High Sensitivity C-Reactive Protein Increases the Risk of Carotid Plaque Instability in Male Dyslipidemic Patients

Background: The aim of this study was to evaluate how the high sensitivity C-reactive protein (hs-CRP) values influence the risk of carotid plaque instability in association with other cardiovascular risk factors. Methods: One hundred and fifty-six carotid plaques from both symptomatic and asymptomatic patients requiring surgical carotid endarterectomy were retrospectively collected. According to the modified American Heart Association, atherosclerosis plaques have been histologically distinguished into unstable and stable. The following anamnestic and hematochemical data were also considered: age, gender, hypertension, diabetes mellitus, smoking habit, therapy, low-density lipoprotein (LDL)-C, kidney failure and hs-CRP. Results: The results of our study clearly show that high levels of hs-CRP significantly increase the carotid plaque instability in dyslipidemic patients. Specifically, a 67% increase of the risk of carotid plaque instability was observed in patients with high LDL-C. Therefore, the highest risk was observed in male dyslipidemic patients 2333 (95% CI 0.73–7.48) and in aged female patients 2713 (95% CI 0.14–53.27). Discussion: These data strongly suggest a biological relationship between the hs-CRP values and the alteration of lipidic metabolism mostly in male patients affected by carotid atherosclerosis. The measurement of hs-CRP might be useful as a potential screening tool in the prevention of atheroscletotic disease.

Download Full-text

HUBUNGAN KADAR KOLESTEROL HIGH DENSITY LIPOPROTEIN DARAH DENGAN KADAR HIGH SENSITIVITY C-REACTIVE PROTEIN PADA REMAJA OBES

Jurnal e-Biomedik ◽

10.35790/ebm.2.1.2014.3684 ◽

2014 ◽

Vol 2 (1) ◽

Author(s):

Jonathan Hanni Surentu

Keyword(s):

High Density Lipoprotein ◽

American Heart ◽

Density Lipoprotein ◽

Heart Association ◽

High Sensitivity ◽

High Density ◽

C Reactive Protein ◽

Cross Sectional ◽

Reactive Protein ◽

Hs Crp

Abstract: World Health Organization declared that obesity was a global epidemy (1,7 billion people obese). Obesity has a strong correlations with low high-density lipoprotein cholesterol (HDLc) level. Low HDLc level is the risk factor of coronary heart disease (CHD). High sensitivity C-reactive protein (hs-CRP) is an inflammatory marker in our body. Joint Committee of American Heart Association recommend hs-CRP examination as a risk factor of CHD. The research have aim to know the correlations of HDLc level with hs-CRP on obese adolescent. This research was an observational analytic cross-sectional approach. The population of this research are all obese students at Faculty of Medicine Sam Ratulangi University Manado with Body Mass Index (BMI) ≥ 95th centile, and the samples are all of the population. The result, more of half (58,8%) obese adolescents have normal HDLc level. And also found that more of half (52,9%) obese adolescents have hs-CRP level with intermediate risk and two samples (11,8%) with high risk. The result of statistical analysis using the Spearman test showed the correlations (r) = -0,219 and the significance (p) = 0,399. There was no correlations between HDLc level with hs-CRP in obes adolescent. Keywords: Obesity, adolescent, HDLc, hs-CRP, CHD Abstrak: Organisasi Kesehatan Dunia (WHO) mendeklarasikan obesitas sebagai epidemik global (1,7 miliar penduduk dunia obes). Obesitas memiliki hubungan yang erat dengan rendahnya kadar kolesterol high density lipoprotein (HDL) darah. Rendahnya kadar kolesterol HDL merupakan faktor risiko penyakit jantung koroner (PJK). High sensitivity C-reactive protein (hs-CRP) merupakan suatu penanda peradangan dalam tubuh. Joint Committee of American Heart Association merekomendasikan pemeriksaan hs-CRP sebagai faktor risiko PJK. Tujuan penelitian ini untuk mengetahui hubungan kadar kolesterol HDL darah dengan kadar hs-CRP pada remaja obes. Penelitian ini menggunakan desain penelitian analitik observasional dengan pendekatan cross-sectional. Populasi pada penelitian ini adalah Mahasiswa obes Fakultas Kedokteran Universitas Sam Ratulangi Manado dengan IMT pada persentil ≥ 95. Sampel diambil dari seluruh populasi. Hasil penelitian didapatkan lebih dari setengah (58,8%) remaja obes memiliki kadar kolesterol HDL di atas normal. Didapati juga lebih dari setengah (52,9%) remaja obes memiliki kadar hs-CRP dengan risiko menengah dan dua sampel (11,8%) dengan risiko tinggi. Hasil uji statistik spearman antar dua variabel didapati koefisien korelasi (r) = -0,219 dan nilai signifikansi (p) = 0,399. Berdasarkan hasil analisis dapat disimpulkan bahwa tidak terdapat hubungan antara kadar kolesterol HDL darah dengan kadar hs-CRP pada remaja obes. Kata kunci: Obesitas, remaja, kolesterol HDL, hs-CRP, PJK

