scholarly journals Effect of individual- versus collective-based nutritional-lifestyle intervention on the atherogenic index of plasma in children with obesity: a randomized trial

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Elvira Verduci ◽  
Giuseppe Banderali ◽  
Elisabetta Di Profio ◽  
Sara Vizzuso ◽  
Gianvincenzo Zuccotti ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Lifestyle Intervention ◽  
Body Mass ◽  
Univariate Analysis ◽  
Atherogenic Index ◽  
Z Score ◽  
Blood Profile ◽  
Atherogenic Index Of Plasma ◽  
Paediatric Obesity ◽  
The Individual

Abstract Background The Atherogenic Index of Plasma is a predictive biomarker of atherosclerosis in adults but there is a lack of studies in paediatric population aimed at evaluating the longitudinal changes of the AIP and of the cardiometabolic blood profile related to nutritional interventions. The aim of this study was to compare the effect of individual- versus collective-based nutritional-lifestyle intervention on the Atherogenic Index of Plasma in schoolchildren with obesity. Methods One-hundred sixty-four children aged 6–12 years with Body Mass Index z-score > 2 referred to the Paediatric Obesity Clinic, San Paolo Hospital, Milan, Italy, were consecutively enrolled and randomized to undergo to either an individual- (n = 82) or a collective- (n = 82) based intervention promoting a balanced normo-caloric diet and physical activity. In addition, the individual intervention included a tailored personalized nutritional advice and education based on the revised Coventry, Aberdeen, and London-Refined taxonomy. Both at baseline and after 12 months of intervention, dietary habits and anthropometric measures were assessed, a fasting blood sample were taken for biochemistry analysis. Results The participation rate at 12 months was 93.3% (n = 153 patients), 76 children in the individual-intervention and 77 children in the collective intervention. At univariate analysis, mean longitudinal change in Atherogenic Index of Plasma was greater in the individual than collective intervention (− 0.12 vs. − 0.05), as well as change in triglyceride-glucose index (− 0.22 vs. − 0.08) and Body Mass Index z-score (− 0.59 vs. − 0.37). At multiple analysis, only change in Body Mass Index z-score remained independently associated with intervention (odds ratio 3.37). Conclusion In children with obesity, an individual-based nutritional and lifestyle intervention, including techniques from the CALO-RE taxonomy, could have an additional beneficial effect over a collective-based intervention, although the actual size of the effect remains to be clarified. Trial Registration Clinical Trials NCT03728621

Comorbidities in Primary vs Secondary School Children With Obesity and Responsiveness to Lifestyle Intervention

2019 ◽  
Vol 104 (9) ◽  
pp. 3803-3811 ◽  
Author(s):  
Kylie Karnebeek ◽  
Supriya Thapar ◽  
Maartje Willeboordse ◽  
Onno C P van Schayck ◽  
Anita C E Vreugdenhil
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Secondary School ◽  
Primary School ◽  
Lifestyle Intervention ◽  
Body Mass ◽  
School Children ◽  
Interquartile Range ◽  
Primary School Children ◽  
Z Score

AbstractContextChildhood obesity increases the risk of diseases as diabetes, cardiovascular disease, and nonalcoholic fatty liver disease.ObjectiveTo evaluate the prevalence of comorbidities in school-age children with obesity and to compare its prevalence and the effect of a lifestyle intervention between children in primary and secondary school and between boys and girls.DesignCross-sectional analysis and lifestyle intervention.SettingCentre for Overweight Adolescent and Children’s Healthcare.PatientsComorbidities were evaluated in 149 primary and 150 secondary school children with (morbid) obesity (162 girls). The effect of lifestyle intervention was studied in 82 primary and 75 secondary school children.InterventionOne-year interdisciplinary lifestyle intervention.ResultsInsulin resistance (37%), impaired glucose tolerance (IGT) (3%), dyslipidemia (48%), hypertension (7%), and elevated liver transaminase levels (54%) were already common in primary school children. Glomerular hyperfiltration and insulin resistance were more prevalent in secondary school children. IGT was more prevalent in girls. The change in body mass index z score after intervention was greater in primary school children (primary vs secondary: −0.25 ± 0.32 vs −0.11 ± 0.47), even as the change in low-density lipoprotein cholesterol concentrations [primary vs secondary: −0.30 (interquartile range, −0.70 to 0.10) vs −0.10 (interquartile range, −0.40 to 0.30)] and systolic blood pressure z score (primary vs secondary: −0.32 ± 1.27 vs 0.24 ± 1.3). The change in body mass index z score, but not in comorbidities, was greater in boys (boys vs girls: −0.33 ± 0.45 vs −0.05 ± 0.31).ConclusionsThe presence of comorbidities is already evident in primary school children with obesity. The effect of a lifestyle intervention on these comorbidities is greater in primary compared with secondary school children, stressing the need for early interventions.

