scholarly journals Plasma Ephrin-A1 level in a cohort of diabetic retinopathy patients

2020 ◽  
Author(s):  
Danna Mao ◽  
Ying Hu ◽  
Qi Bao ◽  
Kewei Wu ◽  
Yaoding Zheng ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Human Plasma ◽  
Statistical Difference ◽  
Pearson Correlation ◽  
Fasting Blood Glucose ◽  
The Other ◽  
Spearman Correlation ◽  
Patients With Diabetes ◽  
Pearson Correlation Analysis ◽  
One Way Anova

Abstract Background: To determine plasma ephrin-A1 and VEGF165 levels in a cohort of diabetic retinopathy patients.Methods: Plasma ephrin-A1 and VEGF165 levels in fifty-five subjects including 19 individuals without diabetes (non-DM), 16 patients with diabetes (DM) but without diabetic retinopathy, and 20 patients with diabetic retinopathy (DR), were determined by ELISA. Serum creatinine, total cholesterol, fasting blood glucose and HbA1c were also measured. One-way ANOVA , Kruskal-Wallis Test, Mann-Whitney U Test corrected by Bonferroni, Pearson Correlation Analysis and Spearman Correlation Coefficient Analysis were used for data analysis.Results: Ephrin-A1 expression could be detected in human plasma with an average of 1.52 ± 0.43 (mean ± SEM) ng/ml. In DR subjects, the plasma ephrin-A1concentration was 3.63 ± 4.63 ng/ml, which was significantly higher than that of the other two groups (non-DM: 0.27 ± 0.13 ng/ml, DM: 0.35 ± 0.34 ng/ml). The expression of VEGF165 in human plasma was 34.00 ± 42.55 pg/ml, with no statistical difference among the three groups. There was no correlation between ephrin-A1 and VEGF165 in human plasma, but there was a correlation between plasma ephrin-A1 and duration of diabetes.Conclusions: Plasma ephrin-A1 was highly expressed in patients with diabetic retinopathy, and there was no difference of plasma VEGF165 expression in patients with diabetic retinopathy compared to the other two groups, suggesting that changes of plasma ephrin-A1 may be a more sensitive biomarker than plasma VEGF165 in detecting diabetic retinopathy.

scholarly journals Plasma Ephrin-A1 level in a cohort of diabetic retinopathy patients

2020 ◽  
Author(s):  
Danna Mao ◽  
Ying Hu ◽  
Qi Bao ◽  
Kewei Wu ◽  
Yaoding Zheng ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Data Analysis ◽  
Blood Glucose ◽  
Serum Creatinine ◽  
Human Plasma ◽  
Statistical Difference ◽  
Fasting Blood Glucose ◽  
The Other ◽  
Spearman Correlation ◽  
Patients With Diabetes

Abstract Background: To determine plasma Ephrin-A1 and VEGF 165 levels in a cohort of diabetic retinopathy patients. Methods: Plasma ephrin-A1 and VEGF 165 levels in fifty-five subjects including 19 individuals without diabetes (non-DM), 16 patients with diabetes (DM) but without diabetic retinopathy, and 20 patients with diabetic retinopathy (DR), were determined by ELISA. Serum creatinine, total cholesterol, fasting blood glucose and HbA1c were also measured. Mann-Whitney U analysis, independent sample T analysis and Spearman correlation coefficient analysis were used for data analysis. Results: Ephrin-A1 expression could be detected in human plasma with an average of 1.52 ± 0.43 (mean ± SEM) ng/ml. In DR subjects, the plasma ephrin-A1concentration was 3.63 ± 4.63 ng/ml, which was significantly higher than that of the other two groups (non-DM: 0.27 ± 0.13 ng/ml, DM: 0.35 ± 0.34 ng/ml). The expression of VEGF 165 in human plasma was 34.00 ± 42.55 pg/ml, with no statistical difference among the three groups. There was no correlation between Ephrin-A1 and VEGF 165 in human plasma. Conclusions: Plasma ephrin-A1 was highly expressed in patients with diabetic retinopathy, and there was no difference of plasma VEGF 165 expression in patients with diabetic retinopathy compared to the other two groups, suggesting that changes of plasma ephrin-A1 may be a more sensitive biomarker than plasma VEGF 165 in detecting diabetic retinopathy.

