Perinatal Mood Disorders in Second Trimester Pregnant Women with Cervical Insufficiency, a Population-based Cohort Study

Abstract Background: Perinatal mood disorders can seriously endanger the health of pregnant women and fetus, affect family relationships and cause heavy burden and potential hazards to family and society. This study aims to investigate anxiety and depression in second trimester pregnant women with cervical insufficiency (CI) and identify its risk factors, so as to provide guidance for daily clinic work.Methods: From April 2019 to July 2020, 98 mid-pregnancy women with CI underwent laparoscopic cervical cerclage in the First Affiliated Hospital of Sun Yat-sen University were selected as observation group and 166 normal pregnant women in second trimester were set as control group. Zung's Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) were applied to evaluate perinatal mood disorders in both groups.Results: Pregnant women in CI group had a SAS score of 46.31±11.29 and SDS score of 54.12±11.72, higher than the SAS score of 41.63±7.70 and SDS score of 47.56±9.31 in control group (both P<0.001). While 32.65% and 67.35% of pregnant women in observation group were considered to have different degrees of anxiety and depression, only 15.06% and 30.72% of normal pregnant women meet the same condition (both P<0.001). Multiple logistic regression analysis indicated that educational experience is an independent protective factor for depression disorder in second trimester pregnant women with CI.Conclusion: Pregnant women with CI are prone to develop anxiety and depression in the second trimester than normal pregnant women, therefore doctors and nurses should pay more attention to them in clinic work.

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POS0058-PARE INCREASING PREECLAMPSIA KNOWLEDGE IN SLE WITH A SPECIFIC EDUCATIONAL TOOL: PRELIMINARY RESULTS

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2021-eular.1480 ◽

2021 ◽

Vol 80 (Suppl 1) ◽

pp. 235.2-235

Author(s):

J. Y. E. Lee ◽

A. Mendel ◽

I. Malhamé ◽

S. Bernatsky ◽

E. Vinet

Keyword(s):

Systemic Lupus Erythematosus ◽

Pregnant Women ◽

Lupus Erythematosus ◽

Intervention Group ◽

Standard Of Care ◽

Vulnerable Population ◽

Control Group ◽

Educational Tool ◽

Second Trimester ◽

Systemic Lupus

Background:Pregnant women with systemic lupus erythematosus (SLE) are at high risk of preeclampsia, leading to substantial maternal and fetal morbidity. Aspirin reduces preeclampsia risk but recent studies suggest aspirin is used only in a minority of SLE pregnancies. There is an urgent need to improve preeclampsia counselling and management in this vulnerable population.Objectives:We are conducting the PREPARE (PREeclamPsia knowledge & Aspirin adheRence in lupus prEgnancies) trial, a randomized controlled trial (RCT) evaluating an educational tool on preeclampsia knowledge and aspirin adherence among pregnant women with SLE. We present preliminary analyses of the effect of this tool on preeclampsia knowledge.Methods:Consecutive pregnant SLE women are recruited until the 16th gestational week at 5Canadian Systemic Lupus International Collaborating Clinics centres (i.e. Montreal, Halifax, Quebec, Winnipeg, and Calgary) since 05/2018. Subjects are randomly assigned to receive either the specifically-designed educational tool (intervention group) or standard of care (control group). At baseline (i.e. first trimester) and second trimester visits, the participants complete self-administered preeclampsia knowledge questionnaires (scored out of 30 by the research team blinded to the intervention). We restricted the current analysis to participants enrolled in Montreal (accounting for nearly half of the total planned sample size). We performed a univariate linear regression analysis to assess the effect of the educational tool on preeclampsia knowledge (i.e. mean score difference between the two groups from baseline to second trimester visit).Results:Thirty-three pregnant SLE women were included in the study, among which 16 were exposed to the intervention and 17 were unexposed. Baseline characteristics were well balanced between the two groups with similar mean maternal age between intervention group (32.2 years, standard deviation, SD, 4.6) and control group (34.1 years, SD 4.2) and identical proportion of subjects with post-secondary education (i.e. 80%). The difference in mean preeclampsia knowledge scores between second trimester and baseline visits in the intervention group was 4.4 points (95% CI -0.1, 9.0) and in the control group was 1.5 points (95% CI -2.7, 5.7). The mean difference in knowledge scores (from baseline to second trimester) for those receiving the educational tool was 2.7 points higher (95% CI -1.5, 6.9) than those receiving standard of care.Conclusion:Approximately midway into the PREPARE trial, we observed a trend for improvement in preeclampsia knowledge from the baseline to the second trimester visit in pregnant women with SLE who received a specifically-designed educational tool compared to the control group, although the CIs included the null. Our RCT is well-poised to provide a new evidence-based approach to improve preeclampsia knowledge in pregnant women with SLE, which could help to optimize aspirin use and outcomes in this vulnerable population.References:[1]Schramm AM, Clowse ME. Aspirin for prevention of preeclampsia in lupus pregnancy. Autoimmune Dis. 2014;2014:920467. doi:10.1155/2014/920467[2]Bujold E, Roberge S, Lacasse Y, et al. Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy: a meta-analysis. Obstet Gynecol. 2010;116(2 Pt 1):402-414. doi:10.1097/AOG.0b013e3181e9322a[3]Andreoli L, Bertsias GK, Agmon-Levin N, et al. EULAR recommendations for women’s health and the management of family planning, assisted reproduction, pregnancy and menopause in patients with systemic lupus erythematosus and/or antiphospholipid syndrome. Ann Rheum Dis. 2017 Mar;76(3):476–85. doi: 10.1136/annrheumdis-2016-209770.[4]Mendel A, Bernatsky SB, Hanly JG, et al. Low aspirin use and high prevalence of preeclampsia risk factors among pregnant women in a multinational SLE inception cohort. Ann Rheum Dis. 2019;78(7):1010-1012. doi:10.1136/annrheumdis-2018-214434Disclosure of Interests:None declared.