scholarly journals Atherogenic index of plasma predicts cerebrovascular accident occurrence in antineutrophil cytoplasmic antibody-associated vasculitis

2020 ◽  
Author(s):  
Sung Soo Ahn ◽  
Lucy Eunju Lee ◽  
Jung Yoon Pyo ◽  
Jason Jungsik Song ◽  
Yong-Beom Park ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Cerebrovascular Accident ◽  
Multivariable Analysis ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Immunosuppressive Drug ◽  
Atherogenic Index ◽  
Atherogenic Index Of Plasma ◽  
And Gender

Abstract Background: We investigated whether the atherogenic index of plasma (AIP) at diagnosis can predict cerebrovascular accident (CVA) and cardiovascular disease during follow-up in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Methods: The medical records of 167 immunosuppressive drug-naïve AAV patients and those of 300 age- and gender-matched controls were retrospectively reviewed. AIP was calculated using the following equation: AIP = Log (triglyceride (mmol/L) / high-density-cholesterol (mmol/L)). AAV patients were divided into two groups according to their AIP, AAV patients with AIP < 0.11 (N=115) and AAV patients with AIP ≥ 0.11 (N=52). Results: The median age and body mass index of AAV patients were 59.0 years and 22.1 kg/m2, respectively. The median calculated AIP of patients was 0.01 and AAV patients with AIP < 0.11 exhibited a lower Birmingham vasculitis activity score than those with AIP ≥ 0.11 but it was not significant (P = 0.064). AAV patients had a significantly lower body mass index than controls, nevertheless, AAV patients had a significantly higher AIP than controls (0.01 vs. -0.12). Sixteen patients were diagnosed with CVA, and AAV patients with AIP ≥ 0.11 had a significantly lower CVA-free survival rate than those with AIP < 0.11. Multivariable analysis indicated that AIP ≥ 0.11 at diagnosis was significantly associated with CVA during follow-up. Conclusions: AIP was significantly higher in AAV patients than in controls. Furthermore, AIP at diagnosis could predict CVA occurrence during follow-up in AAV patients.

Prognostic significance of body mass index in breast cancer patients with hormone receptor-positive tumours after curative surgery

2013 ◽  
Vol 36 (6) ◽  
pp. 297 ◽  
Author(s):  
Peng Xing ◽  
Ji-Guang Li ◽  
Feng Jin ◽  
Ting-Ting Zhao ◽  
Qun Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Mass Index ◽  
Body Mass ◽  
Hormone Receptor ◽  
Univariate Analysis ◽  
Prognostic Significance ◽  
Axillary Lymph ◽  
Nodal Stage ◽  
Hormone Receptor Positive ◽  
High Bmi

Purpose: Obesity has been recognized as a significant risk factor for postmenopausal breast cancer. The aim of this study is to investigate the prognostic significance of body mass index (BMI) in hormone receptor-positive, operable breast cancer. Methods: In this retrospective cohort study, 1,192 consecutive patients with curative resection of primary breast cancer were enrolled. Patients were assigned to two groups according to BMI: normal or underweight (BMI < 23.0 kg/m2) and overweight or obese (BMI ≥23.0 kg/m2). Associations among BMI and clinicopathological characteristics and prognosis of patients were assessed. Results: A high BMI was significantly (P < 0.01) correlated with age, nodal stage, ALNR, ER positivity, PR positivity and menopausal status at diagnosis. Univariate analysis revealed that BMI, pathologic T stage, nodal stage, axillary lymph node ratio (ALNR) and adjuvant radiotherapy history were significantly (P < 0.05) associated with disease-free survival and overall survival, irrespective of tumour hormone receptor status. Multivariate analysis revealed BMI as an independent prognostic factor in all cases and in hormone receptor-positive cases. Conclusion: A high BMI (≥23.0 kg/m^2) is independently associated with poor prognosis in hormone receptor-positive breast cancer.