Serum and vitreous fibulin-1 concentrations in patients with diabetic retinopathy

2016 ◽  
Vol 64 (7) ◽  
pp. 1209-1212
Author(s):  
Meiling Tian ◽  
Jing Wang ◽  
Yuqin Wei ◽  
Qingle Lu ◽  
Baohua Huang
Keyword(s):  
Blood Pressure ◽  
Diabetic Retinopathy ◽  
Correlation Analysis ◽  
Proliferative Diabetic Retinopathy ◽  
Pearson Correlation ◽  
Density Lipoprotein ◽  
The Other ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Pearson Correlation Analysis

Fibulin-1, an extracellular matrix glycoprotein, is closely correlated with angiogenesis. The purpose of this investigation is to determine serum and vitreous fibulin-1 concentrations in diabetic retinopathy (DR). This cross-sectional investigation was carried out in a population of 154 diabetic patients (54 without DR, 42 with non-proliferative diabetic retinopathy (NPDR) and 58 with proliferative diabetic retinopathy (PDR)) and 49 control subjects. The diabetic group showed higher serum and vitreous fibulin-1 concentrations than the controls. Serum and vitreous fibulin-1 concentrations in PDR patients were significantly elevated compared with those in the other 3 groups. NPDR patients showed elevated levels of serum and vitreous fibulin-1 concentrations compared with patients without DR. Logistic regression analysis revealed that serum and vitreous fibulin-1 were risk factors for developing DR. Pearson correlation analysis showed that serum fibulin-1 was correlated with systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose and vitreous fibulin-1. Furthermore, Pearson correlation analysis showed that vitreous fibulin-1 was correlated with SBP, DBP, high-density lipoprotein cholesterol and serum fibulin-1. Serum and vitreous fibulin-1 concentrations are elevated under DR condition.

scholarly journals Comparison of Academic Suspension Levels of Faculty of Sports Sciences Students and Faculty of Education Students

2018 ◽  
Vol 8 (4) ◽  
pp. 1
Author(s):  
Latif Aydos ◽  
Haluk Koç ◽  
Hacı Ahmet Pekel
Keyword(s):  
Pearson Correlation ◽  
Education Level ◽  
Education Students ◽  
Tukey Test ◽  
Academic Suspension ◽  
Pearson Correlation Analysis ◽  
Faculty Of Education ◽  
Sports Sciences ◽  
The Relationship ◽  
One Way Anova

Faculty of Education students in terms of age, gender, active sports making, department, graduated high school,mother education level, father education level, mother profession and father occupation variables have beenexamined. A total of 364 university students studying in the Faculty of Sport Sciences and the Faculty of Educationin Gazi University, Hacettepe University and Ankara University were formed the Research group in the academicyears 2017-2018. The Academic Suspension Scale developed by Çakıcı in 2003 was used in the study. It wascompared average scores in unrelated measures, Variance Analysis (one-way ANOVA, independent sample t-test) forcomparison of mean scores in unrelated measures, the Tukey test to determine which groups had significantdifferences were used. In addition, a Pearson Correlation analysis was conducted to test the relationship between theparticles collected in the single sub-dimension. Findings obtained from this research reveal that the students ofFaculty of Sports Sciences showed more academic suspension behaviors than the students of Faculty of Education.

scholarly journals The role of zonulin in the pathogenesis of diabetic retinopathy

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Fevziye Burcu Sirin ◽  
Hakan Korkmaz ◽  
Bora Torus ◽  
Mustafa Bozkurt ◽  
Duygu Kumbul Doguc
Keyword(s):  
Diabetic Retinopathy ◽  
Statistical Difference ◽  
Fasting Blood Glucose ◽  
Serum Levels ◽  
Independent Effect ◽  
Pairwise Comparisons ◽  
Elisa Method ◽  
Duration Of Diabetes

Abstract Objectives To evaluate serum levels of zonulin and interleukin 6 (IL-6) in type 2 diabetes mellitus (T2DM) patients complicated by diabetic retinopathy and to investigate the effect of intestinal permeability on diabetic retinopathy (DR) progression. Materials and Methods Eighty-nine patients with T2DM and 30 healthy controls aged between 18 and 80 years were enrolled. T2DM patients were grouped as without DR (n=30), with non-proliferative DR (n=29), and with proliferative DR (n=30). Serum zonulin and IL-6 levels were measured with the ELISA method. Results Zonulin levels showed no statistical difference by pairwise comparisons of groups, but IL-6 levels were significantly increased in non-proliferative and proliferative DR groups compared to the HC and without DR groups. Zonulin level was correlated with body mass index and IL-6 level; IL-6 level was correlated with duration of diabetes, fasting blood glucose and HbA1c. While duration of diabetes and serum IL-6 levels had an independent effect on DR development, zonulin had no effect. Conclusions Serum zonulin levels cannot be used as a biomarker for the progression of the diabetic retinopathy complication.