Download Full-text

KORELASI KADAR HIGH SENSITIVITY C-REACTIVE PROTEIN DENGAN KADAR LOW DENSITY LIPOPROTEIN PADA PENYANDANG OBES

Human Care Journal ◽

10.32883/hcj.v5i3.717 ◽

2020 ◽

Vol 5 (3) ◽

pp. 676

Author(s):

Rama Dhanivita Djamin

Keyword(s):

Interleukin 1 ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

High Sensitivity ◽

Low Grade ◽

Low Density ◽

C Reactive Protein ◽

Necrosis Factor Alpha ◽

Reactive Protein ◽

Hs Crp

Obesitas terjadi karena akumulasi lemak berlebih di dalam tubuh. Akumulasi lemak menimbulkan low grade inflammation pada jaringan adiposa, menyebabkan peningkatan sitokin inflamasi seperti tumor necrosis factor-alpha, interleukin-1 beta, dan interleukin-6 (IL-6). Peningkatan sekresi IL-6 merangsang hepar meningkatkan produksi protein fase akut. High sensitivity C-reactive protein (hs-CRP) sebagai penanda inflamasi merupakan protein fase akut. Low density lipoprotein (LDL-kolesterol) adalah lipoprotein yang paling banyak mengandung kolesterol. Peningkatan kadar hs-CRP dan kadar LDL-kolesterol pada obesitas diidentifikasi sebagai faktor risiko aterosklerosis. Penelitian ini bertujuan menganalisis hubungan hs-CRP dengan LDL-kolesterol pada penyandang obes, merupakan penelitian analitik rancangan potong lintang dilakukan September 2018 sampai Agustus 2019. Kadar hs-CRP diperiksa dengan metode enzyme linked immunoassay (ELISA), sedangkan kadar LDL-kolesterol dengan metode kalkulasi (rumus Friedewald). Uji korelasi Spearman digunakan untuk menganalisi data, jika didapatkan nilai p<0,05 korelasi dinyatakan bermakna. Subjek penelitian berjumlah 26 penyandang obes terdiri dari 6 laki-laki (23,1%) dan 20 perempuan (76,9%). Rerata umur subjek penelitian adalah 36,46(7,68) tahun. Rerata kadar hs-CRP dan kadar LDL-kolesterol adalah 5,08(1,28) mg/L dan 154,69(45,8) mg/dL. Analisis korelasi menunjukkan korelasi positif lemah dan tidak bermakna secara statistik antara kadar hs-CRP dengan kadar LDL-kolesterol (r= 0,333, p=0,096). Simpulan: Terdapat korelasi positif lemah antara kadar hs-CRP dengan kadar LDL-kolesterol pada penyandang obes.Kata kunci: Obesitas, High Sensitivity C-Reactive, Low Density Lipoprotein

Download Full-text

Association of Clinical Characteristics with the Proportion of the HDL-Cholesterol Subclasses HDL-2b and HDL-3 Among Patients Undergoing Hemodialysis

10.21203/rs.3.rs-30553/v1 ◽

2020 ◽

Author(s):

Jin-Bor Chen ◽

Wen-Chin Lee ◽

Sin-Hua Moi ◽

Cheng-Hong Yang

Keyword(s):