scholarly journals Serum Periostin as a Potential Biomarker in Pediatric Patients with Primary Hypertension

2021 ◽  
Vol 10 (10) ◽  
pp. 2138
Author(s):  
Michał Szyszka ◽  
Piotr Skrzypczyk ◽  
Anna Stelmaszczyk-Emmel ◽  
Małgorzata Pańczyk-Tomaszewska
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Uric Acid ◽  
Body Mass ◽  
Pediatric Patients ◽  
Univariate Analysis ◽  
Primary Hypertension ◽  
Potential Biomarker ◽  
Arterial Damage ◽  
Serum Periostin

Experimental studies suggest that periostin is involved in tissue repair and remodeling. The study aimed to evaluate serum periostin concentration as potential biomarker in pediatric patients with primary hypertension (PH). We measured serum periostin, blood pressure, arterial damage, biochemical, and clinical data in 50 children with PH and 20 age-matched healthy controls. In univariate analysis, children with PH had significantly lower serum periostin compared to healthy peers (35.42 ± 10.43 vs. 42.16 ± 12.82 [ng/mL], p = 0.038). In the entire group of 70 children serum periostin concentration correlated negatively with peripheral, central, and ambulatory blood pressure, as well as with aortic pulse wave velocity (aPWV). In multivariate analysis, periostin level significantly correlated with age (β = −0.614, [95% confidence interval (CI), −0.831–−0.398]), uric acid (β = 0.328, [95%CI, 0.124–0.533]), body mass index (BMI) Z-score (β = −0.293, [95%CI, −0.492–−0.095]), high-density lipoprotein (HDL)-cholesterol (β = 0.235, [95%CI, 0.054–0.416]), and triglycerides (β = −0.198, [95%CI, −0.394–−0.002]). Neither the presence of hypertension nor blood pressure and aPWV influenced periostin level. To conclude, the role of serum periostin as a biomarker of elevated blood pressure and arterial damage in pediatric patients with primary hypertension is yet to be unmasked. Age, body mass index, uric acid, and lipid concentrations are key factors influencing periostin level in pediatric patients.

Major post-prostate biopsy complications under antibiotic augmentation prophylaxis protocol

2021 ◽  
pp. 205141582098403
Author(s):  
Antônio Antunes Rodrigues ◽  
Valdair Muglia ◽  
Emanuel Veras de Albuquerque ◽  
Rafael Ribeiro Mori ◽  
Rafael Neuppmann Feres ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Antibiotic Prophylaxis ◽  
Body Mass ◽  
Bacterial Resistance ◽  
Univariate Analysis ◽  
Specific Antigen ◽  
Outlet Obstruction ◽  
Psa Density ◽  
Biopsy Complications

Objective: To identify risk factors for major post-biopsy complications under augmented prophylaxis protocol. The risk factors already described mainly comprise outdated antibiotic prophylaxis protocols. Material and methods: This retrospective cohort study included patients that underwent transrectal ultrasound-guided biopsies, from 2011 to 2016. All patients had received antibiotic prophylaxis with ciprofloxacin and gentamicin. Patients were grouped according to the presence or absence of post-biopsy complications. Demographic variables and possible risk factors based on routine clinical assessment were registered. Correlation tests, univariate and multivariate analyses were used to identify risk factors for post-biopsy complications. Results: Of the 404 patients that were included, 25 (6.2%) presented 27 post-biopsy complications, distributed as follows: acute urinary retention ( n = 14, 3.5%), infections ( n = 11, 2.7%) and hemorrhage ( n = 2, 0.5%). On univariate analysis, patients who presented complications showed higher body mass index and post-voiding residual volumes. Multivariate analysis identified ethnicity and prostate-specific antigen (PSA) density as possible risk factors for biopsy complications. The presence of bacterial resistance identified by rectal swabs did not correlate with the incidence of complications and infections. Conclusions: Non-infectious post-biopsy complications were more frequent than infectious ones in this cohort. Higher post-voiding residual volumes and PSA density, that indicates prostate enlargement, were identified as risk factors and interpreted as secondary to bladder outlet obstruction. The higher body mass index and ethnicity were also identified as risk factors and attributed to the heterogeneity of the patients included. Level of evidence: Not applicable for this multicentre audit.