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Evaluation of prenatal changes in fetal cardiac morphology and function in maternal diabetes mellitus using a novel fetal speckle-tracking analysis: a prospective cohort study

Cardiovascular Ultrasound ◽

10.1186/s12947-021-00256-z ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Dong Wang ◽

Caixia Liu ◽

Xinyu Liu ◽

Ying Zhang ◽

Yu Wang

Keyword(s):

Diabetes Mellitus ◽

Cohort Study ◽

Pregnant Women ◽

Gestational Age ◽

Speckle Tracking ◽

Control Group ◽

Second Trimester ◽

Cardiac Morphology ◽

Sphericity Index ◽

And Function

Abstract Background Due to metabolic changes in the second trimester and the increasing number of pregnant women with obesity and advanced maternal age, the incidence of gestational diabetes mellitus (GDM) remains high. This study aimed to evaluate the effects of GDM on fetal cardiac morphology and function, and to determine whether these changes increase with increasing estimated fetal weight (EFW). Methods Fifty-eight women with GDM (GDM group) and 58 women with a healthy pregnancy (control group) were included in this prospective observational cohort study. Each group included subgroups of 31 pregnant women with a gestational age between 24+0 weeks and 27+6 weeks as well as 27 pregnant women with a gestational age between 28+0 weeks and 40+0 weeks. For all fetuses, a cine of 2–3 s in the four-chamber view was obtained, and online speckle-tracking analysis was performed using the GE Automatic Fetal Heart Assessment Tool (fetal HQ; General Electric Healthcare Ultrasound, Zipf, Austria) to measure the global sphericity index (GSI), global longitudinal strain (GLS), fractional area change (FAC), 24-segment sphericity index (SI), and 24-segment end-diastolic diameter of the left ventricle (LV) and right ventricle (RV). Data were analyzed using the independent t-test and Wilcoxon rank-sum test, as applicable. Results The GDM group (mean HbA1c value was 5.3 ± 0.57 mmol/L) showed a lower GSI value than the control group (1.21 vs. 1.27, P = 0.000), which indicated a rounder shape of the heart. In addition, fetuses in the GDM group demonstrated significant impairment in cardiac function compared to those in the control group (LV-GLS: -18.26% vs. -22.70%, RV-GLS: -18.52% vs. -22.74%, LV-FAC: 35.30% vs. 42.36%, RV-FAC: 30.89% vs. 36.80%; P = 0.000 for all). Subgroup analyses according to gestational age (24+0–27+6 weeks and 28+0–40+0 weeks) showed that the statistical differences were retained between the GDM and control groups in each subgroup. Conclusions Fetuses of women with GDM present with signs of biventricular systolic dysfunction according to deformation analysis using fetal HQ. Additionally, the heart had a rounder shape in the GDM group than in the control group. This study showed that fetal HQ can be used to assess fetal cardiac morphology and function easily and quickly, and the effects of GDM on fetal cardiac morphology and function appeared from the second trimester. Thus, whether earlier and stricter clinical intervention was necessary remained to be further studied. Furthermore, future studies will need to supplement the effects of blood glucose levels on GLS, FAC, GSI, and 24-segment SI. Additionally, the long-term follow-up after birth should also be improved to observe the influence of changes in the indicators on the prognosis.