Clinical Characteristics ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

High Sensitivity ◽

Healthy Individuals ◽

C Reactive Protein ◽

Reactive Protein ◽

Diabetic Status ◽

The Mean ◽

Hs Crp

Abstract Background: Altered high-density lipoprotein cholesterol (HDL-C) composition in patients with chronic kidney disease is common. However, reports on the distribution of HDL-C subclasses in patients undergoing hemodialysis (HD) are limited. Objective: We aimed to compare the two main HDL-C subclasses, HDL-2b and HDL-3, in two cohorts of HD patients and healthy individuals and examine their associations with clinical characteristics. Methods: A total of 164 prevalent HD patients and 71 healthy individuals in one hospital-facilitated outpatient clinic were enrolled from May 2019 to July 2019. The HDL-2b and HDL-3 proportions were measured and statistical analysis was performed. Results: The mean ages of HD patients and healthy individuals were 63 and 49.9 years, respectively. HD patients showed lower HDL-2b and HDL-3 proportions compared with those of healthy individuals (23.6% vs. 31.2%, P < 0.001; 31.7% vs. 33.6%, P = 0.137, respectively). The HDL-2b proportion was significantly higher with a high-sensitivity C-reactive protein (hs-CRP) levels of <3 mg/L compared with hs-CRP ≥3mg/L in the HD cohort (P = 0.005). HDL-3 proportion was lower with a hs-CRP level of <3 mg/L compared with hs-CRP ≥3mg/L in the HD cohort (P = 0.022). Sex and diabetes did not influence the HDL-2b and HDL-3 proportions in the HD cohort.Conclusions: HD patients had lower HDL-2b and HDL-3 proportions than those of healthy individuals. The distribution of the HDL-2b and HDL-3 subclasses in HD patients is influenced by proinflammatory status, not by sex and diabetic status.

Download Full-text

Ten-year standardization of lipids and high-sensitivity C-reactive protein in a randomized controlled trial to assess the effects of statins on secondary stroke prevention: Japan Statin Treatment Against Recurrent Stroke

Annals of Clinical Biochemistry International Journal of Laboratory Medicine ◽

10.1177/0004563217693651 ◽

2017 ◽

Vol 55 (1) ◽

pp. 128-135 ◽

Cited By ~ 2

Author(s):

Masakazu Nakamura ◽

Tatsuyuki Fukukawa ◽

Kazuo Kitagawa ◽

Yoji Nagai ◽

Naohisa Hosomi ◽

...

Keyword(s):

Stroke Prevention ◽

Recurrent Stroke ◽

Density Lipoprotein ◽

High Sensitivity ◽

Statin Treatment ◽

Secondary Stroke Prevention ◽

C Reactive Protein ◽

Reactive Protein ◽

Study Results ◽

Hs Crp

Background The Japan Statin Treatment Against Recurrent Stroke (J-STARS) is a clinical trial that administered pravastatin for secondary stroke prevention. Lipid concentrations are a well-established risk factor for cerebrovascular diseases. Elevated high-sensitivity C-reactive protein (hs-CRP) indicates a high risk of inflammatory reactions. In clinical trials, internationally approved standardization is essential for obtaining study results that are comparable with those from overseas. Therefore, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and hs-CRP were standardized throughout a 10-year study period. Methods J-STARS specified a single clinical laboratory for blood analyses. Four lipids were evaluated by calculating the total error: accuracy (absolute mean %bias vs. reference value) + precision (1.96 among-run coefficient of variation [CV, %]). Accuracy for hs-CRP was ensured using a calibrator traceable to the international plasma protein reference material and precision was evaluated by CV. Results Average total errors (standard deviation, %) throughout the study period were as follows: TC 1.35% (0.290%), HDL-C 2.45% (1.087%), LDL-C 2.65% (0.956%) and TG 3.70% (0.559%). Four lipids met the performance criteria of the US Centers for Disease Control and Prevention (CDC). The precision of hs-CRP was 3.28% (0.627%), which met the performance criterion established by the American Heart Association/CDC. Conclusions Based on standardization, the results of J-STARS appear to be comparable with those of similar intervention-based clinical studies on statins overseas. These study results will contribute to the establishment of preventive measures against recurrent stroke in Japanese patients. J-STARS is registered in ClinicalTrials.gov under NCT00221104.