scholarly journals Exploring the Multilevel Perception of Safety Climate on Taiwanese Construction Sites

2019 ◽  
Vol 11 (17) ◽  
pp. 4596 ◽  
Author(s):  
Chen ◽  
Merrett ◽  
Huang ◽  
Lu ◽  
Sun ◽  
...  
Keyword(s):  
Safety Climate ◽  
Pearson Correlation ◽  
High Rate ◽  
Comparison Analysis ◽  
Construction Sites ◽  
Management Level ◽  
Perception Of Safety ◽  
Safety Strategies ◽  
Pearson Correlation Analysis ◽  
One Way Anova

This study investigates multilevel differences in safety climate (SC) perception dimensions between management and laborers on Taiwanese construction sites. With Taiwan’s high rate of construction site safety incidents, implementing successful safety strategies requires understanding differences in SC perceptions between management and laborers. This study used a structured SC questionnaire with responses from 74 managers and 261 laborers. The analysis of collected data includes (1) descriptive statistics comparing the selected dimensions; (2) Pearson correlation analysis examining relationships between SC perception dimensions; (3) t-test and one-way ANOVA to assess relationships between the respondent’s background and SC perception dimensions; and (4) Post-Tukey comparison analysis to compare the SC perception differences between management and laborers. The results indicate that management-level staff show a higher degree of SC perception than laborer-level staff. This level of SC perception varies between individual dimensions. The strongest convergence between the two groups is observed in the dimension of ‘workmate care of each other’, and the greatest divergence is found in ‘risk decision making’. Previous studies regarding SC perception in Taiwan specifically focus on construction workers and neglect the differences in perception between management and laborers. The outcomes of this study contribute to the understanding of multilevel SC perceptions, which can be used in the development of targeted strategies to improve SC on construction sites.

scholarly journals Does Tax Knowledge Motivate Tax Compliance in Malaysia?

2021 ◽  
Vol 12 (1) ◽  
pp. 238
Author(s):  
Sahari Salawati ◽  
Nivakan Sritharan ◽  
Sharon Cheuk Choy Sheung ◽  
Ahmad Syubaili Mohamed
Keyword(s):  
Pearson Correlation ◽  
Tax Compliance ◽  
Demographic Variables ◽  
Survey Method ◽  
Tax Law ◽  
Compliance Level ◽  
Pearson Correlation Analysis ◽  
The Individual ◽  
The Relationship ◽  
One Way Anova

This study aims to clarify whether tax knowledge of individual taxpayers motivates tax compliance in Malaysia. Studies with similar topics express the fact that there still exists a gap in profiling the demographic characteristics of knowledgeable taxpayers and better compliant taxpayers in Malaysia. Age, gender, income groups, and education level were the demographic variables used to study the association. The study applied a survey method for data collection. The population targeted was the individual taxpayers across Malaysia, whereby a sample of 419 respondents involved in this study. T-test, One-Way ANOVA, and Pearson correlation analysis had been employed to analyse the data. The outcome of the study reveals that knowledgeable taxpayers are not better tax complaining of taxpayers in Malaysia. Further, the relationship between tax knowledge and tax compliance is negative and insignificant. This paper studied the association of tax knowledge with tax compliance level, which attempt to contribute to the literature and aids tax administration to intensify not only tax law educations but also tax penalties for tax evaders.

scholarly journals The Phase Shift Correlation function uncovers periodic Ulcerative Colitis microbiome relationships without temporal sampling

2020 ◽  
Author(s):  
Robert E. Brown ◽  
Alena Arlova ◽  
Patrick M. Gillevet
Keyword(s):  
Ulcerative Colitis ◽  
Correlation Function ◽  
Phase Shift ◽  
Pearson Correlation ◽  
The Other ◽  
Biological Processes ◽  
Spearman Correlation ◽  
Temporal Sampling ◽  
Phase Variance ◽  
Microbiome Data

AbstractCorrelation analysis is a fundamental technique to determine potential relationships within biological processes. However, many biological processes have been shown to function in a periodic manner. When modeling correlations, the fluctuations that are associated with periodicity cause significant issues. We have implemented a Phase Shift Correlation (PSC) algorithm, with a corresponding value PSCrho, to address the periodicity and phase variance associated with features that vary with the same frequency -- but are phase shifted. The phase shift could well indicate causality with one feature’s quantitative change leading to the change in the other feature.We applied the PSC algorithm to Ulcerative Colitis (UC) microbiome data and compared the resulting feature relationships with the equivalent Spearman correlation function results. PSC located many instances of higher phase shifted correlations, where the corresponding Pearson correlation was low.