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Modern view on the problem of optimization of therapy in pregnant women with functional cervical insufficiency

Reports of Vinnytsia National Medical University ◽

10.31393/reports-vnmedical-2018-22(1)-33 ◽

2018 ◽

Vol 22 (1) ◽

pp. 173-177

Author(s):

V. F. Oleshko

Keyword(s):

Blood Serum ◽

Pregnant Women ◽

Main Group ◽

Control Group ◽

Cervical Insufficiency ◽

Progesterone Concentration ◽

Therapeutic Dosage ◽

Hormonal Balance ◽

Magnesium Orotate ◽

Micronized Progesterone

A functional cervical insufficiency plays an important role in the etiology of miscarriage and premature birth. The aim of research was to estimate the hormonal balance indexes during the course of pregnancy in pregnant women with functional cervical insufficiency and to correct the revealed violations in order to prevent obstetric complications. 101 pregnant women with confirmed diagnosis of a functional cervical insufficiency in term of gestation 22–32 weeks of pregnancy (the main group) and 34 pregnant women and women in labor with physiological condition of the cervix (the control group) were examined. The content of estradiol, progesterone, cortisol and prolactin was examined in the blood serum. On the second stage of examination 63 pregnant women obtained general basic therapy (I main group) and 38 pregnant women (II main group) received a developed treatment complex which included progesterone support by the micronized progesterone 200–400 mg twice a day up to 34–35 weeks of pregnancy, magnesium support by the magnesium orotate dehydrate in the therapeutic dosage and arginine glutamate in the therapeutic dosage. The correction of cervical insufficiency was performed with the help of a cervical pessary (according to indications). The examination of hormonal balance revealed an accurate decease of progesterone concentration on the background of high concentration of estradiol and increased levels of stress-associated hormones. Propitious influence of the developed therapy is proved by increase of progesterone concentration in the blood serum, normalization in stress-associated hormones balance according to gestational age. All this provideded the decrease of specific weight of threatened preterm labors, placental dysfunction, vaginitis, bacterial vaginosis and delay the labors up to 38–39 weeks of gestation in 97,4% of pregnant women (82,5% in the I main group). Prescription of micronized progesterone, magnesium orotate dehydrate, arginine glutamate to pregnant women with a cervical insufficiency is reasonable and effective one comparing with general and traditional therapy.

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COVID-19 Quarantine is a Risk Factor for Poor Pregnancy Outcomes in GDM Patients: A Retrospective Study

10.21203/rs.3.rs-836921/v1 ◽

2021 ◽

Author(s):

Qin-Yu Cai ◽

Yin Yang ◽

Ling-Ling Ruan ◽

Dang-Dang Wang ◽

Han-Lin Cui ◽

...

Keyword(s):

Pregnant Women ◽

Electronic Medical Records ◽

Pregnancy Outcomes ◽

Medical Records ◽

Control Group ◽

Second Trimester ◽

Public Health Emergencies ◽

Nuchal Cord ◽

Adverse Pregnancy ◽

Glucose Management

Abstract Aims: This study was to evaluate the effects of the home quarantine on pregnancy outcomes of gestational diabetes mellitus (GDM) patients during the COVID-19 outbreak.Methods: Thecomplete electronic medical records of GDM patients with home quarantine history were collected and classified into the home quarantine group from 24 February 2020 to 24 November 2020. The same period of GDM patients without home quarantine historywas included in the control group from 2018 and 2019.Results: A total of 1358 GDM patients were included in the analysis, including 484 in 2018, 468 in 2019, and 406 in 2020. GDM patients with home quarantine in 2020 had higher glycemic levels and worse pregnancy outcomes than 2018 and 2019, including higher cesarean section rate,lower Apgar scores, and higher incidence of macrosomia and nuchal cord. More importantly, the second trimester of home quarantine had brought a broader impactto pregnant women and fetuses.Conclusion: Home quarantine has aggravated the condition of GDM pregnant women and brought more adverse pregnancy outcomes during the COVID-19 outbreak. Therefore, we suggested that governments and hospitals should strengthen lifestyle guidance, glucose management, and antenatal care for GDM patients with home quarantine during public health emergencies.