Download Full-text

HUBUNGAN KADAR KOLESTROL LOW DENSITY LIPOPROTEIN PLASMA DENGAN KADAR HIGH SENSITIVITY C-REACTIVE PROTEIN PADA REMAJA OBES

Jurnal e-Biomedik ◽

10.35790/ebm.2.1.2014.3702 ◽

2014 ◽

Vol 2 (1) ◽

Author(s):

Daniel Budiono

Keyword(s):

Low Density Lipoprotein ◽

Density Lipoprotein ◽

High Sensitivity ◽

Low Density ◽

C Reactive Protein ◽

Cross Sectional ◽

Obese Adolescents ◽

Reactive Protein ◽

Spearman Correlation Test ◽

Hs Crp

Abstract: Atherosclerosis is the leading cause of mortality in the developed countries and in the future, it is predicted to be the leading cause of mortality in the developing countries. Low density lipoprotein, high sensitivity C-reactive protein, and obesity have been identified as risk factors of atherosclerosis. Obesity during childhood and adolescents tends to occur during adults life. The aim of this study is to know the levels of low density lipoprotein and high sensitivity C-reactive protein and the correlation between those two levels in obese adolescents. This observational cross sectional study design involved 17 obese adolescents and analyzed using Spearman Correlation Test. The results showed the mean levels of LDL was 123,0 mg/dL, and hs-CRP was 1,618 mg/L. Spearman correlation test showed significance value (p) was 0,024 and correlation significance value coefficient was 0,544. From the results can be concluded that the levels of low density lipoprotein levels in obese adolescents is in normal range, obese adolescents are associated with a moderate risk of cardiovascular disease at the future and there is a significant positive correlation between low density lipoprotein cholestrol levels and high sensitivity C-reactive protein levels in obese adolescents. Keywords : low density lipoprotein, high sensitivity c-reactive protein, obese adolescents Abstrak: Aterosklerosis merupakan penyebab kematian utama di negara maju saat ini, dan diprediksi akan menjadi penyebab kematian utama di negara berkembang di masa mendatang. Peningkatan kadar low density lipoprotein dan kadar high sensitivity C-reactive protein (hs-CRP) serta obesitas telah diidentifikasi sebagai faktor risiko aterosklerosis. Remaja yang mengalami obesitas cenderung tetap mengalami obesitas pada saat dewasa. Tujuan dari penelitian ini untuk mengetahui gambaran kadar kolestrol low density lipoprotein dan kadar high sensitivity C-reactive protein pada remaja obes, serta hubungan kadar low density lipoprotein dengan kadar high sensitivity C-reactive protein pada remaja obes. Penelitian ini menggunakan desain penelitian analitik observasional dengan pendekatan cross sectional terhadap 17 remaja obes. Nilai rerata kadar LDL pada remaja obes 123,00 mg/dL, dan nilai rerata kadar hs-CRP pada remaja obes 1,618 mg/L. Berdasarkan hasil penelitian, dapat disimpulkan remaja obes memiliki kadar LDL dalam rentang normal, remaja obes memiliki risiko sedang terkena penyakit kardiovaskular di masa mendatang dan terdapat hubungan positif yang signifikan antara kadar low density lipoprotein dengan kadar high sensitivity c-reactive protein pada remaja obes. Kata Kunci: low density lipoprotein, high sensitivity c-reactive protein, remaja obes

Download Full-text

Clinical Efficacy of an Automated High-Sensitivity C-Reactive Protein Assay

Clinical Chemistry ◽

10.1093/clinchem/45.12.2136 ◽

1999 ◽

Vol 45 (12) ◽

pp. 2136-2141 ◽

Cited By ~ 434

Author(s):

Nader Rifai ◽

Russell P Tracy ◽

Paul M Ridker

Keyword(s):

