprotein (LDL)-C, kidney failure and hs-CRP. Results: The results of our study clearly show that high levels of hs-CRP significantly increase the carotid plaque instability in dyslipidemic patients. Specifically, a 67% increase of the risk of carotid plaque instability was observed in patients with high LDL-C. Therefore, the highest risk was observed in male dyslipidemic patients 2333 (95% CI 0.73–7.48) and in aged female patients 2713 (95% CI 0.14–53.27). Discussion: These data strongly suggest a biological relationship between the hs-CRP values and the alteration of lipidic metabolism mostly in male patients affected by carotid atherosclerosis. The measurement of hs-CRP might be useful as a potential screening tool in the prevention of atheroscletotic disease.

scholarly journals HUBUNGAN KADAR KOLESTEROL HIGH DENSITY LIPOPROTEIN DARAH DENGAN KADAR HIGH SENSITIVITY C-REACTIVE PROTEIN PADA REMAJA OBES

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Jonathan Hanni Surentu
Keyword(s):  
High Density Lipoprotein ◽  
American Heart ◽  
Density Lipoprotein ◽  
Heart Association ◽  
High Sensitivity ◽  
High Density ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Hs Crp

Abstract: World Health Organization declared that obesity was a global epidemy (1,7 billion people obese). Obesity has a strong correlations with low high-density lipoprotein cholesterol (HDLc) level. Low HDLc level is the risk factor of coronary heart disease (CHD). High sensitivity C-reactive protein (hs-CRP) is an inflammatory marker in our body. Joint Committee of American Heart Association recommend hs-CRP examination as a risk factor of CHD. The research have aim to know the correlations of HDLc level with hs-CRP on obese adolescent. This research was an observational analytic cross-sectional approach. The population of this research are all obese students at Faculty of Medicine Sam Ratulangi University Manado with Body Mass Index (BMI) ≥ 95th centile, and the samples are all of the population. The result, more of half (58,8%) obese adolescents have normal HDLc level. And also found that more of half (52,9%) obese adolescents have hs-CRP level with intermediate risk  and two samples (11,8%) with high risk. The result of statistical analysis using the Spearman test showed the correlations (r) = -0,219 and the significance (p) = 0,399. There was no correlations between HDLc level with hs-CRP in obes adolescent. Keywords: Obesity, adolescent, HDLc, hs-CRP, CHD     Abstrak: Organisasi Kesehatan Dunia (WHO) mendeklarasikan obesitas sebagai epidemik global (1,7 miliar penduduk dunia obes). Obesitas memiliki hubungan yang erat dengan rendahnya kadar kolesterol high density lipoprotein (HDL) darah. Rendahnya kadar kolesterol HDL merupakan faktor risiko penyakit jantung koroner (PJK). High sensitivity C-reactive protein  (hs-CRP) merupakan suatu penanda peradangan dalam tubuh. Joint Committee of American Heart Association merekomendasikan pemeriksaan hs-CRP sebagai faktor risiko PJK. Tujuan penelitian ini untuk mengetahui hubungan kadar kolesterol HDL darah dengan kadar hs-CRP pada remaja obes. Penelitian ini menggunakan desain penelitian analitik observasional dengan pendekatan cross-sectional. Populasi pada penelitian ini adalah Mahasiswa obes Fakultas Kedokteran Universitas Sam Ratulangi Manado dengan IMT pada persentil ≥ 95. Sampel diambil dari seluruh populasi. Hasil penelitian didapatkan lebih dari setengah (58,8%) remaja obes memiliki kadar  kolesterol HDL di atas normal. Didapati juga lebih dari setengah (52,9%) remaja obes memiliki kadar hs-CRP dengan risiko menengah dan dua sampel (11,8%) dengan risiko tinggi. Hasil uji statistik spearman antar dua variabel didapati koefisien korelasi (r) = -0,219 dan nilai signifikansi (p) = 0,399. Berdasarkan hasil analisis dapat disimpulkan bahwa tidak terdapat hubungan antara  kadar kolesterol HDL darah dengan kadar hs-CRP pada remaja obes. Kata kunci: Obesitas, remaja, kolesterol HDL, hs-CRP, PJK

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