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Depression and Anxiety Among Quarantined People, Community Workers, Medical Staff, and General Population in the Early Stage of COVID-19 Epidemic

Frontiers in Psychology ◽

10.3389/fpsyg.2021.638985 ◽

2021 ◽

Vol 12 ◽

Author(s):

Xiaoling Li ◽

Hegao Yu ◽

Weiqiang Yang ◽

Qihua Mo ◽

Zhanggui Yang ◽

...

Keyword(s):

Medical Staff ◽

General Public ◽

Early Stage ◽

Multiple Logistic Regression Analysis ◽

Depression Scale ◽

Anxiety And Depression ◽

Depression And Anxiety ◽

Cross Sectional Survey ◽

Cross Sectional ◽

Self Rating

Background: We described the prevalence of anxiety and depression related to COVID-19 pandemic among different types of population and examined their potential risk factors.Methods: A cross-sectional survey was conducted to collect demographic characteristics, exposure histories, and many other concerns about COVID-19. The Zung's self-rating anxiety scale (SAS) and self-rating depression scale (SDS), followed by a four-step multiple logistic regression analysis was performed to identify factors associated with mental health outcomes.Results: Out of 3,303 participants, the quarantined people (40.9%), community workstation staffs-policemen-volunteers (CPV) (36.4%) and general public (30.7%) reported higher percentages of depression than the general medical staff (18.4%). Moreover, the quarantined people (19.1%) also showed higher prevalence of anxiety than the general public (9.1%) and the general medical staff (7.8%). The quarantined people had the highest risk of anxiety and depression, whereas the self-rated health was negatively associated with the risks of anxiety and depression. Younger age group (18 to 30 years) showed higher risks of anxiety (OR = 6.22, 95% CI = 2.89–13.38, p < 0.001) and depression (OR = 3.69, 95% CI = 2.40–5.69, p < 0.001). People who had exposure history or contact from Hubei province after December 1, 2019 (OR = 1.57, 95% CI = 1.07–2.30, p < 0.001), had family or friends engaged in front-line health care work (OR = 1.47, 95% CI = 1.02–2.14, p < 0.001), had confirmed case nearby (OR = 2.44, 95% CI = 1.43–4.18, p < 0.001) were all more likely to suffer from anxiety. Moreover, the negligence (OR = 1.85, 95% CI = 1.37–2.51, p < 0.001) or overindulgence (OR = 1.45, 95% CI = 1.03–2.04, p < 0.001) toward the epidemic information was associated with a higher risk of depression and anxiety.Conclusions: Our findings show that the CPV and quarantined people were most at-risk population. We have identified that the young people, people with exposure histories and negligence or overindulgence toward epidemic information are in grave need of attention.

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Pengaruh suplementasi tablet fe mingguan dan harian terhadap kepatuhan minum tablet Fe dan perubahan kadar hemoglobin pada ibu hamil di Kabupaten Bantul Yogyakarta

Jurnal Gizi Klinik Indonesia ◽

10.22146/ijcn.17400 ◽

2005 ◽

Vol 2 (2) ◽

pp. 45

Author(s):

Dwi Susetyo ◽

Mohammad Hakimi ◽

Hamam Hadi

Keyword(s):

Pregnant Women ◽

Iron Status ◽

Multiple Logistic Regression Analysis ◽

Hemoglobin Level ◽

Deficiency Anemia ◽

Control Group ◽

Folate Supplementation ◽

Control Group Design ◽

Significant Difference ◽

Weekly Group

Background: In Indonesia, in 1995, 50.9% pregnant women suffer from Iron Deficiency Anemia (IDA).Objective: To compare the effect of weekly iron/folate vs standard daily iron/folate supplementation in pregnant women on compliance and hemoglobin level.Methods: The study was a quasi-experimental, non-equivalent control group design. Pregnant women with 20-28 week gestation were enrolled in this study in Bantul District. They were divided into two groups. One group (n=70), in Pajangan and Sewon Sub District, was given 120 mg iron/0,50 mg folate once a week, and the second group (n=65), in Bambang Lipuro and Pundong Sub District, received 60 mg iron/0,25 mg folate per day. Compliance with supplementation was assessed by the women self-reporting, pill count, and stool test. To measure hemoglobin level, the cyanmethemoglobin method was conducted.Results: Compliance was significantly higher in the weekly group (84.69% compared with 71.94%, p=0,004). A multiple logistic regression analysis indicated odds ratio 6.605, it means that in the weekly group compliance was 6,6 times higher than in the daily group. Hemoglobin level increased in both groups. There was no significant difference between groups for changes in hemoglobin. Initial haemoglobin values for the weekly (m=11.61 g/dl) and daily (m=11.27 g/dl) groups as well as final hemoglobin values (11.99 g/dl and 11.83 g/dl, respectively) did not differ significantly between the two groups.Conclusion: Supplementation on a weekly basis is as effective as daily supplementation in improving iron status in pregnant women. In the weekly group, compliance can be ensured.