Confidence Interval ◽

Clinical Efficacy ◽

Prospective Studies ◽

Smoking Habit ◽

High Sensitivity ◽

Case Group ◽

C Reactive Protein ◽

Protein Assay ◽

Reactive Protein ◽

Hs Crp

Abstract Background: Prospective studies have shown that C-reactive protein (CRP) can be used to predict risk of future cardiovascular events. High-sensitivity methods for CRP (hs-CRP) measurement are needed for this purpose. Methods: We compared the clinical efficacy of an automated and commercially available latex-enhanced assay (Latex) for hs-CRP (Dade Behring) to a validated in-house ELISA, previously shown to predict future peripheral arterial disease (PAD) in asymptomatic populations. Using a prospective, nested, case-control design, we measured baseline hs-CRP concentrations in 144 apparently healthy men who subsequently developed symptomatic PAD and 144 age- and smoking habit-matched controls who remained free of vascular disease over the follow-up period of 60 months. Results: The two hs-CRP assays correlated highly (r = 0.95; P <0.001), and all but two participants were classified into concordant quartiles or varied by only one quartile. The median hs-CRP of the case group was significantly higher than that of controls when measured by either the ELISA (1.34 vs 0.99 mg/L; P = 0.034) or the Latex method (1.80 vs 1.20 mg/L; P = 0.042). Furthermore, for both ELISA and the Latex method, the calculated relative risks of developing PAD increased significantly with each increasing quartile of hs-CRP. The calculated interquartile increase in relative risk of PAD was 31% (95% confidence interval, 5.2–62.2%; P = 0.01) for ELISA and 34% (95% confidence interval, 8.2–66.1%; P = 0.007) for the Latex method. Conclusions: Our findings indicate that the Latex method is equally as efficacious as the validated ELISA in classifying patients into cutoff points established by prospective studies for risk stratification for coronary and cerebrovascular disease.

Download Full-text

Hubungan Profil Lipid dan Kadar High-Sensitivity C-Reactive Protein dengan Outcome Pasien Stroke Iskemik Akut

Smart Medical Journal ◽

10.13057/smj.v3i2.43779 ◽

2020 ◽

Vol 3 (2) ◽

pp. 48

Author(s):

Stefanus Erdana Putra ◽

Fauzi Novia Isnaening Tyas ◽

Muhammad Hafizhan ◽

Raden Ajeng Hanindia Riani Prabaningtyas ◽

Diah Kurnia Mirawati

Keyword(s):