scholarly journals Life course body mass index and risk of knee osteoarthritis at the age of 53 years: evidence from the 1946 British birth cohort study

2011 ◽  
Vol 71 (5) ◽  
pp. 655-660 ◽  
Author(s):  
Andrew K Wills ◽  
Stephanie Black ◽  
Rachel Cooper ◽  
Russell J Coppack ◽  
Rebecca Hardy ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Knee Osteoarthritis ◽  
Birth Cohort ◽  
Body Mass ◽  
Prolonged Exposure ◽  
Birth Cohort Study ◽  
Activity Levels ◽  
Z Score ◽  
Knee Oa ◽  
High Bmi

IntroductionThe authors examined how body mass index (BMI) across life is linked to the risk of midlife knee osteoarthritis (OA), testing whether prolonged exposure to high BMI or high BMI at a particular period has the greatest influence on the risk of knee OA.MethodsA population-based British birth cohort of 3035 men and women underwent clinical examination for knee OA at age 53 years.Heights and weights were measured 10 times from 2 to 53 years. Analyses were stratified by gender and adjusted for occupation and activity levels.ResultsThe prevalence of knee OA was higher in women than in men (12.9% (n=194) vs 7.4% (n=108)). In men, the association between BMI and later knee OA was evident at 20 years (p=0.038) and remained until 53 years (OR per z-score 1.38 (95% CI 1.11 to 1.71)). In women, there was evidence for an association at 15 years (p=0.003); at 53 years, the OR was 1.89 (95% CI 1.59 to 2.24) per z-score increase in BMI. Changes in BMI from childhood in women and from adolescence in men were also positively associated with knee OA. A structured modelling approach to disentange the way in which BMI is linked to knee OA suggested that prolonged exposure to high BMI throughout adulthood carried the highest risk and that there was no additional risk conferred from adolescence once adult BMI had been accounted for.ConclusionThis study suggests that the risk of knee OA accumulates from exposure to a high BMI through adulthood.

scholarly journals Influence of Rescuers’ Gender and Body Mass Index on Cardiopulmonary Resuscitation according to the American Heart Association 2010 Resuscitation Guidelines

2015 ◽  
Vol 2015 ◽  
pp. 1-5
Author(s):  
Ahmad Jaafar ◽  
Mohammad Abdulwahab ◽  
Eman Al-Hashemi
Keyword(s):  
Body Mass Index ◽  
Cardiopulmonary Resuscitation ◽  
Body Mass ◽  
American Heart Association ◽  
American Heart ◽  
Heart Association ◽  
Resuscitation Guidelines ◽  
The Mean ◽  
The Individual ◽  
Cpr Training

Background and Objectives. The quality of cardiopulmonary resuscitation (CPR) is an important factor in determining its overall outcome. This study aims to test the association between rescuers’ gender, Body Mass Index (BMI), and the accuracy of chest compressions (CC) as well as ventilation, according to American Heart Association (AHA) 2010 resuscitation guidelines. Methods. The study included 72 participants of both genders. All the participants received CPR training according to AHA 2010 resuscitation guidelines. One week later, an assessment of their CPR was carried out. Moreover, the weight and height of the participants were measured in order to calculate their BMI. Results. Our analysis showed no significant association between gender and the CC depth (P=0.53) as well as between gender and ventilation (P=0.42). Females were significantly faster than males in CC (P=0.000). Regarding BMI, participants with a BMI less than the mean BMI of the study sample tended to perform CC with the correct depth (P=0.045) and to finish CC faster than those with a BMI more than the mean (P=0.000). On the other hand, no significant association was found between BMI and ventilation (P=0.187). Conclusion. CPR can be influenced by factors such as gender and BMI, as such the individual rescuer and CPR training programs should take these into account in order to maximize victims’ outcome.