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The Difference Of Effectiveness way to Consume Iron tablets toward haemoglobin level changes to pregnant women in second trimester at the Sindang Barang community health center in 2017

Journal Of Nursing Practice ◽

10.30994/jnp.v3i2.97 ◽

2020 ◽

Vol 3 (2) ◽

pp. 188-192

Author(s):

Triswanti ◽

Tri Maghfiroh

Keyword(s):

Vitamin C ◽

Pregnant Women ◽

Community Health ◽

Health Center ◽

Orange Juice ◽

Community Health Center ◽

Intervention Group ◽

Lemon Juice ◽

Control Group ◽

Second Trimester

Background: Giving iron tablets together with drinking orange juice can increase hemoglobin levels higher than administering iron tablets alone Purpose: This study aims to examine the differences in the effectiveness of taking iron tablets against changes in hemoglobin levels in second trimester pregnant women at Sindang Barang Bogor Community Health Center. Methods: Quasi experimental research with Pretest-Posttest Control Group Design. The sample is divided into two groups, namely the intervention group and the control group. The intervention group was given iron tablets simultaneously by drinking orange juice for 30 days. Result: The provision of iron tablets simultaneously drinking with lemon juice water is more effective than the provision of iron tablets simultaneously drinking with lemon juice water is more effective than the provision of iron tablets simultaneously drink with water in pregnant women second trimester. Conclusion: By giving vitamin C in the form of tablets or orange juice or foods or tablets of vitamin C can increase the absorption og iron pregnant women

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Effect of Psychological Intervention on Emotion of Patients with Tumor Radiotherapy

Journal of Clinical and Nursing Research ◽

10.26689/jcnr.v5i5.2522 ◽

2021 ◽

Vol 5 (5) ◽

pp. 172-176

Author(s):

Chao Wang ◽

Bo Xiang ◽

Bo Han

Keyword(s):

Immune Function ◽

Psychological Intervention ◽

Nursing Intervention ◽

Control Group ◽

Observation Group ◽

Nursing Satisfaction ◽

Widespread Application ◽

Self Rating ◽

Clinical Nursing ◽

The Difference

Objective: To explore the emotional impact of psychological nursing intervention on patients with malignant tumor radiotherapy, and further verify the specific application value of this nursing model in the oncology department. Methods: A total of 129 patients with tumor radiotherapy admitted to our hospital from June 2018 to June 2021 were selected as subjects, and they were divided into control group and observation group by random number method. Among them, 64 cases in the control group received routine clinical nursing. 65 cases in the observation group received psychological nursing intervention. Then, the clinical nursing effect, self-rating anxiety scale (SAS) score, self-rating depression scale (SDS) score, immune function level change condition and clinical nursing satisfaction were compared under the two nursing modes, in order to fully verify the clinical application value of psychological nursing intervention mode for patients with cancer radiotherapy. Results: Comparing the clinical indexes of the two groups, SDS and SAS scores of the observation group were significantly lower than those of the control group. In terms of nursing satisfaction, the observation group is 96.92% and the control group is 90.62%, the difference was significant, and had clinical statistical significance (P < 0.05); After the comprehensive evaluation of the immune function of the two groups, it was found that the observation group was significantly better than the control group, and the difference between the two groups was statistically significant (P < 0.05). Conclusion: In the mode of psychological nursing, medical staff can carry out precise psychological nursing intervention and nutritional nursing for patients according to the specific conditions and treatment process of patients, which can greatly promote the psychological stability of patients, significantly reduce patients’ negative emotions. In addition, the scientific implementation of psychological nursing intervention in the treatment of tumor radiotherapy patients can effectively strengthen the improvement of the immune function of patients, which has a very important application value to improve the physical function of patients, promotes the patient’s body rehabilitation, and is worth in the field of widespread application.

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Changes of Serum Sex Hormone-Binding Globulin, Homocysteine, and Hypersensitive CRP Levels during Pregnancy and Their Relationship with Gestational Diabetes Mellitus

Gynecologic and Obstetric Investigation ◽

10.1159/000515085 ◽

2021 ◽

pp. 1-7

Author(s):

Wenhua Liu ◽

Zheren Huang ◽

Shanshan Tang ◽

Zhifen Zhang ◽

Qing Yu ◽

...