Ischemic Stroke ◽

Lipid Profile ◽

Barthel Index ◽

Density Lipoprotein ◽

High Sensitivity ◽

National Institutes Of Health ◽

C Reactive Protein ◽

Stroke Patients ◽

Reactive Protein ◽

Hs Crp

Pendahuluan: Stroke adalah penyebab utama kecacatan jangka panjang dengan dampak klinis dan sosial ekonomi yang signifikan di seluruh dunia. Hiperlipidemia dan inflamasi memainkan peranan penting dalam patofisiologi stroke iskemik. Meskipun high-sensitivity C-Reactive Protein (hs-CRP) dan kadar lipid merupakan penentu risiko penyakit pembuluh darah, kekuatan penggunaan biomarker ini dalam penentuan prognosis stroke iskemik belum dapat dipastikan. Penelitian ini bertujuan untuk mengetahui hubungan kadar hs-CRP dan profil lipid pada pasien stroke iskemik akut di Rumah Sakit Universitas Sebelas Maret dan memahami hubungan antara biomarker tersebut dengan outcome jangka pendek.Metode penelitian: Penelitian cross-sectional dilakukan pada 34 pasien dengan serangan stroke iskemik pertama kali. Profil lipid dan hs-CRP diukur pada hari pertama masuk rumah sakit. Defisit neurologis diukur menggunakan National Institutes of Health Stroke Scale (NIHSS) dan outcome diukur menggunakan Barthel Index pada hari ke-7 perawatan di unit stroke. Selanjutnya, kadar serum hs-CRP dan profil lipid dianalisis korelasinya dengan defisit neurologis dan outcome jangka pendek.Hasil penelitian: Pasien stroke iskemik memiliki kadar hs-CRP, kolesterol total (TC), trigliserida (TG), low-density lipoprotein (LDL) yang lebih tinggi; serta kadar high-density lipoprotein (HDL) yang lebih rendah dari kriteria normal. Berdasarkan uji korelasi Pearson, LDL memiliki korelasi signifikan dengan NIHSS (r = 0,447; p = 0,008) sedangkan hs-CRP memiliki korelasi signifikan yang lebih kuat dengan Barthel Index daripada NIHSS (r = -0,412; p = 0,015). TC dan HDL juga memiliki korelasi signifikan dengan NIHSS.Kesimpulan: Penelitian ini menunjukkan bahwa profil lipid dan hs-CRP dapat digunakan sebagai prediktor prognosis outcome stroke iskemik akut. Introduction: Stroke is the leading cause of long-term disability with significant clinical and socioeconomic impact worldwide. Hyperlipidemia and inflammation play major roles in ischemic stroke. While high-sensitivity C-Reactive Protein (hs-CRP) and lipid levels are established risk determinants for vascular disease, the relative strength of these biomarkers for ischemic stroke is uncertain. The purpose of this study is to investigate the association of hs-CRP levels and lipid profile in acute ischemic stroke patients and understand correlation between those markers and short-term outcome.Methods: This was a cross-sectional study of 34 first-timer ischemic stroke patients. Lipid profiles and hs-CRP were measured on admission day. The neurological deficit was quantified using National Institutes of Health Stroke Scale (NIHSS) and outcome was quantified using Barthel Index at the 7th day in stroke unit. Serum level of hs-CRP and lipid profile were estimated and correlated with neurological deficit and short-term outcome.Results: Ischemic stroke patients had higher levels of hs-CRP, total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL); and lower level of high-density lipoprotein (HDL) than normal criteria. Based on Pearson correlation test, LDL had significant correlation with NIHSS (r=0.447; p=0.008) while hs-CRP had stronger significant correlation with Barthel Index than NIHSS (r=-0.412; p=0.015). TC and HDL also had significant correlation with NIHSS.Conclusions: This research suggests that lipid profile and hs-CRP can be used as predictors of prognosis for acute ischemic stroke outcome. Keywords: Barthel index, C-reactive protein, National Institutes of Health Stroke Scale, lipid profile, ischemic stroke.

Download Full-text

High Sensitivity C-reactive Protein Concentrations, Lipid Status And Duration Of Type-1 Diabetes

10.21203/rs.3.rs-15946/v1 ◽

2020 ◽

Author(s):

HAUWA BAKO ◽

Salisu Babura Mu'azu ◽

Alkali Mohammed ◽

Muhammmad Yalwa Gwarzo ◽

Ibrahim Danjummai Gezawa ◽

...

Keyword(s):

Type 1 Diabetes ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

High Sensitivity ◽

Lipoprotein Cholesterol ◽

C Reactive Protein ◽

Reactive Protein ◽

Lipid Status ◽

Hs Crp

Abstract Background: Low-grade inflammation, duration of diabetes, hyperglycemia, and dyslipidemia in the presence of other traditional risk factors have been implicated in the development of vascular, neurologic, musculoskeletal and dermatologic complications observed in type 1 diabetes irrespective of other confounding factors. The study was aimed at assessing the relationship between hs-CRP concentrations, lipid status and duration of type-1 diabetes.Methods: Thirty-four patients aged 15-26 years comprising 14 females and 20 males diagnosed with type 1 diabetes ≤10 years duration, who at first clinical assessment and thorough medical examination presented with any or a combination of the symptoms of ketoacidosis, polyuria, polydipsia, malnutrition, blurred vision, paresthesia, body swelling and frothy urine at the Accident and Emergency Unit of Rasheed Shekoni Specialist Hospital, Jigawa Nigeria were enrolled for the study in a cross-sectional pattern after granting informed consent or obtaining assent from parents or guardians. Blood samples for lipid profile, fasting plasma glucose (FPG) and High sensitivity C - reactive protein (hs-CRP) measurement were collected from all patients through venipuncture after 10 hours overnight fast for biochemical testing. Lipid profile and FPG were assayed using enzymatic methods, hs- CRP via Enzyme Linked immunosorbent Assay (ELISA) technique and Urinalysis with point of care urine test strips. Data obtained was analyzed and presented as Frequency, Percentages, Mean ± SD and Pearson’s correlation with statistical significance at p≤0.05.Results: Patients biochemical characteristics were Fasting Plasma Glucose (9.86 ± 4.44), Total Cholesterol (4.77 ± 2.07), High Density Lipoprotein- Cholesterol (1.35±0.54), Triglycerides (2.17 ± 1.06), Low Density Lipoprotein- Cholesterol (2.29 ±1.49), hs-CRP (6.99 ± 5.44). Correlation matrix showed significant relationship between Triglycerides and hs-CRP (r; 0.378**, p; 0.005), Low Density Lipoprotein-Cholesterol and hs-CRP (r; 0.457*, p; 0.007). hs- CRP concentrations in relation to duration of type-1 diabetes were 1-3 years (3.57±4.10), 3-6 years (6.66±4.39) and 6-10 years (10.06±8.69).Conclusions: Evaluation of hs-CRP concentrations irrespective of lipid status may serve as an inexpensive method of predicting the risk of development of diabetic complications in resource poor settings among patients with established type 1 diabetes as the duration progresses.