Fecal Bacterial Communities Differ by Lactation Status in Post-Partum Women and Their Infants

2021 ◽  
pp. 089033442110603
Author(s):  
Eliot N. Haddad ◽  
Lynn E. Ferro ◽  
Kathleen E. B. Russell ◽  
Kameron Y. Sugino ◽  
Jean M. Kerver ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Gut Microbiota ◽  
Human Milk ◽  
Body Mass ◽  
Beta Diversity ◽  
Bifidobacterium Longum ◽  
Univariate Analysis ◽  
Body Mass Index Category ◽  
Fecal Samples ◽  
Milk Feeding

Background: Previous research examined effects of human milk on the infant gut microbiota, but little attention has been given to the microbiota of lactating women. Research Aim: To determine associations between exclusive human milk feeding and gut microbiota characteristics in mothers and infants at 6-weeks postpartum. Methods: A sample of mother–infant dyads ( N = 24) provided fecal samples and questionnaire responses at 6-weeks postpartum as part of the Pregnancy, EAting & POstpartum Diapers study. Deoxyribonucleic acid was extracted from stool samples, followed by (V4) 16S ribosomal ribonucleic acid gene amplicon sequencing. Alpha and beta diversity, in addition to taxa differences, were compared by human milk exposure status, exclusive versus non-exclusive. A subset of dyads (those exclusively fed human milk; n = 14) was analyzed for shared bifidobacterial species using polymerase chain reaction. Results: Alpha diversity was significantly lower in exclusively human milk-fed infants. Maternal lactation status (exclusive vs. partial) and Shannon diversity were associated in univariate analysis but were no longer associated in multivariable regression including body mass index category in the model. Beta diversity (Sorensen dissimilarity) of fecal samples from women and infants was significantly associated with human milk feeding. Of six infants with Bifidobacterium longum subspecies longum in their fecal samples, all their mothers shared the same species. Conclusion: Maternal gut microbiotas differ by lactation status, a relationship potentially confounded by body mass index category. Further research is needed to identify whether lactation directly influences the maternal gut microbiota, which may be another mechanism by which lactation influences health.

scholarly journals Completeness and accuracy of anthropometric measurements in electronic medical records for children attending primary care

2018 ◽  
Vol 25 (1) ◽  
pp. 19-26 ◽  
Author(s):  
Sarah Carsley ◽  
Catherine S. Birken ◽  
Patricia C. Parkin ◽  
Eleanor Pullenayegum ◽  
Karen Tu
Keyword(s):  
Primary Care ◽  
Body Mass Index ◽  
Electronic Medical Records ◽  
Body Mass ◽  
Medical Records ◽  
Data Access ◽  
World Health ◽  
Z Score ◽  
Data Completeness ◽  
Weight Data

BackgroundElectronic medical records (EMRs) from primary care may be a feasible source of height and weight data. However, the use of EMRs in research has been impeded by lack of standardisation of EMRs systems, data access and concerns about the quality of the data.ObjectivesThe study objectives were to determine the data completeness and accuracy of child heights and weights collected in primary care EMRs, and to identify factors associated with these data quality attributes.MethodsA cross-sectional study examining height and weight data for children <19 years from EMRs through the Electronic Medical Record Administrative data Linked Database (EMRALD), a network of family practices across the province of Ontario. Body mass index z-scores were calculated using the World Health Organization Growth Standards and Reference.ResultsA total of 54,964 children were identified from EMRALD. Overall, 93% had at least one complete set of growth measurements to calculate a body mass index (BMI) z-score. 66.2% of all primary care visits had complete BMI z-score data. After stratifying by visit type 89.9% of well-child visits and 33.9% of sick visits had complete BMI z-score data; incomplete BMI z-score was mainly due to missing height measurements. Only 2.7% of BMI z-score data were excluded due to implausible values.ConclusionsData completeness at well-child visits and overall data accuracy were greater than 90%. EMRs may be a valid source of data to provide estimates of obesity in children who attend primary care.

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