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Pregnant Women ◽

Serum Levels ◽

First Trimester ◽

Sex Hormone Binding Globulin ◽

Control Group ◽

Second Trimester ◽

Hormone Binding ◽

Hs Crp

Background: Inflammatory response state is related to the pathogenesis of gestational diabetes mellitus (GDM). Objective: To investigate the changes of serum sex hormone-binding globulin (SHBG), homocysteine (Hcy), and hypersensitive CRP (hs-CRP) levels during pregnancy and their relationship with GDM. Methods: The nested case-control study method was used. Sixty nonobese single pregnant women diagnosed with GDM were divided into the GDM group (GDM, n = 60), together with another 60 pregnant women with normal glucose tolerance who were matched in the same period and divided into the control group (control, n = 60). The serum Hcy, hs-CRP, and SHBG levels were measured. Results: The serum levels of Hcy and hs-CRP were significantly higher in the GDM group compared with the control group, and serum levels of SHBG was significantly lower in the GDM group compared with the control group at different stages of pregnancy. The serum levels of Hcy and hs-CRP in pregnant women increased with the increase of gestational age, and serum levels of SHBG decreased with the increase of gestational age. Increased Hcy and hs-CRP levels in the second trimester and decreased SHBG levels in the first trimester were related to GDM. The odds ratio (OR) and 95% confidence interval (CI) were as follows: OR: 4.5, 95% CI: 1.5–13.0; OR: 4.2, 95% CI: 1.5–10.1; and OR: 0.4, 95% CI: 0.3–0.7, respectively. Conclusion: Increased Hcy and hs-CRP in the second trimester and decreased SHBG in the first trimester were independent predictors of GDM, which provides a new idea for early prevention and treatment of GDM.

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Obesity and body weight deficiency as predictors of gestational hypertension and cardiovascular disease

Medical Science And Education Of Ural ◽

10.36361/1814-8999-2020-21-4-122-126 ◽

2020 ◽

Vol 21 (4) ◽

pp. 112-126

Author(s):

A. D. Popov ◽

◽

T. V. Zuevskaya ◽

E. S. Chernaya ◽

E. V. Sadrieva ◽

...

Keyword(s):

Diabetes Mellitus ◽

Body Weight ◽

Cardiovascular Diseases ◽

Pregnant Women ◽

Gestational Hypertension ◽

Clinical State ◽

Control Group ◽

Clinical Group ◽

Second Trimester ◽

Microbiological Methods

Purpose of work. To reveal possible predictors of cardiovascular diseases on the basis of studying mechanisms of gestational adaptation, parameters of homeostasis in women with obesity and body weight deficiency. Material and methods. During pregnancy in 297 patients with changed body weight and 107 women of the comparison group carried out dynamic study of homeostasis parameters and adaptation mechanisms. The clinical state was assessed using morphological, electrophysiological, hormonal, biochemical and microbiological methods. Results. Analysis of anamnestic data revealed that parents of 87% of patients with obesity and weight deficit had arterial hypertension combined with atherosclerosis, obesity, diabetes mellitus, and depression. The upper distribution of subcutaneous tissue and gestational hypertension were found to be prevalent in women of the main clinical group: during the whole period, the average blood pressure was exceeded in obese women and in women with a deficit of body weight in the second trimester. General cholesterol level in the second trimester was increased due to atherogenic fractions in pregnant women of the first group up to 6.21 ± 0.13 mmol/l, in the second group – 5.95 ± 0.20 mmol/l, against the control group 4.96 ± 0.31 mmol/l. Transitor glucosuria (in case of excluded diabetes mellitus) occurred only in pregnant women with changed body weight in the 2nd trimester. Stress reactions prevailed in women with obesity and deficit of body weight on the eve of labor: 77% (1) and 88% (2), exceeding the parameters of the control group; there was also an increase in the level of norepinephrine and dioxyphenylalanine in daily excretion of urine by 4-6 times. Decrease in species landscape of intestinal and vaginal flora with increasing share of pathogenic microorganisms was registered in 91% of pregnant main groups and only in 33% of control group patients. Conclusion. In women with changed body weight, pregnancy is accompanied by excessive activation and disintegration of adaptation systems, the clinical equivalent of which is gestational hypertension, metabolic and microecology disorders. Gestational stress-test allows to estimate phylogenetic features of response systems of young women and probable ontogenetic risks of cardiovascular diseases.

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