Download Full-text

855 Both ramipril and telmisartan reduce serum levels of high-sensitivity C-reactive protein without affecting low-density lipoprotein cholesterol oxidation in patients with type II diabetes mellitus

European Heart Journal ◽

10.1016/s0195-668x(03)94193-5 ◽

2003 ◽

Vol 24 (5) ◽

pp. 145 ◽

Cited By ~ 1

Author(s):

S KOULOURIS

Keyword(s):

Type Ii Diabetes ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

High Sensitivity ◽

Serum Levels ◽

Type Ii Diabetes Mellitus ◽

Cholesterol Oxidation ◽

C Reactive Protein ◽

Low Density Lipoprotein Cholesterol ◽

Reactive Protein

Download Full-text

Associations between Pre-Bariatric High-Sensitivity C-Reactive Protein and Post-Surgery Outcomes

Diagnostics ◽

10.3390/diagnostics11040721 ◽

2021 ◽

Vol 11 (4) ◽

pp. 721

Author(s):

Tannaz Jamialahmadi ◽

Mohsen Nematy ◽

Simona Bo ◽

Valentina Ponzo ◽

Ali Jangjoo ◽

...

Keyword(s):

Bariatric Surgery ◽

Morbid Obesity ◽

Weight Loss ◽

Success Rate ◽

Liver Stiffness ◽

High Sensitivity ◽

C Reactive Protein ◽

Reactive Protein ◽

Post Surgery ◽

Hs Crp

Background: Obesity is a chronic inflammatory condition associated with increased circulating levels of C-reactive protein (CRP). Bariatric surgery has been reported to be effective in improving both inflammatory and liver status. Our aims were to elucidate the relationships between pre-surgery high sensitivity-CRP (hs-CRP) values and post-surgery weight loss and liver steatosis and fibrosis in patients with severe obesity undergoing Roux-en-Y gastric bypass. Methods: We conducted an observational prospective study on 90 individuals with morbid obesity, who underwent gastric bypass. Anthropometric indices, laboratory assessment (lipid panel, glycemic status, liver enzymes, and hs-CRP), liver stiffness and steatosis were evaluated at baseline and 6-months after surgery. Results: There was a significant post-surgery reduction in all the anthropometric variables, with an average weight loss of 33.93 ± 11.79 kg; the mean percentage of total weight loss (TWL) was 27.96 ± 6.43%. Liver elasticity was significantly reduced (from 6.1 ± 1.25 to 5.42 ± 1.52 kPa; p = 0.002), as well as liver aminotransferases, nonalcoholic fatty liver disease fibrosis score (NFS) and the grade of steatosis. Serum hs-CRP levels significantly reduced (from 9.26 ± 8.45 to 3.29 ± 4.41 mg/L; p < 0.001). The correlations between hs-CRP levels and liver fibrosis (elastography), steatosis (ultrasonography), fibrosis-4 index, NFS, and surgery success rate were not significant. Regression analyses showed that serum hs-CRP levels were not predictive of liver status and success rate after surgery in both unadjusted and adjusted models. Conclusions: In patients with morbid obesity, bariatric surgery caused a significant decrease in hs-CRP levels, liver stiffness and steatosis. Baseline hs-CRP values did not predict the weight-loss success rate and post-surgery liver status.

Download Full-text