The Influence of Single-Clause Sentences on IELTS Writing Task 2 Band Score

2021 ◽  
Vol 2 (1) ◽  
pp. 23-39
Author(s):  
Thanh Tan Tran ◽  
Dinh Minh Dang Truong
Keyword(s):  
Comparative Research ◽  
Quantitative Method ◽  
Pearson Correlation ◽  
Descriptive Analysis ◽  
Negative Relationship ◽  
The Other ◽  
Significant Difference ◽  
Pearson Correlation Analysis ◽  
The Relationship ◽  
Writing Task

This research aims to investigate the frequencies of single-clause sentences (SS) and multi-clause sentences (MS) used by IELTS test-takers in writing task 2 and the relationship between their use of single-clause sentences and band score in this section. The researcher used the descriptive comparative research design and the quantitative method design with convenient sampling with fifty (50) sample essays mainly sourced from the set of Cambridge English IELTS Academic books. After collecting the data, the researchers analyzed the data using statistical and descriptive analysis. The result shows that the percentages of single-clause and multi-clause sentences in the range between 0 and 6.0 bands are relatively equal. On the other hand, these percentages in the range of 6.5-9.0 have a significant difference. Additionally, the results of Pearson Correlation Analysis show that the frequency of single-clause sentences has an insignificant negative relationship with the IELTS writing task 2 band score. Therefore, IELTS writing task 2 compositions with more single-clause sentences are potentially graded with a lower band score.

Comparative Study of Proactivators of the Fibrinolysin System in Three Mammalian Species

1969 ◽  
Vol 21 (03) ◽  
pp. 594-603 ◽  
Author(s):  
Y Takada ◽  
A Takada ◽  
J. L Ambrus
Keyword(s):  
Guinea Pig ◽  
Comparative Study ◽  
Human Plasma ◽  
Mammalian Species ◽  
Gel Filtration ◽  
Plasminogen Activators ◽  
The Other ◽  
Rabbit Plasma ◽  
Plate Test ◽  
Fibrin Plate

SummarySephadex gel filtration of human plasma gave results suggesting the presence of two proactivators of plasminogen, termed proactivators A and B.Activity resembling that of proactivator A was found in rabbit plasma, but not in guinea pig plasma.Plasminogen activators produced by the interaction of proactivator A of human plasma with streptokinase had no caseinolytic or TAMe esterolytic effect.Proactivator A can be separated in a form apparently free from plasminogen, as shown by the heated fibrin plate test and by immunological analysis. On the other hand, proactivator B concentrates prepared so far are contamined with plasminogen.Human proactivators appear to be far more susceptible to streptokinase than are rabbit proactivators.Inhibitors of the fibrinolysin system were observed in the plasmas of all 3 species. These inhibitors are not present in the euglobulin fraction of plasma. Sephadex fractionation of euglobulin fractions results in proactivator preparations that do not contain inhibitors.

Pengaruh Kotbah, Musik Gereja Dan Fasilitas Gereja Terhadap Tingkat Kehadiran Jemaat

2016 ◽  
Vol 1 (1) ◽  
pp. 1-15
Author(s):  
Frederich Oscar Lontoh
Keyword(s):  
Regression Analysis ◽  
Multiple Regression Analysis ◽  
Church Music ◽  
Pearson Correlation ◽  
Descriptive Analysis ◽  
Target Population ◽  
The Other ◽  
Pearson Correlation Coefficient ◽  
Christian Church ◽  
The City

This research is titled " The influence of sermon, church music and church facilities on the level of attendance”. The purpose of research is to identify and analyze whether sermon, church music and church facilities have influence on the the level of attendance. The target population in this study is a Christian church members who live in the city of Surabaya.. Sample required is equal to 47 respondents. Through sampling stratified Random techniques.These influence was measured using Pearson correlation coefficient and multiple regression analysis, t-test and analysis of variance. Descriptive  analysis  were taken to analyze the level of attendance according to demographic groups.The hypothesis in this study are the sermon, church music and church facilities have positive and significant on the level of attendance. The results showed that collectively, there are positive and significant correlation among the sermon, church music and church facilities on the level of attendance  96,2%. It means that 96,2 % of level of attendance influenced by sermon, church music and church facilities and the other 28,9% by others. All of the variable partially have significant correlation to level of attendance.

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